American Journal of Respiratory and Critical Care Medicine




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February 15 Highlight

doi : 10.1164/rccm.2074Pxviii

Volume 207, Issue 4 | February 15 2023

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Asthma: Closing in on the Biology of a Complex Life-course Disease

Andrew Bush 1,2, Fernando Holguin 3, Celeste Porsbjerg 4, and Sejal Saglani 5

doi : 10.1164/rccm.202212-2302ED  

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Over-the-counter Dispensing: Widening Access to Inhaled Corticosteroid/Formoterol Reliever Therapy

Richard Beasley and Lee Hatter

doi : 10.1164/rccm.202212-2297ED

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Evolution of Lung Function within Individuals: Clinical Insights and Data-driven Methods

Adnan Custovic and Sara Fontanella

doi : 10.1164/rccm.202212-2226ED

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Remodeling Phenotypes Take Center Stage in the Prediction of Preschool Wheeze Attacks

Sejal Saglani 1 and Simonetta Baraldo 2

doi : 10.1164/rccm.202209-1833ED

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The Intersection between Autoimmunity, Macrophage Dysfunction, Endotype, and Exacerbations in Severe Asthma

Ryan C. Murphy 1,2, Eric D. Morrell 3, and Teal S. Hallstrand 1,2

doi : 10.1164/rccm.202211-2074ED

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Bronchial Epithelial Cell CC16 mRNA: Novel Asthma Biomarker or the Same Book with a New Cover?

Brinda Desai and Praveen Akuthota

doi : 10.1164/rccm.202209-1768ED

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A Few Bad Airways Can Wreak Havoc: Recognizing Asthma as a Local Disorder

Kenneth Lutchen

doi : 10.1164/rccm.202212-2231ED

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Interplay between Immune and Airway Smooth Muscle Cells in Obese Asthma

Anne E. Dixon 1 and Loretta G. Que 2

doi : 10.1164/rccm.202210-1870ED

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A Call for the United States to Accelerate the Implementation of Reliever Combination Inhaled Corticosteroid–Formoterol Inhalers in Asthma

James G. Krings 1*, Joe K. Gerald 2,3*, Kathryn V. Blake 4, Jerry A. Krishnan 5, Helen K. Reddel 6, Leonard B. Bacharier 7, Anne E. Dixon 8, Kaharu Sumino 1, Lynn B. Gerald 9, Ross C. Brownson 10,11, Stephen D. Persell 12,13, Conrad J. Clemens 14, Katherine M. Hiller 15, Mario Castro 16, and Fernando D. Martinez 3 ... Show less

doi : 10.1164/rccm.202209-1729PP

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Plasticity of Individual Lung Function States from Childhood to Adulthood

Gang Wang 1,2,3,4, Jenny Hallberg 2,5, Rosa Faner 6,7, Hans-Jacob Koefoed 8, Simon Kebede Merid 2, Susanna Klevebro 2,5, Sophia Björkander 2, Olena Gruzieva 3,9, Göran Pershagen 3,9, Marianne van Hage 10, Stefano Guerra 11,12, Matteo Bottai 13, Antonios Georgelis 9, Ulrike Gehring 14, Anna Bergström 3,9, Judith M. Vonk 8,15, Inger Kull 2,5, Gerard H. Koppelman 8,16, Alvar Agusti 6,7,17,18*, and Erik Melén 2,5* ... Show less

doi : 10.1164/rccm.202203-0444OC

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Bronchial Remodeling-based Latent Class Analysis Predicts Exacerbations in Severe Preschool Wheezers

Michael Fayon 1,2,3*, Fabien Beaufils 1,2,3*, Pauline Esteves 1,3, Maryline Campagnac 1,3, Elise Maurat 1,3, Marine Michelet 4,5, Valerie Siao-Him-Fa 1,2,3, Frederic Lavrand 2, Guillaume Simon 2, Hugues Begueret 2, and Patrick Berger 1,2,3; on behalf of P’tit Asthme Study Group

doi : 10.1164/rccm.202205-0913OC   

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Autoantibody-mediated Macrophage Dysfunction in Patients with Severe Asthma with Airway Infections

Kiho Son 1,2, Kate Miyasaki 1,2, Brittany Salter 1, Dessi Loukov 1,3, Joseph Chon 1,3, Nan Zhao 1, Katherine Radford 1,2, Chynna Huang 1,2, Nicola LaVigne 1,2, Anna Dvorkin-Gheva 1,3, Paige Lacy 4, Terence Ho 1,2, Dawn M. E. Bowdish 1,2,3, Parameswaran Nair 1,2, and Manali Mukherjee 1,2,3 ... Show less

doi : 10.1164/rccm.202206-1183OC

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Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity

Xingnan Li 1, Stefano Guerra 2, Julie G. Ledford 2, Monica Kraft 2, Huashi Li 1, Annette T. Hastie 3, Mario Castro 4, Loren C. Denlinger 5, Serpil C. Erzurum 6, John V. Fahy 7, Benjamin Gaston 8, Elliot Israel 9, Nizar N. Jarjour 5, Bruce D. Levy 9, David T. Mauger 10, Wendy C. Moore 3, Joe Zein 6, Naftali Kaminski 11, Sally E. Wenzel 12, Prescott G. Woodruff 7, Deborah A. Meyers 1, and Eugene R. Bleecker 1; for the National Heart, Lung, and Blood Institute (NHLBI) Severe Asthma Research Program (SARP) ... Show less

doi : 10.1164/rccm.202206-1230OC  

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Heterogeneity of Airway Smooth Muscle Remodeling in Asthma

Alan L. James 1,2, Graham M. Donovan 3, Francis H. Y. Green 4, Thais Mauad 5, Michael J. Abramson 6, Alvenia Cairncross 7, Peter B. Noble 7, and John G. Elliot 1,7

doi : 10.1164/rccm.202111-2634OC

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Crosstalk between CD4+ T Cells and Airway Smooth Muscle in Pediatric Obesity-related Asthma

Changsuek Yon 1, David A. Thompson 1, Joseph A. Jude 2, Reynold A. Panettieri Jr.2, and Deepa Rastogi 1

doi : 10.1164/rccm.202205-0985OC

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Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program

Matthew C. Tattersall 1,2, Kristine E. Lee 3, Nanae Tsuchiya 4,5, Fauzia Osman 2, Claudia E. Korcarz 1,2, Kristin M. Hansen 1,2, Michael C. Peters 6, John V. Fahy 6, Colin A. Longhurst 2, Eleanor Dunican 7,8, Sally E. Wentzel 9, Joseph K. Leader 10, Elliot Israel 11,12, Bruce D. Levy 11, Mario Castro 13, Serpil C. Erzurum 14, Jason Lempel 15, Wendy C. Moore 16, Eugene R. Bleecker 17,18, Brenda R. Phillips 19, David T. Mauger 19, Eric A. Hoffman 20,21,22, Sean B. Fain 21, Scott B. Reeder 3, Ron L. Sorkness 23, Nizar N. Jarjour 2,23, Loren C. Denlinger 2,23, and Mark L. Schiebler 4 ... Show less

doi : 10.1164/rccm.202203-0597OC

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Identification of Large Airway Collapse with Symptoms Using Dynamic Chest Radiography

Fred Fyles 1, Amy Nuttall 1, Thomas FitzMaurice 2,3,4, Ryan Robinson 1,5, and Hassan Burhan 1,3,4,5

doi : 10.1164/rccm.202206-1131IM

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A Pilot Randomized Controlled Trial of an Intervention to Improve Perception of Lung Function in Older Adults with Asthma

Jonathan M. Feldman 1,2*, Jyoti Ankam 3, Michele Barry 3, Natalie Fruchter 1, Jacqueline Becker 3, Sunit Jariwala 4, Chang Shim 5,6, Juan P. Wisnivesky 3, and Alex D. Federman 3

doi : 10.1164/rccm.202206-1132LE

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Volume–OXygenation Index to Predict High-flow Nasal Cannula Failure: How to Capture the Tidal Volume Matters

Zhe Li 1, Yuan Gao 1*, and Zhanqi Zhao 2,3

doi : 10.1164/rccm.202209-1659LE  

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Reply to Li et al.

Dongyu Chen 1,2, Leo Heunks 3, Haibo Qiu 1, Yi Yang 1*, and Ling Liu 1*‡

doi : 10.1164/rccm.202209-1830LE  

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Effect of COVID-19 in Pulmonary Hypertension

Ajay Kumar Jha *

doi : 10.1164/rccm.202209-1790LE    

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Reply to Jha

David Montani 1,2,3*, Jason Weatherald 4, Marc Humbert 1,2,3, and Olivier Sitbon 1,2,3

doi : 10.1164/rccm.202210-1889LE

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Resolving the Microbial Burden with Tailored Immune Modulation in COVID-19 Acute Respiratory Distress Syndrome?

Marnix Kuindersma 1* and Peter E. Spronk 1,2

doi : 10.1164/rccm.202210-1928LE

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Efficacy of High-Flow Nasal Cannula Oxygen Therapy in Reducing Future Exacerbations for Patients with Stable Hypercapnia with Chronic Obstructive Pulmonary Disease

Zhenfeng He 1*, Lili Guan 1*, Shanshan Zha 1*, Jianyi Niu 1*, Luqian Zhou 1*, Wei Fu 1, Shengchuan Feng 1, and Rongchang Chen 1,2†

doi : 10.1164/rccm.202210-1877LE

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