American Journal of Respiratory and Critical Care Medicine




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November 1 Highlight

doi : 10.1164/rccm.2069Pxxxii

Volume 206, Issue 9 | November 1 2022

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Mucins MUC5AC and MUC5B in the Airways: MUCing around Together

Mehmet Kesimer

doi : 10.1164/rccm.202208-1459ED

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Obesity, Insulin Resistance, and Asthma

James P. Allinson 1,2, Pujan H. Patel 2, and Gavin C. Donaldson 1

doi : 10.1164/rccm.202207-1271ED

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Sepsis Epidemiology and Outcomes in Asia: Advancing the Needle

Bharath Kumar Tirupakuzhi Vijayaraghavan 1,2 and Neill K. J. Adhikari 3,4

doi : 10.1164/rccm.202207-1257ED

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Heatwaves and Air Pollution: a Deadly Combination

Patrick L. Kinney 1 and Kent E. Pinkerton 2,3

doi : 10.1164/rccm.202207-1372ED

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Goldilocks and the Three Trials: Clinical Trials Targeting the αvβ6 Integrin in Idiopathic Pulmonary Fibrosis

Patricia Sime 1 and Gisli Jenkins 2 + Author Affiliations

doi : 10.1164/rccm.202208-1579ED  

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PTX3 in Granuloma Formation and Sarcoidosis: Helping Macrophages Accept a “Complement�

Genta Ishikawa 1,2 and Erica L. Herzog 1,2

doi : 10.1164/rccm.202207-1277ED

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Household Air Pollution, Passive Smoking, and Lung Cancer: Do We Know Enough about This Conundrum?

Om P. Kurmi 1,2,3

doi : 10.1164/rccm.202209-1641ED

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Science-based Policy Recommendations for Fine Particulate Matter in the United States

Kevin R. Cromar 1,2, Alison G. Lee 3, Jack R. Harkema 4, and Isabella Annesi-Maesano 5

doi : 10.1164/rccm.202203-0507ED

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Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission

Daan Beentjes *, Rebecca K. Shears *, Neil French , Daniel R. Neill , and Aras Kadioglu

doi : 10.1164/rccm.202112-2668TR  

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Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules

Oanh N. Hoang 1*, Anna Ermund 2*, Ana M. Jaramillo 1*, Dalia Fakih 2, Cory B. French 3, Jose R. Flores 3, Harry Karmouty-Quintana 4, Jesper M. Magnusson 2, Giorgio Fois 5, Michael Fauler 5, Manfred Frick 5, Peter Braubach 6, Joshua B. Hales 3, Richard C. Kurten 7, Reynold Panettieri 8, Leoncio Vergara 9, Camille Ehre 10, Roberto Adachi 1, Michael J. Tuvim 1*, Gunnar C. Hansson 2*, and Burton F. Dickey 1* ... Show less

doi : 10.1164/rccm.202202-0309OC

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The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma

Michael C. Peters 1,2, Mark L. Schiebler 3, Juan Carlos Cardet 4, Mats W. Johansson 5,6,7, Ronald Sorkness 7, Mark D. DeBoer 8, Eugene R. Bleecker 9, Deborah A. Meyers 9, Mario Castro 10, Kaharu Sumino 11, Serpil C. Erzurum 12, Matthew C. Tattersall 13, Joe G. Zein 14, Annette T. Hastie 15, Wendy Moore 15, Bruce D. Levy 16, Elliot Israel 16, Melody G. Duvall 16, Brenda R. Phillips 17, David T. Mauger 17, Sally E. Wenzel 18,19, Merritt L. Fajt 19, Suneil K. Koliwad 2, Loren C. Denlinger 7, Prescott G. Woodruff 1, Nizar N. Jarjour 7, and John V. Fahy 1; for the National Heart, Lung, and Blood Institute Severe Asthma Research Program-3

doi : 10.1164/rccm.202112-2745OC

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Epidemiology, Management, and Outcomes of Sepsis in ICUs among Countries of Differing National Wealth across Asia

Andrew Li 1,2, Lowell Ling 3, Hanyu Qin 4, Yaseen M. Arabi 5, Sheila Nainan Myatra 6, Moritoki Egi 7, Je Hyeong Kim 8, Mohd Basri Mat Nor 9, Do Ngoc Son 10, Wen-Feng Fang 11,12, Bambang Wahyuprajitno 13, Madiha Hashmi 14, Mohammad Omar Faruq 15, Boonsong Patjanasoontorn 16, Maher Jaffer Al Bahrani 17, Babu Raja Shrestha 18, Ujma Shrestha 18, Khalid Mahmood Khan Nafees 19, Kyi Kyi Sann 20, Jose Emmanuel M. Palo 21, Naranpurev Mendsaikhan 22, Aidos Konkayev 23,24, Khamsay Detleuxay 25, Yiong Huak Chan 26, Bin Du 4, Jigeeshu Vasishtha Divatia 6, Younsuck Koh 27, Charles D. Gomersall 3, and Jason Phua 1,28; on behalf of the MOSAICS II Study Group; for the Asian Critical Care Clinical Trials Group ... Show less

doi : 10.1164/rccm.202112-2743OC

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The Effects of Coexposure to Extremes of Heat and Particulate Air Pollution on Mortality in California: Implications for Climate Change

Md Mostafijur Rahman 1, Rob McConnell 1, Hannah Schlaerth 2, Joseph Ko 2, Sam Silva 3, Frederick W. Lurmann 4, Lawrence Palinkas 1,5, Jill Johnston 1, Michael Hurlburt 1,5, Hao Yin 6,7, George Ban-Weiss 2,†, and Erika Garcia 1 ... Show less

doi : 10.1164/rccm.202204-0657OC

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A Phase IIb Randomized Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis

Ganesh Raghu 1, Majd Mouded 2*, Daniel C. Chambers 3,4, Fernando J. Martinez 5, Luca Richeldi 6, Lisa H. Lancaster 7, Mark J. Hamblin 8, Kevin F. Gibson 9, Ivan O. Rosas 10‡, Antje Prasse 11, Guolin Zhao 2§, Michael Serenko 2, Natasha Novikov 2�, Amy McCurley 2¶, Prashant Bansal 2**, Christopher Stebbins 2††, Million Arefayene 2‡‡, Stella Ibebunjo 2, Shelia M. Violette 2§§, Diana Gallagher 2, and Jürgen Behr 12 ... Show less

doi : 10.1164/rccm.202112-2824OC

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Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis

Relber A. Gonçales 1,2, Helder Novais Bastos 3,4,5, Cláudio Duarte-Oliveira 1,2, Daniela Antunes 1,2, Oksana Sokhatska 6, Maria Jacob 5, Rui Rolo 7, Cláudia F. Campos 1,2, Sergio D. Sasaki 1,2,8, Alessia Donato 9,10, Sarah N. Mapelli 9,10, Sandra Costa 1,2, Conceição Souto Moura 11, Luís Delgado 6,12, António Morais 5, Egídio Torrado 1,2, Frank L. van de Veerdonk 13, Thomas Weichhart 14, John D. Lambris 15, Ricardo Silvestre 1,2, Cecilia Garlanda 9,10, Alberto Mantovani 9,10,16, Cristina Cunha 1,2, and Agostinho Carvalho 1,2 ... Show less

doi : 10.1164/rccm.202112-2771OC

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Solid Fuel, Secondhand Smoke, and Lung Cancer Mortality: A Prospective Cohort of 323,794 Chinese Never-Smokers

Elvin S. Cheng 1,2, Ka Hung Chan 3,4, Marianne Weber 2, Julia Steinberg 2, Jane Young 1,2, Karen Canfell 2,5, and Xue Qin Yu 2

doi : 10.1164/rccm.202201-0114OC

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Rare Case of Isolated Systemic Arterial Supply to Upper Lobe of Left Lung

Navjot Kaur 1, Swathi Raman 2, Vruksha Upadhyay 3, Maruti Kumaran 4, Parth Rali 1, and Massa Zantah 1

doi : 10.1164/rccm.202203-0500IM

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Randomized Phase IIa Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis

Ganesh Raghu 1*, Majd Mouded 2‡, Antje Prasse 3, Christopher Stebbins 2§, Guolin Zhao 2�, Guochen Song 2�, Million Arefayene 2¶, Shelia M. Violette 2**, Diana Gallagher 2, and Kevin F. Gibson 4; on behalf of the Investigators

doi : 10.1164/rccm.202205-0868LE

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Intrapulmonary Bronchopulmonary Anastomoses in Severe COVID-19–related Acute Respiratory Failure

Jenna Bodmer 1, Alice Levin 1, Christian Westöö 2, Oscar van der Have 2, Niccolò Peruzzi 2, Karin Tran-Lundmark 3, Steven H. Abman 1, and Csaba Galambos 1*

doi : 10.1164/rccm.202205-0922LE

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Phenobarbital for Severe Alcohol Withdrawal Syndrome: A Multicenter Retrospective Cohort Study

Nicholas A. Bosch *‡, Anica C. Law *, and Allan J. Walkey

doi : 10.1164/rccm.202203-0466LE

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Hematopoietic and Lung Platelet Biogenesis as a Prognostic Indicator in Idiopathic Pulmonary Fibrosis

Shigeki Saito 1*, Cheng Han H. Chung 1, Alex Jacob 1, Nebil Nuradin 1, Amy E. Meyer 1, Haoran Yang 1, Jay K. Kolls 1, Victor J. Thannickal 1, Joseph A. Lasky 1‡, Toshie Saito 2, and Yao-Zhong Liu 3‡

doi : 10.1164/rccm.202206-1195LE

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SARS-CoV2 Endotheliopathy: Insights from Single Cell RNAseq

Mst Shamima Khatun 1, Xuebin Qin 1,2, Derek A. Pociask 1, and Jay K. Kolls 1*

doi : 10.1164/rccm.202206-1105LE  

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Reply to Khatun et al.

Jérémie Joffre 1, Michael A. Matthay 2, and Judith Hellman 2*

doi : 10.1164/rccm.202207-1309LE

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Heart Rate Response in OSA: A Clue to Reveal Cardiovascular Benefit from CPAP?

Zhihua Huang 1, Qin Luo 1, Jiyan Chen 2, Ling Wang 2, and Zhihong Liu 1*

doi : 10.1164/rccm.202205-0984LE

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Reply to: Heart Rate Response in Obstructive Sleep Apnea: A Clue to Reveal Cardiovascular Benefit from Continuous Positive Airway Pressure?

Ali Azarbarzin 1*, Andrey Zinchuk 2, Yüksel Peker 1,3,4,5,6, and Scott A. Sands 1; on behalf of all the authors

doi : 10.1164/rccm.202207-1348LE

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Microbial Burden-associated Cytokine Storm May Explain Nonresolving Acute Respiratory Distress Syndrome in Patients with COVID-19

Taro Yasuma , Corina N. D’Alessandro-Gabazza , Tetsu Kobayashi , Esteban C. Gabazza *, and Hajime Fujimoto

doi : 10.1164/rccm.202207-1266LE  

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Reply to: Microbial Burden-associated Cytokine Storm May Explain Non-Resolving ARDS in COVID-19 Patients

Robert F. J. Kullberg *, Justin de Brabander ‡, Leonoor S. Boers ‡, Lieuwe D. J. Bos §, and W. Joost Wiersinga §

doi : 10.1164/rccm.202207-1346LE

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Erratum: Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury

Malgorzata Wygrecka 1*‡ Lukasz Wujak 1 Philipp Markart 1*, Djuro Kosanovic 1, Holger C. Müller-Redetzky 2, Martin Witzenrath 2, Ingrid Henneke 3,4, Ralph T. Schermuly 3,4*, Werner Seeger 3,4*, Liliana Schaefer 5, Grazyna Kwapiszewska 6, Leigh M. Marsh 6, Nelli Baal 7, Holger Hackstein 8*, Steven de Maat 9, and Coen Maas 9 ... Show less

doi : 10.1164/rccm.v206erratum6

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