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World Gastroenterology Organisation - Gut commentary series on digestive health and climate change

M Bishr Omary ,1 Desmond Leddin ,2 Geoffrey Metz,3 Andrew M Veitch ,4 Emad M El-Omar ,5 Guilherme Macedo,6 Mai Ling Perman

doi : 10.1136/gutjnl-2023-331193

December 2023 - Volume 72 - 12

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The fundamentals: understanding the climate change crisis

Desmond Leddin ,1 Hugh Montgomery2

doi : 10.1136/gutjnl-2023-331008

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Effects of climate change on digestive health and preventative measures

Mhairi Claire Donnelly ,1 Nicholas J Talley

doi : 10.1136/gutjnl-2023-331187

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Impact of climate change on vulnerable populations

Govind K Makharia ,1 Anahita Sadeghi,2 Desmond Leddin,3 Anthony Costello

doi : 10.1136/gutjnl-2023-331195

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Approaches for greening endoscopy and reducing waste

Jo?o A Cunha Neves ,1 Enrique Rodr?guez de Santiago ,2 Lars Aabakken

doi : 10.1136/gutjnl-2023-330917

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Green gastroenterology adaptation, resilience and an industry perspective

Cassandra Thiel,1 Emma Pak, 2 Rainer Burkard,3 Harald Huber

doi : 10.1136/gutjnl-2023-331277

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Carbon footprint of gastroenterology practice

Heiko Pohl,1 Robin Baddeley ,2,3 Bu’Hussain Hayee

doi : 10.1136/gutjnl-2023-331230

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NHS efforts in England to mitigate the climate crisis: uniting nurses and gastroenterologists

Robin Baddeley ,1,2 Nick Watts,3 Leigh Donnelly

doi : 10.1136/gutjnl-2023-331275

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Climate change, paediatric health and ways that digestive health professionals can engage

Rebecca Philipsborn,1 Madhumitha Manivannan,2 Todd L Sack

doi : 10.1136/gutjnl-2023-331166

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Gastroenterology climate action opportunities via education, empowerment of trainees and research

Aasma Shaukat,1 Brijen Shah,2 Cassandra DL Fritz,3 M Bishr Omary

doi : 10.1136/gutjnl-2023-331093

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Pleiotropic role of NOTUM in colorectal cancer

Milou S van Driel ,1,2,3,4 Jasmijn D G Linssen ,1,2,3,4,5 Sanne M van Neerven ,1,2,3,4 Louis Vermeulen

doi : 10.1136/gutjnl-2023-330807

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Targeting myeloid signalling pathways to unleash T cells

Patrick Michl , Sebastian Krug

doi : 10.1136/gutjnl-2023-330706

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Potential of personalised approaches in gastric cancer prevention

M?rcis Leja

doi : 10.1136/gutjnl-2023-330215

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Patient-reported experience of colonoscopy in Italy: a multicentre prospective observational study

Lorenzo Fuccio ,1,2 Colin J Rees ,3 Leonardo Frazzoni ,1,2 Laura Neilson,4 Franco Radaelli ,5 Linda Sharp ,6 Cesare Hassan ,7 Cristiano Spada,8,9 The ENDOPREM Study Group

doi : 10.1136/gutjnl-2023-330415

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Eradicating Helicobacter pylori via 13C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method

Wei-Yi Lei,1 Jian- Yu Lee,2 Shu-Ling Chuang,3 Ming- Jong Bair,4 Chien- Lin Chen ,1 Jeng-Yih Wu,5 Deng-Chyang Wu,5 Felice Tien O’Donnell,6 Hui-Wen Tien,7 Yi-Ru Chen,8 Tsung-Hsien Chiang, 8 Yu-Hsin Hsu,9 Tsui-Hsia Hsu, 9 Pei-Chun Hsieh,9 Li- Ju Lin,9 Shu-Li Chia, 9 Chao-Chun Wu,9 Yi-Maun Subeq,10 Shu-Hui Wen,11 Hsiu-Chun Chang,12 Yu-Wen Lin,13 Kuo-Ping Sun,13 Chia- Hsiang Chu,14 Ming-Shiang Wu,8 David Y Graham ,15 Hsiu-Hsi Chen ,16 Yi-Chia Lee

doi : 10.1136/gutjnl-2023-329871

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Optimal measurement of gastric emptying of solids in gastroparesis or functional dyspepsia: evidence to establish standard test

Michael Camilleri , Ting Zheng, Kia Vosoughi , Camille Lupianez- Merly, Deborah Eckert, Irene Busciglio, Duane Burton, Saam Dilmaghani

doi : 10.1136/gutjnl-2023-330733

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Cost-effectiveness of endoscopic, surgical and pharmacological obesity therapies: a microsimulation and threshold analyses

Monica Saumoy,1 Devika Gandhi, 2 Seth Buller,3 Shae Patel,3 Yecheskel Schneider,4 Gregory Cote, 5 Michael L Kochman,6,7 Nikhil R Thiruvengadam ,2 Reem Z Sharaiha

doi : 10.1136/gutjnl-2023-330437

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Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations

Yang Hu ,1 Jun Li ,2 Biqi Wang,3 Lu Zhu ,1 Yanping Li ,1 Kerry L Ivey,1 Kyu Ha Lee,1,4,5 A Heather Eliassen,4,6 Andrew Chan,7,8 Curtis Huttenhower,5,8,9 Frank B Hu, 1,4,6 Qibin Qi,10 Eric B Rimm,1,4,6 Qi Sun1,4,6

doi : 10.1136/gutjnl-2023-330410

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Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1/Kyn/AHR axis

Winnie Fong,1 Qing Li,1,2 Fenfen Ji,1 Wei Liang,3 Harry Cheuk Hay Lau ,1 Xing Kang, 1 Weixin Liu,1 Kenneth Kin- Wah To,4 Zhong Zuo,4 Xiaoxing Li ,3 Xiang Zhang,1 Joseph JY Sung ,5 Jun Yu

doi : 10.1136/gutjnl-2023-329543

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Endoluminal radiofrequency ablation in patients with malignant biliary obstruction: a randomised trial

Jana Jarosova ,1 Lea Zarivnijova,2 Ivana Cibulkova,3 Jan Mares,4 Peter Macinga,1 Alzbeta Hujova,1 Premysl Falt,2 Ondrej Urban,2 Jan Hajer,3 Julius Spicak,1 Tomas Hucl

doi : 10.1136/gutjnl-2023-329700

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APC and P53 mutations synergise to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

Yuhua Tian ,1,2,3 Xin Wang,2 Zvi Cramer, 2 Joshua Rhoades,2 Katrina N. Estep, 4 Xianghui Ma,5 Stephanie Adams-Tzivelekidis,2 Bryson W. Katona,6,7 F Brad Johnson,4,8 Zhengquan Yu,1,3 M Andres Blanco, 2,7,8 Christopher J Lengner ,2,7,8 Ning Li

doi : 10.1136/gutjnl-2022-329140

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Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity

Yongsheng Li ,1,2 Zhiyong Shen,1,2 Zhen Chai, 1,2 Yizhi Zhan,1,2 Yaowei Zhang,3 Zhengyu Liu, 1,2 Yuechen Liu,1,2 Zhenkang Li, 1,2 Mingdao Lin,1,2 Zhanqiao Zhang,1,2 Wei Liu,1,2 Shenyuan Guan,1,2 Jinchao Zhang,1,2 Junying Qian,3 Yi Ding,3 Guoxin Li ,1,2 Yuan Fang,3 Haijun Deng

doi : 10.1136/gutjnl-2022-329147

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Growth rates and histopathological outcomes of small (6–9 mm) colorectal polyps based on CT colonography surveillance and endoscopic removal

B Dustin Pooler, 1 David H Kim ,1 Kristina A Matkowskyj,2,3 Michael A Newton,4,5 Richard B Halberg, 6,7 William M Grady,8,9 Cesare Hassan ,10,11 Perry J Pickhardt

doi : 10.1136/gutjnl-2022-326970

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CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-κB/p65 nuclear translocation in pancreatic ductal adenocarcinoma

Xiaomeng Liu,1,2,3,4 Rong Tang,1,2,3,4 Jin Xu,1,2,3,4 Zhen Tan,5 Chen Liang,1,2,3,4 Qingcai Meng,1,2,3,4 Yubin Lei,6 Jie Hua,1,2,3,4 Yiyin Zhang,7 Jiang Liu,1,2,3,4 Bo Zhang,1,2,3,4 Wei Wang,1,2,3,4 Xianjun Yu,1,2,3,4 Si Shi 1,2

doi : 10.1136/gutjnl-2022-329349

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DNA-methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma

Yenan Wu,1,2 Isabelle Seufert ,1,2 Fawaz N Al-Shaheri,1,3 Roman Kurilov,4 Andrea S Bauer,1 Mehdi Manoochehri,1 Evgeny A Moskalev,5 Benedikt Brors,4 Christin Tjaden, 6 Nathalia A Giese,6 Thilo Hackert,6 Markus W Büchler, 6 J?rg D Hoheisel

doi : 10.1136/gutjnl-2023-330155

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Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people

Zhenqiu Liu,1,2 Chunqing Lin,3 Xianhua Mao, 4 Chengnan Guo ,5,6 Chen Suo,2,5,6 Dongliang Zhu, 5 Wei Jiang,1 Yi Li,5 Jiahui Fan,1 Ci Song,7 Tiejun Zhang,2,5,6 Li Jin,1,2 Catherine De Martel,8 Gary M Clifford,8 Xingdong Chen

doi : 10.1136/gutjnl-2023-330691

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Clinical care pathway to detect advanced liver disease in patients with type 2 diabetes through automated fibrosis score calculation and electronic reminder messages: a randomised controlled trial

Xinrong Zhang ,1,2,3 Terry Cheuk-Fung Yip,1,2,3 Grace Lai-Hung Wong ,1,2,3 Wei-Xuan Leow, 4 Lilian Yan Liang ,1,2,3 Lee-Ling Lim,5 Guanlin Li,1,2,3 Luqman Ibrahim, 5 Huapeng Lin,1,2,3 Jimmy Che To Lai ,1,2,3 Angel Mei-Ling Chim,1,2,3 Henry Lik Yuen Chan,6,7 Alice Pik-Shan Kong,3 Wah Kheong Chan ,4 Vincent Wai-Sun Wong

doi : 10.1136/gutjnl-2023-330269

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Abnormal gastrointestinal motility is a major factor in explaining symptoms and a potential therapeutic target in patients with disorders of gut–brain interaction

Michael Camilleri

doi : 10.1136/gutjnl-2023-330542

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GI highlights from the literature

Philip J Smith

doi : 10.1136/gutjnl-2023-331367

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Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of extrahepatic cancer

Christoph Roderburg,1 Karel Kostev, 2 Alexander Mertens,1 Tom Luedde, 1 Sven H Loosen

doi : 10.1136/gutjnl-2022-328887

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Not all that is corpus restricted is necessarily autoimmune

Edith Lahner ,1 Emanuele Dilaghi ,2 Ludovica Dottori,1 Bruno Annibale

doi : 10.1136/gutjnl-2022-328959

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AGR2 protein expression in colorectal tumour epithelialcompartment

Eric Chevet ,1,2,3 F Bassal,4 Stéphanie Beq,4 Benjamin Bonhomme ,5 Emeric Boisteau,1,6 Julien Calloch,4 Dominique Cazals-Hatem,Frederic Delom ,8,9 Delphine Fessart,8,9 Serge Evrard, 5,8 Roman Hrstka,10 ted hupp,11 Astrid Lièvre, 6 Edouard Louis, 12 Jeremie Mariau,4 Marie-Alice Meuwis, 12 Eric Ogier-Denis ,1,2,3 Valerie Paradis,13 Simon Pernot,5 R Pineau,1,2,3 Xavier Treton,14 Valerie Velasco,5 Sophie Vieujean

doi : 10.1136/gutjnl-2022-328739

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Letter to the editor: Helicobacter pylori eradication – the proof is not in the symptoms

Jan Bornschein ,1 D Mark Pritchard, 2 Peter Malfertheiner

doi : 10.1136/gutjnl-2022-329057

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Response to: Correspondence on ‘On the ethics of digestive health research in historically marginalised communities’ by Velez and Targownick

Emad Mansoor, 1 Scott A Martin,2 Abe Perez,3 Vu Quang Nguyen,1 Jeffry Katz,1 Shubham Gupta,4 Fabio Cominelli

doi : 10.1136/gutjnl-2022-329038

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More than meets the eye: a strange cause of bowel obstruction and perforation

Wei-Feng Huang , 1,2 Yi Ding,3 Jie sun,4 Jin-Yan Zhang,

doi : 10.1136/gutjnl-2023-329568

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Time to treat the climate and nature crisis as one indivisible global health emergency

Chris Zielinski, on behalf of the authorship group listed below

doi : 10.1136/gutjnl-2023-331314

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Correction: Mucus barrier, mucins and gut microbiota: the expected slimy partners?

doi : 10.1136/gutjnl-2020-322260corr1

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