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Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction
Stephan Mueller, MA1,2; Ephraim B. Winzer, MD3; André Duvinage, MD1,2; Andreas B. Gevaert, MD, PhD4,5; Frank Edelmann, MD6,7; Bernhard Haller, Dr rer nat8; Elisabeth Pieske-Kraigher, MD6,7; Paul Beckers, PhD4,5; Anna Bobenko, MD6,7; Jennifer Hommel, MA3; Caroline M. Van de Heyning, MD, PhD4,5; Katrin Esefeld, MD1,2; Pia von Korn, MSc1,2; Jeffrey W. Christle, PhD1,9; Mark J. Haykowsky, PhD10; Axel Linke, MD3; Ulrik Wisl?ff, PhD11; Volker Adams, PhD3; Burkert Pieske, MD6,7; Emeline M. van Craenenbroeck, MD, PhD4,5; Martin Halle, MD1,2; for the OptimEx-Clin Study Group
doi : 10.1001/jama.2020.26812
JAMA. 2021;325(6):542-551
Endurance exercise is effective in improving peak oxygen consumption (peak V?o2) in patients with heart failure with preserved ejection fraction (HFpEF). However, it remains unknown whether differing modes of exercise have different effects.
Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia
Gregory Ducrocq, MD, PhD1; Jose R. Gonzalez-Juanatey, MD2; Etienne Puymirat, MD3; Gilles Lemesle, MD, PhD4,5; Marine Cachanado, MSc6; Isabelle Durand-Zaleski, MD, PhD7; Joan Albert Arnaiz, MD, PhD8,9; Manuel Mart?nez-Sellés, MD, PhD8,9; Johanne Silvain, MD, PhD10; Albert Ariza-Solé, MD11; Emile Ferrari, MD12; Gonzalo Calvo, MD, PhD13; Nicolas Danchin, MD3; Cristina Avenda?o-Sol?, MD14; Jerome Frenkiel, MD7; Alexandra Rousseau, PhD6; Eric Vicaut, MD, PhD15; Tabassome Simon, MD, PhD6,16; Philippe Gabriel Steg, MD1,17; for the REALITY Investigators
doi : 10.1001/jama.2021.0135
JAMA. 2021;325(6):552-560
The optimal transfusion strategy in patients with acute myocardial infarction and anemia is unclear.
Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Newborns in Copenhagen, Denmark
Anne-Sophie Sillesen, MD, PhD1,2,3; Ottilia V?gg, MD2,3,4; Christian Pihl, MD2,3; Anna Axelsson Raja, MD, PhD1,2,3; Karin Sundberg, MD, DMSc3,5; Cathrine Vedel, MD3,5; Helle Zingenberg, MD3,6; Finn Stener J?rgensen, MD, DMSc3,7; Niels Vejlstrup, MD, PhD1,3; Kasper Iversen, MD, DMSc2,3; Henning Bundgaard, MD, DMSc1,3
doi : 10.1001/jama.2020.27205
JAMA. 2021;325(6):561-567
The prevalence and characteristics of bicuspid aortic valve (BAV) are mainly reported from selected cohorts. BAV is associated with aortopathy, but it is unclear if it represents a fetal developmental defect or is secondary to abnormal valve dynamics.
Prevalence and Outcomes of SARS-CoV-2 Infection Among Migrant Workers in Singapore
Iain Beehuat Tan, MBBS, PhD1,2; Clive Tan, MBBS, MPH3,4; Li Yang Hsu, MBBS, MPH2,4; Yock Young Dan, MBBS, PhD2,5; Andrew Aw, MDS6; Alex R. Cook, PhD4; Vernon J. Lee, MBBS, PhD2,4
doi : 10.1001/jama.2020.24071
JAMA. 2021;325(6):584-585
The COVID-19 Pandemic as an Opportunity to Ensure a More Successful Future for Science and Public Health
K. M. Venkat Narayan, MD, MSc1; James W. Curran, MD, MPH1; William H. Foege, MD, MPH1
doi : 10.1001/jama.2020.23479
JAMA. 2021;325(6):525-526
Cancer Care Under the Biden Administration
Stacie B. Dusetzina, PhD1,2
doi : 10.1001/jama.2020.25424
JAMA. 2021;325(6):527-528
Genetic Variants of SARS-CoV-2—What Do They Mean?
Adam S. Lauring, MD, PhD1; Emma B. Hodcroft, PhD2
doi : 10.1001/jama.2020.27124
JAMA. 2021;325(6):529-531
Mandating COVID-19 Vaccines
Lawrence O. Gostin, JD1; Daniel A. Salmon, MPH, PhD2; Heidi J. Larson, PhD3
doi : 10.1001/jama.2020.26553
JAMA. 2021;325(6):532-533
Problems With Paying People to Be Vaccinated Against COVID-19
Emily A. Largent, JD, PhD, RN1; Franklin G. Miller, PhD2
doi : 10.1001/jama.2020.27121
JAMA. 2021;325(6):534-535
Searching for the Optimal Exercise Training Regimen in Heart Failure With Preserved Ejection Fraction
Ambarish Pandey, MD, MSCS1; Dalane W. Kitzman, MD2
doi : 10.1001/jama.2020.26347
JAMA. 2021;325(6):537-539
Bicuspid Aortic Valve—A Common Form of Structural Heart Disease
Gregory Curfman, MD1
doi : 10.1001/jama.2021.0109
JAMA. 2021;325(6):540-541
Diagnosis and Treatment of Hip and Knee Osteoarthritis
Jeffrey N. Katz, MD, MSc1,2,3; Kaetlyn R. Arant, BA1; Richard F. Loeser, MD4
doi : 10.1001/jama.2020.22171
JAMA. 2021;325(6):568-578
Osteoarthritis (OA) is the most common joint disease, affecting an estimated more than 240 million people worldwide, including an estimated more than 32 million in the US. Osteoarthritis is the most frequent reason for activity limitation in adults. This Review focuses on hip and knee OA.
An 18-Month History of Dorsal Foot Lesions
Gordon T. Moffat, MD1; Zhe Ren, BSc2; Andrew A. Simone, MD2
doi : 10.1001/jama.2020.16053
JAMA. 2021;325(6):579-580
Helping People Who Are Homeless Stay Healthy During the Pandemic
Rita Rubin, MA
doi : 10.1001/jama.2020.23436
JAMA. 2021;325(6):517-519
Social Isolation and Loneliness: Imperatives for Health Care in a Post-COVID World
Eve Escalante, MSW, LCSW1; Robyn L. Golden, MA, LCSW1; Diana J. Mason, PhD, RN2
doi : 10.1001/jama.2021.0100
JAMA. 2021;325(6):520-521
Updated Recommendations for Gonorrhea Treatment
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.0241
JAMA. 2021;325(6):523
Accelerated Overdose Deaths Linked With COVID-19
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.0074
JAMA. 2021;325(6):523
CRISPR-Based COVID-19 Smartphone Test in Development
Jennifer Abbasi
doi : 10.1001/jama.2021.0493
JAMA. 2021;325(6):522
Predicting COVID-19 Outcomes in Emergency Department Patients
Jennifer Abbasi
doi : 10.1001/jama.2021.0227
JAMA. 2021;325(6):522
Phone Apps and Wearable Trackers Modestly Improve Activity
Jennifer Abbasi
doi : 10.1001/jama.2021.0495
JAMA. 2021;325(6):522
Death by Massive Hemorrhage in Robert Frost’s “Out, Out–”
Rosalyn Buckland, PhD1; Michael K. Abernethy, MD2
doi : 10.1001/jama.2020.24787
JAMA. 2021;325(6):515-516
To a Firstborn Son
Scott Hendrik Van Hoeven, BSc1
doi : 10.1001/jama.2020.23816
JAMA. 2021;325(6):590
Income Tax Credit for Charity Practice of Physicians
doi : 10.1001/jama.2020.17786
JAMA. 2021;325(6):591
Treatment of Alcohol Use Disorder
Avani K. Patel, MD, MHA1; Alëna A. Balasanova, MD2
doi : 10.1001/jama.2020.2012
JAMA. 2021;325(6):596
Financing of US Graduate Medical Education
Trevor J. Royce, MD, MS, MPH1
doi : 10.1001/jama.2020.23979
JAMA. 2021;325(6):585-586
Financing of US Graduate Medical Education—Reply
Justin A. Grischkan, MD1; Ari B. Friedman, MD, PhD2; Amitabh Chandra, PhD3
doi : 10.1001/jama.2020.23988
JAMA. 2021;325(6):586
Update on Blood Pressure Control Among US Adults With Hypertension
Lara C. Kovell, MD1; Colleen M. Harrington, MD1; Erin D. Michos, MD, MHS2
doi : 10.1001/jama.2020.23982
JAMA. 2021;325(6):586-587
Update on Blood Pressure Control Among US Adults With Hypertension—Reply
Paul Muntner, PhD1; Shakia T. Hardy, PhD1
doi : 10.1001/jama.2020.23991
JAMA. 2021;325(6):587-588
Algorithmic Stewardship in Health Care
Yue Li, MSc1; Junfeng Wang, PhD2
doi : 10.1001/jama.2020.24100
JAMA. 2021;325(6):588
Algorithmic Stewardship in Health Care—Reply
Stephanie Eaneff, MSP1; Ziad Obermeyer, MD2; Atul J. Butte, MD, PhD3
doi : 10.1001/jama.2020.24103
JAMA. 2021;325(6):588-589
