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New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk
Logan K Townsend, Rebecca E K MacPherson, David C Wright
doi : 10.1210/clinem/dgab333
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2147–2163
The world population is aging, leading to increased rates of neurodegenerative disorders. Exercise has countless health benefits and has consistently been shown to improve brain health and cognitive function. The purpose of this review is to provide an overview of exercise-induced adaptations in the brain with a focus on crosstalk between peripheral tissues and the brain. We highlight recent investigations into exercise-induced circulating factors, or exerkines, including irisin, cathepsin B, GPLD1, and ketones and the mechanisms mediating their effects in the brain.
Expression of Cholecystokinin and its Receptors in the Intestinal Tract of Type 2 Diabetes Patients and Healthy Controls
Hannah Gilliam-Vigh, Tina Jorsal, Jens F Rehfeld, Jens Pedersen, Steen S Poulsen, Tina Vilsb?ll, Filip K Knop
doi : 10.1210/clinem/dgab367
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2164–2170
Cholecystokinin (CCK) is a gut hormone originally known for its effects on gallbladder contraction and release of digestive enzymes. CCK, however, also mediates satiety and stimulate insulin secretion. Knowledge of the distribution of CCK-producing enteroendocrine cells (I cells) in humans is sparse. The general notion, based on animal data, is that I cells are present mainly in the proximal small intestine. We examined the occurrence of I cells (immunohistochemically) and the expression of CCK messenger RNA (mRNA) as well as CCK1 and CCK2 receptor mRNA along the intestines in healthy individuals and patients with type 2 diabetes.
A Selective Androgen Receptor Modulator (OPK-88004) in Prostate Cancer Survivors: A Randomized Trial
Karol M Pencina, Arthur L Burnett, Thomas W Storer, Wen Guo, Zhuoying Li, Adam S Kibel, Grace Huang, Michelle Blouin, Donna L Berry, Shehzad Basaria, Shalender Bhasin
doi : 10.1210/clinem/dgab361
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2171–2186
Androgen deficiency is common among prostate cancer survivors, but many guidelines consider history of prostate cancer a contraindication for testosterone replacement. We determined the safety and efficacy of a selective androgen receptor modulator (OPK-88004) in symptomatic, testosterone-deficient men who had undergone radical prostatectomy for low-grade, organ-confined prostate cancer.
Time-Series Analysis of Continuous Glucose Monitoring Data to Predict Treatment Efficacy in Patients with T2DM
Li Li, Jie Sun, Liemin Ruan, Qifa Song
doi : 10.1210/clinem/dgab356
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2187–2197
There is a challenge to predict treatment effects in patients with type 2 diabetes mellitus (T2DM).
Afirma Genomic Sequencing Classifier and Xpression Atlas Molecular Findings in Consecutive Bethesda III-VI Thyroid Nodules
Mimi I Hu, Steven G Waguespack, Chrysoula Dosiou, Paul W Ladenson, Masha J Livhits, Lori J Wirth, Peter M Sadow, Jeffrey F Krane, Brendan C Stack, Mark E Zafereo, Syed Z Ali, Steven P Weitzman, Yangyang Hao, Joshua E Babiarz, Giulia C Kennedy, Richard T Kloos
doi : 10.1210/clinem/dgab304
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2198–2207
Investigate the molecular findings across a large, real-world cohort of thyroid fine-needle aspiration (FNA) samples.
Normal Adrenal and Thyroid Function in Patients Who Survive COVID-19 Infection
Sophie A Clarke, Maria Phylactou, Bijal Patel, Edouard G Mills, Beatrice Muzi, Chioma Izzi-Engbeaya, Sirazum Choudhury, Bernard Khoo, Karim Meeran, Alexander N Comninos, Ali Abbara, Tricia Tan, Waljit S Dhillo
doi : 10.1210/clinem/dgab349
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2208–2220
The COVID-19 pandemic continues to exert an immense burden on global health services. Moreover, up to 63% of patients experience persistent symptoms, including fatigue, after acute illness. Endocrine systems are vulnerable to the effects of COVID-19 as many glands express the ACE2 receptor, used by the SARS-CoV-2 virion for cellular access. However, the effects of COVID-19 on adrenal and thyroid gland function after acute COVID-19 remain unknown.
G Protein–coupled Receptors in Radioiodine-refractory Thyroid Cancer in the Era of Precision Medicine
Valentine Suteau, Valérie Seegers, Mathilde Munier, Rym Ben Boubaker, Cécile Reyes, David Gentien, Méline Wery, Anne Croué, Frédéric Illouz, Antoine Hamy, Patrice Rodien, Claire Briet
doi : 10.1210/clinem/dgab343
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2221–2232
Radioiodine-refractory thyroid cancers have poor outcomes and limited therapeutic options (tyrosine kinase inhibitors) due to transient efficacy and toxicity of treatments. Therefore, combinatorial treatments with new therapeutic approaches are needed. Many studies link G protein–coupled receptors (GPCRs) to cancer cell biology.
MRI-based Texture Analysis of Trabecular Bone for Opportunistic Screening of Skeletal Fragility
Caroline Zaworski, Jonathan Cheah, Matthew F Koff, Ryan Breighner, Bin Lin, Jonathan Harrison, Eve Donnelly, Emily M Stein
doi : 10.1210/clinem/dgab342
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2233–2241
Many individuals at high risk for osteoporosis and fragility fracture are never screened by traditional methods. Opportunistic use of imaging obtained for other clinical purposes is required to foster identification of these patients.
Mortality Risk in Patients With Adrenal Insufficiency Using Prednisolone or Hydrocortisone: A Retrospective Cohort Study
Kanchana Ngaosuwan, Desmond G Johnston, Ian F Godsland, Jeremy Cox, Azeem Majeed, Jennifer K Quint, Nick Oliver, Stephen Robinson
doi : 10.1210/clinem/dgab347
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2242–2251
Prednisolone has been recommended rather than hydrocortisone for glucocorticoid replacement in adrenal insufficiency due its longer duration of action and lower cost.
Sex Differences in the Effect of Testosterone on Adipose Tissue Insulin Resistance From Overweight to Obese Adults
Xiaohui Li, Jia Liu, Biao Zhou, Yinhui Li, Zhengyu Wu, Hua Meng, Guang Wang
doi : 10.1210/clinem/dgab325
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2252–2263
Adipose tissue distribution and glucose metabolism differ between men and women. Few studies have investigated sex differences in adipose tissue insulin resistance (adipose-IR). Herein, we investigated sex differences in adipose-IR in adults ranging from overweight to obese and the potential factors associated with sex differences in adipose-IR.
Clinical and Genetic Analysis of KATP Variants With Heart Failure Risk in Patients With Decreased Serum ApoA-I Levels
Cheng Liu, Yanxian Lai, Jingxian Pei, Huiling Huang, Junfang Zhan, Songsong Ying, Yan Shen
doi : 10.1210/clinem/dgab336
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2264–2278
Lower serum concentration of apolipoprotein A-I (ApoA-I) is causally associated with heart failure (HF) risk. Adenosine triphosphate–sensitive potassium channels (KATP), as gating channels coupling vascular reactivity and metabolism with ischemic protection, become a new potential target of management for HF. The KATP gene sequence is highly polymorphic and has a high degree of genetic heterogeneity.
Maternal Glycemia During Pregnancy and Early Offspring Development: A Prospective Birth Cohort Study
Peng Wang, Jun Xie, Xue-Chun Jiao, Shuang-Shuang Ma, Yang Liu, Wan-Jun Yin, Rui-Xue Tao, Hong-Lin Hu, Ying Zhang, Xian-Xia Chen, Fang-Biao Tao, Peng Zhu
doi : 10.1210/clinem/dgab331
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2279–2290
The association of maternal gestational diabetes mellitus (GDM) with neurodevelopmental outcomes remains controversial and evidence that maternal increasing levels of glucose during pregnancy associated with the risk for impaired neurodevelopment were limited.
Glycemic Patterns Are Distinct in Post-Bariatric Hypoglycemia After Gastric Bypass (PBH-RYGB)
Daniel Lee, Jonathan M Dreyfuss, Amanda Sheehan, Alexa Puleio, Christopher M Mulla, Mary Elizabeth Patti
doi : 10.1210/clinem/dgab323
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2291–2303
To quantify glycemia, glycemic variability, and magnitude/duration of low sensor glucose (SG) values in patients with PBH after Roux-en-Y gastric bypass (PBH-RYGB).
DXA-Based Bone Strain Index: A New Tool to Evaluate Bone Quality in Primary Hyperparathyroidism
Gaia Tabacco, Anda M Naciu, Carmelo Messina, Gianfranco Sanson, Luca Rinaudo, Roberto Cesareo, Stefania Falcone, Silvia Manfrini, Nicola Napoli, John P Bilezikian, Fabio M Ulivieri, Andrea Palermo
doi : 10.1210/clinem/dgab317
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2304–2312
To assess the lumbar spine (LS), femoral neck (FN), and total hip (TH) BSI in PHPT patients compared with controls and to investigate the association of BSI with vertebral fractures (VFs) in PHPT.
Deciphering the Role of PGRMC1 During Human Decidualization Using an In Vitro Approach
Stefania Salsano, Roberto Gonz?lez-Mart?n, Alicia Qui?onero, Silvia Pérez-Debén, Francisco Dom?nguez
doi : 10.1210/clinem/dgab303
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2313–2327
To determine PGRMC1 and mPRs signaling role during decidualization.
Randomized Controlled Trial Evaluating the Use of Zoledronic Acid in Duchenne Muscular Dystrophy
Margaret Zacharin, Angelina Lim, James Gryllakis, Aris Siafarikas, Craig Jefferies, Julie Briody, Natasha Heather, Janne Pitkin, Jaiman Emmanuel, Katherine J Lee, Xiaofang Wang, Peter J Simm, Craig F Munns
doi : 10.1210/clinem/dgab302
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2328–2342
To investigate use of zoledronic acid (ZA) in DMD in improving BMD.
National Trends in Pediatric Admissions for Diabetic Ketoacidosis, 2006–2016
Estelle M Everett, Timothy P Copeland, Tannaz Moin, Lauren E Wisk
doi : 10.1210/clinem/dgab287
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2343–2354
Diabetic ketoacidosis (DKA) rates in the United States are rising. Prior studies suggest higher rates in younger populations, but no studies have evaluated national trends in pediatric populations and differences by subgroups. As such, we sought to examine national trends in pediatric DKA.
[18F]-FDG-PET/CT Correlates With the Response of Radiorefractory Thyroid Cancer to Lenvatinib and Patient Survival
Laura Valerio, Federica Guidoccio, Carlotta Giani, Elisa Tardelli, Giulia Puccini, Luciana Puleo, Elisa Minaldi, Giuseppe Boni, Rossella Elisei, Duccio Volterrani
doi : 10.1210/clinem/dgab278
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2355–2366
We investigated the role of [18F]-FDG-PET/CT in the evaluation of metabolic response and prediction of the outcome of RAI-R DTC patients treated with lenvatinib.
Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance
Isabel Huang-Doran, Alexandra B Kinzer, Mercedes Jimenez-Linan, Kerrie Thackray, Julie Harris, Claire L Adams, Marc de Kerdanet, Anna Stears, Stephen O’Rahilly, David B Savage, Phillip Gorden, Rebecca J Brown, Robert K Semple
doi : 10.1210/clinem/dgab275
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2367–2383
To characterize hyperandrogenemia and ovarian pathology in primary severe IR (SIR), using IR of defined molecular etiology to interrogate disease mechanism. To extend evaluation of gonadotropin-releasing hormone (GnRH) analogue therapy in SIR.
Association of Genetic Variants for Plasma LRG1 With Rapid Decline in Kidney Function in Patients With Type 2 Diabetes
Resham Lal Gurung, Rajkumar Dorajoo, Yiamunaa M, Jian-Jun Liu, Sharon Li Ting Pek, Jiexun Wang, Ling Wang, Xueling Sim, Sylvia Liu, Yi-Ming Shao, Keven Ang, Tavintharan Subramaniam, Wern Ee Tang, Chee Fang Sum, Jian-Jun Liu, Su Chi Lim
doi : 10.1210/clinem/dgab268
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2384–2394
To identify genetic variants associated with plasma LRG1 levels and determine whether genetically predicted plasma LRG1 contributes to a rapid decline in kidney function (RDKF) in patients with T2D.
Life-course Exposure to Perfluoroalkyl Substances in Relation to Markers of Glucose Homeostasis in Early Adulthood
Damaskini Valvi, Kurt H?jlund, Brent A Coull, Flemming Nielsen, Pal Weihe, Philippe Grandjean
doi : 10.1210/clinem/dgab267
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2495–2504
To investigate the prospective associations of life-course perfluoroalkyl substances (PFASs) exposure with glucose homeostasis at adulthood.
Impaired Function and Altered Morphology in the Skeletal Muscles of Adult Men and Women With Type 1 Diabetes
Athan G Dial, Cynthia M F Monaco, Grace K Grafham, Tirth P Patel, Mark A Tarnopolsky, Thomas J Hawke
doi : 10.1210/clinem/dgab261
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2405–2422
To investigate skeletal muscle function and morphology across the adult lifespan in those with and without T1D.
Performance of the Aldosterone to Renin Ratio as a Screening Test for Primary Aldosteronism
Annie Hung, Sumaiya Ahmed, Ankur Gupta, Alexandra Davis, Gregory A Kline, Alexander A Leung, Marcel Ruzicka, Swapnil Hiremath, Gregory L Hundemer
doi : 10.1210/clinem/dgab348
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2423–2435
To evaluate the sensitivity and specificity of the ARR as a screening test for primary aldosteronism.
Clinical Practice Guidelines on the Diagnosis and Management of Polycystic Ovary Syndrome: A Systematic Review and Quality Assessment Study
Bassel H Al Wattar, Maria Fisher, Laura Bevington, Vikram Talaulikar, Melanie Davies, Gerrad Conway, Ephia Yasmin
doi : 10.1210/clinem/dgab232
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2436–2446
We searched MEDLINE, EMBASE, and CENTRAL until December 2020 for all evidence-based CPGs and consensus statements on PCOS. We extracted data in duplicate to map clinical recommendations across prespecified disease domains and assessed CPGs methodological quality of using the Appraisal of Guidelines, Research & Evaluation II tool.
NAFLD and Liver Fibrosis Are Not Associated With Reduced Femoral Bone Mineral Density in the General US Population
Stefano Ciardullo, Emanuele Muraca, Francesca Zerbini, Giuseppina Manzoni, Gianluca Perseghin
doi : 10.1210/clinem/dgab262
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2856–e2865
To assess whether liver steatosis and fibrosis are associated with reduced BMD in the general US population.
LncRNA LPAL2/miR-1287-5p/EGFR Axis Modulates TED-Derived Orbital Fibroblast Activation Through Cell Adhesion Factors
Nuo Wang, Shi-ying Hou, Xin Qi, Mi Deng, Jia-min Cao, Bo-Ding Tong, Wei Xiong
doi : 10.1210/clinem/dgab256
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2866–e2886
We aimed to investigate the mechanism of TED orbital fibroblast activation from the perspective of noncoding RNA regulation.
Soluble Alpha Klotho in Acromegaly: Comparison With Traditional Markers of Disease Activity
J?nia R O L Schweizer, Katharina Schilbach, Michael Haenelt, Alexandre V Giannetti, Mariana F Bizzi, Beatriz S Soares, Eduardo Paulino, Jr, Jochen Schopohl, Sylvère St?rmann, Antônio Ribeiro-Oliveira, Jr, Martin Bidlingmaier
doi : 10.1210/clinem/dgab257
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2887–e2899
To evaluate the potential of s?KL to aid classification of disease activity.
Properly Collected Plasma Metanephrines Excludes PPGL After False-Positive Screening Tests
Gregory A Kline, Jessica Boyd, Brenda Polzin, Adrian Harvey, Janice L Pasieka, Hossein S M Sadrzadeh, Alexander A Leung
doi : 10.1210/clinem/dgab241
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2900–e2906
Determine the correlation between screening urine and seated plasma metanephrines in outpatients where PPGL was absent, compared to meticulously prepared and supine-collected plasma metanephrines with age-adjusted references.
Preoperative Amlodipine Is Efficacious in Preventing Intraoperative HDI in Pheochromocytoma: Pilot RCT
Sanjeet Kumar Jaiswal, Saba Samad Memon, Anurag Lila, Vijaya Sarathi, Manjunath Goroshi, Robin Garg, Rohit Barnabas, Indrani Hemantkumar, Rajendra D Patel, Shrikanta Oak, Abhay Dalvi, Mahadeo Garale, Virendra Patil, Nalini S Shah, Tushar Bandgar
doi : 10.1210/clinem/dgab231
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2907–e2918
We aimed to compare the efficacy of CCB and ?-blockers on intraoperative hemodynamic instability (HDI) in PPGL.
Adolescent Tri-ponderal Mass Index Growth Trajectories and Incident Diabetes Mellitus in Early Adulthood
Yi-Fan Wu, Hsien-Yu Fan, Yang-Ching Chen, Kuan-Liang Kuo, Kuo-Liong Chien
doi : 10.1210/clinem/dgab235
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2919–e2927
Studies have reported the influence of adolescent obesity on development of adult diabetes, but the effect of the growth pattern during this period has rarely been explored. Also, the tri-ponderal mass index (TMI) was thought to be a better estimation of adolescent body fat levels than the body mass index (BMI), so we sought to investigate whether growth trajectories derived by these two indices could predict incident diabetes.
HDL Containing Apolipoprotein C-III is Associated with Insulin Sensitivity: A Multicenter Cohort Study
Rain Yamamoto, Majken K Jensen, Sarah Aroner, Jeremy D Furtado, Bernard Rosner, Frank B Hu, Beverley Balkau, Andrea Natali, Ele Ferrannini, Simona Baldi, Frank M Sacks
doi : 10.1210/clinem/dgab234
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2928–e2940
We investigated the prospective associations between HDL subspecies containing and lacking apolipoprotein (apo) C-III at baseline and insulin sensitivity at year 3.
Maternal Adiposity and Energy Balance After Normotensive and Preeclamptic Pregnancies
Sarah L McLennan, Amanda Henry, Lynne M Roberts, Sai S Siritharan, Melissa Ojurovic, Amanda Yao, Gregory K Davis, George Mangos, Franziska Pettit, Mark A Brown, Anthony J O’Sullivan
doi : 10.1210/clinem/dgab223
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2941–e2952
Preeclampsia is a major pregnancy complication associated with long-term maternal cardiometabolic disease. Research generally is focused on metabolic and pathophysiological changes during pregnancy; however, there is much less focus on the early postpartum period in subjects who suffered preeclampsia. The aim of this study was to (1) characterize energy intake and expenditure 6 months following normotensive and preeclamptic pregnancies and (2) examine associations between energy balance, body composition, insulin resistance measures (HOMA-IR), and clinical characteristics.
Effect of Leptin Therapy on Survival in Generalized and Partial Lipodystrophy: A Matched Cohort Analysis
Keziah Cook, Omer Ali, Baris Akinci, Maria Cristina Foss de Freitas, Renan Magalh?es Montenegro, Jr, Virginia Oliveira Fernandes, Deepshekhar Gupta, Kai-Jye Lou, Edward Tuttle, Elif A Oral, Rebecca J Brown
doi : 10.1210/clinem/dgab216
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2953–e2967
This study aimed to estimate the treatment effect of metreleptin on survival in patients with GL and PL.
Exceptionality of Distant Metastasis in Node-Negative Hereditary and Sporadic Medullary Thyroid Cancer: Lessons Learned
Andreas Machens, Kerstin Lorenz, Frank Weber, Henning Dralle
doi : 10.1210/clinem/dgab214
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2968–e2979
This comprehensive investigation aimed to explore risk factors of lymph node and distant metastases and interdependencies between age at thyroidectomy, primary tumor size, lymph node metastasis, and distant metastasis in patients with hereditary and sporadic MTC.
Denosumab Reduces Lesional Fluoride Skeletal Burden on Na[18F]F PET-CT in Patients With Fibrous Dysplasia/McCune–Albright Syndrome
Wouter van der Bruggen, Dennis Vriens, Maartje E Meier, Frits Smit, Elizabeth M Winter, Lioe-Fee de Geus-Oei, Natasha M Appelman-Dijkstra
doi : 10.1210/clinem/dgab212
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2980–e2994
To investigate treatment response measurements in patients with FD/MAS who underwent Na[18F]F-PET-CT and treatment with antiresorptives.
Population Vitamin D Stores Are Increasing in Tasmania, and This Is Associated With Less BMD Loss Over 10 Years
Michael Thompson, Dawn Aitken, Saliu Balogun, Flavia Cicuttini, Graeme Jones
doi : 10.1210/clinem/dgab197
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2995–e3004
There are limited data that examine the longitudinal change in population 25-hydroxyvitamin D (25[OH]D) and none that evaluate the long-term skeletal outcomes of longitudinal vitamin D status.
Pseudohypoparathyroidism: Focus on Cerebral and Renal Calcifications
Laura Mazoni, Matteo Apicella, Federica Saponaro, Giovanna Mantovani, Francesca M Elli, Simona Borsari, Elena Pardi, Paolo Piaggi, Claudio Marcocci, Filomena Cetani
doi : 10.1210/clinem/dgab208
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3005–e3020
To describe a cohort of 26 patients with PHP followed in a single tertiary center.
PRL Mutation Causing Alactogenesis: Insights Into Prolactin Structure and Function Relationships
Mika Moriwaki, Corrine K Welt
doi : 10.1210/clinem/dgab201
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3021–e3026
We hypothesized a heterozygous genetic mutation.
Long-Term Results of a Phase II Trial of Apatinib for Progressive Radioiodine Refractory Differentiated Thyroid Cancer
Yan-Song Lin, Xin Zhang, Chen Wang, Yan-Qing Liu, Wen-Min Guan, Jun Liang
doi : 10.1210/clinem/dgab196
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3027–e3036
We report here the long-term results of the phase II clinical trial of apatinib, an anti-angiogenic tyrosine kinase inhibitor, for RAIR-DTC.
Diabetes Knowledge and Metabolic Control in Type 1 Diabetes Starting With Continuous Glucose Monitoring: FUTURE-PEAK
Ben Broos, Sara Charleer, Nancy Bolsens, Carolien Moyson, Chantal Mathieu, Pieter Gillard, Christophe De Block
doi : 10.1210/clinem/dgab188
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3037–e3048
To investigate whether diabetes knowledge and health literacy impact glycemic control after 1 year of intermittently scanned continuous glucose monitoring (isCGM) in people with type 1 diabetes ???16 years.
Cord Blood IGF-I, Proinsulin, Leptin, HMW Adiponectin, and Ghrelin in Short or Skinny Small-for-Gestational-Age Infants
Hua He, Wen-Ting Zhu, Anne Monique Nuyt, Isabelle Marc, Pierre Julien, Rong Huang, Lise Dubois, Shu-Qin Wei, Jun Zhang, Emile Levy, William D Fraser, Zhong-Cheng Luo
doi : 10.1210/clinem/dgab178
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3049–e3057
This work aimed to assess whether SGA infants with stunting or wasting have similar alterations in neonatal endocrine metabolic health biomarkers.
Testosterone Therapy Effects on Bone Mass and Turnover in Hypogonadal Men with Type 2 Diabetes
Georgia Colleluori, Lina Aguirre, Nicola Napoli, Clifford Qualls, Dennis T Villareal, Reina Armamento-Villareal
doi : 10.1210/clinem/dgab181
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3058–e3068
Evaluate the skeletal response to testosterone therapy in hypogonadal men with T2D compared with hypogonadal men without T2D.
Radiomics With Ensemble Machine Learning Predicts Dopamine Agonist Response in Patients With Prolactinoma
Yae Won Park, Jihwan Eom, Sooyon Kim, Hwiyoung Kim, Sung Soo Ahn, Cheol Ryong Ku, Eui Hyun Kim, Eun Jig Lee, Sun Ho Kim, Seung-Koo Lee
doi : 10.1210/clinem/dgab159
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3069–e3077
To develop a radiomics model using an ensemble machine learning classifier with conventional magnetic resonance images (MRIs) to predict the DA response in prolactinoma patients.
Association of Genetically Predicted Serum Estradiol With Risk of Thromboembolism in Men: A Mendelian Randomization Study
Maria Nethander, Johan Quester, Liesbeth Vandenput, Claes Ohlsson
doi : 10.1210/clinem/dgab164
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3078–e3086
This work aimed to determine whether endogenous estradiol has a causal role in thromboembolism in men.
Metabolic and Psychological Features are Associated with Weight Loss 12 Months After Sleeve Gastrectomy
Emanuele Muraca, Alice Oltolini, Alberto Binda, Mattia Pizzi, Stefano Ciardullo, Giuseppina Manzoni, Francesca Zerbini, Eleonora Bianconi, Rosa Cannistraci, Silvia Perra, Pietro Pizzi, Guido Lattuada, Gianluca Perseghin, Matteo Villa
doi : 10.1210/clinem/dgab161
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3087–e3097
To establish the association of baseline anthropometric, metabolic, and psychologic features with the percent total weight loss (%TWL) and percent excess weight loss (%EWL) 12 months after surgery.
Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study
Rebekah J Nicholson, Annelise M Poss, J Alan Maschek, James E Cox, Paul N Hopkins, Steven C Hunt, Mary C Playdon, William L Holland, Scott A Summers
doi : 10.1210/clinem/dgab155
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3098–e3109
The studies described herein aimed to characterize the effects of rs267738 on CERS2 enzyme activity, sphingolipid profiles, and metabolic outcomes.
Antenatal Depression and Risk of Gestational Diabetes, Adverse Pregnancy Outcomes, and Postpartum Quality of Life
Caro Minschart, Kyara De Weerdt, Astrid Elegeert, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
doi : 10.1210/clinem/dgab156
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3110–e3124
To determine the impact of depressive symptoms on pregnancy outcomes and postpartum quality of life in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT).
IL-38 Exerts Anti-Inflammatory and Antifibrotic Effects in Thyroid-Associated Ophthalmopathy
Lu Shi, Huijing Ye, Jun Huang, Yanbing Li, Xing Wang, Zhihui Xu, Jingqiao Chen, Wei Xiao, Rongxin Chen, Huasheng Yang
doi : 10.1210/clinem/dgab154
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3125–e3142
We aimed to evaluate the relationship between IL-38 and TAO disease activity and its role in inflammation and fibrosis in TAO.
Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT
Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J Handelsman, Warrick J Inder, Bronwyn G A Stuckey, Bu B Yeap, Ali Ghasem-Zadeh, Kristy P Robledo, David Jesudason, Jeffrey D Zajac, Gary A Wittert, Mathis Grossmann
doi : 10.1210/clinem/dgab149
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3143–e3158
We aimed to determine the effect of testosterone treatment on bone microarchitecture using high resolution–peripheral quantitative computed tomography (HR-pQCT).
Identification and Functional Characterization of Metabolites for Bone Mass in Peri- and Postmenopausal Chinese Women
Rui Gong, Hong-Mei Xiao, Yin-Hua Zhang, Qi Zhao, Kuan-Jui Su, Xu Lin, Cheng-Lin Mo, Qiang Zhang, Ya-Ting Du, Feng-Ye Lyu, Yuan-Cheng Chen, Cheng Peng, Hui-Min Liu, Shi-Di Hu, Dao-Yan Pan, Zhi Chen, Zhang-Fang Li, Rou Zhou, Xia-Fang Wang, Jun-Min Lu, Zeng-Xin Ao, Yu-Qian Song, Chan-Yan Weng, Qing Tian, Martin R Schiller, Christopher J Papasian, Marco Brotto, Hui Shen, Jie Shen, Hong-Wen Deng
doi : 10.1210/clinem/dgab146
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3159–e3177
We aimed to systematically identify metabolites associated with BMD variation and their potential functional mechanisms in peri- and postmenopausal women.
Circulating Galectin-3 Levels Are Not Associated With Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study
Maxime Tremblay, Nicolas Perrot, Nooshin Ghodsian, ?milie Gobeil, Christian Couture, Patricia L Mitchell, Sébastien Thériault, Benoit J Arsenault
doi : 10.1210/clinem/dgab144
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3178–e3184
To evaluate the causal effect of circulating galectin-3 levels on NAFLD as well as >800 other human diseases.
Pregnancy Does not Affect the Prognoses of Differentiated Thyroid Cancer Patients With Lung Metastases
Chuang Xi, Qian Zhang, Hong-Jun Song, Chen-Tian Shen, Guo-Qiang Zhang, Jian-Wen Sun, Zhong-Ling Qiu, Quan-Yong Luo
doi : 10.1210/clinem/dgab111
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3185–e3197
To assess the impact of pregnancy on DTC-LM through the comparison of prognoses between female patients with DTC-LM who did and did not become pregnant after surgery and radioiodine therapy.
Lifestyle Intervention Improves Prothrombotic Coagulation Profile in Individuals at High Risk for Type 2 Diabetes
Sebastian H?rber, Rainer Lehmann, Louise Fritsche, Jürgen Machann, Andreas L Birkenfeld, Hans-Ulrich H?ring, Norbert Stefan, Martin Heni, Andreas Fritsche, Andreas Peter
doi : 10.1210/clinem/dgab124
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3198–e3207
The present study addressed whether this is reversible by lifestyle intervention and elucidated potential underlying associations.
A 4 Gene-based Immune Signature Predicts Dedifferentiation and Immune Exhaustion in Thyroid Cancer
Cui-Wei Li, Xiao Shi, Ben Ma, Yu-Long Wang, Zhong-Wu Lu, Tian Liao, Yu Wang, Qing-Hai Ji, Wen-Jun Wei
doi : 10.1210/clinem/dgab132
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3208–e3220
To construct a significant IRG-based signature indicative of dedifferentiation and immune exhaustion in thyroid cancer.
Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women
Steve Pawsey, Edouard Gregory Mills, Elizabeth Ballantyne, Kirsteen Donaldson, Mary Kerr, Mike Trower, Waljit Singh Dhillo
doi : 10.1210/clinem/dgab108
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3221–e3234
This work aimed to assess the effects of the novel NK1,3 antagonist elinzanetant on reproductive hormone levels in healthy women.
PREVENT: A Randomized, Placebo-controlled Crossover Trial of Avexitide for Treatment of Postbariatric Hypoglycemia
Colleen M Craig, Helen Margaret Lawler, Clare Jung Eun Lee, Marilyn Tan, Dawn Belt Davis, Jenny Tong, Michele Glodowski, Elisa Rogowitz, Rowan Karaman, Tracey L McLaughlin, Lisa Porter
doi : 10.1210/clinem/dgab103
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3235–e3248
To evaluate efficacy and safety of avexitide [exendin (9-39)], a glucagon-like peptide-1 antagonist, for treatment of PBH.
Metabolic Signatures of Genetically Elevated Vitamin D Among Chinese: Observational and Mendelian Randomization Study
Zhenhuang Zhuang, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Qinai Xu, Mingyuan Zou, Junshi Chen, Zhengming Chen, Jun Lv, Tao Huang, Liming Li
doi : 10.1210/clinem/dgab097
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3249–e3260
We aimed to investigate the causal effect of elevated 25(OH)D with a detailed systemic metabolite profile in Chinese adults.
Developmental Patterns of Glycemic Control in T1D and Their Association With Demographic and Clinical Variables
Leon S Farhy
doi : 10.1210/clinem/dgab271
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3261–e3263
A New Potential Treatment for Postprandial Hypoglycemia Following Bariatric Surgery
Sophia M R?ssner, Daniel P Andersson
doi : 10.1210/clinem/dgab264
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3264–e3265
Searching for Monogenic Diabetes in a High-risk Autoimmune Diabetes Cohort: Needles in a Paperclip Stack
Daniel Gamu, William T Gibson
doi : 10.1210/clinem/dgab244
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3266–e3268
T4DM Trial and its T4Bone Substudy Shed Further Light on Effects of Testosterone Treatment in Middle-Aged and Older Men
Shalender Bhasin, Peter J Snyder
doi : 10.1210/clinem/dgab246
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3269–e3271
Higher-level Modulation of GnRH Secretion: Progress Toward Next-generation Reproductive Treatments?
Christopher R McCartney
doi : 10.1210/clinem/dgab242
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3272–e3274
Rates of Conversion of Testosterone to Estradiol May Influence Risk of Venous Thromboembolism in Men
Bu B Yeap
doi : 10.1210/clinem/dgab226
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3275–e3277
Lean (Pre)Diabetes – Underestimated and Underexplored
Andreas F H Pfeiffer, Stefan Kabisch
doi : 10.1210/clinem/dgab198
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3278–e3280
Letter to the Editor from Brunerov? et al: “Association of Cognitive Function and Retinal Neural and Vascular Structure in Type 1 Diabetes”
Ludmila Brunerov?, Jaroslava Raudensk?, Richard Sotorn?k, Elena ?ilhov?, Pavel ?krha, Miroslav Veith, Adam Ernest, Alena Jav?rkov?
doi : 10.1210/clinem/dgab350
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3281–e3282
Letter to the Editor From Lukas Andereggen: “Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review”
Lukas Andereggen, Jürgen Beck, Jan Gralla, Markus M Luedi, Emanuel Christ
doi : 10.1210/clinem/dgab329
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3283–e3284
Letter to the Editor From Helene Lasolle and Gérald Raverot: “USP8 and TP53 Drivers Are Associated With CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors”
Hélène Lasolle, Gérald Raverot
doi : 10.1210/clinem/dgab217
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3285–e3286
Letter to the Editor from William J. Malone et al: “Proper Care of Transgender and Gender-diverse Persons in the Setting of Proposed Discrimination: A Policy Perspective”
William J Malone, Paul W Hruz, Julia W Mason, Stephen Beck
doi : 10.1210/clinem/dgab205
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3287–e3288
Letter to the Editor from Bello-Chavolla et al: “Are the Different Diabetes Subgroups Correlated With All-Cause, Cancer-related, and Cardiovascular-related Mortality?”
Omar Yaxmehen Bello-Chavolla, Neftali Eduardo Antonio-Villa, Luisa Fern?ndez-Chirino, Arsenio Vargas-V?zquez, Jessica Paola Bahena-L?pez
doi : 10.1210/clinem/dgab173
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3289–e3290
Response to Letter to the Editor From Lukas Andereggen: “Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review”
Jordan E Perlman, Robert J Weil, Ferdinand Hui, Pablo F Recinos, Gary Gallia, Debraj Mukherjee, Roberto Salvatori, Laurence Kennedy, Amir H Hamrahian
doi : 10.1210/clinem/dgab330
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3291–e3292
Response to Letter to the Editor from Lasolle and Raverot: “USP8 and TP53 Drivers Are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors”
Andrew V Uzilov, Eliza B Geer
doi : 10.1210/clinem/dgab218
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3293–e3294
Response to Letter to the Editor from Malone: “Proper Care of Transgender and Gender Diverse Persons in the Setting of Proposed Discrimination: A Policy Perspective”
Abby Walch, Caroline Davidge-Pitts, Ximena Lopez, Vin Tangpricha, Sean J Iwamoto, Joshua D Safer
doi : 10.1210/clinem/dgab206
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3295–e3296
Response to Letter to the Editor from Bello-Chavolla et al: “Are the Different Diabetes Subgroups Correlated With All-cause, Cancer-related, and Cardiovascular-related Mortality?”
Peng-Fei Li, Wei-Liang Chen
doi : 10.1210/clinem/dgab174
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3297–e3298
ERRATUM to: “Association Between Maternal Normal Range HbA1c Values and Adverse Birth Outcomes”
doi : 10.1210/clinem/dgab233
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Page e3299
