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Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula
Li Zhao a,b,c,1, Hong Zhang a,b,c,1, Ning Li a,b,c, Jinman Chen a,b,c, Hao Xu a,b,c, Yongjun Wang a,b,c,**, Qianqian Liang
doi : 10.1016/j.jep.2023.116306
Volume 309, 12 June 2023, 116306
Insect tea originated from ethnic minority regions in Southwest China: A review on the types, traditional uses, nutrients, chemistry and pharmacological activities
Kaijin Wang a,*, Kefan Wu a, Ning Li
doi : 10.1016/j.jep.2023.116340
Volume 309, 12 June 2023, 116340
Clinical efficacy and safety of compound Congrong Yizhi Capsules on Alzheimer's disease in mainland China: A systematic review with trial sequential analysis and GRADE assessment
Yefei Wang a,1, Ningqun Wang b,1, Zhenmin Xu a, Shaojiao Liu a, Xiao Liang c, Yunling Zhang c, Xianglan Jin
doi : 10.1016/j.jep.2023.116208
Volume 309, 12 June 2023, 116208
Pharmacovigilance of herbal medicines: Concerns and future prospects
Abinash Choudhury a, Preet Amol Singh b,*, Neha Bajwa b, Subhransu Dash a, Preeti Bisht
doi : 10.1016/j.jep.2023.116383
Volume 309, 12 June 2023, 116383
Polygonati Rhizoma with the homology of medicine and food: A review of ethnopharmacology, botany, phytochemistry, pharmacology and applications
Linxian Zhao a, Chunyi Xu a, Weiling Zhou a, Yanyan Li a, Yongmei Xie b, Huiling Hu a,*, Zhanguo Wang
doi : 10.1016/j.jep.2023.116296
Volume 309, 12 June 2023, 116296
Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation
Li Tao a,b,***,1, Kehui Zhou a,b,1, Yang Zhao a,b,c,1, Xiangyu Xia a,b, Yajie Guo a,b, Yang Gao d, Guoping Peng d,*, Yanqing Liu
doi : 10.1016/j.jep.2023.116295
Volume 309, 12 June 2023, 116295
Determining the chemical profile of Caragana jubata (Pall.) Poir. by UPLC–QTOF–MS analysis and evaluating its anti-ischemic stroke effects
Dingping Zhao a, Xiqing Chen a, Ruiqi Wang a, Hanqing Pang a,b, Jianbin Wang a,b, Liang Liu
doi : 10.1016/j.jep.2023.116275
Volume 309, 12 June 2023, 116275
Patrinia villosa treat colorectal cancer by activating PI3K/Akt signaling pathway
Xiao-chen Li a,b,c,1, Shuai Wang a,b,c,1, Xin-xin Yang a,b,c, Tian-jiao Li a,b,c, Jia-xing Gu d, Lin Zhao a,b,c, Yong-rui Bao a,b,c,*, Xian-sheng Meng a,b
doi : 10.1016/j.jep.2023.116264
Volume 309, 12 June 2023, 116264
Cistanche tubulosa alleviates ischemic stroke-induced blood-brain barrier damage by modulating microglia-mediated neuroinflammation
Yu-cheng Liao a,b,1, Jing-wen Wang b,1, Chao Guo b,1, Min Bai b,1, Zheng Ran a, Li-mei Wen c, Bo-wei Ju a,d, Yi Ding b,***, Jun-ping Hu a,**, Jian-hua Yang c,*
doi : 10.1016/j.jep.2023.116269
Volume 309, 12 June 2023, 116269
The protective effects of Zhi-Gan-Cao-Tang against diabetic myocardial infarction injury and identification of its effective constituents
Mengting Hu a,1, Haoran Li a,1, Shengkun Ni a, Shufang Wang
doi : 10.1016/j.jep.2023.116320
Volume 309, 12 June 2023, 116320
Clinopodium chinense Kuntze ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by reducing systematic inflammation and regulating metabolism
Yumeng Wang, Zhutao Shao, Ce Song, Hongxu Zhou, Jiaming Zhao, Kunqi Zong, Guangxin Zhou, Dali Meng
doi : 10.1016/j.jep.2023.116330
Volume 309, 12 June 2023, 116330
Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome
Xiaonan Zhang a, Zeping Wang a,b, Xiaoya Li a, Jiye Chen a, Zongliang Yu a, Xin Li a,b, Changxin Sun a,b, Lanqing Hu a, Min Wu c,*, Longtao Liu
doi : 10.1016/j.jep.2023.116304
Volume 309, 12 June 2023, 116304
Bioassay guided isolation of caffeoylquinic acids from the leaves of Ilex pubescens Hook. et Arn. and investigation of their anti-influenza mechanism
Fan Wang a, Bobby Lim-Ho Kong a, Yun-Sang Tang a, Hung-Kay Lee c, Pang-Chui Shaw
doi : 10.1016/j.jep.2023.116322
Volume 309, 12 June 2023, 116322
Anti-inflammatory and antinociceptive activities of Daniellia oliveri (Fabaceace) stem bark extract
Margaret O. Sofidiya a,*, Johnbosco U. Ikechukwu a, Victoria E. Nnah a, Olubusola O. Olaleye a, Kazeem Basheeru b, Abimbola A. Sowemimo a, Abayomi M. Ajayi
doi : 10.1016/j.jep.2023.116337
Volume 309, 12 June 2023, 116337
Shaoyao-Gancao-Tang regulates the T-helper-type 1/T-helper-type 2 ratio in the lung and gut and alters gut microbiota in rats with ovalbumin-induced asthma
Rui He a,1, Sihui Wang a,b,1, Shengxi Yang a, Renhui Liu a, Nan Nan a, Xuran Lu a, Muxin Gong a,*, Jing Li
doi : 10.1016/j.jep.2023.116300
Volume 309, 12 June 2023, 116300
Exploring active ingredients of anti-osteoarthritis in raw and wine-processed Dipsaci Radix based on spectrum-effect relationship combined with chemometrics
Yue Lv a,1, Hangsha Wu a,1, Zhihui Hong a, Feiyang Wei a, Mingfang Zhao a, Rui Tang a, Yafei Li a, Weihong Ge a,b,c,**, Changyu Li d, Weifeng Du
doi : 10.1016/j.jep.2023.116281
Volume 309, 12 June 2023, 116281
Toxicological and pharmacological effects of Eugenia brasiliensis Lam. (Myrtaceae) leaves in mice
Scheila Iria Kraus a,b, Jeane Bachi Ferreira a, Jhonatan Augusto Ribeiro a, Kelly Cattelan Bonorino a, Vin?cius Alexandre Wippel a, Michele Debiasi Alberton c, Andr´eia Caroline Fernandes Salgueiro d, Carlos Henrique Lemos Soares e, Morgana Duarte da Silva
doi : 10.1016/j.jep.2023.116309
Volume 309, 12 June 2023, 116309
Evaluation of acute oral toxicity, anti-diabetic and antioxidant effects of Aloe vera flowers extract
Nesreen M.I.M. Elkomy a, Amina El-Shaibany b, Gehad M. Elnagar c, Ahmed S. Abdelkhalek d, Hassan Al-Mahbashi e, Mahmoud M. Elaasser f, Salwa M. Raweh b, Maha A. Aldiyarbi g, Ali E. Raslan
doi : 10.1016/j.jep.2023.116310
Volume 309, 12 June 2023, 116310
Therapeutic effect of Yiyi Fuzi Baijiang formula on TNBS-induced ulcerative colitis via metabolism and Th17/Treg cell balance
Meihua Liu a,1, Zhonghua Wang b,1, Xuan Liu c,1, Hang Xiao d, Yangcheng Liu a, Jiaqi Wang a, Changlan Chen a, Xin Wang a, Wei Liu a, Zheng Xiang a,*, Dongmei Yue
doi : 10.1016/j.jep.2023.116301
Volume 309, 12 June 2023, 116301
A homogeneous Lonicera japonica polysaccharide alleviates atopic dermatitis by promoting Nrf2 activation and NLRP3 inflammasome degradation via p62
Xinyu Bai a,b, Xiuming Rao b, Yuqi Wang b, Hengyan Shen b, Xuejun Jin
doi : 10.1016/j.jep.2023.116344
Volume 309, 12 June 2023, 116344
Cordyceps proteins alleviate lupus nephritis through modulation of the STAT3/mTOR/NF-кB signaling pathway
Li-ying He a, Shu-qi Niu b,c, Cai-xia Yang a, Pan Tang a, Jiao-jiao Fu b, Li Tan a, Yong Li a, Ya-nan Hua b,c, Si-jing Liu b,c,**, Jin-lin Guo
doi : 10.1016/j.jep.2023.116284
Volume 309, 12 June 2023, 116284
Antidepressive mechanisms of rhynchophylline in mice with chronic unpredictable stress-induced depression
En-Yu Liu a,1, Chao-Lin Yang b,1, Jen-Chieh Tsai c, Hao-Yuan Cheng d,**, Wen-Huang Peng
doi : 10.1016/j.jep.2023.116302
Volume 309, 12 June 2023, 116302
Ganoderma lucidum polysaccharides improve lipid metabolism against high-fat diet-induced dyslipidemia
Wenshuai Wang , Yaohan Zhang , Zhiying Wang , Jianjun Zhang **, Le Jia
doi : 10.1016/j.jep.2023.116321
Volume 309, 12 June 2023, 116321
Identification of an effective fraction from Ampelopsis Radix with anti-dengue virus activities in vitro and in vivo
Chunyang Tian a,1, Hefei Huang a,1, Yuanru zheng a,1, Xuemei He a, Lijun Yan a, Lingzhu Shi a, Tangjia Yang a, Xi Chen a, Jiabin Yang a, Zibin Lu a, Huihui Cao a, Wei Zhao b, Zhiran Qin b, Jianhai Yu b, Qingfa Tang c, Xiankun Tong d, Junshan Liu a,c,e,*, Linzhong Yu
doi : 10.1016/j.jep.2023.116339
Volume 309, 12 June 2023, 116339
Chinese herbal formula, modified Xianfang Huoming Yin, alleviates the inflammatory proliferation of rat synoviocytes induced by IL-1β through regulating the migration and differentiation of T lymphocytes
Dongyang Li a,1, Wei Liu a,1, Song Sun a,1, Yingkai Zhang a, Pingxin Zhang a, Guiyu Feng a, Jie Wei b,**, Limin Chai
doi : 10.1016/j.jep.2023.116297
Volume 309, 12 June 2023, 116297
Sparganii Rhizoma alleviates pulmonary fibrosis by inhibiting fibroblasts differentiation and epithelial-mesenchymal transition mediated by TGF-β1/ Smad2/3 pathway
Jing Liu a,1, Dongyang Gao a,1, Qi Ding b, Binbin Zhang a, Wenxiang Zhu b,**, Yuanyuan Shi
doi : 10.1016/j.jep.2023.116305
Volume 309, 12 June 2023, 116305
Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves
Fabiana de Freitas Figueiredo a, Amilcar Sabino Damazo a,b, Karuppusamy Arunachalam c,d, Marcelo Jos´e Dias Silva e, Eduarda Pavan a, Joaquim Corsino da Silva Lima f, Domingos Tabajara de Oliveira Martins
doi : 10.1016/j.jep.2023.116338
Volume 309, 12 June 2023, 116338
The acute oral toxicity test of ethanol extract of salt-processed Psoraleae Fructus and its acute hepatotoxicity and nephrotoxicity risk assessment
Chen Gao a, Chang Liu a,c, Yuanyuan Wei a, Qingtao Wang a,b, Xuan Ni a,b, Shaofeng Wu a, Yizhuo Fang a, Zhihui Hao
doi : 10.1016/j.jep.2023.116334
Volume 309, 12 June 2023, 116334
Glycolipid-enriched fraction of Osmanthus fragrans inhibits LPS-induced expression of inflammatory genes, COX-2, E-selectin, and Interleukin-8
Teresa Pirker a, Eva-Maria Pferschy-Wenzig a, Evangelia Bampali a, Valery Bochkov b, Rudolf Bauer a
doi : 10.1016/j.jep.2023.116328
Volume 309, 12 June 2023, 116328
ErZhiFormula prevents UV-induced skin photoaging by Nrf2/HO-1/NQO1 signaling: An in vitro and in vivo studies
Tao Liu a,b,1, QingMei Xia a,1, Yingshuang Lv b, Zijing Wang a,b, Shan Zhu b, Wenxiao Qin b, Yi Yang b, Tao Liu b, Xiang Wang b, Zhiyue Zhao b, Hongfei Ma b, Linlin Jia b, Han Zhang b, Zongpei Xu a,**, Nan Li
doi : 10.1016/j.jep.2022.115935
Volume 309, 12 June 2023, 115935
Simiao pill attenuates collagen-induced arthritis and bleomycin-induced pulmonary fibrosis in mice by suppressing the JAK2/STAT3 and TGF-β/Smad2/3 signalling pathway
Xin Ba a,1, Hui Wang b,1, Yao Huang c, JiaHui Yan a, Liang Han a, WeiJi Lin a, Pan Shen a, Ying Huang c, SiSi Yang d, Kai Qin c, ShengHao Tu a,c, Zhe Chen
doi : 10.1016/j.jep.2023.116274
Volume 309, 12 June 2023, 116274
Efficacy and safety of Chinese herbal medicine children's Zibei Xuanfei syrup in treating acute trachea-bronchitis with wind-heat invading lung syndrome: A randomized, double-blind, multicentre, controlled trial
Hua-Fang Chen a,*, Gui-Hua Song b,1, Gang Zhao c, Wen-Sheng Zhai b, Meng-Meng Sun b, Zhi-Jun Huang c, Bao-Qing Zhang d, Hui Li e, Jian-Qiao Tang
doi : 10.1016/j.jep.2023.116207
Volume 309, 12 June 2023, 116207
UPLC-QTOF-MS/MS-based metabolomic approach and gastroprotective effect of two chemotypes of Egletes viscosa (L.) less. against ethanol-induced gastric ulcer in mice
Fl´avia Almeida Santos a,*, Ana Fl´avia Seraine Cust´odio Viana a, Paulo Iury Gomes Nunes a, Benedito Yago Machado Portela a, Ana Paula Negreiros Nunes Alves b, Daniel de Ara?jo Viana c, Kaline Rodrigues Carvalho d,e, Rita de C´assia Alves Pereira d, Paulo Riceli Vasconcelos Ribeiro d, Elenilson Godoy Alves-Filho d, Edy Sousa de Brito d, Edilberto Rocha Silveira e, Kirley Marques Canuto
doi : 10.1016/j.jep.2023.116348
Volume 309, 12 June 2023, 116348
The aqueous extracts of Ageratum conyzoides inhibit inflammation by suppressing NLRP3 inflammasome activation
Zhen Xu 1, Rong Ji 1, Xiangru Zha , Huange Zhao , Songlin Zhou
doi : 10.1016/j.jep.2023.116353
Volume 309, 12 June 2023, 116353
Involvement of p38 MAPK/cPLA2 and arachidonic acid metabolic pathway in Shengmai injection-induced pseudo-allergic reactions
Dunfang Wang 1, Chen Pan 1, Jiayin Han 1, Yong Zhao , Suyan Liu , Chunying Li , Yan Yi , Yushi Zhang , Xuan Tang , Aihua Liang
doi : 10.1016/j.jep.2023.116357
Volume 309, 12 June 2023, 116357
TMT quantitative proteomics and network pharmacology reveal the mechanism by which asiaticoside regulates the JAK2/STAT3 signaling pathway to inhibit peritoneal fibrosis
Jinyi Sun a,1, Lei Tang a,1, Yun Shan a, Manshu Yu a, Li Sheng a, Liyan Huang a, Huimin Cao a, Huibo Dai a, Funing Wang a, Juan Zhao b, Meixiao Sheng
doi : 10.1016/j.jep.2023.116343
Volume 309, 12 June 2023, 116343
Jieduquyuziyin prescription alleviates SLE complicated by atherosclerosis via promoting cholesterol efflux and suppressing TLR9/MyD88 activation
Yuanfang He a,b,1, Weiyu Tian a,b,1, Miao Zhang a,b, Haonan Qiu a,b, Haichang Li a,b, Xiaowei Shi a,b, Siyue Song a,b, Chengping Wen a,b,**, Juan Chen
doi : 10.1016/j.jep.2023.116283
Volume 309, 12 June 2023, 116283
Anti-inflammatory effects of Peucedanum japonicum Thunberg leaves extract in Lipopolysaccharide-stimulated RAW264.7Â cells
Ji Hyeon Park a, Jang Hoon Kim b, Jae Young Shin a, Eun Seo Kang a, Byoung Ok Cho
Weierning, a Chinese patent medicine, improves chronic atrophic gastritis with intestinal metaplasia
Liping Han a,1, Ting Li a,1, Yingying Wang a, Weizi Lai a, Hengpu Zhou a, Zhuangwei Niu a, Jie Su a, Guiyuan Lv a, Guangji Zhang b, Jianli Gao a,**, Jianbo Huang b,***, Zhaohuan Lou
doi : 10.1016/j.jep.2023.116345
Volume 309, 12 June 2023, 116345
Ethyl palmitate, an anti-chikungunya virus principle from Sauropus androgynus, a medicinal plant used to alleviate fever in ethnomedicine
A. Sagna a,1, Reshma V.R. Nair b,1, Neha Hulyalkar c,1, S. Rajasekharan a, Vinodkumar T.G. Nair a, K.C. Sivakumar c, S.R. Suja a,***, Sabulal Baby b,**, Easwaran Sreekumar
doi : 10.1016/j.jep.2023.116366
Volume 309, 12 June 2023, 116366
Iridoids from Morinda lucida, (Benth.) Rubiaceae, produced analgesic and anti-inflammatory activities via agonism at the kappa and delta opioid receptors, inhibition of COX-2 besides elevation of CAT and SOD activities
Emmanuel Kofi Kumatia a,b,*, Frederick Ayertey a, Tomoe Ohta c, Takuhiro Uto c, Nguyen Huu Tung
doi : 10.1016/j.jep.2023.116355
Volume 309, 12 June 2023, 116355
Tripterygium wilfordii protects against an animal model of autoimmune hepatitis
Ting Zhang a,b,c, Qianru Rao c, Manyun Dai a,b,c, Zhanxuan E. Wu c, Qi Zhao c, Fei Li
doi : 10.1016/j.jep.2023.116365
Volume 309, 12 June 2023, 116365
Estrogenic and anti-amnesic potential of Millettia griffoniana Baill. (Fabaceae) ethanolic extract on scopolamine-induced memory impairment in ovariectomized Wistar rats
Roland Nhouma Rebe a, Jordan Tonga Lembe b, Simon D´esir´e Guedang Nyayi a, Herv´e Herv´e Abaïssou Ngatanko a, Eglantine Keugong Wado a, Germain Jean Magloire Ketcha Wanda c,1, Derek Tantoh Ndinteh b, Dieudonn´e Njamen c, St´ephane Zingue b,d,*, Harquin Simplice Foyet
doi : 10.1016/j.jep.2023.116325
Volume 309, 12 June 2023, 116325
Sanwei DouKou Decoction ameliorate Alzheimer disease by increasing endogenous neural stem cells proliferation through the Wnt/β-catenin signalling pathway
Shuran Li a,b, Yongbiao Li a, Wenjing Sun a, Zhiping Qin a, Yangyang Lu a, Yujia Song a, Man Ga c, Farong Yuan d, Qingshan Liu
doi : 10.1016/j.jep.2023.116364
Volume 309, 12 June 2023, 116364
Characterization of the volatile profile and its estrogenic activity in Kadsura coccinea fruit
Jin-jin Dong a,1, Jie-yao Ma b,1, Wei-ye Yang a, Wei Cai b,**, Wei-hua Wu
doi : 10.1016/j.jep.2023.116341
Volume 309, 12 June 2023, 116341
Traditional Chinese Medicine Danzhi qing'e decoction inhibits inflammation-associated prostatic hyperplasia via inactivation of ERK1/2 signal pathway
Yang Liu a,b, Rui Shao b,c, Tongchuan Suo d, Junjie Zhu a,b,c, Erwei Liu a,b,c, Yajing Wang b,c, Lin Miao a,b,c,e,*, Xiumei Gao
doi : 10.1016/j.jep.2023.116354
Volume 309, 12 June 2023, 116354
In silico molecular modeling, neuro-behavioral profile, and toxicity assessment of the essential oil of Ferula gummosa Boiss. as an anti-seizure agent
Mahin Bashiri-Nahnjeh a, Abdolrahman Sarihi b,1, Ahmad Ebadi c, Dara Dastan d, Mojdeh Mohammadi
doi : 10.1016/j.jep.2023.116347
Volume 309, 12 June 2023, 116347
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway
Jieying Qi a, Qin Luo a, Qiaoying Zhang a, Mengni Wu a, Lili Zhang a, Linsen Qin a, Qi Xue b,**, Xiaoli Nie
doi : 10.1016/j.jep.2023.116327
Volume 309, 12 June 2023, 116327
The potential antidiabetic properties of green and purple tea [Camellia sinensis (L.) O Kuntze], purple tea ellagitannins, and urolithins
M. Tolmie a,*, M.J. Bester b, J.C. Serem b, M. Nell c, Z. Apostolides
doi : 10.1016/j.jep.2023.116377
Volume 309, 12 June 2023, 116377
Mechanism of the Mongolian medicine Eerdun Wurile basic formula in improving postoperative cognitive dysfunction by inhibiting apoptosis through the SIRT1/p53 signaling pathway
Yan Li a, Yun Qiao a, Huiru Li a, Zhe Wang a, Enboer Su b, Yiri Du b,*, Limuge Che
doi : 10.1016/j.jep.2023.116312
Volume 309, 12 June 2023, 116312
Anti-inflammatory, anti-nociceptive and anti-pyretic activities of Cenchrus ciliaris L.
Iqra Nawaz a, Ayma Tahir a, Shahid Muhammad Iqbal a, Fayyaz Anjum a, Mahrukh Naseem b, Muhammad Irfan Aslam a, Musaddique Hussain a, Qazi Adnan Jamil c, Jafir Hussain Shirazi c, QurratUlAin Jamil
doi : 10.1016/j.jep.2023.116332
Volume 309, 12 June 2023, 116332
