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Comments on vitamin D in asthma, milk allergy diagnosis, and stem cell transplantation in chronic granulomatous disease
Philippe Eigenmann
doi : 10.1111/pai.13468
Volume 32, Issue 3 p. 401-404
Artificial intelligence in the diagnosis of pediatric allergic diseases
Giuliana Ferrante, Amelia Licari, Salvatore Fasola, Gian Luigi Marseglia, Stefania La Grutta
doi : 10.1111/pai.13419
Volume 32, Issue 3 p. 405-413
Artificial intelligence (AI) is a field of data science pertaining to advanced computing machines capable of learning from data and interacting with the human world.
Unmet medical needs in the treatment of atopic dermatitis in infants: An Expert consensus on safety and efficacy of pimecrolimus
Thomas Luger, Matthias Augustin, Julien Lambert, Carle Paul, Carlo Pincelli, Antonio Torrelo, Christian Vestergaard, Ulrich Wahn, Thomas Werfel
doi : 10.1111/pai.13422
Volume 32, Issue 3 p. 414-424
Atopic dermatitis (AD) is a common skin disease during infancy, which imposes a considerable burden on patients, their families, and the society, requiring effective treatment options that result in rapid and sustained symptom relief.
Delayed hypersensitivity to antiepileptic drugs in children
Francesca Mori, Natalia Blanca-Lopez, Jean-Christoph Caubet, Pascal Demoly, George Du Toit, Eva R. Gomes, Semanur Kuyucu, Antonino Romano, Ozge Soyer, Sophia Tsabouri, Marina Atanaskovic-Markovic
doi : 10.1111/pai.13409
Volume 32, Issue 3 p. 425-436
Antiepileptic drugs (AEDs) are widely used for the treatment of epilepsy, but they can be associated with the development of mainly delayed/non-immediate hypersensitivity reactions (HRs).
Validity and repeatability of the Pediatric Allergy Questionnaire for Athletes (AQUAped) for the screening of atopy
Salvatore Fasola, Giuliana Ferrante, Velia Malizia, Noemi Bommarito, Stefano Del Giacco, Matteo Bonini, Ilaria Baiardini, Marianna Bellafiore, Stefania La Grutta
doi : 10.1111/pai.13410
Volume 32, Issue 3 p. 437-444
High atopy prevalence has been reported in athletes. Having an age-specific questionnaire for predicting atopy is important for an optimal management of young athletes.
Maternal antibiotic exposure during pregnancy and the risk of allergic diseases in childhood: A meta-analysis
Yongjin Zhong, Yuheng Zhang, Yan Wang, Ruijie Huang
doi : 10.1111/pai.13411
Volume 32, Issue 3 p. 445-456
Increasing studies suggest that antibiotic exposure during pregnancy may increase the risk of childhood allergic diseases; however, controversy still exists.
Lung function trajectories and bronchial hyperresponsiveness during childhood following severe RSV bronchiolitis in infancy
Maleewan Kitcharoensakkul, Leonard B. Bacharier, Toni L. Schweiger, Brad Wilson, Charles W Goss, Daphne Lew, Kenneth B. Schechtman, Mario Castro
doi : 10.1111/pai.13399
Volume 32, Issue 3 p. 457-464
Children with severe respiratory syncytial virus (RSV) bronchiolitis in infancy have increased risks of asthma and reduced lung function in later life. There are limited studies on the longitudinal changes of lung function and bronchial hyperreactivity from early to late childhood in infants hospitalized for RSV bronchiolitis.
Blood eosinophil count as predictor of asthma exacerbation. A meta-analysis
Narmeen Mallah, Santiago Rodriguez-Segade, Francisco-Javier Gonzalez-Barcala, Bahi Takkouche
doi : 10.1111/pai.13403
Volume 32, Issue 3 p. 465-478
Evidence about the association of high blood eosinophil count with asthma exacerbation is inconsistent and unclear. The objective of this meta-analysis was to determine whether elevated blood eosinophil count predicts asthma exacerbation.
Efficacy of vitamin D supplementation in asthmatic children with vitamin D deficiency: A randomized controlled trial (ESDAC trial)
Kana Ram Jat, Nancy Goel, Nandita Gupta, Chandra Prakash Gupta, Sudip Datta, Rakesh Lodha, Sushil K. Kabra
doi : 10.1111/pai.13415
Volume 32, Issue 3 p. 479-488
Vitamin D supplementations for asthma control had shown inconsistent results. We aimed to study efficacy and safety of vitamin D supplementation in asthmatic children who were vitamin D deficient.
Upper-airway dysbiosis related to frequent sweets consumption increases the risk of asthma in children with chronic rhinosinusitis
Pawe? Majak, Katarzyna Moli?ska, Marta Latek, B?a?ej Rychlik, Marcin Wachulec, Andrzej B?au?, Aleksandra Budniok, Martyna Grucha?a, Jakub Lach, Marta Sobalska-Kwapis, Monika Baranowska, Klaudyna Kr?likowska, Dominik Strapagiel, Joanna Majak, Dorota Czech, Cezary Pa?czy?ski, Piotr Kuna
doi : 10.1111/pai.13417
Volume 32, Issue 3 p. 489-500
Innate immunity response to local dysbiosis seems to be one of the most important immunologic backgrounds of chronic rhinosinusitis (CRS) and concomitant asthma.
Lung function testing and inflammation markers for wheezing preschool children: A systematic review for the EAACI Clinical Practice Recommendations on Diagnostics of Preschool Wheeze
Varpu Elenius, Bo Chawes, Pekka L. Malmberg, Aleksander Adamiec, Marek Ruszczy?ski, Wojciech Feleszko, Tuomas Jartti, EAACI Preschool Wheeze Task Force for Diagnostics of Preschool Wheeze
doi : 10.1111/pai.13418
Volume 32, Issue 3 p. 501-513
Preschool wheeze is highly prevalent; 30%–50% of children have wheezed at least once before age six. Wheezing is not a disorder; it is a symptom of obstruction in the airways, and it is essential to identify the correct diagnosis behind this symptom.
Prevalence of childhood wheeze and modified DNA methylation at 7 years of age according to maternal folate levels during pregnancy in the Hokkaido Study
Chihiro Miyashita, Atsuko Araki, Ryu Miura, Yu Ait Bamai, Sumitaka Kobayashi, Sachiko Itoh, Kumiko Ito, Meng-Shan Tsai, Reiko Kishi
doi : 10.1111/pai.13425
Volume 32, Issue 3 p. 514-523
A high dose of folic acid during pregnancy may increase the risk of asthma, wheezing, and respiratory disease in childhood. Folate acid can modify inflammation and immune susceptibility of offspring with some epigenetic differentiation, including DNA methylation.
Otitis media in children: Which phenotypes are most linked to allergy? A systematic review
Eugenio De Corso, Elena Cantone, Jacopo Galli, Veronica Seccia, Daniela Lucidi, Tiziana Di Cesare, Giancarlo Ottaviano, Bruno Sergi, Gaetano Paludetti, Anna Rita Fetoni
doi : 10.1111/pai.13431
Volume 32, Issue 3 p. 524-534
Allergic rhinitis is a common childhood disease responsible for a major impact on quality of life and healthcare resources. Many hypotheses have been proposed to explain the link between allergy and otitis media, although a definitive mechanism has not been identified yet. One of the major critical points is that authors failed in distinguishing among different phenotypes of middle ear inflammation.
Effects of a self-efficacy theory-based parental education program on eczema control and parental outcomes
Nam Sze Cheng, Janita Pak Chun Chau, Suzanne Hoi Shan Lo, Kai Chow Choi, Kam Lun Ellis Hon, Pok Hong Lam, Ting Fan Leung
doi : 10.1111/pai.13421
Volume 32, Issue 3 p. 535-543
Eczema is the most common childhood skin problem worldwide. Education that enhances parental self-efficacy in carrying out appropriate eczema management is crucial to controlling eczema symptoms of their children.
Evaluation of cross-reactivity between casein components using inhibition assay and in silico analysis
Michihiro Naito, Teruaki Matsui, Chikako Yamada, Kazunori Tagami, Komei Ito, Hidehiko Izumi
doi : 10.1111/pai.13405
Volume 32, Issue 3 p. 544-551
We previously reported that the specific IgE levels to ?s1-casein (CN) and ?-CN in patients with cow's milk allergy decreased with similar dynamics during oral immunotherapy. Therefore, we hypothesized that ?s1- and ?-CN have strong cross-reactivity among CN components, despite the low similarity in the full-length amino acid sequences.
Association of IL-10 gene promoter polymorphisms with food allergy susceptibility and serum IL-10 level in a pediatric Caucasian population
Natalia Nedelkopoulou, Anna Taparkou, Sofia Raftopoulou, Dimos Gidaris, Ioannis Xinias, Antigoni Mavroudi, Anil Dhawan, Evangelia Farmaki
doi : 10.1111/pai.13407
Volume 32, Issue 3 p. 552-559
Interleukin 10 has been shown to play a critical role in the regulation of the immune responses in allergic diseases.
Poor prognosis of food protein–induced enterocolitis syndrome to fish
Sonsoles Infante, Esperanza Pérez-Pallisé, Filip Skrabski, Paula Cabrera-Freitag, Cristina Morales-Cabeza, Victoria Fuentes-Aparicio, Alberto Alvarez-Perea, José M. Zubeldia
doi : 10.1111/pai.13430
Volume 32, Issue 3 p. 560-565
Fish is the most common causative food of food protein–induced enterocolitis syndrome (FPIES) in Southern Europe. In children with FPIES, the development of tolerance varies according to the culprit food and specifically fish seems to have a poorer prognosis than other solid foods. We sought to evaluate the fish-FPIES resolution rate in children.
Novel PGM3 compound heterozygous variants with IgE-related dermatitis, lymphopenia, without syndromic features
Ana Garc?a-Garc?a, Monserrat Buendia Arellano, ?ngela Deyà-Mart?nez, Jaime Lozano Blasco, Mercedes Serrano, Ana Van Den Rym, Blanca Garc?a-Solis, Ana Esteve-Solé, Luo Yiyi, Alexandru Vlagea, Xavier Solanich, Megan R. Fisher, Jonathan J. Lyons, Rebeca Pérez de Diego, Laia Alsina
doi : 10.1111/pai.13398
Volume 32, Issue 3 p. 566-575
Phosphoglucomutase-3 (PGM3) deficiency is a congenital disorder of glycosylation (CDG) with hyperimmunoglobulin IgE, atopy, and a variable immunological phenotype; most reported patients display dysmorphic features.
Outcome of chronic granulomatous disease - Conventional treatment vs stem cell transplantation
Cinzia Dedieu, Michael H. Albert, Nizar Mahlaoui, Fabian Hauck, Christian Hedrich, Ulrich Baumann, Klaus Warnatz, Joachim Roesler, Carsten Speckmann, Johannes Schulte, Alain Fischer, Stephane Blanche, Horst von Bernuth, J?rn-Sven Kühl
doi : 10.1111/pai.13402
Volume 32, Issue 3 p. 576-585
Hematopoietic stem cell transplantation (HSCT) can cure chronic granulomatous disease (CGD), but it remains debated whether all conventionally treated CGD patients benefit from HSCT.
Immunophenotypic analysis of lymphocyte subsets in newborns with biotinidase deficiency
Murat Karaoglan, Gulper Nacarkahya, Mehmet Keskin, Ozlem Keskin
doi : 10.1111/pai.13416
Volume 32, Issue 3 p. 586-598
Biotin is a vital micronutrient that plays a role in metabolic homeostasis and the regulation of innate and adaptive immune system functions. Biotinidase deficiency (BTD) leads to impairment in biotin-dependent immune functions. This study focused on immunophenotypic analysis of lymphocyte subsets in newborns with BTD.
Novel SERPING1 gene mutations and clinical experience of type 1 hereditary angioedema from North India
Ankur K. Jindal, Amit Rawat, Anit Kaur, Dhrubajyoti Sharma, Deepti Suri, Anju Gupta, Ravinder Garg, Sunil Dogra, Biman Saikia, Ranjana W. Minz, Surjit Singh
doi : 10.1111/pai.13420
Volume 32, Issue 3 p. 599-611
There is paucity of literature on long-term follow-up of patients with hereditary angioedema (HAE) from developing countries.
Timing of onset of allergic symptoms following low-dose milk and egg challenges
Noriyuki Yanagida, Sakura Sato, Kyohei Takahashi, Kiyotaka Ohtani, Shigehito Emura, Yasuko Shibukawa, Akiko Murano, Takatsugu Komata, Wako Ishida, Hidetoshi Fujita, Tomoyuki Asaumi, Ken-ichi Nagakura, Kiyotake Ogura, Motohiro Ebisawa
doi : 10.1111/pai.13428
Volume 32, Issue 3 p. 612-615
Usefulness of r Ana o 3 assessment before oral food challenge to pistachio
Flore Amat, Raphaëlla Benharoun-Stern, Mohamed-Rida Benissa, Jocelyne Just
doi : 10.1111/pai.13427
Volume 32, Issue 3 p. 615-618
Food protein-induced enterocolitis syndrome triggered by egg yolk and egg white
Makoto Nishino, Sakura Sato, Ken-ichi Nagakura, Kyohei Takahashi, Tomoyuki Asaumi, Kiyotake Ogura, Motohiro Ebisawa, Noriyuki Yanagida
doi : 10.1111/pai.13406
Volume 32, Issue 3 p. 618-621
SIGLEC1 (CD169) as a potential diagnostical screening marker for monogenic interferonopathies
Banu Orak, Gonza Ngoumou, Frédéric Ebstein, Barbara Zieba, Carl Christoph Goetzke, Ellen Knierim, Angela M. Kaindl, Axel Panzer, Manuela Theophil, Monika Berns, Elke Krüger, Christian Meisel, Nadine Unterwalder, Tilmann Kallinich
doi : 10.1111/pai.13400
Volume 32, Issue 3 p. 621-625
