JAMA

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Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department

Suzanne Schuh, MD1,2; Judy Sweeney, RN, BScN1; Maggie Rumantir, MD1; Allan L. Coates, MDCM, BEng3; Andrew R. Willan, PhD4,5; Derek Stephens, MSc, BSc6; Eshetu G. Atenafu, MSc7; Yaron Finkelstein, MD2,8; Graham Thompson, MD9,10; Roger Zemek, MD11,12; Amy C. Plint, MD, MSc11,12; Jocelyn Gravel, MD, MSc13,14; Francine M. Ducharme, MD, MSc13,14; David W. Johnson, MD15,16; Karen Black, MD, MSc17; Sarah Curtis, MD18; Darcy Beer, MD19,20; Terry P. Klassen, MD, MSc21,22; Darcy Nicksy, BSc, PhM23; Stephen B. Freedman, MDCM, MSc24; for the Pediatric Emergency Research Canada (PERC) Network

doi : 10.1001/jama.2020.19839

JAMA. 2020;324(20):2038-2047

While intravenous magnesium decreases hospitalizations in refractory pediatric acute asthma, it is variably used because of invasiveness and safety concerns. The benefit of nebulized magnesium to prevent hospitalization is unknown.

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Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy

Janice L. Atkins, PhD1; Luke C. Pilling, PhD1,2; Jane A. H. Masoli, MBChB1,3; Chia-Ling Kuo, PhD2; Jeremy D. Shearman, DPhil4; Paul C. Adams, MD5; David Melzer, MBBCh, PhD1,2

doi : 10.1001/jama.2020.21566

JAMA. 2020;324(20):2048-2057

Hereditary hemochromatosis is predominantly caused by the HFE p.C282Y homozygous pathogenic variant. Liver carcinoma and mortality risks are increased in individuals with clinically diagnosed hereditary hemochromatosis, but risks are unclear in mostly undiagnosed p.C282Y homozygotes identified in community genotyping.

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Association of State Certificate of Need Regulation With Procedural Volume, Market Share, and Outcomes Among Medicare Beneficiaries

Tarik K. Yuce, MD, MS1; Jeanette W. Chung, PhD1; Cynthia Barnard, PhD, MBA2; Karl Y. Bilimoria, MD, MS1,2

doi : 10.1001/jama.2020.21115

JAMA. 2020;324(20):2058-2068

Certificate of need laws provide state-level regulation of health system expenditure. These laws are intended to limit spending and control hospital expansion in order to prevent excess capacity and improve quality of care. Several states have recently introduced legislation to modify or repeal these regulations, as encouraged by executive order 13813, issued in October 2017 by the Trump administration.

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COVID-19 and Excess All-Cause Mortality in the US and 18 Comparison Countries

Alyssa Bilinski, MSc1; Ezekiel J. Emanuel, MD, PhD2

doi : 10.1001/jama.2020.20717

JAMA. 2020;324(20):2100-2102

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Pediatric Magnet Ingestions After Federal Rule Changes, 2009-2019

Michael R. Flaherty, DO1; Terry Buchmiller, MD2; Mark Vangel, PhD3; Lois K. Lee, MD, MPH4

doi : 10.1001/jama.2020.19153

JAMA. 2020;324(20):2102-2104

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Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors

US Preventive Services Task Force

doi : 10.1001/jama.2020.21749

JAMA. 2020;324(20):2069-2075

Cardiovascular disease (CVD) is a leading cause of death in the US. Known modifiable risk factors for CVD include smoking, overweight and obesity, diabetes, elevated blood pressure or hypertension, dyslipidemia, lack of physical activity, and unhealthy diet. Adults who adhere to national guidelines for a healthy diet and physical activity have lower cardiovascular morbidity and mortality than those who do not. All persons, regardless of their CVD risk status, benefit from healthy eating behaviors and appropriate physical activity.

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Behavioral Counseling to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors

Elizabeth A. O’Connor, PhD1; Corinne V. Evans, MPP1; Megan C. Rushkin, MPH1; Nadia Redmond, MSPH1; Jennifer S. Lin, MD, MCR1

doi : 10.1001/jama.2020.17108

JAMA. 2020;324(20):2076-2094

Cardiovascular disease is the leading cause of death in the US, and poor diet and lack of physical activity are major factors contributing to cardiovascular morbidity and mortality.

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