Journal of Clinical Oncology




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Flashback Foreword: Gemcitabine for Advanced Pancreatic Cancer.

O'Reilly, Eileen M. MD 1,2,3,,; Ko, Andrew H. MD 3,4,; Friedberg, Jonathan W. MD, MMSc 5,6,7,

doi : 10.1200/JCO.23.01895

Volume 41(36) pgs. 5479-5595,e73-e74 December 20, 2023

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JCO Flashback: Comparing the Performance of Gemcitabine With 5-FU in Treating Advanced Pancreatic Cancer (1997).

doi : 10.1200/JCO.23.02032

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Improvements in Survival and Clinical Benefit With Gemcitabine as First-Line Therapy for Patients With Advanced Pancreas Cancer: A Randomized Trial.

Burris, H A 3rd; Moore, M J; Andersen, J; Green, M R; Rothenberg, M L; Modiano, M R; Cripps, M C; Portenoy, R K; Storniolo, A M; Tarassoff, P; Nelson, R; Dorr, F A; Stephens, C D; Von Hoff, D D

doi : 10.1200/JCO.22.02777

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Maximizing Extent of Resection for Noneloquent Glioblastoma: Fluorescent Dye or Intraoperative Magnetic Resonance Imaging?.

Banu, Matei A. MD 1,; McKhann, Guy M. MD 1,,

doi : 10.1200/JCO.23.00963

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Bayesian Adaptive Randomization: Full of Promise With a Helping of Caution.

Onar-Thomas, Arzu PhD 1,,

doi : 10.1200/JCO.23.01485

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Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits.

Madan, Ravi A. MD 1,,; Karzai, Fatima MD 1; VanderWeele, David J. MD, PhD 2,; Cheng, Heather H. MD, PhD 3,; de Bono, Johann S. MD, PhD, MSc, FRCP, FMedSci 4,5,

doi : 10.1200/JCO.23.01502

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First-Line Pembrolizumab + Chemotherapy Versus Placebo + Chemotherapy for Persistent, Recurrent, or Metastatic Cervical Cancer: Final Overall Survival Results of KEYNOTE-826.

Monk, Bradley J. MD, FACS, FACOG 1,,; Colombo, Nicoletta MD, PhD 2,3,; Tewari, Krishnansu S. MD 4,; Dubot, Coraline MD 5; Caceres, M. Valeria MD, PhD 6; Hasegawa, Kosei MD, PhD 7,; Shapira-Frommer, Ronnie MD 8,; Salman, Pamela MD 9,; Yanez, Eduardo MD 10,; Gumus, Mahmut MD 11,; Olivera Hurtado de Mendoza, Mivael MD 12; Samouelian, Vanessa MD, PhD 13,; Castonguay, Vincent MD 14,; Arkhipov, Alexander MD, PhD 15; Tekin, Cumhur MD 16,; Li, Kan PhD 16,; Keefe, Stephen M. MD 16,; Lorusso, Domenica MD, PhD 17,; on behalf of the KEYNOTE-826 Investigators

doi : 10.1200/JCO.23.00914

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Intraoperative MRI-Guided Resection Is Not Superior to 5-Aminolevulinic Acid Guidance in Newly Diagnosed Glioblastoma: A Prospective Controlled Multicenter Clinical Trial.

Roder, Constantin MD 1,; Stummer, Walter MD 2,; Coburger, Jan MD 3,; Scherer, Moritz MD 4; Haas, Patrick MD 1; von der Brelie, Christian MD 5,6; Kamp, Marcel Alexander MD 7,8; Lohr, Mario MD 9; Hamisch, Christina A. MD 10; Skardelly, Marco MD 1,11; Scholz, Torben MD 12; Schipmann, Stephanie MD; PhD 2,13,; Rathert, Julian MD 14,; Brand, Catrin Marlene MD 15; Pala, Andrej MD 3; Ernemann, Ulrike MD 16; Stockhammer, Florian MD 15; Gerlach, Rudiger MD 14; Kremer, Paul MD 12; Goldbrunner, Roland MD 10,; Ernestus, Ralf-Ingo MD 9; Sabel, Michael MD 7,; Rohde, Veit MD 5,; Tabatabai, Ghazaleh MD, PhD 17,; Martus, Peter PhD 18; Bisdas, Sotirios MD, PhD 19,; Ganslandt, Oliver MD 20; Unterberg, Andreas MD 4,; Wirtz, Christian Rainer MD 3; Tatagiba, Marcos MD 1

doi : 10.1200/JCO.22.01862

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Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization.

Rahman, Rifaquat MD 1,2,; Trippa, Lorenzo PhD 1,; Lee, Eudocia Q. MD, MPH 1,2,; Arrillaga-Romany, Isabel MD, PhD 3,; Fell, Geoffrey MS 1; Touat, Mehdi MD 2,4,; McCluskey, Christine BA 1; Wiley, Jennifer BA 1; Gaffey, Sarah MBA 1,; Drappatz, Jan MD 5,; Welch, Mary R. MD 6,; Galanis, Evanthia MD 7,; Ahluwalia, Manmeet S. MD 8,; Colman, Howard MD, PhD 9,; Nabors, L. Burt MD 10,; Hepel, Jaroslaw MD 11; Elinzano, Heinrich MD 11; Schiff, David MD 12,; Chukwueke, Ugonma N. MD, MPH 1,2,; Beroukhim, Rameen MD, PhD 1,2,; Nayak, Lakshmi MD 1,2,; McFaline-Figueroa, J. Ricardo MD, PhD 1,2; Batchelor, Tracy T. MD, MPH 1,2,; Rinne, Mikael L. MD, PhD 1,; Kaley, Thomas J. MD 13; Lu-Emerson, Christine MD 14,; Mellinghoff, Ingo K. MD 13,; Bi, Wenya Linda MD, PhD 1,2,; Arnaout, Omar MD 2; Peruzzi, Pier Paolo MD, PhD 2,; Haas-Kogan, Daphne MD, PhD 1,2,; Tanguturi, Shyam MD 1,2,; Cagney, Daniel MD 15; Aizer, Ayal MD 1,2,; Doherty, Lisa NP 1; Lavallee, Maria MPH 1; Fisher-Longden, Brittany MPH 1,; Dowling, Shanna MPH 1; Geduldig, Jack BSc 1; Watkinson, Fiona BSc 1; Pisano, William BSc 1; Malinowski, Seth MBE 1; Ramkissoon, Shakti MD, PhD 1,; Santagata, Sandro MD, PhD 2; Meredith, David M. MD, PhD 2; Chiocca, E. Antonio MD, PhD 2,; Reardon, David A. MD 1,2,; Alexander, Brian M. MD, MPH 1,2,; Ligon, Keith L. MD, PhD 1,2,; Wen, Patrick Y. MD 1,2,,

doi : 10.1200/JCO.23.00493

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Tisotumab Vedotin in Combination With Carboplatin, Pembrolizumab, or Bevacizumab in Recurrent or Metastatic Cervical Cancer: Results From the innovaTV 205/GOG-3024/ENGOT-cx8 Study.

Vergote, Ignace MD, PhD 1,,; Van Nieuwenhuysen, Els MD, PhD 1,; O'Cearbhaill, Roisin E. MD 2,; Westermann, Anneke MD, PhD 3; Lorusso, Domenica MD, PhD 4,; Ghamande, Sharad MD 5,; Collins, Dearbhaile C. PhD, MBBCh, MA 6,; Banerjee, Susana PhD, MBBS, MA, FRCP 7,; Mathews, Cara A. MD 8,; Gennigens, Christine MD, PhD 9,; Cibula, David MD, PhD 10,; Tewari, Krishnansu S. MD 11,; Madsen, Kristine MD 12,; Kose, Fatih MD 13,; Jackson, Amanda L. MD 14,; Boere, Ingrid A. MD, PhD 15,; Scambia, Giovanni MD 16,; Randall, Leslie M. MD 17,; Sadozye, Azmat MBBS 18; Baurain, Jean-Francois MD, PhD 19,; Gort, Eelke MD, PhD 20; Zikan, Michal MD, PhD 21; Denys, Hannelore G. MD, PhD 22,; Ottevanger, Nelleke MD, PhD 23,; Forget, Frederic MD 24,; Mondrup Andreassen, Camilla PhD 25,; Eaton, Lamar BS 26; Chisamore, Michael J. PhD 27,; Viana Nicacio, Leonardo MD 28,; Soumaoro, Ibrahima MD 26,; Monk, Bradley J. MD 29,

doi : 10.1200/JCO.23.00720

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Patritumab Deruxtecan (HER3-DXd), a Human Epidermal Growth Factor Receptor 3-Directed Antibody-Drug Conjugate, in Patients With Previously Treated Human Epidermal Growth Factor Receptor 3-Expressing Metastatic Breast Cancer: A Multicenter, Phase I/II Trial.

Krop, Ian E. MD, PhD 1,,; Masuda, Norikazu MD, PhD 2,; Mukohara, Toru MD, DMedSci 3,; Takahashi, Shunji MD, PhD 4,; Nakayama, Takahiro MD, PhD 5,; Inoue, Kenichi MD, PhD 6,; Iwata, Hiroji MD, PhD 7,; Yamamoto, Yutaka MD, PhD 8,; Alvarez, Ricardo H. MD, MSc 9,; Toyama, Tatsuya MD, PhD 10,; Takahashi, Masato MD 11,; Osaki, Akihiko MD, PhD 12,; Saji, Shigehira MD, PhD 13,; Sagara, Yasuaki MD, MPH 14,; O'Shaughnessy, Joyce MD 15,; Ohwada, Shoichi PhD 16,; Koyama, Kumiko PhD 16,; Inoue, Tatsuya MD, PhD 17,; Li, Li PhD 18,; Patel, Parul MS 18,; Mostillo, Joseph PharmD 18,; Tanaka, Yoshimi MA 18,; Sternberg, David W. MD, PhD 18,; Sellami, Dalila MD 18,; Yonemori, Kan MD, PhD 19,

doi : 10.1200/JCO.23.00882

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Stereotactic Body Radiation Therapy and Abiraterone Acetate for Patients Affected by Oligometastatic Castrate-Resistant Prostate Cancer: A Randomized Phase II Trial (ARTO).

Francolini, Giulio MD 1,; Gaetano Allegra, Andrea MD 2; Detti, Beatrice MD 1; Di Cataldo, Vanessa MD 1; Caini, Saverio MD 3; Bruni, Alessio MD 4,; Ingrosso, Gianluca MD 5,; D'Angelillo, Rolando Maria MD 6,; Alitto, Anna Rita MD 7,; Augugliaro, Matteo MD 8,; Triggiani, Luca MD 9; Parisi, Silvana MD 10; Facchini, Gaetano MD 11; Banini, Marco MD 2; Simontacchi, Gabriele MD 1,; Desideri, Isacco MD 2; Meattini, Icro MD 2,; Valicenti, Richard K. MD 12; Livi, Lorenzo MD 2; on behalf of the ARTO Working Group members; Marvaso, Giulia; Alongi, Filippo; Arcidiacono, Fabio; Lancia, Andrea; Genovesi, Domenico; Franzese, Ciro; Timon, Giorgia; Greto, Daniela; Loi, Mauro; Valzano, Marianna; Bonomo, Pierluigi; Mangoni, Monica; Becherini, Carlotta; Tagliagambe, Angiolo; Doro, Raffaela; Masi, Laura

doi : 10.1200/JCO.23.00985

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Tucatinib and Trastuzumab for Previously Treated Human Epidermal Growth Factor Receptor 2-Positive Metastatic Biliary Tract Cancer (SGNTUC-019): A Phase II Basket Study.

Nakamura, Yoshiaki MD, PhD 1,,; Mizuno, Nobumasa MD, PhD 2,; Sunakawa, Yu MD, PhD 3,; Canon, Jean-Luc MD 4,; Galsky, Matthew D. MD 5,; Hamilton, Erika MD 6,; Hayashi, Hidetoshi MD, PhD 7,; Jerusalem, Guy MD, PhD 8,; Kim, Seung Tae MD 9; Lee, Keun-Wook MD, PhD 10,; Kankeu Fonkoua, Lionel Aurelien MD 11,; Monk, Bradley J. MD 12,; Nguyen, Danny MD 13,; Oh, Do-Youn MD, PhD 14,; Okines, Alicia MD, MBChB 15,; O'Malley, David M. MD 16,; Pohlmann, Paula MD 17,; Reck, Martin MD, PhD 18,; Shin, Sang Joon MD 19; Sudo, Kazuki MD, PhD 20,; Takahashi, Shunji MD, PhD 21,; Van Marcke, Cedric MD, PhD 22,; Yu, Evan Y. MD 23,; Groisberg, Roman MD 24,; Ramos, Jorge DO 25,; Tan, Sherry PhD 25,; Stinchcombe, Thomas E. MD 26,; Bekaii-Saab, Tanios MD 27,

doi : 10.1200/JCO.23.00606

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Advancing Diagnostics and Therapy to Reach Universal Cure in Childhood ALL.

Pieters, Rob MD, PhD, MSc 1,,; Mullighan, Charles G. MD, PhD 2,; Hunger, Stephen P. MD 3,

doi : 10.1200/JCO.23.01286

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Gift of Truth.

Hellmann, Ilana MBBCh 1,2,

doi : 10.1200/JCO.23.01268

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Disclosure of Prediction Model.

Mulder, Frits I. MD; Guman, Noori A.M. MD; Buller, Harry R. MD, PhD; Van Es, Nick MD

doi : 10.1200/JCO.23.00449

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Reply to F.I. Mulder et al.

Munoz, Andres MD, PhD; Salas, Eduardo MD, PhD; Soria, Jose Manuel PhD, BSc

doi : 10.1200/JCO.23.00817

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