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Organoids and organ chips in ophthalmology
Navid Manafi, Fereshteh Shokri, Kevin Achberger, Masatoshi Hirayama, ... Alireza Mashaghi
doi : 10.1016/j.jtos.2020.11.004
Volume 19, January 2021, Pages 1-15
Recent advances have driven the development of stem cell-derived, self-organizing, three-dimensional miniature organs, termed organoids, which mimic different eye tissues including the retina, cornea, and lens. Organoids and engineered microfluidic organ-on-chips (organ chips) are transformative technologies that show promise in simulating the architectural and functional complexity of native organs
Ocular surface complications of local anticancer drugs for treatment of ocular tumors
Jayoon Moon, Se Hyun Choi, Min Joung Lee, Dong Hyun Jo, ... Joo Youn Oh
doi : 10.1016/j.jtos.2020.11.006
Volume 19, January 2021, Pages 16-30
Local chemotherapy is increasingly used, either in combination with surgery or as monotherapy, for management of ocular tumors. Yet many of the local chemotherapeutic agents used for ocular tumors are cytotoxic drugs that are frequently associated with toxicities in normal ocular tissues.
Relationship between eyelid margin irregularity and meibomian gland dropout
Minji Ha, Jin Soo Kim, Seo-Yeon Hong, Dong-Jin Chang, ... Ho Sik Hwang
doi : 10.1016/j.jtos.2020.11.007
Volume 19, January 2021, Pages 31-37
To examine the relationship between lid margin abnormalities and meibomian gland loss in infrared meibography.
Cicatrizing conjunctivitis as an uncommon manifestation of primary Sj?gren's syndrome
Yael Sharon, David Cui, Esen K. Akpek, David S. Chu
doi : 10.1016/j.jtos.2020.11.014
Volume 19, January 2021, Pages 38-42
To report occurrence of cicatrizing conjunctivitis as an extraglandular ocular manifestation of primary Sj?gren's syndrome (SS).
Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease
Michael M?ller-Hansen, Ann-Cathrine Larsen, Peter Bjerre Toft, Charlotte Duch Lynggaard, ... Steffen Heegaard
doi : 10.1016/j.jtos.2020.11.013
Volume 19, January 2021, Pages 43-52
To evaluate the safety and feasibility of injecting allogeneic adipose-derived mesenchymal stem cells (ASCs) into the lacrimal gland (LG) as a treatment of aqueous deficient dry eye disease (ADDE).
Creation and grading of experimental corneal scars in mice models
Devon Cogswell, Mei Sun, Erin Greenberg, Curtis E. Margo, Edgar M. Espana
doi : 10.1016/j.jtos.2020.11.008
Volume 19, January 2021, Pages 53-62
To develop a stromal wound healing model and a reliable scar classification score system that correlates photographic evaluation with changes in the structure and organization of the extracellular matrix.
Handing it to pterygium: Explaining pterygium laterality
Minas T. Coroneo, Lien Tat, Helen Chen, Dimitar I. Grupchev, ... Matthew H. Ip
doi : 10.1016/j.jtos.2020.12.001
Volume 19, January 2021, Pages 63-67
To evaluate any correlation between pterygium laterality and patient handedness.
