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Updated APLAR consensus statements on care for patients with rheumatic diseases during the COVID-19 pandemic
Lai-Shan Tam, Yoshiya Tanaka, Rohini Handa, Zhanguo Li, Jose Paulo Lorenzo, Worawit Louthrenoo, Catherine Hill, Kevin Pile, Philip C. Robinson, Leonila F. Dans, Li Yang Hsu, Sang-Min Lee, Jiacai Cho, A. T. M. Tanveer Hasan, Babur Salim, Saba Samreen, Syahrul Sazliyana Shaharir, Priscilla Wong, Jeffrey Chau, Debashish Danda, Syed Atiqul Haq
doi : 10.1111/1756-185X.14124
Volume24, Issue6,Pages 733-745
To update previous guidance of the Asia Pacific League of Associations for Rheumatology (APLAR) on the management of patients with rheumatic and musculoskeletal diseases (RMD) during the coronavirus disease 2019 (COVID-19) pandemic.
Recommendations for COVID-19 vaccination in people with rheumatic disease: Developed by the Singapore Chapter of Rheumatologists
Amelia Santosa, Chuanhui Xu, Thaschawee Arkachaisri, Kok Ooi Kong, Aisha Lateef, Tau Hong Lee, Keng Hong Leong, Andrea Hsiu Ling Low, Melonie K. Sriranganathan, Teck Choon Tan, Gim Gee Teng, Bernard Yu-hor Thong, Warren Fong, Manjari Lahiri
doi : 10.1111/1756-185X.14107
Volume24, Issue6,Pages 746-757
People with rheumatic diseases (PRD) remain vulnerable in the era of the COVID-19 pandemic. We formulated recommendations to meet the urgent need for a consensus for vaccination against SARS-CoV-2 in PRD.
Update on pregnancy in Takayasu arteritis—A narrative review
Shivraj Padiyar, Prathyusha Manikuppam, Jayakanthan Kabeerdoss, Swati Rathore, Debashish Danda
doi : 10.1111/1756-185X.14109
Volume24, Issue6,Pages 758-765
Takayasu arteritis (TA) is a chronic, idiopathic large-vessel vasculitis that affects women of reproductive age, and has significant maternal and fetal implications. Although there are contrasting data on the effect of TA on fertility, most studies have shown that fertility outcomes remain unaffected. The disease activity of TA usually either remains stable or decreases during pregnancy. The important fetomaternal complications are maternal hypertension, pre-eclampsia, prematurity, and intrauterine growth restriction. To reduce maternal and fetal morbidity, controlling the disease before conception is important. This review article discusses the various implications, challenges, and medical and endovascular management of TA during pregnancy.
Frailty in relation to psycho-social factors in elderly patients with rheumatoid arthritis: A cross-sectional mixed qualitative-quantitative study
Fiona Cleutjens, Anne van Moerbeke, Annelies Boonen, Marloes van Onna
doi : 10.1111/1756-185X.14110
Volume24, Issue6,Pages 766-773
The aim of the study was to explore in patients with rheumatoid arthritis (RA) ?55 years: (1) whether the occurrence of frailty as measured by the Groningen Frailty Indicator (GFI) increases with age (survey 1); and (2) to gain insight into which frailty characteristics (eg, loneliness) contribute to frailty (survey 2).
Prevalence of chronic obstructive pulmonary disease in patients with rheumatoid arthritis: A cross-sectional study
Jae Hyun Jung, Ji Hyun Lim, Cho Hee Bang, Hongdeok Seok, Gwan Gyu Song, Sung Jae Choi
doi : 10.1111/1756-185X.14129
Volume24, Issue6,Pages 774-780
Rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD) are both chronic inflammatory diseases; the prevalence of COPD in RA patients is known to be high. However, the prevalence of both RA and COPD differs according to sex; the relationship between RA and COPD may also vary according to sex. Therefore, we investigated the prevalence of COPD and its association in patients with RA in Korea by sex.
Limited utility of novel serological biomarkers in patients newly suspected of having giant cell arteritis
Anthony M. Sammel, Meilang Xue, Elisabeth Karsten, Christopher B. Little, Susan Smith, Katherine Nguyen, Rodger Laurent
doi : 10.1111/1756-185X.14111
Volume24, Issue6,Pages 781-788
Diagnosing and monitoring vascular activity in giant cell arteritis (GCA) is difficult due to the paucity of specific serological biomarkers. We assessed the utility of 8 novel biomarkers in an inception cohort of newly suspected GCA patients.
Serum VEGF-A and VEGFR-1 levels in patients with adult immunoglobulin A vasculitis
?i?dem Yücel, Erdim Serto?lu, Esra F?rat O?uz, Y?ld?z Hayran, Ahmet Omma, Taner ?zgürta?
doi : 10.1111/1756-185X.14115
Volume24, Issue6,Pages 789-794
Immunoglobulin A vasculitis (IgAV) is classified as a leukocytoclastic vasculitis characterized by immune deposits in endothelial walls of small vessels causing vascular endothelial injury. The aim of the present study is to evaluate levels of vascular endothelial growth factor-A (VEGF-A) and VEGF receptor-1 (VEGFR-1) levels in adult IgAV patients.
Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin-17 levels in bleomycin-induced dermal fibrosis
Ahmet Karatas, Cigdem Celik, Burak Oz, Zeynel Abidin Akar, Ebru Onalan Etem, Adile Ferda Dagli, Suleyman Serdar Koca
doi : 10.1111/1756-185X.14114
Volume24, Issue6,Pages 795-802
Although the pathogenesis of systemic sclerosis is not exactly known, it is thought that immune activation has prominent roles in pathogenesis. Secukinumab is a monoclonal antibody against interleukin (IL)-17A. Metformin, a widely used antidiabetic medication, has anti-proliferative, immunomodulating and anti-fibrotic activities. The purpose of our study is to determine the therapeutic efficacy of secukinumab and metformin on bleomycin (BLM) induced dermal fibrosis. Fifty Balb/c female mice were divided into 5 groups: (group 1 control, 2 sham, 3 secukinumab, 4 metformin and 5 secukinumab + metformin). The mice in the control group received 100 ?L phosphate-buffered saline (PBS), while the mice in other groups received 100 ?L (100 ?g) BLM in PBS subcutaneously (sc) every day for 4 weeks. In addition, mice in groups 3 and 5 received secukinumab at a dose of 10 mg/kg/wk sc, and mice in the groups 4 and 5 received oral metformin 50 mg/kg/d for 28 days. All groups of mice were sacrificed at the end of the 4th week and tissue samples were taken for analysis. In addition to histopathological analysis, skin tissue messenger RNA (mRNA) expressions of IL-17 and collagen 3A were measured by real-time polymerase chain reaction. Repeated BLM injections had caused dermal fibrosis. In addition, the mRNA expressions of IL-17 and collagen 3A were increased in the BLM group. Secukinumab and metformin ameliorated dermal fibrosis. They decreased dermal thickness and tissue IL-17A and collagen 3A mRNA levels. Secukinumab and metformin exhibit anti-fibrotic effects in the BLM-induced dermal fibrosis.
Characteristics of Japanese patients with systemic sclerosis complicated with calcinosis
Kae Takagi, Manabu Kawamoto, Tomoaki Higuchi, Akiko Tochimoto, Hikaru Hirose, Masayoshi Harigai, Yasushi Kawaguchi
doi : 10.1111/1756-185X.14121
Volume24, Issue6,Pages 803-808
Calcinosis is often observed in systemic sclerosis (SSc), but its pathogenesis remains unclear. The aim of the present study was to explore the association of clinical features with calcinosis in patients with SSc.
Health-related quality of life and work impairment in idiopathic inflammatory myopathies in South Australia
Alan Xu, Caitlyn Sun, Robert Metcalf, Vidya Limaye
doi : 10.1111/1756-185X.14120
Volume24, Issue6,Pages 809-814
The idiopathic inflammatory myopathies (IIM) are rare autoimmune diseases that are usually chronic and often present with skeletal muscle inflammation and weakness. We sought to examine the impact of IIM in a cohort of 50 South Australian patients on health-related quality of life (HRQOL) and work productivity (WP). We uniquely categorized patients across gender, IIM subtypes, employment status, and also whether there was extramuscular involvement from IIM.
Analysis of risk factors of interstitial lung disease and mortality rates in Chinese patients with idiopathic inflammatory myopathy
Zhiqian Bai, Guifen Shen, Lingli Dong
doi : 10.1111/1756-185X.14128
Volume24, Issue6,Pages 815-827
To investigate the risk factors for interstitial lung disease (ILD) and prognosis in patients with idiopathic inflammatory myopathy (IIM).
Enthesis lesions are associated with X-ray progression in psoriatic arthritis
Cristina Mac?a-Villa, Ana Cruz Valenciano, Eugenio De Miguel
doi : 10.1111/1756-185X.14122
Volume24, Issue6,Pages 828-833
To analyze the relationship among enthesis ultrasound (US) lesions and radiological structural damage in psoriatic arthritis (PsA) patients.
The infrapatellar fat pad produces interleukin-6-secreting T cells in response to a proteoglycan aggrecan peptide and provides dominant soluble mediators different from that present in synovial fluid
Thitiya Sae-jung, Nitigorn Leearamwat, Nichakarn Chaiseema, Panjana Sengprasert, Srihatach Ngarmukos, Pongsak Yuktananda, Aree Tanavalee, Nattiya Hirankarn, Rangsima Reantragoon
doi : 10.1111/1756-185X.14126
Volume24, Issue6,Pages 834-846
The purpose of this study was to investigate the effects of osteoarthritis (OA) peripheral blood mononuclear cell (PBMC) -stimulating proteoglycan aggrecan peptides on T cells present in infrapatellar fat pads (IPFPs) and synovial tissues, and to correlate these findings with mediators present in synovial fluid of OA patients.
A multicenter longitudinal study of the prevalence and mortality rate of systemic lupus erythematosus patients in Oman: Oman Lupus Study
Nasra K. Al-Adhoubi, Farida Al-Balushi, Issa Al Salmi, Maha Ali, Talal Al Lawati, Batool S. H. Al Lawati, Reem Abdwani, Ali Al Shamsi, Juma Al Kaabi, Musallam Al Mashaani, Divij Krishna Jha, Sherin Sayed, Tariq Al-Araimi, Prabha Liyanage, Ali Al Shirawi, Humaid A. Al Wahshi
doi : 10.1111/1756-185X.14130
Volume24, Issue6,Pages 847-854
This study is a longitudinal multicenter study which aims to find the prevalence, the demographic data, survival and mortality rates of patients with systemic lupus erythematosus (SLE) in Oman.
Is Tai Chi beneficial for rheumatoid arthritis?—A Cochrane Review summary with commentary
Francesco Negrini
doi : 10.1111/1756-185X.14132
Volume24, Issue6,Pages 855-857
Explaining the natural course of gout to people living in the tropics
Kanon Jatuworapruk, Nicola Dalbeth
doi : 10.1111/1756-185X.14133
Volume24, Issue6,Pages 858-859
Your help is needed in the fight against COVID-19: Please contribute to the COVID-19 Global rheumatology alliance registry
doi : 10.1111/1756-185X.14117
Volume24, Issue6,Pages 860-860
