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Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation
Mickael Vourc’h, MD1; Charlotte Garret, MD2; Arnaud Gacouin, MD3; Jean-Claude Lacherade, MD4; Maud Jonas, MD5; Kada Klouche, MD6; Martine Ferrandiere, MD7; Samir Jaber, MD8; Laurent Flet, PharmD9; Eric Dailly, PharmD10; Caroline Pouplet, MD4; Adel Maamar, MD3; Jean Reignier, MD2; Antoine Roquilly, MD1; Fanny Feuillet, PhD11,12; Pierre-Joachim Mahe, MD1; Karim Asehnoune, MD1; for the BACLOREA study group
doi : 10.1001/jama.2021.0658
JAMA. 2021;325(8):732-741
To assess whether high-dose baclofen reduces agitation-related events compared with placebo in patients with unhealthy alcohol use receiving mechanical ventilation.
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis
Jonathan E. Sevransky, MD, MHS1,2; Richard E. Rothman, MD, PhD3; David N. Hager, MD, PhD4; Gordon R. Bernard, MD5; Samuel M. Brown, MD6; Timothy G. Buchman, PhD, MD2,7; Laurence W. Busse, MD, MBA1,2; Craig M. Coopersmith, MD2,7; Christine DeWilde, PhD8; E. Wesley Ely, MD, PhD5,9,10; Lindsay M. Eyzaguirre, MS11; Alpha A. Fowler, MD8; David F. Gaieski, MD12; Michelle N. Gong, MD13; Alex Hall, DHSc, MS14; Jeremiah S. Hinson, MD, PhD3; Michael H. Hooper, MD15; Gabor D. Kelen, MD3; Akram Khan, MD16; Mark A. Levine, MD17; Roger J. Lewis, MD, PhD18,19,20,21; Chris J. Lindsell, PhD22; Jessica S. Marlin, CCRP23; Anna McGlothlin, PhD19; Brooks L. Moore, MD14; Katherine L. Nugent, MD14; Samuel Nwosu, MS22; Carmen C. Polito, MD, MSc1,2; Todd W. Rice, MD, MSc5; Erin P. Ricketts, MSPH3; Caroline C. Rudolph, MBA14; Fred Sanfilippo, MD, PhD24; Kert Viele, PhD19,25; Greg S. Martin, MD, MSc1,2; David W. Wright, MD14; for the VICTAS Investigators
doi : 10.1001/jama.2020.24505
JAMA. 2021;325(8):742-750
Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye
The Genetics of Exfoliation Syndrome Partnership
doi : 10.1001/jama.2021.0507
JAMA. 2021;325(8):753-764
Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber of the eye. This disorder is the most commonly known cause of glaucoma and a major cause of irreversible blindness.
All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020
Jeremy Samuel Faust, MD, MS1; Harlan M. Krumholz, MD, SM2; Chengan Du, PhD3; Katherine Dickerson Mayes, MD, PhD4; Zhenqiu Lin, PhD3; Cleavon Gilman, MD5; Rochelle P. Walensky, MD, MPH6
doi : 10.1001/jama.2020.24243
JAMA. 2021;325(8):785-787
Surprise Billing—A Flashpoint for Major Policy Issues in Health Care
Carrie Colla, PhD1
doi : 10.1001/jama.2020.26779
JAMA. 2021;325(8):715-716
From Digitization to Digital Transformation
Julia Adler-Milstein, PhD1
doi : 10.1001/jama.2020.27014
JAMA. 2021;325(8):717-718
Racial and Ethnic Health Disparities Related to COVID-19
Leo Lopez III, MD, MHS1; Louis H. Hart III, MD1; Mitchell H. Katz, MD1
doi : 10.1001/jama.2020.26443
JAMA. 2021;325(8):719-720
A Viral Pandemic, Vaccine Safety, and Compensation for Adverse Events
H. Cody Meissner, MD1
doi : 10.1001/jama.2020.26792
JAMA. 2021;325(8):721-722
When Physicians Engage in Practices That Threaten the Nation’s Health
Philip A. Pizzo, MD1; David Spiegel, MD2; Michelle M. Mello, JD, PhD3,4
doi : 10.1001/jama.2021.0122
JAMA. 2021;325(8):723-724
COVID-19 Communication—The Need for Humanity, Empathy, and Grace
Lisa M. Meeks, PhD1
doi : 10.1001/jama.2021.0119
JAMA. 2021;325(8):725-726
Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU
Michael C. Reade, MBBS, DPhil1,2,3
doi : 10.1001/jama.2021.0597
JAMA. 2021;325(8):727-729
Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis
Kristin L. Walter, MD, MS1; Christopher W. Seymour, MD, MSc2,3,4
doi : 10.1001/jama.2020.26029
JAMA. 2021;325(8):730-731
Diagnosis and Treatment of Multiple Sclerosis
Marisa P. McGinley, DO1; Carolyn H. Goldschmidt, DO1; Alexander D. Rae-Grant, MD1,2
doi : 10.1001/jama.2020.26858
JAMA. 2021;325(8):765-779
Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system characterized by inflammatory demyelination with axonal transection. MS affects an estimated 900?000 people in the US. MS typically presents in young adults (mean age of onset, 20-30 years) and can lead to physical disability, cognitive impairment, and decreased quality of life. This review summarizes current evidence regarding diagnosis and treatment of MS.
Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine
Tom Shimabukuro, MD, MPH, MBA1; Narayan Nair, MD2
doi : 10.1001/jama.2021.0600
JAMA. 2021;325(8):780-781
A Purpuric Rash
Kevin D. He, MD1; Ken He, MD2,3; Paul B. Cornia, MD2,3
doi : 10.1001/jama.2020.19186
JAMA. 2021;325(8):782-783
Funding and DSMB Membership in the VICTAS Clinical Trial
Howard Bauchner, MD1; Phil B. Fontanarosa, MD, MBA2; Robert M. Golub, MD3
doi : 10.1001/jama.2020.25952
JAMA. 2021;325(8):751-752
“Important Conversations” Are Needed to Explain the Nocebo Effect
Anita Slomski, MA
doi : 10.1001/jama.2020.25840
JAMA. 2021;325(8):707-709
From Economic Recovery to Health Resilience
Dave A. Chokshi, MD, MSc1
doi : 10.1001/jama.2020.24936
JAMA. 2021;325(8):710-711
COVID-19 Rates Increased Where In-Person College Classes Were Held
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.0621
JAMA. 2021;325(8):714
Drug-Resistant Yeast Infections Spread in COVID-19 Unit
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.1031
JAMA. 2021;325(8):714
Oral Rimegepant Safe, Effective for Migraine Prevention
Anita Slomski, MA
doi : 10.1001/jama.2021.0651
JAMA. 2021;325(8):713
Finerenone for Patients With CKD and Type 2 Diabetes
Anita Slomski, MA
doi : 10.1001/jama.2021.1255
JAMA. 2021;325(8):713
Common Weight Loss Surgeries’ Benefits Sustained at Year 7
Anita Slomski, MA
doi : 10.1001/jama.2021.1257
JAMA. 2021;325(8):713
Navigators Improve Autism Evaluations but Not Referrals to Care
Anita Slomski, MA
doi : 10.1001/jama.2021.1259
JAMA. 2021;325(8):713
Physician Videos Improve COVID-19 Knowledge Among Minorities
Anita Slomski, MA
doi : 10.1001/jama.2021.1261
JAMA. 2021;325(8):713
Collecting Data About COVID-19–Related Brain Symptoms
Rita Rubin, MA
doi : 10.1001/jama.2021.0791
JAMA. 2021;325(8):712
Detecting Heart Transplant Rejection Earlier, More Easily
Rita Rubin, MA
doi : 10.1001/jama.2021.1228
JAMA. 2021;325(8):712
Locating COVID-19 Monoclonal Antibody Therapies
Rita Rubin, MA
doi : 10.1001/jama.2021.1230
JAMA. 2021;325(8):712
Nystagmus
Malcolm M. Kates, BS, BA1; Casey J. Beal, MD1
doi : 10.1001/jama.2020.3911
JAMA. 2021;325(8):798
Risk of Spinal Hematoma After Lumbar Puncture
Tao Xu, PhD1; You Wang, MD1; Yangmei Chen, PhD1
doi : 10.1001/jama.2020.24595
JAMA. 2021;325(8):787
Risk of Spinal Hematoma After Lumbar Puncture
Chloe Kimi Nobuhara, BS1; Miles Berger, MD, PhD2
doi : 10.1001/jama.2020.24601
JAMA. 2021;325(8):787-788
Risk of Spinal Hematoma After Lumbar Puncture—Reply
Jacob Bodilsen, MD, PhD1; Henrik Nielsen, MD, DMSci1
doi : 10.1001/jama.2020.24607
JAMA. 2021;325(8):788
The Effect of Surgical Treatment on Obstructive Sleep Apnea
Vanessa Alderman, MBBS1; Joshua Agbetile, MD1
doi : 10.1001/jama.2020.25121
JAMA. 2021;325(8):788-789
The Effect of Surgical Treatment on Obstructive Sleep Apnea—Reply
Stuart MacKay, MD1; R. Doug McEvoy, MD2; Edward M. Weaver, MD, MPH3
doi : 10.1001/jama.2020.25124
JAMA. 2021;325(8):789-790
Cervical Cancer Screening in Low- and Middle-Income Countries
Miriam Cremer, MD, MPH1; Karla Alfaro, MD, MPH2; Rachel Masch, MD, MPH3
doi : 10.1001/jama.2020.25214
JAMA. 2021;325(8):790
Cervical Cancer Screening in Low- and Middle-Income Countries—Reply
Pascal Geldsetzer, MBChB, ScD, MPH1; Julia M. Lemp, MSc2
doi : 10.1001/jama.2020.25217
JAMA. 2021;325(8):790-791
