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From AI to the Y chromosome (and everything in between)

doi : 10.1038/s41587-023-02076-0

Volume 41 Issue 12, December 2023

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Top ten news stories in 2023

Lisa Melton 

doi : 10.1038/s41587-023-02063-5

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Bioengineered spider silk without critters

Kenna Hughes-Castleberry 

doi : 10.1038/s41587-023-02064-4

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First in vivo base editing lowers cholesterol

doi : 10.1038/s41587-023-02070-6

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Nature Biotechnology’s academic spinouts 2022

Michael Eisenstein, Charles Schmidt & Laura DeFrancescoÂ

doi : 10.1038/s41587-023-02023-z

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The global patent landscape of artificial intelligence applications for cancer

Luiza Braga, Renato Lopes, Luiz Alves & Fabio MotaÂ

doi : 10.1038/s41587-023-02051-9

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A neuroprosthesis for Parkinson’s disease

Anahita Bishop 

doi : 10.1038/s41587-023-02067-1

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Wireless multisite physiological sensor with clinical-grade accuracy

Rong Li 

doi : 10.1038/s41587-023-02068-0

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Yeast with a half-synthetic genome

Anne Doerr 

doi : 10.1038/s41587-023-02069-z

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Subtle cell states resolved in single-cell data

Caleb Lareau 

doi : 10.1038/s41587-023-01797-6

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Augmenting electron microscopy with barcoded gene reporters

doi : 10.1038/s41587-023-01731-w

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Engineered upstream open reading frames predictably downregulate mRNA translation in plants

doi : 10.1038/s41587-023-01729-4

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Measuring the impact of chromatin context on transcription factor binding affinities

doi : 10.1038/s41587-023-01752-5

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Expanding access to CAR T cell therapies through local manufacturing

Magdi Elsallab & Marcela V. MausÂ

doi : 10.1038/s41587-023-01981-8

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The chemistry of next-generation sequencing

Raphaël Rodriguez & Yamuna KrishnanÂ

doi : 10.1038/s41587-023-01986-3

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Soil microbiome engineering for sustainability in a changing environment

Janet K. Jansson, Ryan McClure & Robert G. EgbertÂ

doi : 10.1038/s41587-023-01932-3

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Trans-segmental imaging in the spinal cord of behaving mice

Pavel Shekhtmeyster, Daniela Duarte, Erin M. Carey, Alexander Ngo, Grace Gao, Jack A. Olmstead, Nicholas A. Nelson & Axel NimmerjahnÂ

doi : 10.1038/s41587-023-01700-3

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Genetically encoded barcodes for correlative volume electron microscopy

Felix Sigmund, Oleksandr Berezin, Sofia Beliakova, Bernhard Magerl, Martin Drawitsch, Alberto Piovesan, Filipa Gonçalves, Silviu-Vasile Bodea, Stefanie Winkler, Zoe Bousraou, Martin Grosshauser, Eleni Samara, Jesús Pujol-Martí, Sebastian Schädler, Chun So, Stephan Irsen, Axel Walch, Florian Kofler, Marie Piraud, Joergen Kornfeld, Kevin Briggman & Gil Gregor WestmeyerÂ

doi : 10.1038/s41587-023-01713-y

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SEACells infers transcriptional and epigenomic cellular states from single-cell genomics data

Sitara Persad, Zi-Ning Choo, Christine Dien, Noor Sohail, Ignas Masilionis, Ronan Chaligné, Tal Nawy, Chrysothemis C. Brown, Roshan Sharma, Itsik Pe’er, Manu Setty & Dana Pe’erÂ

doi : 10.1038/s41587-023-01716-9

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Tuning plant phenotypes by precise, graded downregulation of gene expression

Chenxiao Xue, Fengti Qiu, Yuxiang Wang, Boshu Li, Kevin Tianmeng Zhao, Kunling Chen & Caixia GaoÂ

doi : 10.1038/s41587-023-01707-w

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Multimodal spatiotemporal phenotyping of human retinal organoid development

Philipp Wahle, Giovanna Brancati, Christoph Harmel, Zhisong He, Gabriele Gut, Jacobo Sarabia del Castillo, Aline Xavier da Silveira dos Santos, Qianhui Yu, Pascal Noser, Jonas Simon Fleck, Bruno Gjeta, Dinko Pavlinić, Simone Picelli, Max Hess, Gregor W. Schmidt, Tom T. A. Lummen, Yanyan Hou, Patricia Galliker, David Goldblum, Marton Balogh, Cameron S. Cowan, Hendrik P. N. Scholl, Botond Roska, Magdalena Renner, …J. Gray CampÂ

doi : 10.1038/s41587-023-01747-2

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Global detection of human variants and isoforms by deep proteome sequencing

Pavel Sinitcyn, Alicia L. Richards, Robert J. Weatheritt, Dain R. Brademan, Harald Marx, Evgenia Shishkova, Jesse G. Meyer, Alexander S. Hebert, Michael S. Westphall, Benjamin J. Blencowe, Jürgen Cox & Joshua J. CoonÂ

doi : 10.1038/s41587-023-01714-x

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Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease

Anna B. Meier, Dorota Zawada, Maria Teresa De Angelis, Laura D. Martens, Gianluca Santamaria, Sophie Zengerle, Monika Nowak-Imialek, Jessica Kornherr, Fangfang Zhang, Qinghai Tian, Cordula M. Wolf, Christian Kupatt, Makoto Sahara, Peter Lipp, Fabian J. Theis, Julien Gagneur, Alexander Goedel, Karl-Ludwig Laugwitz, Tatjana Dorn & Alessandra MorettiÂ

doi : 10.1038/s41587-023-01718-7

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Quantification of absolute transcription factor binding affinities in the native chromatin context using BANC-seq

Hannah K. Neikes, Katarzyna W. Kliza, Cathrin Gräwe, Roelof A. Wester, Pascal W. T. C. Jansen, Lieke A. Lamers, Marijke P. Baltissen, Simon J. van Heeringen, Colin Logie, Sarah A. Teichmann, Rik G. H. Lindeboom & Michiel VermeulenÂ

doi : 10.1038/s41587-023-01715-w

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Protein structure prediction with in-cell photo-crosslinking mass spectrometry and deep learning

Kolja Stahl, Andrea Graziadei, Therese Dau, Oliver Brock & Juri RappsilberÂ

doi : 10.1038/s41587-023-01704-z

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Contamination source modeling with SCRuB improves cancer phenotype prediction from microbiome data

George I. Austin, Heekuk Park, Yoli Meydan, Dwayne Seeram, Tanya Sezin, Yue Clare Lou, Brian A. Firek, Michael J. Morowitz, Jillian F. Banfield, Angela M. Christiano, Itsik Pe’er, Anne-Catrin Uhlemann, Liat Shenhav & Tal KoremÂ

doi : 10.1038/s41587-023-01696-w

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Collectively building a mentor–mentee relationship through a one-day workshop

Julie Foncy, Marta Kwapisz, Martine Knibiehler & Julie BatutÂ

doi : 10.1038/s41587-023-02056-4

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