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Issue Information
doi : 10.1111/jocd.14344
Journal of Cosmetic DermatologyVolume 20, Issue S2 p. i-i
Combined approach to facial rejuvenation
Maurizio Cavallini MD
doi : 10.1111/jocd.14280
Journal of Cosmetic DermatologyVolume 20, Issue S2 p. 1-1
Efficacy of a combined chemical peel and topical salicylic acid-based gel combination in the treatment of active acne
Lucia Calvisi MD
doi : 10.1111/jocd.14281
Journal of Cosmetic DermatologyVolume 20, Issue S2 p. 2-6
Acne vulgaris is a common skin condition affecting the pilosebaceous unit of the skin characterized by the presence of comedones, papules, pustules, nodules, and cysts, which might result in permanent scars. It commonly affects adolescents, but it can occur in any age-group with the second group of incidence in young women in their 30s.
Midface 3D restoration with an innovative high G’ filler
Gabriele F. Muti MD
doi : 10.1111/jocd.14282
Journal of Cosmetic DermatologyVolume 20, Issue S2 p. 7-11
In the evaluation of the facial aging, the midface certainly represents the part that undergoes the most modifications and in which the aging process is most evident. The filling and redefinition of this part are fundamental to modify the perception of the age of the face and create a global rejuvenation effect. In general, high G’ fillers with a deep implant are used to treat the midface, taking advantage of the high lifting capacity and persistence of the implant in place.
Jawline reshape technique with suspension threads to improve the effect of blepharoplasty on face rejuvenation
Daniele Bollero MD
doi : 10.1111/jocd.14283
Journal of Cosmetic DermatologyVolume 20, Issue S2 p. 12-17
Blepharochalasis, induced by the aging process, is an important esthetic blemish which can be solved by blepharoplasty, the most performed cosmetic surgical procedure in the world today to repair droopy eyelids. Nowadays, there is a greater interest to combine blepharoplasty with minimally invasive treatments to harmonize the oval shape of the face. Therefore, blepharoplasty technique could be associated with face thread lifting, a safe and effective technique that optimizes the rejuvenation of the central and lower part of the face.
JCD editorial – July 2021
Michael H. Gold MD
doi : 10.1111/jocd.14262
Volume 20, Issue 7 p. 1959-1959
20 Post-COVID-19 vaccine-related shingles cases seen at the Las Vegas Dermatology clinic and sent to us via social media
Cynthia Lee BS, David Cotter MD, PhD, Jasmine Basa CMA, H.L. Greenberg MD
doi : 10.1111/jocd.14210
Volume 20, Issue 7 p. 1960-1964
Local skin reaction to the AZD1222 vaccine in a patient who survived COVID-19
Antonella Tammaro MD, PhD, Ganiyat Adenike Ralitsa Adebanjo MD, Francesca Magri MD, Francesca Romana Parisella MD, Camilla Chello MD, Gabriella De Marco MD, PhD
doi : 10.1111/jocd.14205
Volume 20, Issue 7 p. 1965-1966
Children with trichotillomania in COVID-19 outbreak
?mran ?ner MD
doi : 10.1111/jocd.14200
Volume 20, Issue 7 p. 1967-1968
Oral isotretinoin treatment in patients with acne vulgaris during the COVID-19 pandemic: A retrospective cohort study in a tertiary care hospital
Neslihan Demirel ??üt MD, ?mer Kutlu MD, Ece Erba?c? MD
doi : 10.1111/jocd.14168
Volume 20, Issue 7 p. 1969-1974
Patients with acne vulgaris continue to present increasingly in dermatology outpatient clinics and seek treatment during the COVID-19 pandemic. As far as we know, the effect of isotretinoin on COVID-19 has not been studied before.
Recognition and the development potential of mobile shopping of customized cosmetic on untact coronavirus disease 2019 period: Focused on 40's to 60's women in Seoul, Republic of Korea
Jinkyung Lee BA, Ki Han Kwon PhD
doi : 10.1111/jocd.14150
Volume 20, Issue 7 p. 1975-1991
Our research results will be helpful in the development of the K-beauty customized cosmetics industry as well as consumers who are having difficulty in purchasing cosmetics due to the rapid transition to a non-face-to-face society due to COVID-19.
Perception and attitude of adults toward cosmetic products amid COVID-19 pandemic in Malaysia
Ali Haider Mohammed MD, Ali Blebil PhD, Juman Dujaili PhD, Bassam Abdul Rasool Hassan PhD
doi : 10.1111/jocd.14147
Volume 20, Issue 7 p. 1992-2000
The use of cosmetics is growing among both male and female consumers due to the availability of different brands. While there is an increase in the usage of cosmetic products, it is concerning whether the consumers are aware of the safety of the products.
COVID-19 and human papillomavirus: Paradoxical immunity
Abdullah Demirba? MD, Hediye Eker MD, ?mer Faruk Elmas MD, G?zde Uluta? Demirba? MD, Mustafa Atasoy MD, ?mit Türsen MD, Torello Lotti MD
doi : 10.1111/jocd.14022
Volume 20, Issue 7 p. 2001-2003
Coronavirus disease 2019 (COVID-19) is a multisystemic disease that can cause progressive lung failure, organ dysfunction, and coagulation disorder associated with high mortality and morbidity. COVID-19 is known to either primarily cause skin symptoms or increase existing skin diseases. Human papillomavirus (HPV) is a DNA virus that can cause benign and malignant neoplasms. Mucocutaneous verruca vulgaris are common benign lesions of HPV. Here, we report a case of verruca vulgaris regressed after COVID-19.
New onset of alopecia areata in a patient with SARS-CoV-2 infection: Possible pathogenetic correlations?
Alfredo Rossi MD, PhD, Francesca Magri MD, Simone Michelini MD, Alvise Sernicola MD, Marta Muscianese MD, Gemma Caro MD, Marco Di Fraia MD, Camilla Chello MD, Maria Caterina Fortuna MD, Teresa Grieco MD, PhD
doi : 10.1111/jocd.14080
Volume 20, Issue 7 p. 2004-2005
Noninvasive diagnostic techniques of port wine stain
Jeta Buch MD, Priyanka Karagaiah MD, Prerana Raviprakash MBBS, MD, Anant Patil MD, George Kroumpouzos MD, Martin Kassir MD, Mohamad Goldust MD
doi : 10.1111/jocd.14087
Volume 20, Issue 7 p. 2006-2014
Port-wine stain (PWS) is a benign capillary malformation that most commonly occurs in the head and neck. It is present at birth and progresses over time. It is formed by progressive dilatation of post-capillary venules and is associated with hypertrophy and nodularity with increasing age, leading to cosmetic disfigurement and psychological aggravation. It is caused by genetic mosaicism in GNAQ and GNA11 genes. Histopathology is the gold standard for assessment of PWS but it is invasive and may cause scarring. Inadequate characterization of the lesions may predispose to inadequate treatment protocols as well as higher treatment dosages. Clinical evaluation of treatment efficacy is subjective and may not be a representative of actual results. Therefore, an objective visualization modality is required. With evolving technology, numerous optical instruments have been developed for objective evaluation and visualization of subsurface structures. These include VISIA-CR™ system, videodermoscopy, high-frequency ultrasound (HFUS), laser speckle contrast imaging (LSCI), reflectance spectrophotometers and tristimulus colorimeter, laser Doppler flowmetry (LDF), cross-polarized diffuse reflectance imaging system (CDR), reflectance confocal microscopy (RCM), optical coherence tomography (OCT), and spatial frequency domain imaging (SFDI). These semi-quantitative modes of diagnosis are complementary to each other. Some can be used in the clinical setting while others, due to high instrument cost, are limited to the research settings. In this review, we bring to you a brief overview of noninvasive diagnostic modalities in PWS.
Lipidomics demonstrates the association of sex hormones with sebum
Feng Chen BS, Xueqing Hu BS, Yang He PhD, Dianchao Huang MS
doi : 10.1111/jocd.14055
Volume 20, Issue 7 p. 2015-2019
The regulation of sebocytes by hormones has been unanimously certified by scholars. But how sebocytes are affected has not been fully demonstrated by the regulation of multiple hormones.
A review of cosmetic skin delivery
Xueqing Hu BS, Huaming He PhD
doi : 10.1111/jocd.14037
Volume 20, Issue 7 p. 2020-2030
Cosmetic Skin Delivery has a very important impact on the action of cosmetics. More and more cosmetic manufacturers are focusing on cosmetic delivery. Meanwhile, it also brings safety issues and the customization of national laws and regulations.
Consistency changes of potential lipid markers in acne patients of different ages and their role in acne pathogenesis
Feng Chen BS, Xueqing Hu BS, Kun Dong PhD
doi : 10.1111/jocd.14009
Volume 20, Issue 7 p. 2031-2035
With the development of studies on skin lipid profile changes in acne patients, changes of skin surface lipidome are considered to be another important factor in acne pathogenesis. However, the studies of skin surface lipidome in acne patients of different ages have not been precisely discussed.
Dapsone for acne: Still in use after half a century!
Tamara Searle BSc, Firas Al-Niaimi MRCP, Faisal R. Ali PhD, MRCP
doi : 10.1111/jocd.14011
Volume 20, Issue 7 p. 2036-2039
Sixty years ago, Ross discussed the use of oral dapsone in the treatment of acne vulgaris. Ross was fundamental in demonstrating the importance of this medication in dermatology. Following this, topical formulations have been used for the treatment of acne vulgaris which has not responded to traditional therapies. We explore the impact that the discovery of dapsone has had on subsequent research and clinical practice and explore the typical doses and side effects of this often sidelined therapy.
Saline in Dermatology: A literature review
Heba Saed El-Amawy MSc, Sameh Magdy Sarsik MSc
doi : 10.1111/jocd.13813
Volume 20, Issue 7 p. 2040-2051
Saline, with its different concentrations, is the most used crystalloid solution in medicine. In dermatology, no large studies investigated the benefits of saline. The aim of this article is to review the different possible uses of saline in dermatology, in order to give final recommendations based on the literature review and our experience.
Microneedle systems as medical devices for esthetical treatments: A risk assessment approach
Luis Alberto del Rio PharmD, PhD, David Baeza PharmD, PhD, Nuria Salazar PharmD, PhD
doi : 10.1111/jocd.13888
Volume 20, Issue 7 p. 2052-2057
Microneedling devices are being used as a surgical technique without a clear regulatory category. They can become dangerous considering that these kind of devices can easily be bought and used by nonqualified people.
Does sensitive skin represent a skin condition or manifestations of other disorders?
Lihong Chen MD, Jie Zheng MD, PhD
doi : 10.1111/jocd.13829
Volume 20, Issue 7 p. 2058-2061
Sensitive skin or cutaneous sensory syndrome is defined as a skin condition that is hypersensitive to stimuli, presented with itching, irritant, erythema, and dryness. However, is it associated with more than impairment of epidermal functions, psychological stress and topical medication or products? We think that it can be a skin condition or manifestation of other cutaneous or extracutaneous disorders. In this paper, we brief relation of sensitive skin syndrome with cutaneous and extracutaneous disorders, clinically, and pathophysiologically.
Growing role for arnica in cosmetic dermatology: Lose the bruise
Alexander Sherban BM, Jordan V. Wang MD, MBE, MBA, Roy G. Geronemus MD
doi : 10.1111/jocd.14191
Volume 20, Issue 7 p. 2062-2068
This commentary examines the utility of arnica in cosmetic dermatology. For many years, arnica has been used to reduce the morbidity associated with various procedures, including surgeries and treatments with lasers and other energy-based devices. Arnica is a traditional homeopathic remedy that can reduce post-procedural edema and bruising. Although it has been used clinically by many physicians and is widely and readily available to patients, the available data is limited and often conflicting. We reviewed the relevant information on arnica and offer our own insights into its use in order to shed more light on its periprocedural utility.
Multi-Dimensional Aesthetic Scan Assessment (MD ASA™): Initial experience with a novel consultation, facial assessment, and treatment planning tool
Mauricio de Maio MD, ScM, PhD, Vandana Chatrath MD, Sarah Hart MBChB, Anna Jen Shi Hoo MD, Alexandre Marchac MD, Dimitris Sykianakis MD, PhD, Izzy Lung I. Lee MD
doi : 10.1111/jocd.14216
Volume 20, Issue 7 p. 2069-2082
Comprehensive patient assessment and planning are central to esthetic treatment with injectables. MD ASA™ (Multi-Dimensional Aesthetic Scan Assessment) is a novel tool developed for this purpose.
Exaggerated lower frontalis and glabella after Botox injection
Ebtisam Elghblawi MBBCh, MScRes, DRH, ADD, Dip dermatoscope
doi : 10.1111/jocd.14146
Volume 20, Issue 7 p. 2083-2085
Botox is well known to be safe and effective; however, in some rare instances, there are unwanted side effects that every clinician should be aware of and can address to their clients. A rare encounter in the upper face is mild ptosis of the forehead along with mid-horizontal line that divided and parted the forehead into two distinctive nearly equal horizontal portions. A woman experienced a deep furrow line across her forehead post-Azzalure injection by a week, with noticeable glabella projection. This line should expect to resolve by itself within few weeks. This could be attributed to overactivity and overcompensation of the surrounding untreated muscles in the same vicinity. Also, it could be attributed to different forehead muscle patterns.
Minimally invasive aesthetic treatment of male patients: The importance of consultation and the lower third of the face
Erminio Mastroluca MD, PhD, Mariagrazia Patalano MD, PhD, Dario Bertossi MD
doi : 10.1111/jocd.14231
Volume 20, Issue 7 p. 2086-2092
Men worry disproportionately about potential negative consequences of facial aesthetic treatment with injectable therapies, such as side effects or appearing more feminine. Features of the lower third of the face (eg, prominent chin and jaw) are particularly important in perceptions of masculinity. A strategy has been developed for male patients based on an initial consultation emphasizing the safety and masculinizing potential of injectables, followed by treatment with a high G’ hyaluronic acid filler targeting the lower third.
Is there a rationale for the use of botulinum toxin in the treatment of Androgenetic Alopecia?
Daniel Fernandes Melo MSc, MD, Paulo Muller Ramos MD, MSc, PhD, Daniela Alves Pereira Antelo MD, MSc, PhD, Carla Jorge Machado PhD, Carlos Baptista Barcaui MD, MSc, PhD
doi : 10.1111/jocd.14177
Volume 20, Issue 7 p. 2093-2095
The role and clinical benefits of high-intensity focused electromagnetic devices for non-invasive lipolysis and beyond: A narrative review and position paper
David J. Goldberg MD MJ, Kaitlyn M. Enright MSc, Richard Goldfarb MD FACS, Bruce Katz MD, Michael Gold MD FAAD
doi : 10.1111/jocd.14203
Volume 20, Issue 7 p. 2096-2101
In 2018, the first device to use high-intensity focused electromagnetic (HIFEM) technology to non-invasively build muscle was brought to market. Even more recently, the first HIFEM and radiofrequency combination device designed to both build muscle and eliminate fat cells came into use (HIFEM+). In view of the increase in recently published original data pertaining to HIFEM, an advisory board recently convened to discuss the group's clinical experiences with this technology.
Quasi long-pulsed 1064nm Nd:YAG (micro pulsed) technology for the treatment of active acne: A case series
Ofir Artzi MD, Amir Koren MD, Wasim Shehadeh MD, Or Friedman MD
doi : 10.1111/jocd.14128
Volume 20, Issue 7 p. 2102-2107
Acne vulgaris is common dermatologic condition with an estimated prevalence of 80%. Acne has been shown to have a significant impact on patient quality of life and mental health, especially as inflammatory lesions typically occur on cosmetically sensitive areas with the potential for permanent scarring. There have been numerous advances in the treatment of inflammatory acne with light-based and laser devices. This technology permits effective treatment of active acne and scarring, with a short recovery and a decreased side effect profile as compared to medicinal standard-of-care and photodynamic therapies.
The comparative study of efficacy between 1064-nm long-pulsed Nd:YAG laser and 595-nm pulsed dye laser for the treatment of acne vulgaris
Napith Chalermsuwiwattanakan MD, Salinee Rojhirunsakool MD, MSc, Nanticha Kamanamool MD, PhD, Silada Kanokrungsee MD, Montree Udompataikul MD
doi : 10.1111/jocd.13832
Volume 20, Issue 7 p. 2108-2115
The popularity of laser therapy in acne treatment has been increasing recently due to its safety, effectiveness, and convenience. Both 595-nm pulsed dye laser (PDL) and 1064-nm long-pulsed neodymium:yttrium-aluminum-garnet laser (Nd:YAG) have been successful in treating inflammatory acne lesions. However, clinical data from controlled comparative studies are still lacking.
Erythematotelangiectatic rosacea: The combination of 0.5% brimonidine tartrate gel and broadband pulse light therapy to reverse its effects
Tatiana Rusina, Elena Snarskaya PhD, MD
doi : 10.1111/jocd.13834
Volume 20, Issue 7 p. 2116-2118
Rosacea is a common skin disease that is troublesome for both the patients and the dermatologists. Erythema, telangiectasia, papulopustular changes, and phymatous changes are the main problems faced by the patients and dermatologists in everyday practice. Due to the chronic and relapsing nature of the disease, patients are usually unsatisfied with conventional treatment methods. We report a case of a patient with rosacea, erythematotelangiectatic subtype with an eight-year history of progressive worsening and experience of combined therapy based on the broadband pulse light and topical 0.5% brimonidine tartrate gel. The effectiveness of the therapy was evaluated using multispectral skin imaging that enables to define morphological patterns of the pathological skin areas in a real-time mode as well as to create the map of hemoglobin distribution and to measure its concentration in the rosacea foci. In this case report, an efficacy and very good tolerability of the abovementioned treatment have been demonstrated.
Fractional CO2 laser therapy for cesarean scar under the guidance of multiple evaluation methods: A retrospective study
Nan Zhang MD, Xin Yu MD, Jingchun Zhao PhD, Jiaao Yu PhD, Kai Shi PhD, Tongjun Liu PhD
doi : 10.1111/jocd.13840
Volume 20, Issue 7 p. 2119-2124
To introduce the treatment experience of fractional CO2 laser for cesarean scar under the guidance of multiple evaluation methods.
Thermal effects of percutaneous application of plasma/radiofrequency energy on porcine dermis and fibroseptal network
Paul G. Ruff IV MD, FACS
doi : 10.1111/jocd.13845
Volume 20, Issue 7 p. 2125-2131
Skin laxity is one of the defining characteristics of aging and can be the result of various factors including intrinsic aging, genetics, diet, stress, lifestyle, sun exposure, weight fluctuations, and smoking. Recent reports suggest the ability of subdermal energy application to reduce skin laxity. Thermal energy can be delivered using different devices including lasers, radiofrequency (RF) monopolar and bipolar devices, and plasma/RF devices. Plasma-based energy platforms generate a plasma gas, allowing heat to be applied to the tissue. This study focused on the evaluation of thermal effect of plasma/RF compared to a monopolar RF device applied percutaneously to the subdermis and connective fibroseptal network in a porcine model.
Fractional ablative carbon dioxide laser treatment of facial scars: Improvement of patients' quality of life, scar quality, and cosmesis
Anna Meynk?hn MD, Sebastian Fischer MD, MHBA, Clara Neuss MD, Lina Marie Willkomm MD, Ulrich Kneser MD, Dimitra Kotsougiani-Fischer MD
doi : 10.1111/jocd.13850
Volume 20, Issue 7 p. 2132-2140
Disfiguring facial scars can be a massive burden on patients' psychosocial health and severely impact patients' self-esteem.
Topical Band-pass Filter Cream (TBFC)-assisted home-based NB-UVB: A must-know Alternative to artificial phototherapy
Sidharth Sonthalia MD, DNB, MNAMS
doi : 10.1111/jocd.14215
Volume 20, Issue 7 p. 2141-2147
Treatment-refractory lesions of vitiligo and psoriasis are typically associated with significant psychological morbidity. Although narrowband-ultraviolet B (NB-UVB) phototherapy remains one of the safest and effective treatment modalities, the cost and logistics related to the access and high cost of therapy delivered artificially via devices/chambers become highly restrictive. The use of topical Photocil®, a novel topical band-pass filter cream (TBFC), that selectively filters solar radiation, biasing toward delivery of 311–313 nm (action spectrum of NB-UVB) to the treated lesions, following the exposure of TBFC-smeared lesions to natural sunlight offsets many aforementioned limitations of artificial phototherapy. The non-inferior efficacy of Photocil® as an alternative to artificial NB-UVB has recently been reported in patients with lighter skin phototypes (SPT) with non-segmental vitiligo and psoriasis.
89% Vichy mineralizing water with hyaluronic acid is a well-tolerated adjunct treatment that helps restore skin barrier function in dry skin-related inflammatory dermatoses and post-procedure skin care: A Canadian study
Chih-Ho Hong MD, FRCPC, Jordana Schachter MD, FRCPC, Allison B. Sutton MD, FRCPC, FAAD, Jennifer M. Salsberg MD, FRCPC, Monica K. Li MD, FRCPC, Shannon D. Humphrey MD, FRCPC, Nour R. Dayeh PhD
doi : 10.1111/jocd.14116
Volume 20, Issue 7 p. 2148-2155
Minéral 89 (M89), comprised of 89% Vichy mineralizing water and hyaluronic acid, has been formulated to help strengthen and restore skin barrier.
The necessity of patch testing in determining the causative drug of AGEP
Ramin Mofarrah MD, Ramina Mofarrah, Mostafa Oshriehye MD, Sueshianth Ghobadi Aski MD, Nazanin Nazemi, Peyman Nooshiravanpoor MD
doi : 10.1111/jocd.13841
Volume 20, Issue 7 p. 2156-2159
Acute Generalized Exanthematous Pustulosis (AGEP)is a rare, severe skin reactionmainly caused by medications such as antibiotics, anti fungals, Calcium channel blockers and Anti malarias. Although it resolves spontaneously in most patients, systemic corticosteroids are neededin severe cases.
Para rubber seed oil: The safe and efficient bio-material for hair loss treatment
Nattaya Lourith PhD, Mayuree Kanlayavattanakul PhD, Puxvadee Chaikul PhD
doi : 10.1111/jocd.13843
Volume 20, Issue 7 p. 2160-2167
Para rubber (Hevea brasiliensis (Willd. ex A. Juss.) Müll. Arg.)) is the important crop of the word. It has been vastly used in biomedical products. However, its pharmacologically application besides the latex is sparely to be explored especially the seed. Cellular biological activities of the standardized para rubber seed oil for hair loss treatment were therefore assessed.
The Tam formula: A pilot study for a new treatment for melasma
Radhika Srivastava MD, Ann M. John MD, Alison Tam DO, FAAD, Bahar F. Firoz MD, FAAD
doi : 10.1111/jocd.13849
Volume 20, Issue 7 p. 2168-2171
Melasma is a common hyperpigmentation disorder with numerous, but often unsatisfactory treatment options.
Relationship between acne and the use of cosmetics: Results of a questionnaire study in 539 Korean individuals
Dong-Hye Suh MD, Haneul Oh MD, Sang Jun Lee MD, Hyun Joo Kim MD, Hwa Jung Ryu MD, PhD
doi : 10.1111/jocd.13853
Volume 20, Issue 7 p. 2172-2178
Acne vulgaris is one of the most common dermatological diseases, and it is known that various factors are related to triggering this condition in a patient. In particular, although the use of cosmetics is thought to be associated with the onset of a patient developing acne, there are few studies that have been conducted to date on this disease and its related factors.
Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of WNT/signaling, mitochondrial activity, and stem cells maintenance
Mamy Honda Igarashi MD, Sheila Gomes da Silva, Maurizio Mercuri, Fl?via Macedo de Oliveira Neves Zuardi, Gustavo Facchini PhD, Gustavo Henrique da Silva, Ana Lucia Tabarini Alves Pinheiro MD, Samara Eberlin PhD
doi : 10.1111/jocd.13815
Volume 20, Issue 7 p. 2179-2189
Mechanisms involved in hair metabolism are diverse, and the availability of ingredients that normalize dysfunctions or mitigate the effects of extrinsic stress suffered daily is greatly desired by consumers to improve the aesthetic appearance of hair.
A new phytocosmetic preparation from Thymus vulgaris stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double-blind placebo-controlled clinical trial
Jeanifer Caverzan MS, Lilian Mussi MS, Bianca Sufi MS, Giovana Padovani MS, Lucas Nazato MS, Flavio B. Camargo Junior PhD, Wagner V. Magalh?es MS, Luiz C. Di Stasi PhD
doi : 10.1111/jocd.13818
Volume 20, Issue 7 p. 2190-2202
The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long-term application. Efforts to develop new topically active anti-aging products with fewer adverse effects are a huge challenge that should be faced.
Self-stigma and psychosocial burden of patients with port-wine stain: A systematic review and meta-analysis
Rungsima Wanitphakdeedecha MD, MA, MSc, Tatchalerm Sudhipongpracha MPA, PhD, Janice Natasha C. Ng MD, Chadakan Yan MD, Tatre Jantarakolica PhD
doi : 10.1111/jocd.14199
Volume 20, Issue 7 p. 2203-2210
Port-wine stain (PWS) is a congenital malformation that does not resolve spontaneously and can lead to social and self-stigma. However, little is known about how PWS affects the patients' quality of life (QoL) and psychosocial well-being. In this article, we examine the existing empirical evidence on self-stigma caused by PWS.
Personalized video consent in Blepharoplasty: A new paradigm in the preoperative consent giving process
Debraj Shome MD, FRCS, FACS, FAACS, MBA, Komal Doshi MDS, Sapna Vadera MDS, Vaibhav Kumar MDS, Supriya S. Vyavahare MDS, Rinky Kapoor MD
doi : 10.1111/jocd.14172
Volume 20, Issue 7 p. 2211-2223
Informed consent is not simply the signing of a form by the patient but more significantly, a process of an in-depth communication between the doctor and the patient.
Expert consensus on the facial rejuvenation using the Mint Lift® in Koreans: Perspectives of plastic surgeons
Tae Seob Kim MD,Seung Soo Kim MD,Cheol Jeong MD,Yu Kwan Song MD
doi : 10.1111/jocd.14072
Volume 20, Issue 7 p. 2224-2231
It would be mandatory for plastic surgeons to consider anthropometric and anatomical differences between Asians and Caucasians in performing facial rejuvenation procedures using absorbable threadlifts in Asians.
Anxiety and depression in pediatric patients with vitiligo and alopecia areata and their parents: A cross-sectional controlled study
Sevil Sava? Erdo?an MD, Tu?ba Falay Gür MD, Bilal Do?an MD
doi : 10.1111/jocd.13807
Volume 20, Issue 7 p. 2232-2239
Alopecia areata (AA) and vitiligo are associated with various psychiatric comorbidities, and the care of a child with AA or vitiligo may be associated with higher anxiety and depression than healthy children.
Efficacy and safety of homologous autoinoculation in treatment of multiple recalcitrant warts of different types
Nsreen A Abdelmonaem MBBCh, M.A Shaheen MD, Tamer Mohsen Mohamed Foad MD, Rania El-Husseiny MD
doi : 10.1111/jocd.13831
Volume 20, Issue 7 p. 2240-2246
Homologous autoinoculation is a novel minimally invasive procedure that treats warts by stimulating specific immune response.
Evaluation of facial artery course variations and depth by Doppler ultrasonography
Bar?? Ten MD, Taylan Kara MD, Tamer ?rfan Kaya MD, Mustafa An?l Y?lmaz MD, Gülhan Temel PhD, Yüksel Balc? MD, ?mit Türsen MD, Kaan Esen MD
doi : 10.1111/jocd.13838
Volume 20, Issue 7 p. 2247-2258
As deep nasolabial folds (NLF) are associated with facial aging, there is an increasing demand for esthetic correction with filler injections. Understanding the anatomy of the angular artery (AA) and facial artery (FA) around the NLF region is essential for ensuring the safety of dermal filler injections into the NLF. The purpose of this study was to provide detailed vascular anatomical information on the course and depth of AA and FA around NLF using Doppler ultrasound on live cases.
Evaluation of cochlear involvement and hearing function in lipoid proteinosis patients
Ahmet Yukkald?ran MD, ?sa An MD, Osman Erdo?an MD
doi : 10.1111/jocd.13839
Volume 20, Issue 7 p. 2259-2263
Lipoid proteinosis (LP) is a rare genodermatosis involving amorphous hyaline accumulation in the skin, oral mucosa, larynx, mucous membranes, and viscera.
Comparison of tumescent local anesthesia vs normal anesthesia technology in upper blepharoplasty in Asian women
Lin Cao BS, Fei Zhu Ph.D
doi : 10.1111/jocd.13855
Volume 20, Issue 7 p. 2264-2269
Blepharoplasty is the most common type of plastic surgery, used to improve most of the eyelid skin sag caused by aging. In the past, local infiltration anesthesia was widely used in blepharoplasty. Tumescent local analgesia (TLA) is safe and reliable method for anesthesia, even children can use this method.
Metabolic syndrome in androgenetic alopecia patients; Is serum regulated on activation, normal T-cell expressed and secreted the missing link?
Amany Ibraim Mustafa MD, Walid Abd Ellatif Abel Halim MD, Fawzy Eman PhD, El-Habbak Doaa MD
doi : 10.1111/jocd.13802
Volume 20, Issue 7 p. 2270-2276
Androgenetic alopecia (AGA) is the most common cause of hair loss affecting both men and women. There are many conflicting results about the relationship between AGA and metabolic syndrome, (MetS) and the pathogenesis of the metabolic disorders in AGA patients is not completely elucidated.
Collagen and soy peptides attenuate contractile loss from UVA damage and enhance the antioxidant capacity of dermal fibroblasts
Sophia Y. Zhang PhD, Molly Hood PhD, Iris X. Zhang MS, Clark L. Chen PhD, Lynn L. Zhang PhD, Jun Du PhD
doi : 10.1111/jocd.13805
Volume 20, Issue 7 p. 2277-2286
Wrinkles and extracellular matrix (ECM) loss are common signs of skin aging and are thought to be the result of damage caused by reactive oxygen species (ROS); ROS induces an imbalance between ECM degradation and production.
Inhibitory effect of glutathione S-transferase A3 in the progression of cutaneous squamous cell carcinoma
Weiwei Li MD, MSc, Cheng Qiu BSc, Shujun Wang MSc, Lijun Wu MD, Tianlan Zhao MD
doi : 10.1111/jocd.13806
Volume 20, Issue 7 p. 2287-2295
Cutaneous squamous cell carcinoma (cSCC) is the second most common cutaneous malignancy with an incidence rate increasing each year. Glutathione S-transferase A3 (GSTA3), a member of the glutathione S-transferase family, is considered an antioxidative protease, but its role in cSCC remains unclear.
The role of hyaluronic acid and amino acid against the aging of the human skin: A clinical and histological study
Antonio Scarano, Andrea Sbarbati, Roberto Amore, Eugenio Luigi Iorio, Giueseppe Ferraro, Marco Marchetti, Domenico Amuso
doi : 10.1111/jocd.13811
Volume 20, Issue 7 p. 2296-2304
In esthetic medicine, different techniques have been used against the aging of the human skin especially in the facial area. Hyaluronic acid is used for improving the quantity of water and extracellular matrix molecule. The aim of this study is a clinical and histological evaluation of the effect of low-molecular-weight hyaluronic acid fragments mixed with amino acid (HAAM) on the rejuvenation the face skin treated with intradermal microinjections.
Cross talk between oxidative stress and inflammation in alopecia areata
Amany Ibrahim Mustafa MD, Rana Atef Khashaba MD, Eman Fawzy PhD, Shimaa Mohamad AbdElRahman Baghdady MD, Shymaa Mostafa Rezk MD
doi : 10.1111/jocd.13814
Volume 20, Issue 7 p. 2305-2310
Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development.
The change of causative pathogens in toenail onychomycosis
Yesim Akpinar Kara MD
doi : 10.1111/jocd.13819
Volume 20, Issue 7 p. 2311-2316
Toenail dystrophies are among the most common diseases in adulthood. Onychomycosis is one of the most frequently observed infectious diseases of the nail.
Development and cathodic iontophoretic permeation evaluation of liquid crystalline systems provided of retinoic acid microparticles
Silas Arandas Monteiro e Silva PhD, Gislaine Ricci Leonardi PhD
doi : 10.1111/jocd.13826
Volume 20, Issue 7 p. 2317-2327
The intracellular form of action of retinoids requires these agents to reach deeper layers of the skin with viable cells to ensure therapeutic efficiency. However, studies on swine skin models show that some retinoids have low skin permeability. Thus, the association of innovative formulations with technological strategies involving physical permeation promoters can be employed to increase the permeability of this active, ensuring a targeting effect of the active.
Evaluation of the correlation between scales determining disease severity in patients with moderate-severe chronic plaque-type psoriasis
Mustafa Gundogdu, Nihal Kundakci
doi : 10.1111/jocd.13827
Volume 20, Issue 7 p. 2328-2331
Psoriasis is a chronic erythematous-squamous disease. The results of studies related with the correlation between methods used in determining disease severity are contradictory.
Investigation of partially myristoylated carboxymethyl chitosan, an amphoteric-amphiphilic chitosan derivative, as a new material for cosmetic and dermal application
Haruyoshi Seino MAg, Naoko Kawaguchi MPharm, Yukari Arai MEng, Noriyasu Ozawa MSci, Kazuhiko Hamada PhD, Norio Nagao PhD
doi : 10.1111/jocd.13833
Volume 20, Issue 7 p. 2332-2340
Cationic amphiphilic chitosan derivatives can form polymeric micelles, which are useful cosmetic materials, but they form polyion complexes with anionic polymers, which can cause formulation difficulties.
Extracts of Antrodia cinnamomea mycelium as a highly potent tyrosinase inhibitor
Hung-Yueh Chen PhD Candidate, Kuan-Chen Cheng PhD, Hsueh-Ting Wang PhD, Chang-Wei Hsieh PhD, Ying-Jang Lai PhD
doi : 10.1111/jocd.13847
Volume 20, Issue 7 p. 2341-2349
Ganoderma has been known as a cure for diseases since ancient times, and been used as a medicinal mushroom for more than 2000 years. By many accounts, Ganoderma lucidum extracts from fruit bodies exhibited the comparable tyrosinase inhibition activity.
Retinoid stability and degradation kinetics in commercial cosmetic products
?ane Temova Raku?a MS, Petja ?kufca BS, Albin Kristl PhD, Robert Ro?kar PhD
doi : 10.1111/jocd.13852
Volume 20, Issue 7 p. 2350-2358
Retinoids as dermatological agents are effective against acne, psoriasis, skin aging, and other skin conditions. However, their susceptibility to degradation is a limiting factor for their widespread use.
Associations of methylenetetrahydrofolate reductase gene (MTHFR) rs1801131 and rs1801133 polymorphisms with susceptibility to vitiligo: A meta-analysis
Hua-Zhu Zhang MS, Jiang-Hai Wu MD, Qian Huang MS, Qin Yang MS, Quan Sima MS, Ke-Yan Chen MS, Zhi-Ran Li MS, Gong-Hao He MD, PhD
doi : 10.1111/jocd.13857
Volume 20, Issue 7 p. 2359-2368
Vitiligo is a common pigmentary skin disorder, and genetic factors were acknowledged to be greatly associated with the pathogenesis of this disease. Recently, increasing studies investigated the associations of methylenetetrahydrofolate reductase (MTHFR) rs1801131 and rs1801133 polymorphisms with risks of vitiligo, but the results still remained controversial.
Is it time for dermatologists to review our professional consumer-brand relationships?
Bernard Ho MBBS, MRCP, Nazish Mansoor MD
doi : 10.1111/jocd.13822
Volume 20, Issue 7 p. 2369-2370
Papular angioplasia: A case report
Cong-cong He MD, Shi-fa Zhang MD, PhD, Rui-qun Qi MD, PhD
doi : 10.1111/jocd.13835
Volume 20, Issue 7 p. 2371-2372
