Journal of Investigative Dermatology




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Editorial Board

doi : 10.1016/S0022-202X(23)02346-1

Volume 143, Issue 8, August 2023, Page A1

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Subscription Information

doi : 10.1016/S0022-202X(23)02347-3

Volume 143, Issue 8, August 2023, Page A2

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Table of Contents

doi : 10.1016/S0022-202X(23)02348-5

Volume 143, Issue 8, August 2023, Pages A3-A7

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Clinical Snippets

doi : 10.1016/j.jid.2023.06.188

Volume 143, Issue 8, August 2023, Page 1333

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Editors’ Picks: Selections by Johann Gudjonsson, Reviews Editor

doi : 10.1016/j.jid.2023.06.187

Volume 143, Issue 8, August 2023, Page 1334

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The Cornified Envelope: A Versatile Contributor to the Epidermal Barrier

Nathalie Jonca1,2 and Michel Simon

doi : 10.1016/j.jid.2023.02.008

Volume 143, Issue 8, August 2023, Pages 1335-1337

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Demystifying Hand Eczema

Ayman Grada1 and Christopher G. Bunick

doi : 10.1016/j.jid.2023.03.1666

Volume 143, Issue 8, August 2023, Pages 1338-1339

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T Cells Remember SARS-CoV-2 in Rituximab-Treated Pemphigus Vulgaris

David O. Croitoru1,2 and Vincent Piguet

doi : 10.1016/j.jid.2023.02.002

Volume 143, Issue 8, August 2023, Pages 1340-1341

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Spatial Cancer Systems Biology Resolves Heterotypic Interactions and Identifies Disruption of Spatial Hierarchy as a Pathological Driver Event

Fabian V. Filipp

doi : 10.1016/j.jid.2023.02.006

Volume 143, Issue 8, August 2023, Pages 1342-1347

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Flooding and Climate Change and its Effect on Skin Disease

Muhammad H. Junejo1 , Sidra Khan 2 , Ehsan A. Larik3 , Ayesha Akinkugbe4 , Edel A. O’Toole1,5 and Aisha Sethi

doi : 10.1016/j.jid.2023.02.024

Volume 143, Issue 8, August 2023, Pages 1348-1350

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A Call for Discovery and Therapeutic Development for Cutaneous Neurofibromas

Jaishri O. Blakeley1 , Lu Q. Le2 , Sang Y. Lee 1 , Ina Ly3 , Steven D. Rhodes4,5,6,7 , Carlos G. Romo1 , Kavita Y. Sarin 8 , Verena Staedtke1 , Matthew R. Steensma9,10,11 and Pierre Wolkenstein12 , on Behalf of the 2022 NTAP Cutaneous Neurofibroma Symposium Participants

doi : 10.1016/j.jid.2022.11.027

Volume 143, Issue 8, August 2023, Pages 1351-1357

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RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights

Steven D. Rhodes1,2,3,4 , Frank McCormick5,6 , Ross L. Cagan7 , Annette Bakker8 , Verena Staedtke9 , Ina Ly10 , Matthew R. Steensma11,12,13 , Sang Y. Lee 9 , Carlos G. Romo9 , Jaishri O. Blakeley9 and Kavita Y. Sarin

doi : 10.1016/j.jid.2023.01.043

Volume 143, Issue 8, August 2023, Pages 1358-1368

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Cutaneous Neurofibroma Heterogeneity: Factors that Influence Tumor Burden in Neurofibromatosis Type 1

Chunhui Jiang1 , Rene´e M. McKay 1 , Sang Y. Lee2 , Carlos G. Romo2 , Jaishri O. Blakeley2 , Muzlifah Haniffa3,4 , Eduard Serra 5 , Matthew R. Steensma6 , David Largaespada7,8 and Lu Q. Le

doi : 10.1016/j.jid.2022.12.027

Volume 143, Issue 8, August 2023, Pages 1369-1377

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Existing and Developing Preclinical Models for Neurofibromatosis Type 1−Related Cutaneous Neurofibromas

Verena Staedtke1 , Piotr Topilko2 , Lu Q. Le3 , Kevin Grimes4,5 , David A. Largaespada6 , Ross L. Cagan7 , Matthew R. Steensma8,9,10 , Anat Stemmer-Rachamimov 11 , Jaishri O. Blakeley1 , Steven D. Rhodes12,13,14,15 , Ina Ly16 , Carlos G. Romo1 , Sang Y. Lee 1 and Eduard Serra

doi : 10.1016/j.jid.2023.01.042

Volume 143, Issue 8, August 2023, Pages 1378-1387

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Target Product Profile for Cutaneous Neurofibromas: Clinical Trials to Prevent, Arrest, or Regress Cutaneous Neurofibromas

Ina Ly1 , Carlos G. Romo2 , Sally Gottesman3,4 , Kristen M. Kelly 5 , Deanna Kornacki6 , Zachary York7 , Sang Y. Lee2 , Steven D. Rhodes8 , Verena Staedtke2 , Matthew R. Steensma9 , Jaishri O. Blakeley2 and Pierre Wolkenstein10

doi : 10.1016/j.jid.2023.01.041

Volume 143, Issue 8, August 2023, Pages 1388-1396

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Current and Emerging Imaging Techniques for Neurofibromatosis Type 1–Associated Cutaneous Neurofibromas

Yingjoy Li 1 , Jaishri O. Blakeley2 , Ina Ly 3 , Yemima Berman4 , Jonathan Lau 4,5 , Pierre Wolkenstein6,7 , Christina Bergqvist7 , Wangcun Jia 8 , Thomas E. Milner8,9 , Nitesh Katta 8 , Anthony J. Durkin8,9 , Gordon T. Kennedy 8 , Rebecca Rowland8 , Carlos G. Romo2 , Jane Fleming4 and Kristen M. Kelly

doi : 10.1016/j.jid.2023.03.1681

Volume 143, Issue 8, August 2023, Pages 1397-1405

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Sunscreens: Misconceptions and Misinformation

Sara Moradi Tuchayi1,2 , Zixiao Wang3 , Jiajun Yan3 , Lilit Garibyan1,2 , Xuefei Bai 4 and Barbara A. Gilchrest

doi : 10.1016/j.jid.2023.03.1677

Volume 143, Issue 8, August 2023, Pages 1406-1411

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Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology

Ryland D. Mortlock1,2 , Emilie C. Ma 3 , Jeffrey M. Cohen1 and William Damsky

doi : 10.1016/j.jid.2023.04.005

Volume 143, Issue 8, August 2023, Pages 1412-1422

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Improving Artificial Intelligence−Based Diagnosis on Pediatric Skin Lesions

Paras P. Mehta1 , Mary Sun1 , Brigid Betz-Stablein2 , Allan Halpern1 , H. Peter Soyer 2 , Jochen Weber1 , Kivanc Kose1,3 and Veronica Rotemberg

doi : 10.1016/j.jid.2022.08.058

Volume 143, Issue 8, August 2023, Pages 1423-1429.e1

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Quantifying Inflammatory Response and Drug-Aided Resolution in an Atopic Dermatitis Model with Deep Learning

Daniel A. Greenfield1,2 , Amin Feizpour1 and Conor L. Evans

doi : 10.1016/j.jid.2023.01.026

Volume 143, Issue 8, August 2023, Pages 1430-1438.e4

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Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population

Qilin Zhang1,2 , Peidian Shi 2 , Zhenzhen Wang2 , Lele Sun2 , Wenchao Li2 , Qing Zhao2 , Tingting Liu2 , Qing Pan2 , Yuanhang Sun2 , Fengming Jia2 , Wenjie Chen2 , Xi’an Fu2 , Gongqi Yu 2 , Fangfang Bao2 , Zihao Mi2 , Chuan Wang2 , Yonghu Sun2 , Bingqing Li 3 , Jianjun Liu 4 , Hong Liu 2 , Heng Gu1,5 and Furen Zhang2,

doi : 10.1016/j.jid.2023.01.023

Volume 143, Issue 8, August 2023, Pages 1439-1448.e21

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PD-L1 Enhanced by cis-Urocanic Acid on Langerhans Cells Inhibits Vγ4+ γδT17 Cells in Imiquimod-Induced Skin Inflammation

Chen-Yun Yeh1 , Sheng-Han Su1 , Yeh Fong Tan1,2 , Tsen-Fang Tsai3 , Pi-Hui Liang 4 , Musin Kelel 1 , Hao-Jui Weng3,5,6 , Yu-Ping Hsiao7 , Chun-Hao Lu 1 , Ching-Hui Tsai1 , Chih-Hung Lee 8 , Bjo¨ rn E. Clausen9 , Fu-Tong Liu 1 and Yungling Leo Lee

doi : 10.1016/j.jid.2023.02.018

Volume 143, Issue 8, August 2023, Pages 1449-1460

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Gene Expression–Based Molecular Test as Diagnostic Aid for the Differential Diagnosis of Psoriasis and Eczema in Formalin-Fixed and Paraffin-Embedded Tissue, Microbiopsies, and Tape Strips

Felix Fischer1,12 , Anais Doll2,12 , Deniz Uereyener1 , Sophie Roenneberg2 , Christina Hillig 1 , Lucca Weber3 , Verena Hackert3 , Martin Meinel1 , Ali Farnoud1 , Peter Seiringer2 , Jenny Thomas7 , Philipp Anand2 , Larissa Graner5 , Franziska Schlenker5 , Roland Zengerle4,5 , Pontus Jonsson6 , Manja Jargosch2,7 , Fabian J. Theis1,8 , Carsten B. Schmidt-Weber7 , Tilo Biedermann2 , Michael Howell9 , Kristian Reich 10 , Kilian Eyerich 11 , Michael Menden1 , Natalie Garzorz-Stark 2 , Felix Lauffer2,12 and Stefanie Eyerich

doi : 10.1016/j.jid.2023.02.015

Volume 143, Issue 8, August 2023, Pages 1461-1469.e5

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Atopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics

Ali Al-Janabi1 , Steve Eyre1,2,3 , Amy C. Foulkes1 , Adnan R. Khan 4 , Nick Dand5 , Ekaterina Burova6 , Bernadette DeSilva7 , Areti Makrygeorgou8 , Emily Davies9 , Catherine H. Smith10,11 , Christopher E.M. Griffiths1 , Andrew P. Morris2,3 and Richard B. Warren1 , on behalf of the BSTOP Study Group and the BADBIR Study Group

doi : 10.1016/j.jid.2023.01.021

Volume 143, Issue 8, August 2023, Pages 1470-1478.e1

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Disease Endotypes Predict the Severity of Mucous Membrane Pemphigoid

Janet A. Fairley 1 , Tyler P. Crowe 1 , Maryam Fakhimi1 , Samuel J. Palmer1 , Mark A. Greiner2 , John W. Hellstein3 , Douglas J. Van Daele4 and Kelly N. Messingham

doi : 10.1016/j.jid.2023.02.012

Volume 143, Issue 8, August 2023, Pages 1479-1486.e3

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Loss of RhoE Function in Dermatofibroma Promotes Disorganized Dermal Fibroblast Extracellular Matrix and Increased Integrin Activation

Sofia Endzhievskaya 1 , Chao-Kai Hsu2,3,4 , Hsing-San Yang2,3 , Hsin-Yu Huang2 , Yu-Chen Lin 2 , Yi-Kai Hong2 , John Y.W. Lee 5 , Alexandros Onoufriadis5 , Takuya Takeichi6 , Julia Yu-Yun Lee2 , Tanya J. Shaw7 , John A. McGrath5 and Maddy Parsons1

doi : 10.1016/j.jid.2023.01.019

Volume 143, Issue 8, August 2023, Pages 1487-1497.e9

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CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late Cornified Envelope Proteins

Hanna Niehues1 , Gijs Rikken1 , Ferry F.J. Kersten1 , Jorine M. Eeftens2 , Ivonne M.J.J. van Vlijmen-Willems1 , Diana Rodijk-Olthuis1 , Patrick A.M. Jansen1 , Wiljan J.A.J. Hendriks3 , Thomas H.A. Ederveen 4 , Joost Schalkwijk1 , Ellen H. van den Bogaard1,5 and Patrick L.J.M. Zeeuwen

doi : 10.1016/j.jid.2023.01.022

Volume 143, Issue 8, August 2023, Pages 1498-1508.e7

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PANX3 Channels Regulate Architecture, Adhesion, Barrier Function, and Inflammation in the Skin

Brooke L. O’Donnell1 , Rafael E. Sanchez-Pupo1 , Samar Sayedyahossein2 , Mehdi Karimi3 , Mehrnoosh Bahmani4 , Christopher Zhang1 , Danielle Johnston1 , John J. Kelly1 , C. Brent Wakefield1,5 , Kevin Barr1 , Lina Dagnino2 and Silvia Penuela

doi : 10.1016/j.jid.2023.01.030

Volume 143, Issue 8, August 2023, Pages 1509-1519.e14

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Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes

Jos P.H. Smits1,2 , Noa J.M. van den Brink1 , Luca D. Meesters1,3 , Hadia Hamdaoui1 , Hanna Niehues1 , Patrick A.M. Jansen1 , Ivonne M.J.J. van Vlijmen-Willems1 , Diana Rodijk-Olthuis1 , Ce´line Evrard4 , Yves Poumay4 , Michel van Geel5,6,7 , Wiljan J.A.J. Hendriks8 , Joost Schalkwijk1 , Patrick L.J.M. Zeeuwen1 and Ellen H. van den Bogaard

doi : 10.1016/j.jid.2023.02.021

Volume 143, Issue 8, August 2023, Pages 1520-1528.e5

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Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis

Abigail R. Wark1 , Daniel Aldea2,3 , Reiko R. Tomizawa 1,3 , Blerina Kokalari2 , Bailey Warder2 and Yana G. Kamberov

doi : 10.1016/j.jid.2023.02.007

Volume 143, Issue 8, August 2023, Pages 1529-1537.e2

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Significant Association of Poly-A and Fok1 Polymorphic Alleles of the Vitamin D Receptor with Vitamin D Serum Levels and Incidence of Squamous Cutaneous Neoplasia

Taylor A. Bullock 1,7 , Judith A. Mack 2,7 , Jeffrey Negrey 3 , Urvashi Kaw 1 , Bo Hu 4 , Sanjay Anand1,2,5 , Tayyaba Hasan6 , Christine B. Warren 1,5 and Edward V. Maytin

doi : 10.1016/j.jid.2023.01.028

Volume 143, Issue 8, August 2023, Pages 1538-1547

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Met-Signaling Controls Dendritic Cell Migration in Skin by Regulating Podosome Formation and Function

Ahmed E.I. Hamouda1,2 , Carmen Schalla 1,2,3 , Antonio Sechi1,2,3 , Martin Zenke1,2,4 , Rebekka K. Schneider3 and Thomas Hieronymus

doi : 10.1016/j.jid.2022.12.025

Volume 143, Issue 8, August 2023, Pages 1548-1558.e13

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The Proteome of Hand Eczema Assessed by Tape Stripping

Julie B.K. S?lberg1,2 , Anna S. Quaade1 , Lylia Drici 3 , Karolina Sulek 3 , Nina H. Ulrich 1 , Marianne B. L?vendorf2,4 , Jacob P. Thyssen 1 , Matthias Mann3 , Beatrice Dyring-Andersen2,3,4 and Jeanne D. Johansen

doi : 10.1016/j.jid.2022.12.024

Volume 143, Issue 8, August 2023, Pages 1559-1568.e5

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Blockade of the Immune Checkpoint CD47 by TTI-621 Potentiates the Response to Anti−PD-L1 in Cutaneous T-Cell Lymphoma

Zhen Han1,2 , Xiwei Wu2,3,4 , Hanjun Qin2,3 , Yate-Ching Yuan2,4,5 , Jasmine Zain6 , D. Lynne Smith6 , Oleg E. Akilov 7 , Steven T. Rosen2,6 , Mingye Feng2,8 and Christiane Querfeld

doi : 10.1016/j.jid.2023.02.017

Volume 143, Issue 8, August 2023, Pages 1569-1578.e5

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N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma

Gaofeng Wang1,2,6,7 , Dongqiang Zeng3,6 , Evan Sweren 2 , Yong Miao1 , Ruosi Chen1 , Junjun Chen2 , Jin Wang1 , Wangjun Liao3 , Zhiqi Hu 1 , Sewon Kang2 and Luis A. Garza

doi : 10.1016/j.jid.2023.01.027

Volume 143, Issue 8, August 2023, Pages 1579-1590.e5

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Gene Expression Profiling Suggests that Complement Activation Is Important for Blister Formation in Bullous Pemphigoid

Aniek Lamberts 1,4 , Nika Kotnik1,2,4 , Joost M. Meijer1 , Leon C. van Kempen 3 , Gilles F.H. Diercks3 and Barbara Horva´th

doi : 10.1016/j.jid.2023.01.029

Volume 143, Issue 8, August 2023, Pages 1591-1594.e2

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Differential DNA Methylation of MicroRNA-Encoding Genes in Psoriatic Epidermis Highlights the Wnt Pathway

Deepti Verma1 , Nada-Katarina Kasic 1 , Freja Jeppsson1 , Cecilia Bivik Eding1 , Ma?gorzata ?ysiak2 , Shora Zamani Fekri 1 , Jyotirmoy Das3 and Charlotta Enerba¨ck 1,*

doi : 10.1016/j.jid.2023.01.031

Volume 143, Issue 8, August 2023, Pages 1594-1597.e14

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Genetic Validation of Psoriasis Phenotyping in UK Biobank Supports the Utility of Self-Reported Data and Composite Definitions for Large Genetic and Epidemiological Studies

Jake R. Saklatvala 1 , Ken B. Hanscombe 1,2 , Satveer K. Mahil3 , Lam C. Tsoi4,5,6 , James T. Elder4,7 , Jonathan N. Barker3 , Michael A. Simpson1 , Catherine H. Smith3 and Nick Dand

doi : 10.1016/j.jid.2023.02.010

Volume 143, Issue 8, August 2023, Pages 1598-1601.e10

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SARS-CoV-2 Vaccination Effectiveness in Rituximab-Treated Patients Affected by Pemphigus Vulgaris

Claudio Fenizia1,2,5,* , Chiara Moltrasio 3,4,5 , Luisa Ottobrini 1 , Olga Utyro2 , Giovanni Genovese 1,3 , Claudia Vanetti2 , Daria Trabattoni 2,6 and Angelo V. Marzano

doi : 10.1016/j.jid.2022.12.023

Volume 143, Issue 8, August 2023, Pages 1601-1604

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Response to Gattinger et al

Christian Lupinek 1,* , Irene Mittermann 1 , Peter Forstenlechner1 and Sandra Wieser

doi : 10.1016/j.jid.2023.02.009

Volume 143, Issue 8, August 2023, Pages 1604-1606

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Improved Sensitivity in BRAFV600E Detection in Combined Tissue and Extracellular Vesicle-Based Liquid Biopsy in Melanoma

Susana Garc?´a-Silva 1 , Cristina Vico- Alonso 2 , Lisa Meyer3 , Daniel Enderle3 , J. Aquiles Sanchez4 , Mar?´a del Mar Onteniente2 , Mikkel Noerholm3 , Johan Skog4 , Jose´-Luis Rodr?´guez- Peralto5 , Pablo-Luis Ortiz-Romero 2 and He´ctor Peinado

doi : 10.1016/j.jid.2023.01.025

Volume 143, Issue 8, August 2023, Pages 1606-1610

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Germline Variants in Childhood Cutaneous Melanoma

Peter A. Johansson 1 , Jane M. Palmer 1 , Hayley R. Hamilton1 , David C. Whiteman 1 , Antonia L. Pritchard 1,2 and Nicholas K. Hayward 1

doi : 10.1016/j.jid.2023.02.014

Volume 143, Issue 8, August 2023, Pages 1610-1613

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Staphylococcus Aureus and Streptococcus Pyogenes Induce Psoriasis-Related Transcriptomes Augmented by IL-17A and TNF-α

Shunsuke Miura 1,3 , Yohei Ichimura1,3 , Uri Sela2 , Sandra Garcet 1 , Charissa Salud-Gnilo1 , Xuan Li1 , Juana Gonzalez1 , Mika Murai- Yamamura1 , Kazuhiko Yamamura1 , Darshna Rambhia 1 , Norma Kunjravia 1 and James G. Krueger 1,*

doi : 10.1016/j.jid.2022.12.026

Volume 143, Issue 8, August 2023, Pages 1613-1617.e5

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Sensory Nerve Sprouting into Human Skin Explants Confers Improved Survival to Merkel Cells Independent of Merkel Cell–Neurite Complexes

Moe Tsutsumi 1,* , Saito Sakaguchi1 , Kazuki Takagaki 1 , Je´re´my Che´ret2,3 , Ralf Paus2,3 and Kentaro Kajiya

doi : 10.1016/j.jid.2023.02.016

Volume 143, Issue 8, August 2023, Pages 1617-1620.e4

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