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Cardiovascular Safety and Sclerostin Inhibition
Bente Lomholt Langdahl, Lorenz Christian Hofbauer, John Colin Forfar
doi : 10.1210/clinem/dgab193
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1845–1853
Sclerostin, which is primarily produced by the osteocytes, inhibits the canonical Wnt pathway and thereby the osteoblasts and stimulates RANKL release by the osteocytes and thereby osteoclast recruitment. Inhibition of sclerostin therefore causes stimulation of bone formation and inhibition of resorption. In clinical trials, romosozumab, an antibody against sclerostin, increases bone mineral density and reduces the risk of fractures compared with placebo and alendronate.
Long-Term Weight Loss Strategies for Obesity
Karim Kheniser, David R Saxon, Sangeeta R Kashyap
doi : 10.1210/clinem/dgab091
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1854–1866
Obesity is a chronic disease that is difficult to manage without holistic therapy. The therapeutic armamentarium for obesity primarily consists of 4 forms of therapy: lifestyle modification (ie, diet and exercise), cognitive behavioral therapy, pharmacotherapy, and bariatric surgery.
A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis
Mariano Mart?n, Carlos Pablo Modenutti, Mauco Lucas Gil Rosas, Victoria Peyret, Romina Celeste Geysels
doi : 10.1210/clinem/dgab283
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1867–1881
Iodide transport defect (ITD) (Online Mendelian Inheritance in Man No. 274400) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells.
Successful Delivery in 17,20-Lyase Deficiency
Zeev Blumenfeld, Ilana Koren
doi : 10.1210/clinem/dgab222
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1882–1886
Pregnancy achievement in an infertile patient with 17,20-lyase deficiency.
Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption
Melanie H Jacobson, Cheryl R Stein, Mengling Liu, Marra G Ackerman, Jennifer K Blakemore
doi : 10.1210/clinem/dgab199
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1887–1899
Postpartum depression (PPD) is a serious psychiatric disorder. While causes remain poorly understood, perinatal sex hormone fluctuations are an important factor, and allopregnanolone in particular has emerged as a key determinant. Although synthetic environmental chemicals such as bisphenols and phthalates are known to affect sex hormones, no studies have measured allopregnanolone and the consequences of these hormonal changes on PPD have not been interrogated.
Basal Ganglia Calcification Is Associated With Local and Systemic Metabolic Mechanisms in Adult Hypoparathyroidism
Guido Zavatta, Peter J Tebben, Cynthia H McCollough, Lifeng Yu, Thomas Vrieze
doi : 10.1210/clinem/dgab162
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1900–1917
Hypoparathyroidism is characterized by low serum calcium, increased serum phosphorus, and inappropriately low or decreased serum parathyroid hormone, which may be associated with soft tissue calcification in the basal ganglia of the brain.
A Polygenic Risk Score to Predict Future Adult Short Stature Among Children
Tianyuan Lu, Vincenzo Forgetta, Haoyu Wu, John R B Perry, Ken K Ong
doi : 10.1210/clinem/dgab215
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1918–1928
Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height.
Progesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models
Laura J Mauro, Megan I Seibel, Caroline H Diep, Angela Spartz, Carlos Perez Kerkvliet
doi : 10.1210/clinem/dgab195
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1929–1955
The ability of ovarian steroids to modify ovarian cancer (OC) risk remains controversial. Progesterone is considered to be protective; recent studies indicate no effect or enhanced OC risk. Knowledge of progesterone receptor (PR) signaling during altered physiology that typifies OC development is limited.
Comprehensive Identification of Pathogenic Gene Variants in Patients With Neuroendocrine Disorders
Sebastian Alexis Vishnopolska, Maria Florencia Mercogliano, Maria Andrea Camilletti, Amanda Helen Mortensen, Debora Braslavsky
doi : 10.1210/clinem/dgab177
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1956–1976
Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mutations in multiple genes can cause CH, and the use of a genetic screening panel could establish the prevalence of mutations in known and candidate genes for this disorder. It could also increase the proportion of patients that receive a genetic diagnosis.
Mediators Linking Maternal Weight to Birthweight and Neonatal Fat Mass in Healthy Pregnancies
Oddrun Kristiansen, Manuela Zucknick, Trine M Reine, Svein O Kolset, Thomas Jansson
doi : 10.1210/clinem/dgab166
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1977–1993
Lifestyle interventions have not efficaciously reduced complications caused by maternal weight on fetal growth, requiring insight into explanatory mediators.
The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19
Inge Grondman, Aline H de Nooijer, Nikolaos Antonakos, Nico A F Janssen, Maria Mouktaroudi
doi : 10.1210/clinem/dgab148
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 1994–2009
Lymphopenia is a key feature of immune dysfunction in patients with bacterial sepsis and coronavirus disease 2019 (COVID-19) and is associated with poor clinical outcomes, but the cause is largely unknown. Severely ill patients may present with thyroid function abnormalities, so-called nonthyroidal illness syndrome, and several studies have linked thyrotropin (thyroid stimulating hormone, TSH) and the thyroid hormones thyroxine (T4) and 3,5,3?-triiodothyronine (T3) to homeostatic regulation and function of lymphocyte populations.
Circulating Glycerolipids, Fatty Liver Index, and Incidence of Type 2 Diabetes: A Prospective Study Among Chinese
Zhenhua Niu, Qingqing Wu, Liang Sun, Qibin Qi, He Zheng
doi : 10.1210/clinem/dgab165
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2010–2020
Few lipidomic studies have specifically investigated the association of circulating glycerolipids and type 2 diabetes (T2D) risk, especially among Asian populations. It remains unknown whether or to what degree fatty liver could explain the associations between glycerolipids and T2D.
Effect of Transdermal Estradiol and Insulin-like Growth Factor-1 on Bone Endpoints of Young Women With Anorexia Nervosa
Vibha Singhal, Amita Bose, Meghan Slattery, Melanie S Haines, Mark A Goldstein ...
doi : 10.1210/clinem/dgab145
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2021–2035
Anorexia nervosa (AN) is prevalent in adolescent girls and is associated with bone impairment driven by hormonal alterations in nutritional deficiency.
The Impact of Low-dose Gliclazide on the Incretin Effect and Indices of Beta-cell Function
Ruth L M Cordiner, Andrea Mari, Andrea Tura, Ewan R Pearson
doi : 10.1210/clinem/dgab151
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2036–2046
Studies in permanent neonatal diabetes suggest that sulphonylureas lower blood glucose without causing hypoglycemia, in part by augmenting the incretin effect. This mechanism has not previously been attributed to sulphonylureas in patients with type 2 diabetes (T2DM). We therefore aimed to evaluate the impact of low-dose gliclazide on beta-cell function and incretin action in patients with T2DM.
Machine Learning-based Prediction Model for Treatment of Acromegaly With First-generation Somatostatin Receptor Ligands
Luiz Eduardo Wildemberg, Aline Helen da Silva Camacho, Renan Lyra Miranda, Paula C L Elias, Nina R de Castro Musolino
doi : 10.1210/clinem/dgab125
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2047–2056
Artificial intelligence (AI), in particular machine learning (ML), may be used to deeply analyze biomarkers of response to first-generation somatostatin receptor ligands (fg-SRLs) in the treatment of acromegaly.
Reducing NF-?B Signaling Nutritionally is Associated with Expedited Recovery of Skeletal Muscle Function After Damage
Tom S O Jameson, George F Pavis, Marlou L Dirks, Benjamin P Lee, Doaa R Abdelrahman
doi : 10.1210/clinem/dgab106
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2057–2076
The early events regulating the remodeling program following skeletal muscle damage are poorly understood.
In Silico, In Vitro, and In Vivo Analysis Identifies Endometrial Circadian Clock Genes in Recurrent Implantation Failure
Junyu Zhai, Shang Li, Jingwen Hu, Minzhi Gao, Yun Sun
doi : 10.1210/clinem/dgab119
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2077–2091
Previous work has demonstrated the role of the circadian clock in ovarian steroid hormone synthesis and attributed embryo implantation failure associated with arrhythmic circadian clock genes to insufficient ovarian-derived progesterone synthesis. Research on expression of core circadian clock genes in the endometrium itself and possible roles in compromised endometrial receptivity and recurrent implantation failure (RIF) are limited.
Alfacalcidol vs Calcitriol in the Management of Patient With Hypoparathyroidism: A Randomized Controlled Trial
Soma Saha, Vishnubhatla Sreenivas, Ravinder Goswami
doi : 10.1210/clinem/dgab114
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2092–2102
Alfacalcidol and calcitriol are commonly used for managing hypoparathyroidism. Their relative merits have not been systematically assessed.
Aversion to Off-label Prescribing in Clinical Pediatric Weight Management: The Quintessential Double Standard
Christine B San Giovanni, Brooke Sweeney, Joseph A Skelton, Megan M Kelsey, Aaron S Kelly
doi : 10.1210/clinem/dgab276
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2103–2113
Pediatric obesity is now recognized as a chronic disease; yet few treatment options exist besides lifestyle modification therapy and bariatric surgery. We describe the limited availability of United States Food and Drug Administration (FDA)–approved antiobesity medications for adolescents and compare this to what is available for adults. We offer a rationale for off-label prescribing to assist with lifestyle modification therapy. We also highlight the need for more pharmacotherapy options and additional research into novel treatments for pediatric obesity.
Approach to the Patient Treated with Steroidogenesis Inhibitors
Frederic Castinetti, Lynnette K Nieman, Martin Reincke, John Newell-Price
doi : 10.1210/clinem/dgab122
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2114–2123
Steroidogenesis inhibitors can be given to control the hypercortisolism of Cushing’s syndrome in various situations: when surgery has been unsuccessful or not possible; in metastatic adrenocorticotropin hormone (ACTH) or cortisol-secreting tumors; when waiting for the maximal efficacy of radiation techniques; for rapid treatment of severe hypercortisolism in patients with occult ACTH-producing tumors; or as a presurgical treatment in patients with severe comorbidities. Whilst biochemical “control” can be achieved in more than 50% of cases, daily management of such drugs can be challenging. Indeed, with a “dose-titration” or a “block and replace” approach, defining eucortisolism is usually difficult, requiring the measurement of several biological markers. Moreover, each drug has its own side effects, which must be monitored closely. The aim of this “approach to the patient” is to shed light on the management of hypercortisolism with 4 steroidogenesis inhibitors (ketoconazole, levoketoconazole, metyrapone, osilodrostat) to help endocrinologists dealing with patients with Cushing’s syndrome. Various points will be discussed, such as initial dose of treatment, dose schedule, monitoring of efficacy, and side effects of monotherapy. The combination of steroidogenesis inhibitors will also be discussed.
Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height
Mingjian Shi, Ali M Manouchehri, Christian M Shaffer, Nataraja Sarma Vaitinadin, Jacklyn N Hellwege
doi : 10.1210/clinem/dgab272
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2124–2132
A genetic predisposition to lower thyrotropin (TSH) levels is associated with increased atrial fibrillation (AF) risk through undefined mechanisms.
Clinical Adverse Events Associated with Sodium–Glucose Cotransporter 2 Inhibitors: A Meta-Analysis Involving 10 Randomized Clinical Trials and 71 553 Individuals
Donna Shu-Han Lin, Jen-Kuang Lee, Wen-Jone Chen
doi : 10.1210/clinem/dgab274
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages 2133–2145
SGLT2is are first-line antidiabetic agents with demonstrated cardiovascular benefits. Prior meta-analyses have examined adverse events (AEs) associated with these drugs in general, but such knowledge needs to be updated with the results of more recent trials. In addition, the occurrence of various AEs with different underlying diseases is unknown.
The Impact of the COVID-19 Pandemic on Self-Reported Outcomes in Patients With Adrenal Insufficiency
Dingfeng Li, Malavika Suresh, Tiffany Abbondanza, Anand Vaidya, Irina Bancos
doi : 10.1210/clinem/dgab334
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2469–e2479
To determine the impact of the pandemic on self-reported outcomes in patients with adrenal insufficiency (AI).
Meal Timing of Subtypes of Macronutrients Consumption With Cardiovascular Diseases: NHANES, 2003 to 2016
Wanying Hou, Jian Gao, Wenbo Jiang, Wei Wei, Huanyu Wu
doi : 10.1210/clinem/dgab288
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2480–e2490
Emerging evidence suggests that not only the quantity but also the quality and food sources of macronutrients plays an important role in CVD. However, limited studies have examined the association of meal timing of different quality of macronutrients with CVD risk.
Faster Lumbar Spine Bone Loss in Midlife Predicts Subsequent Fracture Independent of Starting Bone Mineral Density
Albert Shieh, Arun S Karlamangla, Mei-Hua Huang, Weijuan Han, Gail A Greendale
doi : 10.1210/clinem/dgab279
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2491–e2501
Bone mineral density (BMD) decreases rapidly during menopause transition (MT), and continues to decline in postmenopause.
Genetically Determined Higher TSH Is Associated With a Lower Risk of Diabetes Mellitus in Individuals With Low BMI
Maxime M Bos, Nicolien A van Vliet, Simon P Mooijaart, Raymond Noordam, Diana van Heemst
doi : 10.1210/clinem/dgab277
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2502–e2511
Thyroid status is hypothesized to be causally related with the risk of diabetes mellitus (DM), but previous results were conflicting possibly because of a complex interaction between thyrotropin (TSH), body mass index (BMI) and DM.
Treatment of Hyperthyroidism Reduces Systemic Oxidative Stress, as Measured by Markers of RNA and DNA Damage
Camilla B Larsen, Kamilla R Riis, Kristian H Winther, Emil L Larsen, Christina Ellervik
doi : 10.1210/clinem/dgab273
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2512–e2520
Whole-body oxidative stress can be estimated by the urine excretion of oxidized guanosine species, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These oxidative stress markers are not well explored in thyroid disorders.
Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study
Susanna C Larsson, Wei-Hsuan Lee, Stephen Burgess, Elias Allara
doi : 10.1210/clinem/dgab219
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2521–e2526
Atrial fibrillation (AF), cardiac arrhythmias, and related risk factors are common in patients with Cushing’s syndrome, or clinical chronic hypercortisolism. While hypercortisolism may be associated with AF, this association has not yet been ascertained causally.
Bone Material Strength Index as Measured by Impact Microindentation is Low in Patients with Primary Hyperparathyroidism
Manuela Schoeb, Elizabeth M Winter, Maria A Sleddering, Mirjam A Lips, Abbey Schepers
doi : 10.1210/clinem/dgab207
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2527–e2534
In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at peripheral sites but also at the spine, and fractures occur at higher BMD values than expected. We hypothesized that components of bone quality other than BMD are affected in PHPT as well.
One Year of GH Treatment for Growth Failure in Children With Anorexia Nervosa: A Randomized Placebo-Controlled Trial
Juliane Léger, Anne Fjellestad-Paulsen, Anne Bargiacchi, Justine Pages, Didier Chevenne
doi : 10.1210/clinem/dgab203
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2535–e2546
Children with anorexia nervosa (AN) are at risk of adult height deficit due to prolonged low height velocity (HV).
Genetic Predisposition to Type 2 Diabetes and Insulin Levels Is Positively Associated With Serum Urate Levels
Jiahao Zhu, Lingling Sun, Jing Yang, Jiayao Fan, Lap Ah Tse
doi : 10.1210/clinem/dgab200
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2547–e2556
Previous epidemiological evidence showed that type 2 diabetes (T2D) is related with gout. However, the causality and the direction of this association are still not definitely elucidated. We investigated bidirectional associations of T2D and glycemic traits with serum urate concentrations and gout using a Mendelian randomization approach.
Cranial MRI Abnormalities and Long-term Follow-up of the Lesions in 770 Girls With Central Precocious Puberty
Didem Helvac?o?lu, Serap Demircio?lu Turan, Tülay Güran, Zeynep Atay, Adnan Da?ç?nar ...
doi : 10.1210/clinem/dgab190
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2557–e2566
Central precocious puberty (CPP) may arise from central nervous system (CNS) lesions in a few affected girls. Recently, the incidence of girls with CPP has increased mostly in 6-8 year olds, in whom the necessity of magnetic resonance imaging (MRI) is debated.
Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women
Katherine W Reeves, Gabriela Vieyra, Nydjie P Grimes, Jaymie Meliker, Rebecca D Jackson
doi : 10.1210/clinem/dgab189
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2567–e2579
Phthalates are endocrine-disrupting chemicals that could disrupt normal physiologic function, triggering detrimental impacts on bone.
Radioactive Iodine Treatment for Children and Young Adults with Thyroid Cancer in South Korea: A Population-based Study
Gi Hyeon Seo, Kyoung Ae Kong, Bom Sahn Kim, Seo Young Kang, Byung Seok Moon
doi : 10.1210/clinem/dgab192
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2580–e2588
This study investigated radioactive iodine treatment (RAIT) patterns and the secondary cancer incidence among children and young adults receiving RAIT after thyroidectomy for thyroid cancer.
Revisiting the Role of Insulin-like Growth Factor-1 Measurement After Surgical Treatment of Acromegaly
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee ...
doi : 10.1210/clinem/dgab186
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2589–e2599
In the management of growth hormone (GH)–secreting pituitary adenomas, the oral glucose tolerance test (OGTT) has been the gold standard not only for diagnoses but also for the determination of biochemical remission. Insulin-like growth factor-1 (IGF-1) is an essential biomarker, although it should be adjusted for both age and sex.
Low Intake of Vegetable Protein is Associated With Altered Ovulatory Function Among Healthy Women of Reproductive Age
Keewan Kim, Samrawit F Yisahak, Carrie J Nobles, Victoria C Andriessen, Elizabeth A DeVilbiss ..
doi : 10.1210/clinem/dgab179
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2600–e2612
Diets high in plant-based protein have gained popularity due to increasing health concerns regarding consumption of animal products. Though links between intakes of certain protein-rich foods and reproductive disorders have been suggested, the relationship of overall animal and vegetable proteins with reproductive hormones among reproductive-aged women is unknown.
An Updated Reference for Calculating Bone Mineral Density T-Scores
Shanshan Xue, Yuzheng Zhang, Wenjing Qiao, Qianqian Zhao, Dingjie Guo
doi : 10.1210/clinem/dgab180
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2613–e2621
Bone mineral density (BMD) T-score references may be updated when the peak BMD of the population is unclear and warrants reevaluation.
Two-Year Treatment With Metformin During Puberty Does Not Preserve ?-Cell Function in Youth With Obesity
Megan M Kelsey, Allison Hilkin, Laura Pyle, Cameron Severn, Kristina Utzschneider
doi : 10.1210/clinem/dgab170
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2622–e2632
Youth-onset type 2 diabetes is a disease of pubertal onset, associated with additional burden of pubertal insulin resistance on the ?-cell.
Prenatal Exposure to Butyl Paraben Is Associated With Fat Percentage in 7-Year-Old Boys
Frederik Damsgaard H?jsager, Henriette Boye Kyhl, Hanne Frederiksen, Anders Juul, Anna-Maria Andersson
doi : 10.1210/clinem/dgab167
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2633–e2638
Parabens are used as preservatives in consumer products but are suspected of having endocrine-disrupting properties. A recent study reported an association between in utero exposure to butyl paraben and overweight in childhood, with a stronger trend in girls.
The Interactive Effect of Prepregnancy Overweight/Obesity and Isolated Maternal Hypothyroxinemia on Macrosomia
Yindi Liu, Fei Guo, Yulai Zhou, Xi Yang, Yong Zhang
doi : 10.1210/clinem/dgab171
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2639–e2646
Prepregnancy overweight/obesity (OWO) and isolated maternal hypothyroxinemia (IMH) may increase the risk of macrosomia, but little is known about their potential combined effect on macrosomia.
Relationship Between Maternal Bone Biomarkers and Fetal Adiposity Through Normal Pregnancy
George Mastorakos, Dimosthenis Maliopoulos, Spyridoula Kasioni, Alexandra Bargiota, Thomas M Barber
doi : 10.1210/clinem/dgab152
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2647–e2655
To examine the association of maternal bone markers [sclerostin, soluble receptor activator of nuclear factor-?B ligand (sRANKL), osteocalcin, 25-hydroxyvitamin D3] with fetal intra-abdominal and subcutaneous adipose tissue deposition and birthweight during normal pregnancy.
Primary Ovarian Insufficiency in Women With Addison’s Disease
Elinor C Vogt, Lars Breivik, Ellen C R?yrvik, Marianne Grytaas, Eystein S Husebye
doi : 10.1210/clinem/dgab140
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2656–e2663
Primary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison’s disease (AAD) than in the general population, but their clinical characteristics are insufficiently studied.
Serum Insulin-like Factor 3 Levels Are Reduced in Former Androgen Users, Suggesting Impaired Leydig Cell Capacity
Jon Jarl?v Rasmussen, Jakob Albrethsen, Mikkel Nicklas Frandsen, Niels J?rgensen, Anders Juul
doi : 10.1210/clinem/dgab129
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2664–e2672
Illicit use of anabolic androgenic steroids (AAS) is frequently observed in men and is associated with subsequent testosterone deficiency although the long-term effect on gonadal function is still unclear. Serum insulin-like factor 3 (INSL3) has been suggested to be a superior biomarker of Leydig cell secretory capacity compared to testosterone.
Biochemical Parameters of Diabetes Ketoacidosis in Patients with End-stage Kidney Disease and Preserved Renal Function
Rodolfo J Galindo, Francisco J Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury
doi : 10.1210/clinem/dgab126
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2673–e2679
Differences in biochemical parameters of diabetic ketoacidosis in patients with end-stage kidney disease (ESKD) has not been established. Accordingly, we assessed the relationship between degree of metabolic acidosis and ?-hydroxybutyrate in patients with ESKD (eGFR < 15 mL/min/1.73 m2), moderate renal failure (eGFR 15–60), or preserved renal function (eGFR > 60).
Unmet Information Needs Among Hispanic Women with Thyroid Cancer
Debbie W Chen, David Reyes-Gastelum, Sarah T Hawley, Lauren P Wallner, Ann S Hamilton
doi : 10.1210/clinem/dgab128
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2680–e2687
To determine the relationship between acculturation level and unmet information needs among Hispanic women with thyroid cancer.
Identification of Circulating hsa_circ_0063425 and hsa_circ_0056891 as Novel Biomarkers for Detection of Type 2 Diabetes
Ya-Ke Lu, Xi Chu, Shuo Wang, Yue Sun, Jie Zhang ...
doi : 10.1210/clinem/dgab101
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2688–e2699
Circular RNAs (circRNAs), which are involved in the development of diseases by regulating gene expression, have become promising novel biomarkers for diseases.
Prediction of Adult Height by Machine Learning Technique
Michael Shmoish, Alina German, Nurit Devir, Anna Hecht, Gary Butler
doi : 10.1210/clinem/dgab093
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2700–e2710
Prediction of AH is frequently undertaken in the clinical setting. The commonly used methods are based on the assessment of skeletal maturation. Predictive algorithms generated by machine learning, which can already automatically drive cars and recognize spoken language, are the keys to unlocking data that can precisely inform the pediatrician for real-time decision making.
A High Proportion of Novel ACAN Mutations and Their Prevalence in a Large Cohort of Chinese Short Stature Children
Li Lin, Mengting Li, Jingsi Luo, Pin Li, Shasha Zhou
doi : 10.1210/clinem/dgab088
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2711–e2719
Aggrecan, encoded by the ACAN gene, is the main proteoglycan component in the extracellular cartilage matrix. Heterozygous mutations in ACAN have been reported to cause idiopathic short stature. However, the prevalence of ACAN pathogenic variants in Chinese short stature patients and clinical phenotypes remain to be evaluated.
Acute Kidney Injury and Renal Tubular Damage in Children With Type 1 Diabetes Mellitus Onset
Pierluigi Marzuillo, Dario Iafusco, Angela Zanfardino, Stefano Guarino, Alessia Piscopo
doi : 10.1210/clinem/dgab090
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2720–e2737
Acute kidney injury (AKI) and renal tubular damage (RTD), especially if complicated by acute tubular necrosis (ATN), could increase the risk of later chronic kidney disease. No prospective studies on AKI and RTD in children with type1diabetes mellitus (T1DM) onset are available.
The Association of Passive Smoking and Dyslipidemia Among Adolescence in Japan: Results From A-CHILD Study
Keitaro Miyamura, Nobutoshi Nawa, Aya Isumi, Satomi Doi, Manami Ochi
doi : 10.1210/clinem/dgab094
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2738–e2748
Passive smoking in childhood has been reported to be associated with dyslipidemia in Western countries. However, this association in Asian countries remains unclear. Further, no study has investigated the sex difference of the association.
Elevated Apolipoprotein A1 and HDL Cholesterol Associated with Age-related Macular Degeneration: 2 Population Cohorts
Liv Tybj?rg Nordestgaard, Anne Tybj?rg-Hansen, Ruth Frikke-Schmidt, B?rge Gr?nne Nordestgaard
doi : 10.1210/clinem/dgab095
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2749–e2758
To enable prevention and treatment of age-related macular degeneration (AMD), understanding risk factors for AMD is important.
Increased Mortality Risk in Patients With Primary and Secondary Adrenal Insufficiency
Kanchana Ngaosuwan, Desmond G Johnston, Ian F Godsland, Jeremy Cox, Azeem Majeed
doi : 10.1210/clinem/dgab096
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2759–e2768
Mortality data in patients with adrenal insufficiency are inconsistent, possibly due to temporal and geographical differences between patients and their reference populations.
Association of Parental Consanguinity With Papillary Thyroid Carcinoma: A Case-Control Study
Ayman A Zayed, Justin Z Amarin, Abdallah T Al-Ani, Tareq L Altell, Sultan S Abdelhamid
doi : 10.1210/clinem/dgab071
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2769–e2774
Papillary thyroid carcinoma (PTC) is the most common type of nonmedullary thyroid carcinoma. Uncommonly, PTC is associated with multiple genetic alterations and chromosomal abnormalities and displays familial patterns of inheritance. Parental consanguinity increases susceptibility to many genetic disorders.
Chinese Adults Are More Susceptible to Effects of Overall Obesity and Fat Distribution on Cardiometabolic Risk Factors
Ruizhi Zheng, Mian Li, Min Xu, Jieli Lu, Tiange Wang
doi : 10.1210/clinem/dgab049
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2775–e2788
The body mass index (BMI) and waist circumference (WC) as diagnostic tools of obesity do not reflect the same level of fat mass and whether obesity leads to various effects on cardiometabolic risk factors among different racial/ethnic population is unknown.
Ehlers–Danlos Syndrome: Molecular and Clinical Characterization of TNXA/TNXB Chimeras in Congenital Adrenal Hyperplasia
Roxana Marino, Natalia Perez Garrido, Pablo Ramirez, Guillermo Notaristéfano, Angélica Moresco
doi : 10.1210/clinem/dgab033
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2789–e2802
The syndrome CAH-X is due to a contiguous gene deletion of CYP21A2 and TNXB resulting in TNXA/TNXB chimeras.
Youth Along the T2D Risk Continuum Remain Concerningly Refractory to Therapeutic Interventions
Peter M Wolfgram, Susanne M Cabrera
doi : 10.1210/clinem/dgab292
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2803–e2805
no abstract
Brain MRI in Girls With Central Precocious Puberty: A Time for New Approaches
Ana Pinheiro Machado Canton, Ana Claudia Latronico
doi : 10.1210/clinem/dgab293
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2806–e2808
no abstract
Explainable Artificial Intelligence in Endocrinological Medical Research
Bobbie-Jo M Webb-Robertson
doi : 10.1210/clinem/dgab237
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2809–e2810
no abstract
REWIND Diabetes for Octogenarians
Tarekegn Geberhiwot
doi : 10.1210/clinem/dgab163
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2811–e2812
no abstract
Male Fertility After Androgenic Steroid Use: How Little We Know
Bradley D Anawalt
doi : 10.1210/clinem/dgab236
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2813–e2815
no abstract
Cushing “Blues”
Alicia Santos, Susan M Webb
doi : 10.1210/clinem/dgab239
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2816–e2818
no abstract
Statins: A New Hope on the Horizon of Graves Orbitopathy?
Michele Marin?, Giulia Lanzolla, Claudio Marcocci
doi : 10.1210/clinem/dgab184
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2819–e2821
no abstract
Long-term Fasting Glycemic Variability and Microvascular Complications in Type 2 Diabetes
Pandora L Wander, Edward J Boyko
doi : 10.1210/clinem/dgab172
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2822–e2824
no abstract
Impaired Bone Matrix: The Key to Fragility in Type 2 Diabetes?
Christopher J Hernandez, Emily M Stein, Eve Donnelly
doi : 10.1210/clinem/dgab150
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2825–e2827
no abstract
Endocrine Workup for Primary Aldosteronism Should Include Adrenal Venous Sampling in Young Patients
Anders Palmstr?m J?rgensen
doi : 10.1210/clinem/dgab142
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2828–e2829
no abstract
Uncovering the Molecular Cause of Preeclampsia—The Role of Glutathionylation of the Na+/K+ ATPase Transporter
Fiona Claire Brownfoot
doi : 10.1210/clinem/dgab117
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2830–e2832
no abstract
Letter to the Editor From Zhu and Briganti: “Denosumab Safety and Efficacy Among Participants in the FREEDOM Extension Study With Mild to Moderate Chronic Kidney Disease”
Jasmine Zhu, Esther M Briganti
doi : 10.1210/clinem/dgab305
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2833–e2834
no abstract
Letter to the Editor from Lao and Merke: “Ehlers–Danlos Syndrome: Molecular and Clirnical Characterization of TNXA/TNXB Chimeras in Congenital Adrenal Hyperplasia”
Qizong Lao, Deborah P Merke
doi : 10.1210/clinem/dgab280
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2835–e2836
no abstract
Response to Letter to the Editor from Lao and Merke: “Ehlers-Danlos Syndrome: Molecular and Clinical Characterization of TNXA/TNXB Chimeras in Congenital Adrenal Hyperplasia”
Roxana Marino, Natalia Perez Garrido, Pablo Ramirez, Alicia Belgorosky
doi : 10.1210/clinem/dgab281
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2837–e2838
no abstract
Response to Letter to the Editor from Sukor et al.: “Evaluation and Treatment of Amiodarone-induced Thyroid Disorders”
Dorina Ylli, Leonard Wartofsky, Kenneth D Burman
doi : 10.1210/clinem/dgab105
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Pages e2839–e2840
no abstract
Corrigendum to: “Hepatic Fat in Participants With and Without Incident Diabetes in the Diabetes Prevention Program Outcome Study”
empty
doi : 10.1210/clinem/dgab332
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2841
no abstract
Corrigendum to: “Phase 3 Trial of a Small-Volume Subcutaneous 6-Month Duration Leuprolide Acetate Treatment for Central Precocious Puberty”
empty
doi : 10.1210/clinem/dgab294
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2842
no abstract
Corrigendum to: “Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab306
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2843
no abstract
Corrigendum to: “Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab307
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2844
no abstract
Corrigendum to: “Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab308
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2845
no abstract
Corrigendum to: “Prevention and Treatment of Pediatric Obesity: An Endocrine Society Clinical Practice Guideline Based on Expert Opinion”
empty
doi : 10.1210/clinem/dgab309
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2846
no abstract
Corrigendum to: “Primary Prevention of Cardiovascular Disease and Type 2 Diabetes in Patients at Metabolic Risk: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab310
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2847
no abstract
Corrigendum to: “Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab311
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2848
no abstract
Corrigendum to: “Evaluation and Treatment of Adult Growth Hormone Deficiency: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab312
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2849
no abstract
Corrigendum to: “Androgen Therapy in Women: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab313
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2850
no abstract
Corrigendum to: “Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab314
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2851
no abstract
Corrigendum to: “Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab315
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2852
no abstract
Corrigendum to: “Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline”
empty
doi : 10.1210/clinem/dgab316
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2853
no abstract
Corrigendum to: “Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring”
empty
doi : 10.1210/clinem/dgab285
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2854
no abstract
Corrigendum to: “Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: a 2-Year RCT”
empty
doi : 10.1210/clinem/dgab284
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 7, July 2021, Page e2855
no abstract
