Nature Reviews Drug Discovery




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eTRANSAFE: data science to empower translational safety assessment

Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Shoji Asakura, Alexander Amberg, Nathalie Bécourt-Lhote, Niklas Blomberg, Nicolas Bosc, Katharine Briggs, Frank Bringezu, Claire Brulle-Wohlhueter, Søren Brunak, Ruud Bueters, Giulia Callegaro, Salvador Capella-Gutierrez, Emilio Centeno, Javier Corvi, Mark T. D. Cronin, Philip Drew, Guillemette Duchateau-Nguyen, Gerhard F. Ecker, Sylvia Escher, Eloy Felix, … David Wilkinson

doi : 10.1038/d41573-023-00099-5

Volume 22 Issue 8, August 2023

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Personalized cancer vaccines pass first major clinical test

Elie Dolgin

doi : 10.1038/d41573-023-00118-5

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FDA approves first gene therapy for Duchenne muscular dystrophy, despite internal objections

Asher Mullard

doi : 10.1038/d41573-023-00103-y

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Massive misuse of chemical probes undermines the utility of these tools

Asher Mullard

doi : 10.1038/d41573-023-00105-w

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FDA approves first cell therapy for type 1 diabetes

Asher Mullard

doi : 10.1038/d41573-023-00113-w

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Trends in the use of liquid biopsy in oncology

Wen Xie1,2 , Smruthi Suryaprakash3 , Chun Wu4 , Andrew Rodriguez5 & Sven Fraterman

doi : 10.1038/d41573-023-00111-y

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FDA new drug approvals in Q2 2023

Lisa Urquhart

doi : 10.1038/d41573-023-00117-6

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The case for cell-penetrating peptides

Asher Mullard

doi : 10.1038/d41573-023-00106-9

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Herding in the drug development pipeline

Christian Fougner, Julie Cannon, Lydia The, Jeffrey F. Smith & Olivier Leclerc

doi : 10.1038/d41573-023-00063-3

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Selective activation of Wnt ameliorates idiopathic pulmonary fibrosis

M. Teresa Villanueva

doi : 10.1038/d41573-023-00116-7

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Reading through stop codons with engineered tRNAs

Sarah Crunkhorn

doi : 10.1038/d41573-023-00104-x

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A strategy for small-molecule RNA degraders

Alex Eccleston

doi : 10.1038/d41573-023-00112-x

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A non-covalent inhibitor with pan-KRAS potential

Katie Kingwell

doi : 10.1038/d41573-023-00115-8

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Towards polio eradication

Sarah Crunkhorn

doi : 10.1038/d41573-023-00107-8

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Antibody offers broad alphavirus protection

Sarah Crunkhorn

doi : 10.1038/d41573-023-00108-7

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Extrahepatic oligonucleotide delivery

Sarah Crunkhorn

doi : 10.1038/d41573-023-00109-6

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Treating cannabis use disorder

Sarah Crunkhorn

doi : 10.1038/d41573-023-00110-z

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Trends in the approval of cancer therapies by the FDA in the twenty-first century

Emma C. Scott, Andrea C. Baines, Yutao Gong, Rodney Moore Jr, Gulsum E. Pamuk, Haleh Saber, Ashim Subedee, Matthew D. Thompson, Wenming Xiao, Richard Pazdur, V. Ashutosh Rao, Julie Schneider & Julia A. BeaverÂ

doi : 10.1038/s41573-023-00723-4

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Antibody–drug conjugates come of age in oncology

Charles Dumontet, Janice M. Reichert, Peter D. Senter, John M. Lambert & Alain BeckÂ

doi : 10.1038/s41573-023-00709-2

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Disease modification in inflammatory skin disorders: opportunities and challenges

Thomas Bieber 

doi : 10.1038/s41573-023-00735-0

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