American Journal of Respiratory and Critical Care Medicine




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December 1 Highlight

doi : 10.1164/rccm.20611Pxl

Volume 206, Issue 11 | December 1 2022

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High Flow Nasal Oxygen at Home to Prevent Chronic Obstructive Pulmonary Disease Exacerbations?

Jean-Pierre Frat 1,2,3 and Arnaud W. Thille 1,2,3

doi : 10.1164/rccm.202207-1311ED  

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Airway Mucus Dysfunction in COVID-19

Burton F. Dickey 1, Jichao Chen 1, and R. Stokes Peebles 2

doi : 10.1164/rccm.202207-1306ED

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Understanding Sex-based Differences in Intensive Care Unit Mortality: Moving Beyond the Biology

Elizabeth M. Viglianti 1,2,3, Christina Yek 4, and Sameer S. Kadri 4

doi : 10.1164/rccm.202207-1443ED  

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Evidence for Early Cystic Fibrosis Transmembrane Conductance Regulator Modulator Treatment for Children with Cystic Fibrosis Keeps Growing

Jordana E. Hoppe 1,2, Edith T. Zemanick 1,2, and Stacey L. Martiniano 1,2

doi : 10.1164/rccm.202208-1507ED

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Particle Constituents and Oxidative Potential: Insights into Differential Fine Particulate Matter Toxicity

Ana M. Rule and Kirsten A. Koehler

doi : 10.1164/rccm.202208-1513ED

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An Experimental Human Colonization Model with Pneumococcal Serotype 3 has the Potential to be Used for Vaccine Studies

Birgitta Henriques-Normark 1,2 and Ana Rita Narciso 1,2

doi : 10.1164/rccm.202207-1342ED

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Using Real-World Data to Understand Who Has Cardiovascular Benefits from Continuous Positive Airway Pressure: The Importance of Male Sex, Excessive Sleepiness, and Primary Prevention

Brendan T. Keenan 1 and Raphael Heinzer 2

doi : 10.1164/rccm.202207-1359ED

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Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

Bartolome Celli 1, Leonardo Fabbri 2, Gerard Criner 3, Fernando J. Martinez 4, David Mannino 5, Claus Vogelmeier 6, Maria Montes de Oca 7, Alberto Papi 2, Don D. Sin 8, MeiLan K. Han 9, and Alvar Agusti 10

doi : 10.1164/rccm.202204-0671PP

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Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial

Kazuma Nagata 1, Takeo Horie 2, Naohiko Chohnabayashi 3, Torahiko Jinta 3, Ryosuke Tsugitomi 3, Akira Shiraki 4, Fumiaki Tokioka 5, Toru Kadowaki 6, Akira Watanabe 7, Motonari Fukui 8, Takamasa Kitajima 8, Susumu Sato 9, Toru Tsuda 10, Nobuhito Kishimoto 11, Hideo Kita 12, Yoshihiro Mori 13, Masayuki Nakayama 14, Kenichi Takahashi 15, Tomomasa Tsuboi 16, Makoto Yoshida 17, Osamu Hataji 18, Satoshi Fuke 19, Michiko Kagajo 4, Hiroki Nishine 20, Hiroyasu Kobayashi 21, Hiroyuki Nakamura 22, Miyuki Okuda 23, Sayaka Tachibana 24, Shohei Takata 25, Hisayuki Osoreda 26, Kenichi Minami 27, Takashi Nishimura 28, Tadashi Ishida 5, Jiro Terada 29, Naoko Takeuchi 30, Yasuo Kohashi 31, Hiromasa Inoue 32, Yoko Nakagawa 33, Takashi Kikuchi 33, and Keisuke Tomii 1; on behalf of FLOCOP Study Investigators ... Show less

doi : 10.1164/rccm.202201-0199OC

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Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease

Takafumi Kato 1*, Takanori Asakura 1*, Caitlin E. Edwards 2, Hong Dang 1, Yu Mikami 1, Kenichi Okuda 1, Gang Chen 1, Ling Sun 1, Rodney C. Gilmore 1, Padraig Hawkins 1, Gabriela De la Cruz 3, Michelle R. Cooley 2, Alexis B. Bailey 2, Stephen M. Hewitt 4, Daniel S. Chertow 5, Alain C. Borczuk 6, Steven Salvatore 6, Fernando J. Martinez 7, Leigh B. Thorne 8, Frederic B. Askin 8, Camille Ehre 1, Scott H. Randell 1, Wanda K. O’Neal 1, Ralph S. Baric 2‡, Richard C. Boucher 1‡, and NIH COVID-19 Autopsy Consortium ... Show less

doi : 10.1164/rccm.202111-2606OC

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Sex Differences in Mortality of ICU Patients According to Diagnosis-related Sex Balance

Lucy J. Modra 1,2, Alisa M. Higgins 3, David V. Pilcher 3,4,5, Michael J. Bailey 3, and Rinaldo Bellomo 1,2,3,6

doi : 10.1164/rccm.202203-0539OC

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Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3b, Randomized, Placebo-controlled Study

Marcus A. Mall 1,2,3, Rossa Brugha 4, Silvia Gartner 5, Julian Legg 6, Alexander Moeller 7, Pedro Mondejar-Lopez 8, Dario Prais 9,10, Tacjana Pressler 11, Felix Ratjen 12, Philippe Reix 13, Paul D. Robinson 14, Hiran Selvadurai 14, Florian Stehling 15, Neil Ahluwalia 16, Emilio Arteaga-Solis 16, Bote G. Bruinsma 16, Mark Jennings 16, Samuel M. Moskowitz 16, Sabrina Noel 16, Simon Tian 16, Tanya G. Weinstock 16, Pan Wu 16, Claire E. Wainwright 17*, and Jane C. Davies 18,19,20*; for the VX19-445-116 Study Group ... Show less

doi : 10.1164/rccm.202202-0392OC  

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Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential

Jill Korsiak 1, Eric Lavigne 2,3, Hongyu You 2, Krystal Pollitt 4, Ryan Kulka 2, Marianne Hatzopoulou 5, Greg Evans 6, Richard T. Burnett 7, and Scott Weichenthal 1,2

doi : 10.1164/rccm.202205-0896OC  

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Human Infection Challenge with Serotype 3 Pneumococcus

Ryan E. Robinson, Elena Mitsi, Elissavet Nikolaou, Sherin Pojar, Tao Chen, Jesús Reiné, Tinashe K. Nyazika, James Court, Kelly Davies, Madlen Farrar, Patricia Gonzalez-Dias, Josh Hamilton, Helen Hill, Lisa Hitchins, Ashleigh Howard, Angela Hyder-Wright, Maia Lesosky, Konstantinos Liatsikos, Agnes Matope, Daniella McLenaghan, Christopher Myerscough, Annabel Murphy, Carla Solórzano, Duolao Wang, Hassan Burhan, Manish Gautam, Elizabeth Begier, Christian Theilacker, Rohini Beavon, Annaliesa S. Anderson, Bradford D. Gessner, Stephen B. Gordon, Andrea M. Collins, and Daniela M. Ferreira

doi : 10.1164/rccm.202112-2700OC

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Positive Airway Pressure Adherence, Mortality, and Cardiovascular Events in Patients with Sleep Apnea

Chloé Gervès-Pinquié 1*, Sebastien Bailly 2*, François Goupil 3, Thierry Pigeanne 4, Sandrine Launois 5, Laurene Leclair-Visonneau 6, Philippe Masson 7, Acya Bizieux-Thaminy 8, Margaux Blanchard 9,10, AbdelKebir Sabil 1,11, Dany Jaffuel 12, Jean-Louis Racineux 1, Wojciech Trzepizur 13,14, and Frédéric Gagnadoux 13,14; on behalf of Pays de la Loire Sleep Cohort Study Group ... Show less

doi : 10.1164/rccm.202202-0366OC

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A Dancing Trapped Intracardiac Thrombus

Aurélien Vallee 1,2, Thomas Lemann 3, Laurent Savale 1,4,5, Julien Guihaire 1,2,4, and Olaf Mercier 1,4,6

doi : 10.1164/rccm.202203-0454IM

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Giant Bronchial Arteriovenous Malformation Managed with Embolization and Radical Pneumonectomy

Eamon P. McCarron 1,2, Firas Aljanadi 1, Clinton Boyd 1, Anton Collins 1, Graham McNeilly 1, Terence E. McManus 3, Alastair Graham 1, Mark Jones 1, and Jason Wieboldt 3

doi : 10.1164/rccm.202204-0724IM

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Selected Bibliography of Recent Research in Chronic Obstructive Pulmonary Disease

Ashraf Fawzy 1, Jonathan R. Baker 2, Thomas L. Keller 3, Laura C. Feemster 3,4, Louise E. Donnelly 2, and Nadia N. Hansel 1

doi : 10.1164/rccm.202202-0335UP

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Prognostic Value of Exercise as Compared to Resting Pulmonary Hemodynamics in Patients with Normal or Mildly Elevated Pulmonary Arterial Pressure

Philipp Douschan 1,2*, Alexander Avian 1, Vasile Foris 1,2, Teresa Sassmann 1,2, Gerhard Bachmaier 1, Piet Rosenstock 1,2, Katarina Zeder 1,2, Horst Olschewski 1,2, and Gabor Kovacs 1,2

doi : 10.1164/rccm.202112-2856LE

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Matrix Metalloproteinase-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma

Chloe J. Pyle 1, Dhiren F. Patel 1, Teresa Peiró 1,2, Régis Joulia 1, Aleksander M. Grabiec 3,4, Tracy Hussell 3, Gael Tavernier 3,5, Angela Simpson 3,5, James Pease 1, James A. Harker 1, Clare M. Lloyd 1, and Robert J. Snelgrove 1* ... Show less

doi : 10.1164/rccm.202109-2082LE

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Voltage-Gated Sodium Channel NaV1.8 Dysregulates Na and Ca, Leading to Arrhythmias in Patients with Sleep-Disordered Breathing

Simon Lebek 1,2*, Philipp Hegner 1*, Rosa Hultsch 1, Jonas Rohde 1, Leopold Rupprecht 1, Christof Schmid 1, Samuel Sossalla 1,3, Lars Siegfried Maier 1, Michael Arzt 1, Stefan Wagner 1‡

doi : 10.1164/rccm.202205-0981LE

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Extracorporeal Membrane Oxygenation Transport for Severe COVID-19: Why We Can and Should!

Sebastian Mang 1,2, Tobias Wengenmayer 3, Guy Danziger 1,2, Ralf M. Muellenbach 4, and Philipp M. Lepper 1,2*

doi : 10.1164/rccm.202207-1305LE  

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Reply to Mang et al.

Whitney D. Gannon 1*, John W. Stokes 1, Sean A. Francois 1, Yatrik J. Patel 1, Meredith E. Pugh 1, Clayne Benson 1, Todd W. Rice 1, Matthew Bacchetta 1,2, Matthew W. Semler 1, and Jonathan D. Casey 1

doi : 10.1164/rccm.202207-1415LE  

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High-flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: Just Good Enough?

Yi Wang , Yong Jie Ding *, and Qing Yun Li *

doi : 10.1164/rccm.202207-1366LE  

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Erratum: Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts Mycobacterium tuberculosis Pathogenicity

doi : 10.1164/rccm.v206erratum12

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