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Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease
Orly Vardeny, PharmD, MS1; KyungMann Kim, PhD2; Jacob A. Udell, MD, MPH3; Jacob Joseph, MD4,5; Akshay S. Desai, MD, MPH5; Michael E. Farkouh, MD, MSc6; Sheila M. Hegde, MD, MPH5; Adrian F. Hernandez, MD7; Allison McGeer, MD, MSc8; H. Keipp Talbot, MD, MPH9; Inder Anand, MD1; Deepak L. Bhatt, MD, MPH5; Christopher P. Cannon, MD5; David DeMets, PhD2; J. Michael Gaziano, MD4,5; Shaun G. Goodman, MD, MSc10; Kristin Nichol, MD, MPH1; Matthew C. Tattersall, DO, MS11; Jonathan L. Temte, MD, PhD12; Janet Wittes, PhD13; Clyde Yancy, MD14; Brian Claggett, PhD15; Yi Chen, MS2; Lu Mao, PhD2; Thomas C. Havighurst, MS2; Lawton S. Cooper, MD, MPH16; Scott D. Solomon, MD5; for the INVESTED Committees and Investigators
doi : 10.1001/jama.2020.23649
JAMA. 2021;325(1):39-49
Influenza is temporally associated with cardiopulmonary morbidity and mortality among those with cardiovascular disease who may mount a less vigorous immune response to vaccination. Higher influenza vaccine dose has been associated with reduced risk of influenza illness.
Effect of Capecitabine Maintenance Therapy Using Lower Dosage and Higher Frequency vs Observation on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer Who Had Received Standard Treatment
Xi Wang, MD1; Shu-Sen Wang, MD2; Heng Huang, MD3; Li Cai, MD4; Li Zhao, MD5; Rou-Jun Peng, MD6; Ying Lin, MD7; Jun Tang, MD1; Jian Zeng, MD8; Le-Hong Zhang, MD9; Yong-Li Ke, MD10; Xian-Ming Wang, MD11; Xin-Mei Liu, MD12; Qian-Jun Chen, MD13; An-Qin Zhang, MD14; Fei Xu, MD2; Xi-Wen Bi, MD2; Jia-Jia Huang, MD2; Ji-Bin Li, PhD15; Dan-Mei Pang, MD16; Cong Xue, MD2; Yan-Xia Shi, MD2; Zhen-Yu He, MD17; Huan-Xin Lin, MD17; Xin An, MD2; Wen Xia, MD2; Ye Cao, PhD15; Ying Guo, PhD15; Yan-Hong Su, MD18; Xin Hua, MD2; Xin-Yue Wang, MD2; Ruo-Xi Hong, MD2; Kui-Kui Jiang, MD2; Chen-Ge Song, MD2; Zhang-Zan Huang, MD2; Wei Shi, MD19; Yong-Yi Zhong, MD2; Zhong-Yu Yuan, MD2; for the South China Breast Cancer Group (SCBCG)
doi : 10.1001/jama.2020.23370
JAMA. 2021;325(1):50-58
Among all subtypes of breast cancer, triple-negative breast cancer has a relatively high relapse rate and poor outcome after standard treatment. Effective strategies to reduce the risk of relapse and death are needed.
Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms
Francis Couturaud, MD, PhD1,2,3; Laurent Bertoletti, MD, PhD3,4,5; Jean Pastre, MD6,7; Pierre-Marie Roy, MD, PhD3,8,9; Raphael Le Mao, MD1,2,3; Frédéric Gagnadoux, MD, PhD10,11; Nicolas Paleiron, MD, MS12; Jeannot Schmidt, MD3,13,14; Olivier Sanchez, MD, PhD3,6,7; Elodie De Magalhaes, MD3,4,5; Mariam Kamara, MD, MS15; Clément Hoffmann, MD2,16; Luc Bressollette, MD, PhD2,3,16; Michel Nonent, MD, PhD2,17; Cécile Tromeur, MD, PhD1,2,3; Pierre-Yves Salaun, MD, PhD3,18,19; Sophie Barillot, MS20; Florence Gatineau, MS20; Patrick Mismetti, MD, PhD3,4,5; Philippe Girard, MD3,21; Karine Lacut, MD, PhD1,2,3; Catherine A. Lemarié, PhD1,2,3,22; Guy Meyer, MD3,6,23; Christophe Leroyer, MD, PhD1,2,3; for the PEP Investigators
doi : 10.1001/jama.2020.23567
JAMA. 2021;325(1):59-68
The prevalence of pulmonary embolism in patients with chronic obstructive pulmonary disease (COPD) and acutely worsening respiratory symptoms remains uncertain.
Stillbirths During the COVID-19 Pandemic in England, April-June 2020
Julia Stowe, PhD1; Helen Smith, BSc(Hons)2; Kate Thurland, MPH2; Mary E. Ramsay, MBBS1; Nick Andrews, PhD1; Shamez N. Ladhani, PhD1
doi : 10.1001/jama.2020.21369
JAMA. 2021;325(1):86-87
Changes in Preterm Birth Phenotypes and Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic, March-June 2020
Sara C. Handley, MD, MSCE1; Anne M. Mullin, BS2; Michal A. Elovitz, MD2; Kristin D. Gerson, MD, PhD2; Diana Montoya-Williams, MD1; Scott A. Lorch, MD, MSCE1; Heather H. Burris, MD, MPH1
doi : 10.1001/jama.2020.20991
JAMA. 2021;325(1):87-89
How to Leverage the Medicare Program for a COVID-19 Vaccination Campaign
Nicole Lurie, MD, MSPH1; Bettina Experton, MD, MPH2
doi : 10.1001/jama.2020.22720
JAMA. 2021;325(1):21-22
Diversity in Medical Schools
Valerie Montgomery Rice, MD1
doi : 10.1001/jama.2020.21576
JAMA. 2021;325(1):23-24
Presidents’ Health and Medical Confidentiality
Robert Klitzman, MD1
doi : 10.1001/jama.2020.23476
JAMA. 2021;325(1):25-26
A Medical and Scientific New Year’s Wish List
Howard Bauchner, MD1
doi : 10.1001/jama.2020.23346
JAMA. 2021;325(1):29-30
Diversity in Medical Schools—Need for a New Bold Approach
Clyde W. Yancy, MD1; Howard Bauchner, MD2
doi : 10.1001/jama.2020.23601
JAMA. 2021;325(1):31-32
Influenza Vaccine for Patients With High-risk Cardiovascular Disease
Manish M. Patel, MD, MS1; Timothy M. Uyeki, MD, MPH, MPP1
doi : 10.1001/jama.2020.23948
JAMA. 2021;325(1):33-35
Adjuvant Capecitabine in Triple-Negative Breast Cancer
Heather A. Parsons, MD, MPH1; Harold J. Burstein, MD, PhD1
doi : 10.1001/jama.2020.23371
JAMA. 2021;325(1):36-38
Management of Crohn Disease
Kelly Cushing, MD, MSCI1; Peter D. R. Higgins, MD, PhD, MSc1
doi : 10.1001/jama.2020.18936
JAMA. 2021;325(1):69-80
Crohn disease, a chronic gastrointestinal inflammatory disease, is increasing in incidence and prevalence in many parts of the world. Uncontrolled inflammation leads to long-term complications, including fibrotic strictures, enteric fistulae, and intestinal neoplasia. Therefore, early and effective control of inflammation is of critical importance.
Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA
AbdulRahman Dia, MD1; Adam S. Cifu, MD1; Atman P. Shah, MD1
doi : 10.1001/jama.2020.22176
JAMA. 2021;325(1):81-82
A Patient With Dizziness, Chest Pain, Rash, and Nail Changes
Myron Zhang, MD1; Shari R. Lipner, MD, PhD1
doi : 10.1001/jama.2020.15176
JAMA. 2021;325(1):83-84
Surgeon Fills COVID-19 Testing Gap in Philadelphia’s Black Neighborhoods
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.22796
JAMA. 2021;325(1):14-16
Antiviral Drug Approved for Postexposure Flu Prevention
Rebecca Voelker, MSJ
doi : 10.1001/jama.2020.25618
JAMA. 2021;325(1):20
First Progeria Drug Is Approved
Rebecca Voelker, MSJ
doi : 10.1001/jama.2020.24348
JAMA. 2021;325(1):20
New Tool Offers Faster Notice of Foodborne Illness Outbreaks
Rebecca Voelker, MSJ
doi : 10.1001/jama.2020.25620
JAMA. 2021;325(1):20
A 7-Point Action Agenda to End the COVID-19 Pandemic for President-elect Biden
Lawrence O. Gostin, JD1
doi : 10.1001/jama.2020.23848
JAMA. 2021;325(1):17-18
Could Baking Soda Fight Leukemia Relapse After Stem Cell Transplant?
Tracy Hampton, PhD
doi : 10.1001/jama.2020.24504
JAMA. 2021;325(1):19
The Art of Losing—Three Poems for the COVID-19 Pandemic
Rafael Campo, MA, MD1,2; Elisa New, PhD3,4
doi : 10.1001/jama.2020.24699
JAMA. 2021;325(1):12-13
Bisphosphonates for Postmenopausal Osteoporosis
Kristine E. Ensrud, MD1
doi : 10.1001/jama.2020.2923
JAMA. 2021;325(1):96
Postexercise Ankle-Brachial Index Testing to Diagnose Peripheral Artery Disease
Guillaume Mahé, MD, PhD1; Damien Lanéelle, MD2; Alexis Le Faucheur, PhD3
doi : 10.1001/jama.2020.22475
JAMA. 2021;325(1):89
Postexercise Ankle-Brachial Index Testing to Diagnose Peripheral Artery Disease—Reply
Anurag Mehta, MD1; Laurence S. Sperling, MD1; Bryan J. Wells, MD1
doi : 10.1001/jama.2020.22490
JAMA. 2021;325(1):89-90
