Nature Reviews Drug Discovery




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Defining rare conditions in the era of personalized medicine

Daniel J. O’Connor, Michela Gabaldo, Annemieke Aartsma-Rus & Anneliene Hechtelt Jonker

doi : 10.1038/d41573-023-00145-2

Volume 22 Issue 11, November 2023

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CAR T cell therapies raise hopes — and questions — for lupus and autoimmune disease

Asher Mullard

doi : 10.1038/d41573-023-00166-x

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FDA approves fourth JAK inhibitor for myelofibrosis

Asher Mullard

doi : 10.1038/d41573-023-00163-0

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Novel schizophrenia therapy filed for FDA approval

Asher Mullard

doi : 10.1038/d41573-023-00164-z

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MDMA-assisted therapy for PTSD passes phase III trial

Asher Mullard

doi : 10.1038/d41573-023-00165-y

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Genetic support for FDA-approved drugs over the past decade

Polina V. Rusina, Maria J. Falaguera, Juan Maria R. Romero, Ellen M. McDonagh, Ian Dunham & David Ochoa

doi : 10.1038/d41573-023-00158-x

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Neglected tropical diseases go global

Asher Mullard

doi : 10.1038/d41573-023-00167-w

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The R&D landscape for infectious disease vaccines

doi : 10.1038/d41573-023-00119-4

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Antipsychotic displays dual GPCR binding mode

Sarah Crunkhorn

doi : 10.1038/d41573-023-00154-1

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Stress can be exhausting for T cells

Kirsty Minton

doi : 10.1038/d41573-023-00157-y

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Rewired proteostasis in KRAS inhibitor resistance

Alex Eccleston

doi : 10.1038/d41573-023-00155-0

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Microbial ‘dark matter’ yields new antibiotic

Katie Kingwell

doi : 10.1038/d41573-023-00156-z

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Reshaping the tumour microenvironment

Sarah Crunkhorn

doi : 10.1038/d41573-023-00159-w

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Targeting expanded trinucleotide repeats

Sarah Crunkhorn

doi : 10.1038/d41573-023-00160-3

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Understanding GABAA receptor pharmacology

Sarah Crunkhorn

doi : 10.1038/d41573-023-00162-1

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Drug delivery systems for CRISPR-based genome editors

Victoria Madigan, Feng Zhang & James E. DahlmanÂ

doi : 10.1038/s41573-023-00762-x

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Artificial intelligence for natural product drug discovery

Michael W. Mullowney, Katherine R. Duncan, Somayah S. Elsayed, Neha Garg, Justin J. J. van der Hooft, Nathaniel I. Martin, David Meijer, Barbara R. Terlouw, Friederike Biermann, Kai Blin, Janani Durairaj, Marina Gorostiola González, Eric J. N. Helfrich, Florian Huber, Stefan Leopold-Messer, Kohulan Rajan, Tristan de Rond, Jeffrey A. van Santen, Maria Sorokina, Marcy J. Balunas, Mehdi A. Beniddir, Doris A. van Bergeijk, Laura M. Carroll, Chase M. Clark, …Marnix H. MedemaÂ

doi : 10.1038/s41573-023-00774-7

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Therapeutic approaches for Duchenne muscular dystrophy

Thomas C. Roberts, Matthew J. A. Wood & Kay E. DaviesÂ

doi : .1038/s41573-023-00775-6

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Author Correction: Bridging the gap between innovation and later-stage financing for biotech in Europe

Jing Gong, Jean-Loup Romet-Lemonne & Brandy HouserÂ

doi : 10.1038/s41573-023-00792-5

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Author Correction: Disease modification in inflammatory skin disorders: opportunities and challenges

Thomas Bieber 

doi : 10.1038/s41573-023-00790-7

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