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Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): Study protocol for a randomized, blinded, crossover trial
Xiexiong Zhao, MD a , Ye Chen, MD a , Guoping Yang, PhD b,c , Xingli Li, PhD d , Xiaohong Tang, MD, PhD a , Qiong Yang, MD, PhD a , Liping Peng, MD, PhD a , Jingle Li, MD, PhD a , Zhongshu Liang, MD, PhD a , Anying Li, MD, PhD a , Wenjuan Wang, PhD a , Miao Huang, MD a , Tao Liu, MM a , Xiaogang Li, MD, PhD a , and Weihong Jiang, MD, PhD a,e Changsha, Hunan, China
doi : 10.1016/j.ahj.2023.05.019
Volume 264, October 2023, Pages 10-19
Preventive PCI or medical therapy alone for vulnerable atherosclerotic coronary plaque: Rationale and design of the randomized, controlled PREVENT trial
Jung-Min Ahn, MD a,# , Do-Yoon Kang, MD a,# , Pil Hyung Lee, MD a , Young-Keun Ahn, MD b , Won-Jang Kim c , Chang-Wook Nam, MD d , Jin-Ok Jeong, MD e , In-Ho Chae, MD f , Hiroki Shiomi, MD g , Paul Hsien Li Kao, MD h , Joo-Yong Hahn, MD i , Sung-Ho Her, MD j , Bong-Ki Lee, MD k , Tae Hoon Ahn, MD l , Kiyuk Chang m , Jei Keon Chae, MD n , David Smyth o , Gregg W. Stone, MD p , Duk-Woo Park, MD a , and Seung-Jung Park, MD, PhD a , for the PREVENT Investigators Seoul, Korea; Gwangju, Korea; Goyang, Korea; Daegu, Korea; Daejeon, Korea; Sungnam, Korea; Kyoto, Japan; Taipei, Taiwan; Suwon, Korea; Chuncheon, Korea; Gwangmyeong, Korea; Jeonju, Korea; Christchurch, New Zealand; New York, NY
doi : 10.1016/j.ahj.2023.05.017
Volume 264, October 2023, Pages 83-96
Near-infrared spectroscopy-intravascular ultrasound to improve assessment of coronary artery disease severity in patients referred for transcatheter aortic valve implantation (The IMPACTavi registry): Design and rationale
Masaru Seguchi, MD, PhD a,b , Alp Aytekin, MD a , Lena Steiger a , Philipp Nicol, MD a , Costanza Pellegrini, MD a , Tobias Rheude, MD a , Leif-Christopher Engel, MD a , Hector A. Alvarez-Covarrubias, MD, PhD a,c , Erion Xhepa, MD, PhD a , N. Patrick Mayr, MD d , Martin Hadamitzky, MD e , Adnan Kastrati, MD a,f , Heribert Schunkert, MD a,f , Michael Joner, MD a,f , and Tobias Lenz, MD a Copenhagen, Denmark; Copenhagen, Denmark; Odense, Denmark; Copenhagen, Denmark; Barcelona, Spain; Skejby, Denmark; Aarhus, Denmark; Gothenburg, Sweden; Gothenburg, Sweden; Barcelona, Spain; Copenhagen, Denmark; Hospital, Denmark; Hvidovre, Denmark; Hilleroed, Denmark; Copenhagen, Denmark; Koge, Denmark; Copenhagen, Denmark; Herlev, Denmark
doi : 10.1016/j.ahj.2023.06.004
Volume 264, October 2023, Pages 114-122
Rationale and design of a randomized study comparing the Watchman FLX device to DOACs in patients with atrial fibrillation
Saibal Kar, MD a,# , Shephal K. Doshi, MD b,# , Mohamad Alkhouli, MD c , A. John Camm, MD d , Megan Coylewright, MD e , Michael C. Gibson, MD f , Christopher B. Granger, MD g , Mahmut E. Gurol, MD h , Kenneth Huber, MD i , Moussa Mansour, MD j , Devi G. Nair, MD k , Andrea Natale, MD l , Stuart J. Pocock, MD m , Vivek R. Reddy, MD n , Walid Saliba, MD o , Thomas Christen, MD, PhD p , Dominic J. Allocco, MD p , Kenneth A. Ellenbogen, MD q , and Martin B. Leon, MD r Thousand Oaks, CA; Santa Monica, CA; Rochester, MN; London, United Kingdom; Chattanooga, TN; Boston, MA; Durham, NC; Kansas City, MO; Jonesboro, AR; Austin, TX; New York, NY; Cleveland, OH; Marlborough, MA; Richmond, VA
doi : 10.1016/j.ahj.2023.05.022
Volume 264, October 2023, Pages 123-132
The left atrial appendage closure by surgery-2 (LAACS-2) trial protocol rationale and design of a randomized multicenter trial investigating if left atrial appendage closure prevents stroke in patients undergoing open-heart surgery irrespective of preoperative atrial fibrillation status and stroke risk
Christoffer L?ss?e Madsen, MD a,b , Jesper Park-Hansen, MD, PhD n , Akhmadjon Irmukhamedov, MD c , Christian Lildal Carranza, MD d , Sulman Rafiq, MD, PhD d , Rafael Rodriguez-Lecoq, MD, PhD e , Neiser Palmer-Camino, MD, PhD e , Ivy Susanne Modrau, MD, DMSc f,g , Emma C. Hansson, MD, PhD h,i , Anders Jeppsson, MD, PhD h,i , Rakin Hadad, MD a , Angel Moya-Mitjans, MD, PhD j , Anders M?ller Greve, MD, PhD k , Robin Christensen, MD, PhD l,m , Helle Gervig Carstensen, MD, PhD a , Nis Baun H?st, MD, PhD a , Ulrik Dixen, MD, PhD n , Christian Torp-Pedersen, MD, DMSc o , Lars K?ber, MD, DMSc p , Ismail G?genur, MD, DMSc q , Thomas Clement Truelsen, MD, DMSc r , Christina Kruuse, MD, DMSc s , Ahmad Sajadieh, MD, DMSc a , and Helena Dom?nguez, MD, PhD a,b , on behalf of the LAACS-2 trial Investigators Copenhagen, Denmark; Odense, Denmark; Barcelona, Spain; Skejby, Denmark; Aarhus, Denmark; Gothenburg, Sweden; Hvidovre, Denmark; Hilleroed, Denmark; Koge, Denmark; Herlev, Denmark
doi : 10.1016/j.ahj.2023.06.003
Volume 264, October 2023, Pages 133-142
Incorporating a polygenic risk score-triaged coronary calcium score into cardiovascular disease examinations to identify subclinical coronary artery disease (ESCALATE): Protocol for a prospective, nonrandomized implementation trial
Michael P. Gray, MPH a,b , Yemima Berman, PhD a,c , Giordano Bottà , PhD d , Stuart M. Grieve, DPhil e,f , Amy Ho, MBBS g , Jessica Hu, BSc a,b , Karice Hyun, PhD h,i , Jodie Ingles, PhD a,j,k,l,m , Garry Jennings, MD a , Gary Kilov, MBBCh n,o , Jean-Frederic Levesque, PhD p,q , Peter Meikle, PhD r,s , Julie Redfern, PhD t,u , Tim Usherwood, PhD h , Stephen T. Vernon, PhD a,v , Stephen J. Nicholls, PhD w , and Gemma A. Figtree, DPhil a,b,v , On behalf of the PPP-CAD Collaborators NSW, Australia; Rome Italy
doi : 10.1016/j.ahj.2023.06.009
Volume 264, October 2023, Pages 163-173
Gut barrier dysfunction and endotoxemia in heart failure: A dangerous connubium?
Francesco Violi, MD a,b , Valentina Castellani, MSc c , Danilo Menichelli, MD c , Pasquale Pignatelli, MD a,b , and Daniele Pastori, MD a Rome, Italy; Naples, Italy
doi : 10.1016/j.ahj.2023.06.002
Volume 264, October 2023, Pages 40-48
Patient characteristics and long-term outcomes in patients undergoing transcatheter aortic valve implantation in a failed surgical prosthesis vs in a native valve: A Danish nationwide study
Xenia Begun, MD a , Jawad H. Butt, MD a , S?ren L. Kristensen, MD, PhD a , Peter E. Weeke, MD, PhD a , Ole De Backer, MD, PhD a , Jarl E. Strange, MD a , Morten Schou, MD, DMSc b , Lars K?ber, MD, DMSc a , and Emil L. Fosb?l, MD, PhD a Copenhagen, Denmark; Hellerup, Denmark
doi : 10.1016/j.ahj.2023.05.007
Volume 264, October 2023, Pages 183-189
Temporal Changes in Clinical Characteristics and Outcomes of Adults With Congenital Heart Disease
Alexander C. Egbe, MD, MPH, MS a , William R. Miranda, MD a , C. Charles Jain, MD a , Elizabeth H. Stephens, MD, PhD b , Kartik Andi, MBBS a , Omar Abozied, MBBS a , and Heidi M. Connolly, MD a Rochester, MN
doi : 10.1016/j.ahj.2023.05.025
Volume 264, October 2023, Pages 1-9
Impact of standard modifiable cardiovascular risk factors on 2-year all-cause mortality: Insights from an international cohort of 23,489 patients with acute coronary syndrome
Maribel Gonz?lez-Del-Hoyo, MD, PhD a , Xavier Rossello, MD, PhD a,b,c , Vicente Peral, MD, PhD a,c , Stuart Pocock, PhD c,d , Frans Van de Werf, MD, PhD e , Chee Tang Chin, MD f , Nicolas Danchin, MD, PhD g , Stephen W-L Lee, MD h , Jes?s Medina, PhD i , Yong Huo, MD, PhD j,# , and Héctor Bueno, MD, PhD b,k,l,m,# Palma, Spain; UK; Belgium; Singapore; France; China; Spain; Madrid, Spain
doi : 10.1016/j.ahj.2023.05.023
Volume 264, October 2023, Pages 20-30
Comparison of the effectiveness and safety of 2 aspirin doses in secondary prevention of cardiovascular outcomes in patients with chronic kidney disease: A subgroup analysis of ADAPTABLE
Kamal Gupta a , Harsh Mehta a , Hwasoon Kim b , Amanda Stebbins b , Lisa M. Wruck b , Daniel Mu?oz c , Mark B. Effron d , R. David Anderson e , Carl J. Pepine e , Sandeep K. Jain f , Saket Girotra g , Darren A. DeWalt h , Jeff Whittle i , Catherine P. Benziger j , Peter Farrehi k , Li Zhou l , Kirk U. Knowlton m , Tamar S. Polonsky n , Steven M. Bradley o , Robert A. Harrington p , Russell L. Rothman c , W. Schuyler Jones b , and Adrian F. Hernandez b Kansas City, KS; Durham, NC; Nashville, TN; New Orleans, LA; Gainesville, FL; Pittsburgh, PA; Dallas, TX; Chapel Hill, NC; Milwaukee, WI; Duluth, MN; Ann Arbor, MI; Winston Salem, NC; Salt Lake City, UT; Chicago, IL; Minneapolis, MN; Stanford, CA
doi : 10.1016/j.ahj.2023.06.001
Volume 264, October 2023, Pages 31-39
Associations of N-terminal pro-B-type natriuretic peptide, estimated glomerular filtration rate, and mortality in US adults
Bige Ozkan, MD, ScM a,b , Morgan E. Grams, MD, PhD c , Josef Coresh, MD, PhD a , John W. McEvoy, MB, BCh, BAO, MHS, PhD d , Justin B. Echouffo-Tcheugui, MD, PhD e , Scott Z. Mu, MD, MHS a , Olive Tang, MD, PhD f , Natalie R. Daya, MPH a , Hyunju Kim, PhD, MPH a , Robert H. Christenson, PhD g , Chiadi E. Ndumele, MD, PhD b , and Elizabeth Selvin, PhD, MPH a Baltimore, MD; New York, NY; Galway, Ireland
doi : 10.1016/j.ahj.2023.05.014
Volume 264, October 2023, Pages 49-58
Transcatheter edge-to-edge repair for chronic functional mitral regurgitation in patients with very severe left ventricular dysfunction
Alon Shechter, MD, MHA a,b,c , Ofir Koren, MD a,d , Sabah Skaf, MD a , Moody Makar, MD a , Tarun Chakravarty, MD a , Keita Koseki, MD a,e , Danon Kaewkes, MD a,f , Aum Solanki, MD a , Vivek Patel, MS a , Raj R. Makkar, MD a , and Robert J. Siegel, MD a,g Los Angeles, CA; Petach Tikva, Israel; Tel Aviv, Israel; Haifa, Israel; Tokyo, Japan; Khon Kaen, Thailand
doi : 10.1016/j.ahj.2023.05.020
Volume 264, October 2023, Pages 59-71
Relationship between stent length and very long-term target lesion failure following percutaneous coronary intervention for ST-elevation myocardial infarction in the drug-eluting stents era: insights from the EXAMINATION-EXTEND study
Kamil Bujak, MD a,b , Pablo Vidal-Cales, MD a , Rami Gabani, MD a , Riccardo Rinaldi, MD a,c , Josep Gomez-Lara, MD, PhD d , Luis Ortega-Paz, MD, PhD a,e , Victor Jimenez-Diaz, MD, PhD f , Marcelo Jimenez-Kockar, MD g , Pilar Jimenez-Quevedo, MD, PhD h , Roberto Diletti, MD, PhD i , Gianluca Campo, MD, PhD j , Antonio Silvestro, MD k , Jaume Maristany, MD, PhD l , Xacobe Flores, MD, PhD m , Loreto Oyarzabal, MD d , Antonio De Miguel-Castro, MD f , Andrés I?iguez, MD, PhD f , Luis Nombela-Franco, MD, PhD h , Alfonso Ielasi, MD, PhD k , Maurizio Tespili, MD, PhD k , Mattie Lenzen, MD, PhD i , Simone Biscaglia, MD j , Soheil Al-Shaibani, MD i , Rafael Romaguera, MD d , Joan Antoni Gomez-Hospital, MD, PhD d , Mariusz Gasior, MD, PhD b , Patrick W. Serruys, MD, PhD n,o , Manel Sabate, MD, PhD a , and Salvatore Brugaletta, MD, PhD a Barcelona, Spain; Katowice, Poland; Rome, Italy; Jacksonville, FL; Vigo, Spain; Madrid, Spain; Rotterdam, The Netherlands; Cona, Italy; Bergamo; Italy; Palma de Mallorca, Spain; London, United Kingdom; Galway, Ireland
doi : 10.1016/j.ahj.2023.05.021
Volume 264, October 2023, Pages 72-82
The First Brazilian Cardiovascular Registry of Atrial Fibrillation: Primary Results of the RECALL Study
Renato D. Lopes, MD, MHS, PhD a,b , Pedro G.M. de Barros e Silva, MD, MHS, PhD a,c,d , Conrado Roberto Hoffmann Filho, MD, MSc e , Margaret Assad Cavalvante, MD, MSc f , Claudia Madeira Miranda, MD, MSc g , Rodrigo Barbosa Esper, MD, PhD h , Gustavo Glotz de Lima, MD, PhD i , Luiz Eduardo Fonteles Ritt, MD, PhD j,k , Rose Mary Ferreira Lisboa da Silva, MD, PhD l , Marcelo A. Nakazone, MD, PhD m , Adail Paix?o Almeida, MD n , Ricardo Pavanello, MD, PhD c , Carlos Eduardo Batista de Lima, MD, PhD o , Luciano Marcelo Backes, MD p , Lucas Hollanda Oliveira, MD, MSc q , Olga Ferreira de Souza, MD, PhD r , Adalberto Menezes Lorga Filho, MD, PhD s , Epotamenides Maria Good God, MD, PhD t , José Carlos Moura Jorge, MD, PhD u , Alcirley de Almeida Luiz, MD v,w , Simone Fialho Pereira Pimentel Martins, MD x , Rogério Carregoza Dantas, MD, MSc y , Ricardo D ´Oliveira Vieira, MD, PhD z , Leandro Ioschpe Zimerman, MD, PhD aa , ?lvaro Rabelo Alves J?nior, MD bb , M?rcio Jansen de Oliveira Figueiredo, MD, PhD cc , Samara Pinheiro do Carmo Gomes, BSc c , Lucas Martins de Lima, RMD c , Lucas Petri Damiani, PhD a,c , Ricardo Alkmim Teixeira, MD, PhD dd,ee,ff , Alexandro Alves Fagundes, MD dd , and Eduardo Benchimol Saad, MD, PhD dd,gg,hh , on behalf of the RECALL Investigators Sao Paulo, SP; Durham, NC; Joinville, SC; Presidente Prudente, SP; Belo Horizonte, MG; Porto Alegre, RS; Salvador, BA; Sao Jose do Rio Preto, SP; Vitoria da Conquista, BA; Teresina, PI; Passo Fundo, RS; Rio de Janeiro, RJ; Curitiba, PR; Cascavel, PR; Vitoria, ES; Curvelo, MG; Ipiau, BA; Porto Alegre, RS; Campinas, SP; Pouso Alegre, MG; Rio de Janeiro, RJ
doi : 10.1016/j.ahj.2023.06.007
Volume 264, October 2023, Pages 97-105
Hemodialysis and its impact on patient characteristics, microbiology, cardiac surgery, and mortality in infective endocarditis
Anna Stahl, MB a , Eva Havers-Borgersen, MD a , Lauge ?stergaard, MD, PhD a , Jeppe K. Petersen, MB a , Niels E. Bruun, MD, DMSc b , Peter E. Weeke, MD, PhD a , S?ren L. Kristensen, MD, PhD a , Marianne Voldstedlund, MD, PhD c , Lars K?ber, MD, DMSc a , and Emil L. Fosb?l, MD, PhD a Copenhagen, Denmark; Roskilde, Denmark
doi : 10.1016/j.ahj.2023.05.015
Volume 264, October 2023, Pages 106-113
Association between racial residential segregation and Black-White disparities in cardiovascular disease mortality
Kriyana P. Reddy, BS a , Lauren A. Eberly, MD, MPH a,b,c,d , Howard M. Julien, MD, MPH a,b,c,d,e , Jay Giri, MD, MPH a,b,c,e , Alexander C. Fanaroff, MD, MHS a,b,c , Peter W. Groeneveld, MD, MS a,c,e,f , Sameed Ahmed M. Khatana, MD, MPH a,b,c,e , and Ashwin S. Nathan, MD, MS a,b,c,e Philadelphia, PA
doi : 10.1016/j.ahj.2023.06.010
Volume 264, October 2023, Pages 143-152
Cardiac imaging and biomarkers for assessing myocardial fibrosis in children with hypertrophic cardiomyopathy
Sonya Kirmani, MD a , Pamela K. Woodard, MD b , Ling Shi, PhD c , Taye H. Hamza, PhD d , Charles E. Canter, MD e , Steven D. Colan, MD f , Elfriede Pahl, MD g , Jeffrey A. Towbin, MD h , Steven A. Webber, MBChB i , Joseph W. Rossano, MD, MS j , Melanie D. Everitt, MD k , Kimberly M. Molina, MD l , Paul F. Kantor, MBBCh, MSc m , John L. Jefferies, MD n , Brian Feingold, MD, MS o , Linda J. Addonizio, MD p , Stephanie M. Ware, MDPhD q , Wendy K. Chung, MDPhD p , Jean A. Ballweg, MD r , Teresa M. Lee, MD p , Neha Bansal, MD s , Hiedy Razoky, MBA t , Jason Czachor, MS t , Fatima I. Lunze, MD, ScD, PhD f,u , Edward Marcus, MSc f , Paul Commean, BEE b , James D. Wilkinson, MD, MPH i , and Steven E. Lipshultz, MD v Madison, WI; St. Louis, MO; Watertown, MA; Boston, MA; Chicago, IL; Memphis, TN; Nashville, TN; Philadelphia, PA; Aurora, CO; Salt Lake City, UT; Los Angeles, CA; Pittsburgh, PA; New York, NY; Indianapolis, IN; Omaha, NE; Bronx, NY; Detroit, MI; Berlin, Germany; Buffalo, NY
doi : 10.1016/j.ahj.2023.06.005
Volume 264, October 2023, Pages 153-162
Geographic distribution of United States clinical trial sites utilized for guideline changing studies of cholesterol management
Marwah E. Alnewais, PharmD a,b , Lauren Adams, BA a , Abdulaziz S. Alfehaid, PharmD a,c , Shayma Alzaidi, PharmD a,d , and Erin R. Weeda, PharmD a Charleston, SC; Alahsa, Saudi Arabia; Taif, Saudi Arabia
doi : 10.1016/j.ahj.2023.03.020
Volume 264, October 2023, Pages 174-176
The effect of vitamin D3 supplementation on atrial fibrillation in generally healthy men and women: The Finnish Vitamin D Trial
Jyrki K. Virtanen, PhD a , Sari Hantunen, PhD a , Christel Lamberg-Allardt, PhD b , JoAnn E. Manson, MD, DrPH c,d , Tarja Nurmi, PhD a , Matti Uusitupa, MD, PhD a , Ari Voutilainen, PhD a , and Tomi-Pekka Tuomainen, MD, PhD a Kuopio, Finland; Helsinki, Finland; Boston, MA
doi : 10.1016/j.ahj.2023.05.024
Volume 264, October 2023, Pages 177-182
