Pediatric Allergy and Immunology




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Issue Information - Editorial Board

doi : 10.1111/pai.13286

Volume 32, Issue 4 p. 627-627

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Issue Information - TOC

doi : 10.1111/pai.13285

Volume 32, Issue 4 p. 629-630

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Comments on nitric oxide in children with asthma, low-dose oral immunotherapy for cow's milk allergy, and SARS-Cov-2 testing in school children

Philippe Eigenmann

doi : 10.1111/pai.13499

Volume 32, Issue 4 p. 631-634

PAI regularly publishes reviews to update you on major topics. This issue features a first review article on pediatric rhinitis by Papadopoulos and colleagues, followed by an update on food allergy written by current and past associate editors.

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New concepts in pediatric rhinitis

Nikolaos G. Papadopoulos, Xenophon Aggelides, Sofia Stamataki, Emmanuel Prokopakis, Michael Katotomichelakis, Paraskevi Xepapadaki

doi : 10.1111/pai.13454

Volume 32, Issue 4 p. 635-646

Rhinitis—and especially allergic rhinitis (AR)—remains the most frequent hypersensitivity condition, affecting up to a quarter of the population and impacting the quality of life of individual patients and the health economy.

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Update on food allergy

Rachel L. Peters, Marta Krawiec, Jennifer J. Koplin, Alexandra F. Santos

doi : 10.1111/pai.13443

Volume 32, Issue 4 p. 647-657

Food allergy is a major public health issue with growing prevalence in the urbanized world and significant impact on the lives of allergic patients and their families.

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Addressing risk management difficulties in children with food allergies

Philippe A. Eigenmann, Motohiro Ebisawa, Matthew Greenhawt, Jonathan O’B Hourihane, Tamara T. Perry, Benjamin C. Remington, Robert A. Wood

doi : 10.1111/pai.13455

Volume 32, Issue 4 p. 658-666

Risk is a concept inherent in every medical procedure. It can be defined as the probability of an adverse event in a defined population over a specified period of time.

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Hydrolysed formula and allergy prevention

Jon Genuneit, Robert J. Boyle

doi : 10.1111/pai.13470

Volume 32, Issue 4 p. 667-669

no Abstract

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Effect of extensively hydrolyzed casein vs. conventional formula on the risk of asthma and allergies: The TRIGR randomized clinical trial

Suvi M. Virtanen, David Cuthbertson, Marisa Couluris, Erkki Savilahti, Mikael Knip, Jeffrey P. Krischer, the TRIGR Investigators

doi : 10.1111/pai.13452

Volume 32, Issue 4 p. 670-678

The role of hydrolyzed infant formulas in the prevention of asthma and allergies remains inconsistent. We tested whether extensively hydrolyzed casein formula compared to conventional cow's milk–based formula prevented asthma, allergic rhinitis, or atopic eczema.

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High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze

Nicklas Brustad, Jens H. Greve, Hooman Mirzakhani, Casper-Emil T. Pedersen, Anders U. Eliasen, Jakob Stokholm, Jessica Lasky-Su, Klaus B?nnelykke, Augusto A. Litonjua, Scott T. Weiss, Hans Bisgaard, Bo L. Chawes

doi : 10.1111/pai.13453

Volume 32, Issue 4 p. 679-689

Randomized controlled trials (RCTs) suggest a protective effect of high-dose vitamin D supplementation in pregnancy on offspring risk of persistent wheeze, but only in some individuals, which might be explained by variations in vitamin D pathway genes. This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs.

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Neonatal jaundice, phototherapy and childhood allergic diseases: An updated systematic review and meta-analysis

Yasutaka Kuniyoshi, Yasushi Tsujimoto, Masahiro Banno, Shunsuke Taito, Takashi Ariie

doi : 10.1111/pai.13456

Volume 32, Issue 4 p. 690-701

Neonatal jaundice and phototherapy have been associated with the development of allergic diseases. It has been suggested, however, that effect estimates of the associations might be smaller than expected. We sought to update the evidence of their associations including recently published large longitudinal studies.

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Emergence of pollen food allergy syndrome in asthmatic children in Paris

Christine Loraud, Charlotte Thibaut de Ménonville, Mélisande Bourgoin-Heck, Nathalie Cottel, Stéphanie Wanin, Jocelyne Just

doi : 10.1111/pai.13435

Volume 32, Issue 4 p. 702-708

Over the last few decades, the level of pollen from birch and homologous trees has increased in parts of Europe. Sensitization to birch pollen allergens (principally Bet v 1) has been associated with food cross-reactivity called pollen food allergy syndrome (PFAS).

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Genetic effects of allergen-specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study

Anna M. Hedman, Ralf Kuja-Halkola, Anne K. ?rtqvist, Marianne van Hage, Catarina Almqvist, Bj?rn Nordlund

doi : 10.1111/pai.13438

Volume 32, Issue 4 p. 709-719

Exhaled nitric oxide and blood eosinophils are clinical asthma T-helper type 2 markers in use. Immunoglobulin E (IgE) is often involved in the inflammation associated with atopic asthma. The effect of both blood eosinophils and allergen-specific IgE on exhaled nitric oxide levels is not completely understood.

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Safety and effectiveness of omalizumab for the treatment of chronic urticaria in pediatric patients

Coco Dekkers, Mehran Alizadeh Aghdam, Marlies de Graaf, André C. Knulst, Yolanda Meijer, Juul M. P.A. van den Reek, Marike B. Stadermann, Heike R?ckmann

doi : 10.1111/pai.13426

Volume 32, Issue 4 p. 720-726

Evidence on safety and effectiveness of omalizumab for treatment of chronic urticaria in pediatric patients is scarce and limited to case reports. In particular, drug survival of omalizumab has not yet been investigated, which is a key element in the evaluation of its clinical performance. The aim of this study was to investigate safety, effectiveness, and drug survival rates of omalizumab in a daily practice cohort of pediatric patients with chronic urticaria (CU).

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The natural course of cow’s milk allergy and the development of atopic diseases into adulthood

Michaela M. Hansen, Susanne P. Nissen, Susanne Halken, Arne H?st

doi : 10.1111/pai.13440

Volume 32, Issue 4 p. 727-733

Previous studies have investigated the natural course of cow's milk allergy (CMA) and development of atopic diseases into adolescence. Studies with long-term follow-up into adulthood are lacking. The aim of this study was to investigate (a) the natural course of CMA in a 1-year birth cohort of Danish children from birth until 15 and 26 years of age and (b) the development of atopic diseases in a group of children with CMA (group A) compared to a random sample of 276 children from the same birth cohort (group B).

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Long-term follow-up of fixed low-dose oral immunotherapy for children with severe cow’s milk allergy

Yoko Miura, Ken-ichi Nagakura, Makoto Nishino, Mari Takei, Kyohei Takahashi, Tomoyuki Asaumi, Kiyotake Ogura, Sakura Sato, Motohiro Ebisawa, Noriyuki Yanagida

doi : 10.1111/pai.13442

Volume 32, Issue 4 p. 734-741

The efficacy and safety of cow's milk (CM) low-dose oral immunotherapy (LOIT) at one-year follow-up have been previously reported. We investigated the outcome of fixed long-term LOIT in children with severe CM allergy.

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An exploration of factors associated with food protein-induced enterocolitis syndrome: Birth, infant feeding and food triggers

Eric Lee, Elizabeth H. Barnes, Sam Mehr, Dianne E. Campbell

doi : 10.1111/pai.13448

Volume 32, Issue 4 p. 742-749

Food protein-induced enterocolitis syndrome (FPIES) is a non–IgE-mediated food allergic disorder with a well-characterized phenotype, but limited understanding of factors associated with food cross-reactivity, severity and tolerance.

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Use of premedication with intravenous immune globulin in Kawasaki disease: A retrospective review

Elaine Liu, Jimmy Gonzalez, Anita Siu

doi : 10.1111/pai.13432

Volume 32, Issue 4 p. 750-755

Kawasaki disease (KD) is a significant febrile illness in children and is the leading cause of acquired pediatric heart disease in developed countries. Its recommended treatment is high-dose intravenous immune globulin (IVIG) plus aspirin.

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Association between human leukocyte antigens (HLAs) and human neutrophil antigens (HNAs) and autoimmune neutropenia of infancy in Danish patients

Kaspar René Nielsen, Signe Rolskov Bojsen, Tania Nicole Masmas, Anne-Louise Fjordside, John Baech, Thure Mors Haunstrup, Rudi Steffensen

doi : 10.1111/pai.13450

Volume 32, Issue 4 p. 756-761

Autoimmune neutropenia of infancy (AIN) is a frequent cause of neutropenia in children. The disease is caused by antibodies against epitopes on the immunoglobulin G (IgG) Fc receptor type 3b (Fc?IIIb). We investigated the possible association of human neutrophil antigens (HNA), human leukocyte antigen (HLA)-DR, and HLA-DQ alleles with AIN and the association of these genotypes with the presence of autoantibodies.

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Lessons from low seroprevalence of SARS-CoV-2 antibodies in schoolchildren: A cross-sectional study

Zsolt Szépfalusi, Klara Schmidthaler, Justyna Sieber, Sonja Kopanja, Florian G?tzinger, Anja Schoof, Jakub Hoz, Birgit Willinger, Athanasios Makristathis, Lukas Weseslindtner, Karin Stiasny, Barbara Bohle, Pavla Krotka, Alexandra Graf, Thomas Frischer

doi : 10.1111/pai.13459

Volume 32, Issue 4 p. 762-770

Children are discussed as hidden SARS-CoV-2 virus reservoir because of predominantly mild or even asymptomatic course of disease. The objective of this cross-sectional study in May-July 2020 was to assess the prevalence of SARS-CoV-2 antibodies and virus RNA in schoolchildren, consistent with previous infection by contact tracing.

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Vitamin D insufficiency is associated with reduced regulatory T cell frequency in food-allergic infants

Melanie R. Neeland, Amanda R. Tursi, Kirsten P. Perrett, Richard Saffery, Jennifer J. Koplin, Kari C. Nadeau, Sandra Andorf

doi : 10.1111/pai.13439

Volume 32, Issue 4 p. 771-775

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Machine learning approach and oral food challenge with heated egg

Yasutaka Kuniyoshi, Haruka Tokutake, Natsuki Takahashi, Azusa Kamura, Sumie Yasuda, Makoto Tashiro

doi : 10.1111/pai.13433

Volume 32, Issue 4 p. 776-778

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Recurrent food anaphylaxis and risk factors in children

Guillaume Pouessel, Marie Balerdi, Stéphanie Lejeune, Valérie Deken, François Dubos, Matthieu Antoine, Antoine Deschildre, on behalf of the Pediatric Emergency Medicine Group

doi : 10.1111/pai.13429

Volume 32, Issue 4 p. 779-782

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Impact of age on adherence and efficacy of peanut oral-immunotherapy using a standardized protocol

Rongbo Zhu, Kara Robertson, Jennifer L.P. Protudjer, Andrea Macikunas, Rebecca Kim, Samira Jeimy, Harold Kim

doi : 10.1111/pai.13447

Volume 32, Issue 4 p. 783-786

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Maternal psychological distress during gestation is associated with infant food allergy

Minna Lukkarinen, Emma Puosi, Eeva-Leena Kataja, Laura S. Korhonen, Heikki Lukkarinen, Linnea Karlsson, Hasse Karlsson

doi : 10.1111/pai.13449

Volume 32, Issue 4 p. 787-792

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More severe than CVID: Combined immunodeficiency due to a novel NFKB2 mutation

Marc Bienias, Anastasia Gabrielyan, Linda Geberzahn, Angela R?sen-Wolff, Angela Huebner, Eva-Maria Jacobsen, Nicole Toepfner, Mingyan Fang, Min Ae Lee-Kirsch, Joachim Roesler, Catharina Schuetz

doi : 10.1111/pai.13441

Volume 32, Issue 4 p. 793-797

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STAT 1 mutation associated with chronic mucocutaneous candidiasis and pancytopenia

Aashima Dabas, Prerna Arora, Somesh Kumar, Seema Kapoor, Sangeeta Yadav

doi : 10.1111/pai.13451

Volume 32, Issue 4 p. 798-800

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Peculiar immunophenotypic signature in MIS-C-affected children

Francesco Licciardi, Letizia Baldini, Marco Denina, Emanuela Ricotti, Carlotta Covizzi, Marta Dellepiane, Federica Mignone, Marisa Zoppo, Enrico Felici, Davide Montin

doi : 10.1111/pai.13434

Volume 32, Issue 4 p. 801-804

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