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All that Nobel glitters is not biotech gold
doi : 10.1038/s41587-023-02045-7
Volume 41 Issue 11, November 2023
Can gene editing drive out HIV and hepatitis viruses from inside cells?
Cormac SheridanÂÂ
AI for drug discovery is booming, but who owns the patents?
Matthew HutsonÂÂ
Drug pipeline 3Q23 � ERT, bispecifics and CRISPR in sickle cell disease
John HodgsonÂÂ
3Q23 � VCs feed ‘older children’ as IPO markets stagnate
John HodgsonÂÂ
DNA writing technologies moving toward synthetic genomes
Caroline SeydelÂÂ
Scalable genomic data exchange and analytics with sBeacon
Anuradha Wickramarachchi, Brendan Hosking, Yatish Jain, John Grimes, Mitchell J. O’Brien, Tracey Wright, Mark A. Burgess, Victor San Kho Lin, Florian Reisinger, Oliver Hofmann, Michael Lawley, Laurence O. W. Wilson, Natalie A. Twine & Denis C. BauerÂ
The digital and analog worlds of protein engineering
Lada Nuzhna & Tess van StekelenburgÂ
Do patent applications and Cooperative Research and Development Agreements between the National Cancer Institute and industry serve the public interest?
Austin Wesevich & Mark J. RatainÂ
Gene therapy for walking recovery after paralysis
Alexandra DespangÂÂ
Imaging large cell populations with fast, automated super-resolution
The next generation of single-cell sequencing methods can be microfluidics-free
Precision RNA base editing with engineered and endogenous effectors
Laura S. Pfeiffer & Thorsten StafforstÂ
High-resolution alignment of single-cell and spatial transcriptomes with CytoSPACE
An integrated platform for high-throughput nanoscopy
Andrew E. S. Barentine, Yu Lin, Edward M. Courvan, Phylicia Kidd, Miao Liu, Leonhard Balduf, Timy Phan, Felix Rivera-Molina, Michael R. Grace, Zach Marin, Mark Lessard, Juliana Rios Chen, Siyuan Wang, Karla M. Neugebauer, Joerg Bewersdorf & David BaddeleyÂ
Microfluidics-free single-cell genomics with templated emulsification
Iain C. Clark, Kristina M. Fontanez, Robert H. Meltzer, Yi Xue, Corey Hayford, Aaron May-Zhang, Chris D’Amato, Ahmad Osman, Jesse Q. Zhang, Pabodha Hettige, Jacob S. A. Ishibashi, Cyrille L. Delley, Daniel W. Weisgerber, Joseph M. Replogle, Marco Jost, Kiet T. Phong, Vanessa E. Kennedy, Cheryl A. C. Peretz, Esther A. Kim, Siyou Song, William Karlon, Jonathan S. Weissman, Catherine C. Smith, Zev J. Gartner & Adam R. AbateÂ
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
Retrospective analysis of enhancer activity and transcriptome history
Ruben Boers, Joachim Boers, Beatrice Tan, Marieke E. van Leeuwen, Evelyne Wassenaar, Erlantz Gonzalez Sanchez, Esther Sleddens, Yasha Tenhagen, Eskeatnaf Mulugeta, Joop Laven, Menno Creyghton, Willy Baarends, Wilfred F. J. van IJcken & Joost GribnauÂ
Single-cell mapping of combinatorial target antigens for CAR switches using logic gates
Joonha Kwon, Junho Kang, Areum Jo, Kayoung Seo, Dohyeon An, Mert Yakup Baykan, Jun Hyeong Lee, Nayoung Kim, Hye Hyeon Eum, Sohyun Hwang, Ji Min Lee, Woong-Yang Park, Hee Jung An, Hae-Ock Lee, Jong-Eun Park & Jung Kyoon ChoiÂ
Deconvolution of clinical variance in CAR-T cell pharmacology and response
Daniel C. Kirouac, Cole Zmurchok, Avisek Deyati, Jordan Sicherman, Chris Bond & Peter W. ZandstraÂ
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia
Adrian Gottschlich, Moritz Thomas, Ruth Grünmeier, Stefanie Lesch, Lisa Rohrbacher, Veronika Igl, Daria Briukhovetska, Mohamed-Reda Benmebarek, Binje Vick, Sertac Dede, Katharina Müller, Tao Xu, Dario Dhoqina, Florian Märkl, Sophie Robinson, Andrea Sendelhofert, Heiko Schulz, Öykü Umut, Vladyslav Kavaka, Christina Angeliki Tsiverioti, Emanuele Carlini, Sayantan Nandi, Thaddäus Strzalkowski, Theo Lorenzini, …Sebastian KoboldÂ
Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4
Aitor Blanco-MÃÂguez, Francesco Beghini, Fabio Cumbo, Lauren J. McIver, Kelsey N. Thompson, Moreno Zolfo, Paolo Manghi, Leonard Dubois, Kun D. Huang, Andrew Maltez Thomas, William A. Nickols, Gianmarco Piccinno, Elisa Piperni, Michal PunÄÂ�ochář, Mireia Valles-Colomer, Adrian Tett, Francesca Giordano, Richard Davies, Jonathan Wolf, Sarah E. Berry, Tim D. Spector, Eric A. Franzosa, Edoardo Pasolli, Francesco Asnicar, …Nicola SegataÂ
scPrisma infers, filters and enhances topological signals in single-cell data using spectral template matching
Jonathan Karin, Yonathan Bornfeld & Mor NitzanÂ
Author Correction: Deconvolution of clinical variance in CAR-T cell pharmacology and response
Daniel C. Kirouac, Cole Zmurchok, Avisek Deyati, Jordan Sicherman, Chris Bond & Peter W. ZandstraÂ
Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning
Luke W. Koblan, Mandana Arbab, Max W. Shen, Jeffrey A. Hussmann, Andrew V. Anzalone, Jordan L. Doman, Gregory A. Newby, Dian Yang, Beverly Mok, Joseph M. Replogle, Albert Xu, Tyler A. Sisley, Jonathan S. Weissman, Britt Adamson & David R. LiuÂ
Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation
Julia M. Gauglitz, Kiana A. West, Wout Bittremieux, Candace L. Williams, Kelly C. Weldon, Morgan Panitchpakdi, Francesca Di Ottavio, Christine M. Aceves, Elizabeth Brown, Nicole C. Sikora, Alan K. Jarmusch, Cameron Martino, Anupriya Tripathi, Michael J. Meehan, Kathleen Dorrestein, Justin P. Shaffer, Roxana Coras, Fernando Vargas, Lindsay DeRight Goldasich, Tara Schwartz, MacKenzie Bryant, Gregory Humphrey, Abigail J. Johnson, Katharina Spengler, …Pieter C. DorresteinÂ
ChatGPT and medicine: how AI language models are shaping the future and health related careers
Michael Yan, Giovanni G. Cerri & Fabio Y. MoraesÂ
