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US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021
Isaac See, MD1; John R. Su, MD, PhD, MPH1; Allison Lale, MD, MPH1; Emily Jane Woo, MD, MPH2; Alice Y. Guh, MD, MPH1; Tom T. Shimabukuro, MD, MPH, MBA1; Michael B. Streiff, MD3; Agam K. Rao, MD1; Allison P. Wheeler, MD, MSCI4; Suzanne F. Beavers, MD1; Anna P. Durbin, MD3; Kathryn Edwards, MD4; Elaine Miller, RN, MPH1; Theresa A. Harrington, MD, MPH&TM1; Adamma Mba-Jonas, MD, MPH2; Narayan Nair, MD2; Duong T. Nguyen, DO1; Kawsar R. Talaat, MD3; Victor C. Urrutia, MD3; Shannon C. Walker, MD4; C. Buddy Creech, MD4; Thomas A. Clark, MD, MPH1; Frank DeStefano, MD, MPH1; Karen R. Broder, MD1
doi : 10.1001/jama.2021.7517
JAMA. 2021;325(24):2448-2456
Cerebral venous sinus thrombosis (CVST) with thrombocytopenia, a rare and serious condition, has been described in Europe following receipt of the ChAdOx1 nCoV-19 vaccine (Oxford/AstraZeneca), which uses a chimpanzee adenoviral vector. A mechanism similar to autoimmune heparin-induced thrombocytopenia (HIT) has been proposed. In the US, the Ad26.COV2.S COVID-19 vaccine (Janssen/Johnson & Johnson), which uses a human adenoviral vector, received Emergency Use Authorization (EUA) on February 27, 2021. By April 12, 2021, approximately 7 million Ad26.COV2.S vaccine doses had been given in the US, and 6 cases of CVST with thrombocytopenia had been identified among the recipients, resulting in a temporary national pause in vaccination with this product on April 13, 2021.
Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers
Yoel Angel, MD, MBA1,2; Avishay Spitzer, MD2,3,4; Oryan Henig, MD2,5; Esther Saiag, MD, MHA2,6; Eli Sprecher, MD, PhD, MBA2,7,8; Hagit Padova, MD, MHA2,9; Ronen Ben-Ami, MD2,5
doi : 10.1001/jama.2021.7152
JAMA. 2021;325(24):2457-2465
Randomized clinical trials have provided estimates of the effectiveness of the BNT162b2 vaccine against symptomatic SARS-CoV-2 infection, but its effect on asymptomatic infections remains unclear.
Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma
Lisa H. Y. Kim, MD1; Carol Saleh, MD1; Anna Whalen-Browne, MD1; Paul M. O’Byrne, MB1; Derek K. Chu, MD, PhD1,2,3
doi : 10.1001/jama.2021.7872
JAMA. 2021;325(24):2466-2479
The benefits and harms of adding long-acting muscarinic antagonists (LAMAs) to inhaled corticosteroids (ICS) and long-acting ?2-agonists (LABAs) for moderate to severe asthma remain unclear.
Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination in a Routinely Screened Workforce
Li Tang, PhD1; Diego R. Hijano, MD, MSc2; Aditya H. Gaur, MD, MBBS2; Terrence L. Geiger, MD, PhD3; Ellis J. Neufeld, MD, PhD4; James M. Hoffman, PharmD, MS5; Randall T. Hayden, MD3
doi : 10.1001/jama.2021.6564
JAMA. 2021;325(24):2500-2502
Association of Initial Treatment With Antibiotics vs Surgery With Treatment Success and Disability in Subgroups of Children With Uncomplicated Appendicitis
Peter C. Minneci, MD, MHSc1; Erinn M. Hade, PhD2; Gregory A. Metzger, MD1; Jacqueline M. Saito, MD3; Grace Z. Mak, MD4; Katherine J. Deans, MD, MHSc1; for the Midwest Pediatric Surgery Consortium
doi : 10.1001/jama.2021.6710
JAMA. 2021;325(24):2502-2504
When Vaccine Apathy, Not Hesitancy, Drives Vaccine Disinterest
Stacy Wood, PhD1; Kevin Schulman, MD2,3
doi : 10.1001/jama.2021.7707
JAMA. 2021;325(24):2435-2436
Implementing High-Quality Primary Care
Robert L. Phillips Jr, MD, MSPH1; Linda A. McCauley, RN, PhD2; Christopher F. Koller, MA3
doi : 10.1001/jama.2021.7430
JAMA. 2021;325(24):2437-2438
A National Goal to Advance Health Equity Through Value-Based Payment
Joshua M. Liao, MD, MSc1,2; Risa J. Lavizzo-Mourey, MD, MBA3; Amol S. Navathe, MD, PhD3,4
doi : 10.1001/jama.2021.8562
JAMA. 2021;325(24):2439-2440
Progress With the All of Us Research Program
Andrea H. Ramirez, MD, MS1,5; Kelly A. Gebo, MD, MPH2,3; Paul A. Harris, PhD4
doi : 10.1001/jama.2021.7702
JAMA. 2021;325(24):2441-2442
Vaccinated but Not Protected—Living Immunocompromised During the Pandemic
Lindsay Ryan, MD1
doi : 10.1001/jama.2021.9321
JAMA. 2021;325(24):2443-2444
Assessing a Rare and Serious Adverse Event Following Administration of the Ad26.COV2.S Vaccine
Ruth A. Karron, MD1; Nigel S. Key, MD2; Joshua M. Sharfstein, MD3
doi : 10.1001/jama.2021.7637
JAMA. 2021;325(24):2445-2447
Transcatheter Treatment of Valvular Heart Disease
Laura J. Davidson, MD, MS1; Charles J. Davidson, MD1
doi : 10.1001/jama.2021.2133
JAMA. 2021;325(24):2480-2494
More than 40 million people are living with either mitral or aortic valve disease worldwide, and more than 180?000 heart valve replacement surgeries are performed each year in the US. Transcatheter valve repair has emerged as an important therapeutic option for patients who are candidates for heart valve replacement.
The Pandemic Stay-at-Home Order and Opioid-Involved Overdose Fatalities
Maryann Mason, PhD1; Ponni Arukumar, MD2; Joe Feinglass, PhD3
doi : 10.1001/jama.2021.6700
JAMA. 2021;325(24):2495-2496
Assessment of Depressive Symptoms in Medically Ill Patients
Patrick Baumgart, MD1; Thomas Garrick, MD1
doi : 10.1001/jama.2021.2320
JAMA. 2021;325(24):2497-2498
Community-Based Organizations Step Up to Confront HIV in Southern States
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.8428
JAMA. 2021;325(24):2421-2423
Could Statins Do More Than Lower Cholesterol in Patients With COVID-19?
Rita Rubin, MA
doi : 10.1001/jama.2021.8201
JAMA. 2021;325(24):2424-2425
Adults Lag Behind Children in Reduced Head Injuries From Biking
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.9339
JAMA. 2021;325(24):2428
Botulism Guidelines Aim to Help Prepare Clinicians for Outbreaks
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.8969
JAMA. 2021;325(24):2428
Online Exercise Plus Text Messages Improve Knee Osteoarthritis
Anita Slomski
doi : 10.1001/jama.2021.8750
JAMA. 2021;325(24):2427
Vagus Nerve Stimulation Restores Arm Function Years After Stroke
Anita Slomski
doi : 10.1001/jama.2021.9693
JAMA. 2021;325(24):2427
Tranexamic Acid Reduces Blood Loss After Cesarean, but Not by Much
Anita Slomski
doi : 10.1001/jama.2021.9694
JAMA. 2021;325(24):2427
Hospital-at-Home Rivals Inpatient Care for Some Older Adults
Anita Slomski
doi : 10.1001/jama.2021.9695
JAMA. 2021;325(24):2427
Ready-to-Use Glucagon Analogue Quickly Reverses Hypoglycemia
Anita Slomski
doi : 10.1001/jama.2021.9696
JAMA. 2021;325(24):2427
Vaccination in Residential Facilities
Rita Rubin, MA
doi : 10.1001/jama.2021.9727
JAMA. 2021;325(24):2426
NIH Addresses COVID-19 Disparities
Rita Rubin, MA
doi : 10.1001/jama.2021.9728
JAMA. 2021;325(24):2426
Artificial Heart Valves
William C. Frankel, MD1; Tom C. Nguyen, MD2
doi : 10.1001/jama.2020.19936
JAMA. 2021;325(24):2512-2513
Review of Hip and Knee Osteoarthritis
Raymond E. Phillips, MD1
doi : 10.1001/jama.2021.6018
JAMA. 2021;325(24):2504-2505
Review of Hip and Knee Osteoarthritis—Reply
Jeffrey N. Katz, MD, MSc1; Kaetlyn Arant, BA1; Richard F. Loeser, MD2
doi : 10.1001/jama.2021.6024
JAMA. 2021;325(24):2505
Effect of Restrictive or Liberal Blood Transfusion on Major Cardiovascular Events in Patients With Acute Myocardial Infarction and Anemia
Tomohiko Sato, MD, PhD1; Rui Terada, MD, PhD2; Toshiyuki Ikeda, MD2
doi : 10.1001/jama.2021.6033
JAMA. 2021;325(24):2505-2506
Effect of Restrictive or Liberal Blood Transfusion on Major Cardiovascular Events in Patients With Acute Myocardial Infarction and Anemia—Reply
Gregory Ducrocq, MD, PhD1; Tabassome Simon, MD, PhD2; P. Gabriel Steg, MD1; for the REALITY Investigators
doi : 10.1001/jama.2021.6039
JAMA. 2021;325(24):2506-2507
Addition of Nonauthor Collaborator Names of the INTUBE Study Collaborators
doi : 10.1001/jama.2021.9012
JAMA. 2021;325(24):2507
