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A novel small-molecular CCR5 antagonist promotes neural repair after stroke
Qing-lin Wu, Li-yuan Cui, Wen-yu Ma, Sha-sha Wang, Zhao Zhang, Zhong-ping Feng, Hong-shuo Sun, Shi-feng Chu, Wen-bin He & Nai-hong ChenÂ
doi : 10.1038/s41401-023-01100-y
Volume 44 Issue 10, October 2023
Loss of DJ-1 function contributes to Parkinson’s disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation
Le-le Liu, Yu Han, Zi-jia Zhang, Yi-qi Wang, Yu-wei Hu, Elena Kaznacheyeva, Jian-qing Ding, Dong-kai Guo, Guang-hui Wang, Bin Li & Hai-gang RenÂ
Bioinspired PROTAC-induced macrophage fate determination alleviates atherosclerosis
Jiong-hua Huang, Chuang-jia Huang, Li-na Yu, Xiao-ling Guan, Shang-wen Liang, Jian-hong Li, Lu Liang, Min-yan Wei & Ling-min ZhangÂ
Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation
Min-chun Jiang, Huan-yu Ding, Yu-hong Huang, Chak Kwong Cheng, Chi Wai Lau, Yin Xia, Xiao-qiang Yao, Li Wang & Yu HuangÂ
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis
Zhen-duo Zhu, Mei Zhang, Zhen Wang, Chun-ru Jiang, Chong-jian Huang, Hui-juan Cheng, Qiu-yun Guan, Tian-tian Su, Man-man Wang, Yi Gao, Hong-fei Wu, Wei Wei, Yong-sheng Han & Qing-tong WangÂ
FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis
De-pu Zhou, Lian-cheng Deng, Xiao Feng, Hui-jing Xu, Ye Tian, Wei-wei Yang, Ping-ping Zeng, Li-hui Zou, Xi-hua Yan, Xia-yan Zhu, Dan-hua Shu, Qiang Guo, Xiao-ying Huang, Saverio Bellusci, Zhenkun Lou, Xiao-kun Li & Jin-San ZhangÂ
Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly
Si-yuan Chen, Ya-ping Li, Yi-ping You, Hong-rui Zhang, Zi-jian Shi, Qi-qi Liang, Tao Yuan, Rong Xu, Li-hui Xu, Qing-bing Zha, Dong-yun Ou-Yang & Xian-hui HeÂ
Peroxisome proliferator-activated receptor α agonist induces mouse hepatomegaly through the spatial hepatocyte enlargement and proliferation
Jie Yang, Xiao Yang, Yi-fei Zhang, Jia-ning Tian, Shi-cheng Fan, Yue Gao, Hui-lin Li, Cheng-hui Cai, Min Huang & Hui-chang BiÂ
β-arrestin2 deficiency ameliorates S-100-induced autoimmune hepatitis in mice by inhibiting infiltration of monocyte-derived macrophage and attenuating hepatocyte apoptosis
Ting-ting Chen, Xiu-qin Li, Nan Li, Ya-ping Xu, Yu-han Wang, Zi-ying Wang, Sheng-nan Zhang, Meng Qi, Shi-hao Zhang, Wei Wei, Hua Wang & Wu-yi SunÂ
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway
Ting-feng Zou, Zhi-gang Liu, Pei-chang Cao, Shi-hong Zheng, Wen-tong Guo, Tian-xiang Wang, Yuan-li Chen, Ya-jun Duan, Qing-shan Li, Chen-zhong Liao, Zhou-ling Xie, Ji-hong Han & Xiao-xiao YangÂ
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling
Wen-hua Ming, Zhi-lin Luan, Yao Yao, Hang-chi Liu, Shu-yuan Hu, Chun-xiu Du, Cong Zhang, Yi-hang Zhao, Ying-zhi Huang, Xiao-wan Sun, Rong-fang Qiao, Hu Xu, You-fei Guan & Xiao-yan ZhangÂ
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity
Sai-ya Zhu, Wen-qian Zhou, Yang-yang Niu, Chao Zheng, Xi Liu, Ying-ying Zhang & Chen YuÂ
Bis(benzonitrile) dichloroplatinum (II) interrupts PD-1/PD-L1 interaction by binding to PD-1
Rui-na Wang, Qian Yu, Xiao-bo Wang, Di Zhu, Guo-long Li, Zeng-xia Li, Wei Jiang, Wei Li & Yong-jun DangÂ
Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition
Lei Yu, Ya-fang Wang, Jian Xiao, Qian-qian Shen, Shuai-shuai Chi, Ying-lei Gao, Dong-ze Lin, Jian Ding, Yan-fen Fang & Yi ChenÂ
Activated SIRT1 contributes to DPT-induced glioma cell parthanatos by upregulation of NOX2 and NAT10
Shi-peng Liang, Xuan-zhong Wang, Mei-hua Piao, Xi Chen, Zhen-chuan Wang, Chen Li, Yu-bo Wang, Shan Lu, Chuan He, Yan-li Wang, Guang-fan Chi & Peng-fei GeÂ
