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Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury
Antoine Roquilly, MD, PhD1; Jean Denis Moyer, MD2; Olivier Huet, MD, PhD3; Sigismond Lasocki, MD, PhD4; Benjamin Cohen, MD5; Claire Dahyot-Fizelier, MD, PhD6; Kevin Chalard, MD7; Philippe Seguin, MD, PhD8; Caroline Jeantrelle, MD2; Véronique Vermeersch, MD3; Thomas Gaillard, MD4; Raphael Cinotti, MD1; Dominique Demeure dit Latte, MD1; Pierre Joachim Mahe, MD1; Mickael Vourc’h, MD1; Florian Pierre Martin, MD1; Alice Chopin, MD1; Celine Lerebourg, MSc1; Laurent Flet, PharmD9; Anne Chiffoleau, MD10; Fanny Feuillet, PhD11,12; Karim Asehnoune, MD, PhD1; for the Atlanrea Study Group and the Société Française d’Anesthésie Réanimation (SFAR) Research Network
doi : 10.1001/jama.2021.5561
JAMA. 2021;325(20):2056-2066
Importance Fluid therapy is an important component of care for patients with traumatic brain injury, but whether it modulates clinical outcomes remains unclear.
?2-Adrenergic Agonists or Stimulants for Preschool-Age Children With Attention-Deficit/Hyperactivity Disorder
Elizabeth Harstad, MD, MPH1; Justine Shults, PhD2,3; William Barbaresi, MD1; Ami Bax, MD4; Jaclyn Cacia, MS2; Alexis Deavenport-Saman, DrPH5,6; Sandra Friedman, MD, MPH7; Angela LaRosa, MD, MSCR8; Irene M. Loe, MD9; Shruti Mittal, MD10; Shelby Tulio, MS2; Douglas Vanderbilt, MD, MS5; Nathan J. Blum, MD3,11
doi : 10.1001/jama.2021.6118
JAMA. 2021;325(20):2067-2075
Importance Attention-deficit/hyperactivity disorder (ADHD) is diagnosed in approximately 2.4% of preschool-age children. Stimulants are recommended as first-line medication treatment. However, up to 25% of preschool-age children with ADHD are treated with ?2-adrenergic agonist medications, despite minimal evidence about their efficacy or adverse effects in this age range.
Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes
Mikael Norman, MD1,2,3; Lars Navér, MD1,2; Jonas S?derling, PhD4; Mia Ahlberg, PhD4,5; Helena Hervius Askling, MD6; Bernice Aronsson, MD7; Emma Bystr?m, MSc7; Jerker Jonsson, MD7; Verena Sengpiel, MD8,9; Jonas F. Ludvigsson, MD10,11; Stellan H?kansson, MD3,12; Olof Stephansson, MD4,5
doi : 10.1001/jama.2021.5775
JAMA. 2021;325(20):2076-2086
Importance The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.
S-Gene Target Failure as a Marker of Variant B.1.1.7 Among SARS-CoV-2 Isolates in the Greater Toronto Area, December 2020 to March 2021
Kevin A. Brown, PhD1; Jonathan Gubbay, MBBS, MMedSc1; Jessica Hopkins, MD, MHSc1; Samir Patel, PhD1; Sarah A. Buchan, PhD1; Nick Daneman, MD, MSc2; Lee William Goneau, PhD3
doi : 10.1001/jama.2021.5607
JAMA. 2021;325(20):2115-2116
Preliminary Investigation of In situ Thrombus Within Patent Foramen Ovale in Patients With and Without Stroke
Chaowu Yan, PhD, MD1; Hua Li, MD2
doi : 10.1001/jama.2021.4359
JAMA. 2021;325(20):2116-2118
Behavioral Counseling Interventions for Healthy Weight and Weight Gain in Pregnancy
US Preventive Services Task Force
doi : 10.1001/jama.2021.6949
JAMA. 2021;325(20):2087-2093
Importance The prevalence of overweight and obesity is increasing among persons of childbearing age and pregnant persons. In 2015, almost half of all persons began pregnancy with overweight (24%) or obesity (24%). Reported rates of overweight and obesity are higher among Black, Alaska Native/American Indian, and Hispanic women and lower among White and Asian women. Excess weight at the beginning of pregnancy and excess gestational weight gain have been associated with adverse maternal and infant health outcomes such as a large for gestational age infant, cesarean delivery, or preterm birth.
Counseling and Behavioral Interventions for Healthy Weight and Weight Gain in Pregnancy
Amy G. Cantor, MD, MPH1,2,3; Rebecca M. Jungbauer, DrPH, MPH, MA1; Marian McDonagh, PharmD1; Ian Blazina, MPH1; Nicole E. Marshall, MD, MCR3; Chandler Weeks, MPH1; Rongwei Fu, PhD1,4; Erin S. LeBlanc, MD, MPH5; Roger Chou, MD1
doi : 10.1001/jama.2021.4230
JAMA. 2021;325(20):2094-2109
Importance Counseling and active behavioral interventions to limit excess gestational weight gain (GWG) during pregnancy may improve health outcomes for women and infants. The 2009 National Academy of Medicine (NAM; formerly the Institute of Medicine) recommendations for healthy GWG vary according to prepregnancy weight category.
Precision Medicine for COVID-19
Kimberley DeMerle, MD, MSc1; Derek C. Angus, MD, MPH1,2; Christopher W. Seymour, MD, MSc1,3
doi : 10.1001/jama.2021.5248
JAMA. 2021;325(20):2041-2042
Designing a Successful Primary Care Physician Capitation Model
Ezekiel J. Emanuel, MD, PhD1; Farzad Mostashari, MD, ScM2; Amol S. Navathe, MD, PhD1,3
doi : 10.1001/jama.2021.5133
JAMA. 2021;325(20):2043-2044
High and Rising Working-Age Mortality in the US
Kathleen Mullan Harris, PhD1,2; Steven H. Woolf, MD, MPH3,4; Darrell J. Gaskin, PhD5,6
doi : 10.1001/jama.2021.4073
JAMA. 2021;325(20):2045-2046
Defense Against Numbness
Cynthia X. He, MD, PhD1
doi : 10.1001/jama.2021.7137
JAMA. 2021;325(20):2047-2048
Comparison of Medication Treatments for Preschool Children With ADHD
Tanya E. Froehlich, MD, MS1
doi : 10.1001/jama.2021.5603
JAMA. 2021;325(20):2049-2050
Understanding Risk for Newborns Born to SARS-CoV-2–Positive Mothers
Dani Dumitriu, MD, PhD1; Cynthia Gyamfi-Bannerman, MD, MS2
doi : 10.1001/jama.2021.6210
JAMA. 2021;325(20):2051-2052
Behavioral Counseling Interventions for Healthy Weight During Pregnancy
D. Yvette LaCoursiere, MD, MPH1
doi : 10.1001/jama.2021.5720
JAMA. 2021;325(20):2053-2055
Adjusting for Nonadherence or Stopping Treatments in Randomized Clinical Trials
Amanda I. Adler, MD, PhD1,2; Nicholas R. Latimer, MSc, PhD3
doi : 10.1001/jama.2021.2433
JAMA. 2021;325(20):2110-2111
Indoor Air Changes and Potential Implications for SARS-CoV-2 Transmission
Joseph G. Allen, DSc, MPH1; Andrew M. Ibrahim, MD, MSc2,3
doi : 10.1001/jama.2021.5053
JAMA. 2021;325(20):2112-2113
Researchers Tie Severe Immunosuppression to Chronic COVID-19 and Virus Variants
Jennifer Abbasi
doi : 10.1001/jama.2021.7212
JAMA. 2021;325(20):2033-2035
An Inside Look at a Post–COVID-19 Clinic
Kristin Walter, MD, MS
doi : 10.1001/jama.2021.2426
JAMA. 2021;325(20):2036-2037
Massive Costs of the US Opioid Epidemic in Lives and Dollars
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.7464
JAMA. 2021;325(20):2040
Sexually Transmitted Disease Cases Continue to Break Records
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.6937
JAMA. 2021;325(20):2040
Clear Surgical Masks Create More Positive Interactions With Patients
Anita Slomski
doi : 10.1001/jama.2021.6793
JAMA. 2021;325(20):2039
Upadacitinib Noninferior to Adalimumab for Psoriatic Arthritis
Anita Slomski
doi : 10.1001/jama.2021.7716
JAMA. 2021;325(20):2039.
Patients Favor Surgical Repair of Ruptured ACL
Anita Slomski
doi : 10.1001/jama.2021.7718
JAMA. 2021;325(20):2039
Shorter Antibiotic Therapy Safe for Inpatients With Pneumonia
Anita Slomski
doi : 10.1001/jama.2021.7721
JAMA. 2021;325(20):2039
Patient Navigation Reduces Substance Abuse Disorder Readmissions
Anita Slomski
doi : 10.1001/jama.2021.7723
JAMA. 2021;325(20):2039
Allergic Reactions to mRNA Vaccines
Rita Rubin, MA
doi : 10.1001/jama.2021.6941
JAMA. 2021;325(20):2038
Free, At-Home Rapid SARS-CoV-2 Tests
Rita Rubin, MA
doi : 10.1001/jama.2021.7585
JAMA. 2021;325(20):2038
The Social Responsibilities of Modern Medicine
doi : 10.1001/jama.2020.17954
JAMA. 2021;325(20):2122
Behavioral Interventions for Healthy Weight Gain During Pregnancy
Jill Jin, MD, MPH1
doi : 10.1001/jama.2021.7530
JAMA. 2021;325(20):2126
Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission
Wentao Sang, MS1; Feng Xu, MD1
doi : 10.1001/jama.2021.4064
JAMA. 2021;325(20):2118
Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission—Reply
Francis Kim, MD1; Charles Maynard, PhD2; Graham Nichol, MD, MPH1
doi : 10.1001/jama.2021.4067
JAMA. 2021;325(20):2118-2119
US Hospital Data About Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses
Marjorie Meyer, MD1; Jerilyn Metayer, RN2
doi : 10.1001/jama.2021.4510
JAMA. 2021;325(20):2119-2120
US Hospital Data About Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses—Reply
Ashley H. Hirai, PhD1; Jean Y. Ko, PhD2; Stephen W. Patrick, MD, MPH, MS3
doi : 10.1001/jama.2021.4519
JAMA. 2021;325(20):2120
Addition of Nonauthor Collaborator Names of the COVID-19 Lombardy ICU Network
doi : 10.1001/jama.2021.5060
JAMA. 2021;325(20):2120
