American Journal of Respiratory and Critical Care Medicine




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September 15 Highlight

doi : 10.1164/rccm.2066Pxix   

Volume 206, Issue 6 | September 15 2022

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Bronchoscopic Lung Volume Reduction: To the Heart of the Matter

Justin L. Garner 1,2 and Pallav L. Shah 1,2,3

doi : 10.1164/rccm.202206-1026ED  

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The Serpin-tine Search for Factors Associated with COVID-19 Severity in Patients with Chronic Obstructive Pulmonary Disease

Aaron Scott 1, Sinéad Weldon 2, and Clifford C. Taggart 2

doi : 10.1164/rccm.202205-0956ED

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Outcomes from COVID-19 Clinical Trials in Hospitalized Patients: Seeking the Truth That Matters

David M. Griffith and Timothy S. Walsh

doi : 10.1164/rccm.202205-0907ED

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Anabolic Resistance: An Uncomfortable Truth for Clinical Trials in Preventing Intensive Care–acquired Weakness and Physical Functional Impairment

Zudin Puthucheary 1,2 and Olav Rooyackers 3

doi : 10.1164/rccm.202206-1059ED  

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The Long-Term Respiratory Perils of War

Kerri A. Johannson 1,2,3 and Mark J. Utell 4,5

doi : 10.1164/rccm.202206-1064ED  

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Of Registries and Disease Classification: Unmasking the Challenges of Pediatric Pulmonary Hypertension

Steven H. Abman 1 and Mary P. Mullen 2,3

doi : 10.1164/rccm.202206-1180ED  

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Continuous Positive Airway Pressure and Cardiovascular Risk Reduction in Patients without Excessive Sleepiness: Importance of the Pulse Rate Response

Sushmita Pamidi 1 and Neomi Shah 2

doi : 10.1164/rccm.202206-1050ED   

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Be the Change: Advancing Lung Health and Closing the Global Healthcare Gap

Gregory P. Downey 1,2, M. Patricia Rivera 3,4, Lynn Schnapp 5, Irina Petrache 6,7, Jesse Roman 8, and Karen Collishaw 9

doi : 10.1164/rccm.202207-1423ED  

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Lung Health for All: Chronic Obstructive Lung Disease and World Lung Day 2022

David M. G. Halpin 1, Claus F. Vogelmeier 2, and Alvar Agusti 3; for the Global Initiative for Chronic Obstructive Lung Disease

doi : 10.1164/rccm.202207-1407ED

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Palliative Care Early in the Care Continuum among Patients with Serious Respiratory Illness: An Official ATS/AAHPM/HPNA/SWHPN Policy Statement

Donald R. Sullivan , Anand S. Iyer , Susan Enguidanos , Christopher E. Cox , Morag Farquhar , Daisy J. A. Janssen , Kathleen O. Lindell , Richard A. Mularski , Natasha Smallwood , Alison E. Turnbull , Anne M. Wilkinson , Katherine R. Courtright , Matthew Maddocks , Mary Lynn McPherson , J. Daryl Thornton , Margaret L. Campbell , Tracy K. Fasolino , Patricia M. Fogelman , Larry Gershon , Thayer Gershon , Christiane Hartog , Judy Luther , Diane E. Meier , Judith E. Nelson , Elliot Rabinowitz , Cynda H. Rushton , Danetta H. Sloan , Erin K. Kross *, and Lynn F. Reinke *;

doi : 10.1164/rccm.202207-1262ST

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Susceptibility of Patients with Airway Disease to SARS-CoV-2 Infection

Francesca M. Conway 1,2,3, Chloe I. Bloom 3, and Pallav L. Shah 1,2,3

doi : 10.1164/rccm.202111-2547PP  

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Reduction of Lung Hyperinflation Improves Cardiac Preload, Contractility, and Output in Emphysema: A Clinical Trial in Patients Who Received Endobronchial Valves

Marieke C. van der Molen 1,2, Jorine E. Hartman 1,2, Lowie E. G. W. Vanfleteren 3,4, Huib A. M. Kerstjens 1,2, Joost P. van Melle 5, Tineke P. Willems 6, and Dirk-Jan Slebos 1,2

doi : 10.1164/rccm.202201-0214OC

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Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing

Matt D. Johansen 1, Rashad M. Mahbub 1, Sobia Idrees 1, Duc H. Nguyen 1, Stefan Miemczyk 1, Prabuddha Pathinayake 2, Kristy Nichol 2, Nicole G. Hansbro 1, Linden J. Gearing 3, Paul J. Hertzog 3, David Gallego-Ortega 4,5,6, Warwick J. Britton 7, Bernadette M. Saunders 1, Peter A. Wark 2*, Alen Faiz 1*, and Philip M. Hansbro 1,2*

doi : 10.1164/rccm.202108-1901OC   

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Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery

David J. Douin 1, Lianne Siegel 2, Greg Grandits 2, Andrew Phillips 3, Neil R. Aggarwal 4, Jason Baker 5,6, Samuel M. Brown 7,8, Christina C. Chang 9, Anna L. Goodman 10,11, Birgit Grund 12, Elizabeth S. Higgs 13, Catherine L. Hough 14, Daniel D. Murray 15,16, Roger Paredes 17,18, Mahesh Parmar 19, Sarah Pett 19, Mark N. Polizzotto 9,19, Uriel Sandkovsky 20, Wesley H. Self 21,22, Barnaby E. Young 23,24,25, Abdel G. Babiker 19, Victoria J. Davey 26, Virginia Kan 27, Annetine C. Gelijns 28, Gail Matthews 9, B. Taylor Thompson 29, H. Clifford Lane 13, James D. Neaton 2, Jens D. Lundgren 15,16, and Adit A. Ginde 30;

doi : 10.1164/rccm.202112-2836OC

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Muscle Protein Synthesis after Protein Administration in Critical Illness

Lee-anne S. Chapple 1,2,3, Imre W. K. Kouw 1,2,3,4, Matthew J. Summers 1,2, Luke M. Weinel 1,2, Samuel Gluck 1,2, Eamon Raith 1,2, Peter Slobodian 5, Stijn Soenen 3,6, Adam M. Deane 7, Luc J. C. van Loon 4, and Marianne J. Chapman 1,2,3

doi : 10.1164/rccm.202112-2780OC

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Agent Orange Exposure and Risk of Idiopathic Pulmonary Fibrosis among U.S. Veterans

Bhavika Kaul 1,2, Joyce S. Lee 3, David V. Glidden 4, Paul D. Blanc 1, Ning Zhang 2, Harold R. Collard 1, and Mary A. Whooley 1,2,4

doi : 10.1164/rccm.202112-2724OC

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Twenty-Year Experience and Outcomes in a National Pediatric Pulmonary Hypertension Service

Andrew Constantine 1,2,3, Konstantinos Dimopoulos 2,3, Sheila G. Haworth 1,4†, Vivek Muthurangu 4, and Shahin Moledina 1,4

doi : 10.1164/rccm.202110-2428OC  

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Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness

Ali Azarbarzin 1, Andrey Zinchuk 2, Andrew Wellman 1, Gonzalo Labarca 1, Daniel Vena 1, Laura Gell 1, Ludovico Messineo 1,3, David P. White 1, Daniel J. Gottlieb 1,4, Susan Redline 1, Yüksel Peker 1,5,6,7,8*, and Scott A. Sands 1*

doi : 10.1164/rccm.202111-2608OC

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Diffuse Decreased Blood Flow in the Right Lung: Mitral Regurgitation-induced Pulmonary Hypertension

Akihito Okazaki 1,2, Keiko Kinuya 3, and Manabu Fujimoto 4

doi : 10.1164/rccm.202110-2339IM

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Four-Dimensional Computed Tomography of Paradoxical Motion of Eventrated Diaphragm Induced by Reverse Triggering

Ken Tonai , Shinshu Katayama , Kansuke Koyama , and Shin Nunomiya

doi : 10.1164/rccm.202201-0120IM

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One-Year Outcomes of Mechanically Ventilated COVID-19 ICU Survivors: A Prospective Cohort Study

Julia L. M. Bels 1,2*, Rob J. J. van Gassel 1,2, Lieneke Timmerman 1, Bena Hemmen 1,2,3, Marcel C. G. van de Poll 1,2, Nicky H. G. M. Peters 1, Martijn A. Spruit 1,2,4, Susanne van Santen 1, Hester A. Gietema 1,2‡, and Rein Posthuma 1,2,4‡

doi : 10.1164/rccm.202112-2789LE

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Allergen Immunotherapy Reverses Immune Response to SARS-CoV-2 Vaccine in Patients with Allergic Rhinitis: A Prospective Observational Trial

Yin Yao 1*, Ao Huang 1*, Yi-Ke Deng 1*, Yan Liu 1, Hong-Yu Zhu 1, Nan Wang 1, Zhe-Zheng Wang 1, Rong-Fei Zhu 1, Di Yu 2, and Zheng Liu 1‡

doi : 10.1164/rccm.202203-0608LE

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Effect of a Transitional Care Intervention on Rehospitalization and Mortality after Sepsis: A 12-Month Follow-up of a Randomized Clinical Trial

Marc A. Kowalkowski *, Aleta Rios , Joan McSweeney , Stephanie Murphy , Andrew McWilliams , Shih-Hsiung Chou , Timothy Hetherington , Whitney Rossman , and Stephanie P. Taylor

doi : 10.1164/rccm.202203-0590LE

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The Severity of Functional Small Airway Disease in Military Personnel with Constrictive Bronchiolitis as Measured by Quantitative Computed Tomography

Caroline W. Davis 1, Camden L. Lopez 1, Alexander J. Bell 1, Robert F. Miller 2, Alexander S. Rabin 1,3, Susan Murray 1, Michael J. Falvo 4,5, MeiLan K. Han 1, Craig J. Galban 1, and John J. Osterholzer 1,3,*

doi : 10.1164/rccm.202201-0153LE

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U.S. Occupational Historical Perspective on Race and Lung Function

Mary C. Townsend 1,2* and Clayton T. Cowl 3

doi : 10.1164/rccm.202203-0565LE

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Race/Ethnicity and Reference Equations for Spirometry

Martin R. Miller 1*, Brian L. Graham 2, and Bruce R. Thompson 3

doi : 10.1164/rccm.202201-0197LE  

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Reply by Elmaleh-Sachs et al. to Townsend and Cowl, and to Miller et al.

Arielle Elmaleh-Sachs 1, Pallavi Balte 1, Elizabeth C. Oelsner 1, Norrina B. Allen 2, Aaron Baugh 3, Alain G. Bertoni 4, John L. Hankinson 5, James S. Pankow 6, Wendy S. Post 7, Joseph E. Schwartz 8, Benjamin M. Smith 1, Karol Watson 9, and R. Graham Barr 1*

doi : 10.1164/rccm.202204-0628LE

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Reply by McCormack et al. to Townsend and Cowl, and to Miller et al.

Meredith McCormack 1*, Aparna Balasubramanian 1, Robert A. Wise 1, Corinne A. Keet 1, Elizabeth C. Matsui 2, and Roger D. Peng 3

doi : 10.1164/rccm.202202-0378LE

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Reply to Townsend and Cowl

Aaron D. Baugh *, Neeta Thakur , and Prescott G. Woodruff

doi : 10.1164/rccm.202204-0655LE

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Genetic Ancestry Has the Same Major Problems as Phenotypic Ancestry

Peter Burney

doi : 10.1164/rccm.202204-0702LE  

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Finite Element Modeling of Pulmonary Mechanics in Severe Acute Respiratory Distress Syndrome: Explaining the Inclination Angle?

Eline Oppersma 1*, Stijn Geraats 1, Nicolien H. Heikens 1, Arjen Welleweerd 1, Chiel A. Woerts 1, Libera Fresiello 1, Christiaan L. Meuwese 2, and Dirk W. Donker 1,3

doi : 10.1164/rccm.202205-0931LE

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Reply to Oppersma et al.

Francesco Marrazzo 1, Stefano Spina 1, Roberto Fumagalli 1,2, and Thomas Langer 1,2*

doi : 10.1164/rccm.202205-0987LE

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Erratum: Optimizing the Design of Latent Tuberculosis Treatment Trials: Insights from Mathematical Modeling

doi : 10.1164/rccm.v206erratum8

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Erratum: Anti-Granulocyte–Macrophage Colony–Stimulating Factor Monoclonal Antibody Gimsilumab for COVID-19 Pneumonia: A Randomized, Double-Blind, Placebo-controlled Trial

doi : 10.1164/rccm.v206erratum9

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