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Not-so-creepy crawlies

doi : 10.1038/s41587-023-01921-6

Volume 41 Issue 8, August 2023

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Innovators hit by ruling in dispute over cholesterol antibody patent

Charlotte Harrison 

doi : 10.1038/s41587-023-01894-6

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First cell therapy for diabetes approved

doi : 10.1038/s41587-023-01912-7

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Fungal architecture is a thing, and it’s eye-catching

Lisa Melton 

doi : 10.1038/s41587-023-01903-8

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US approves ‘no kill’ meat for sale

doi : 10.1038/s41587-023-01913-6

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CRISPR upgrades insect proteins for feed

Karl Gruber & Lisa MeltonÂ

doi : 10.1038/s41587-023-01902-9

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Drug pipeline 2Q23 � controversy and complexity

John Hodgson 

doi : 10.1038/s41587-023-01886-6

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2Q23 � merger premiums reveal valuation gulf

John Hodgson 

doi : 10.1038/s41587-023-01889-3

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Bat biotech takes flight

Elie Dolgin 

doi : 10.1038/s41587-023-01880-y

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Defining a longevity biotechnology company

doi : 10.1038/s41587-023-01854-0

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Democratizing knowledge representation with BioCypher

Sebastian Lobentanzer, Patrick Aloy, Jan Baumbach, Balazs Bohar, Vincent J. Carey, Pornpimol Charoentong, Katharina Danhauser, Tunca DoÄŸan, Johann Dreo, Ian Dunham, Elias Farr, Adrià Fernandez-Torras, Benjamin M. Gyori, Michael Hartung, Charles Tapley Hoyt, Christoph Klein, Tamas Korcsmaros, Andreas Maier, Matthias Mann, David Ochoa, Elena Pareja-Lorente, Ferdinand Popp, Martin Preusse, Niklas Probul, Benno Schwikowski, Bünyamin Sen, Maximilian T. Strauss, Denes Turei, Erva Ulusoy, Dagmar Waltemath, Judith A. H. Wodke & Julio Saez-RodriguezÂ

doi : 10.1038/s41587-023-01848-y

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FAIR data policies can benefit biotech startups

Kate Hardy & Stephan HeyseÂ

doi : 10.1038/s41587-023-01892-8

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Comparing efficiency of patent production between US institutions using a hybrid NIH–USPTO dataset

Rocco M. DiSanto, Mark Van Dyke, Michael J. Barker & Robert G. GourdieÂ

doi : 10.1038/s41587-023-01890-w

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Spatial transcriptomics of the human heart

Jared B. FudgeÂ

doi : 10.1038/s41587-023-01918-1

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Diffusion model expands RoseTTAFold’s power

Jared B. FudgeÂ

doi : 10.1038/s41587-023-01919-0

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Models of the early human embryo

Jared B. Fudge 

doi : 10.1038/s41587-023-01920-7

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Hallucinating functional protein sequences

David Belanger & Lucy J. ColwellÂ

doi : 10.1038/s41587-022-01634-2

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Single-cell recording of cellular RNAs in bacteria

doi : 10.1038/s41587-022-01625-3

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Protein identification using a digestion-free nanopore approach

doi : 10.1038/s41587-022-01599-2

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Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase

Huawei Tong, Xuchen Wang, Yuanhua Liu, Nana Liu, Yun Li, Jiamin Luo, Qian Ma, Danni Wu, Jiyong Li, Chunlong Xu & Hui YangÂ

doi : 10.1038/s41587-022-01595-6

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Solid-phase capture and profiling of open chromatin by spatial ATAC

Enric Llorens-Bobadilla, Margherita Zamboni, Maja Marklund, Nayanika Bhalla, Xinsong Chen, Johan Hartman, Jonas Frisén & Patrik L. StÃ¥hlÂ

doi : 10.1038/s41587-022-01603-9

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Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms

Rocco Mazzolini, Irene Rodríguez-Arce, Laia Fernández-Barat, Carlos Piñero-Lambea, Victoria Garrido, Agustín Rebollada-Merino, Anna Motos, Antoni Torres, Maria Jesús Grilló, Luis Serrano & Maria Lluch-SenarÂ

doi : 10.1038/s41587-022-01584-9

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Large language models generate functional protein sequences across diverse families

Ali Madani, Ben Krause, Eric R. Greene, Subu Subramanian, Benjamin P. Mohr, James M. Holton, Jose Luis Olmos Jr., Caiming Xiong, Zachary Z. Sun, Richard Socher, James S. Fraser & Nikhil NaikÂ

doi : 10.1038/s41587-022-01618-2

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RNA recording in single bacterial cells using reprogrammed tracrRNAs

Chunlei Jiao, Claas Reckstadt, Fabian König, Christina Homberger, Jiaqi Yu, Jörg Vogel, Alexander J. Westermann, Cynthia M. Sharma & Chase L. BeiselÂ

doi : 10.1038/s41587-022-01604-8

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A universal deep-learning model for zinc finger design enables transcription factor reprogramming

David M. Ichikawa, Osama Abdin, Nader Alerasool, Manjunatha Kogenaru, April L. Mueller, Han Wen, David O. Giganti, Gregory W. Goldberg, Samantha Adams, Jeffrey M. Spencer, Rozita Razavi, Satra Nim, Hong Zheng, Courtney Gionco, Finnegan T. Clark, Alexey Strokach, Timothy R. Hughes, Timothee Lionnet, Mikko Taipale, Philip M. Kim & Marcus B. NoyesÂ

doi : 10.1038/s41587-022-01624-4

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Unidirectional single-file transport of full-length proteins through a nanopore

Luning Yu, Xinqi Kang, Fanjun Li, Behzad Mehrafrooz, Amr Makhamreh, Ali Fallahi, Joshua C. Foster, Aleksei Aksimentiev, Min Chen & Meni WanunuÂ

doi : 10.1038/s41587-022-01598-3

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Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening

Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco Boccalatte, Palaniraja Thandapani, Jane Skok, Iannis Aifantis, David Fenyö, Bo Xia & Aristotelis TsirigosÂ

doi : 10.1038/s41587-022-01612-8

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Predicting prime editing efficiency and product purity by deep learning

Nicolas Mathis, Ahmed Allam, Lucas Kissling, Kim Fabiano Marquart, Lukas Schmidheini, Cristina Solari, Zsolt Balázs, Michael Krauthammer & Gerald SchwankÂ

doi : 10.1038/s41587-022-01613-7

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Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment

Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kai-Wei Chang, Scott Hadley, Noora Ba Sunbul, Martha M. Matuszak, Christopher J. Tichacek, Eduardo G. Moros, Paul L. Carson, Kyle C. Cuneo, Xueding Wang & Issam El NaqaÂ

doi : 10.1038/s41587-022-01593-8

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Grand challenges in bioinformatics education and training

Esra Büşra Işık, Michelle D. Brazas, Russell Schwartz, Bruno Gaeta, Patricia M. Palagi, Celia W. G. van Gelder, Prashanth Suravajhala, Harpreet Singh, Sarah L. Morgan, Hilyatuz Zahroh, Maurice Ling, Venkata P. Satagopam, Annette McGrath, Kenta Nakai, Tin Wee Tan, Ge Gao, Nicola Mulder, Christian Schönbach, Yun Zheng, Javier De Las Rivas & Asif M. KhanÂ

doi : 10.1038/s41587-023-01891-9

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1H23 biotech job picture

Michael Francisco 

doi : 10.1038/s41587-023-01895-5

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