American Journal of Respiratory and Critical Care Medicine




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September 1 Highlight

doi : 10.1164/rccm.2065Pxvi

Volume 206, Issue 5 | September 1 2022

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Type 2 or Non–Type 2 Asthma Exacerbations? That Is the Question

Andi Hudler , Fernando Holguin , and Sunita Sharma

doi : 10.1164/rccm.202205-0857ED

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Is It Time to Abandon the Postbronchodilator Requirement in Defining Chronic Obstructive Pulmonary Disease?

David M. Mannino 1,2

doi : 10.1164/rccm.202204-0802ED  

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The Clinical Spectrum of PRISm

Emily S. Wan 1,2

doi : 10.1164/rccm.202205-0965ED

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Double Jeopardy: Precapillary Pulmonary Hypertension Increases the Risk of Hospitalization and Death from COVID-19

George A. Alba

doi : 10.1164/rccm.202205-0884ED   

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Calcineurin Inhibitors in Lung Donors to Attenuate Ischemia–Reperfusion Injury in Recipients: Next Steps?

Dmitry Rozenberg 1,2,3 and Maureen O. Meade 4

doi : 10.1164/rccm.202205-0840ED

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From Biomarker to Mechanism? F2-isoprostanes in Pulmonary Fibrosis

Thomas H. Thatcher 1 and Marc Peters-Golden 2

doi : 10.1164/rccm.202205-0914ED   

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Misbehaving Guests in the Right Ventricle: Macrophage–NLRP3 Activation in Pulmonary Hypertension

Rafael Sobrano Fais 1 and Tim Lahm 1,2,3

doi : 10.1164/rccm.202205-0977ED

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Therapeutic Targeting of the Respiratory Microbiome

Sanjay H. Chotirmall 1,2, Debby Bogaert 3,4, James D. Chalmers 5, Michael J. Cox 6, Philip M. Hansbro 7,8, Yvonne J. Huang 9,10, Philip L. Molyneaux 11, David N. O’Dwyer 9, Alexa A. Pragman 12,13, Geraint B. Rogers 14,15, Leopoldo N. Segal 16, and Robert P. Dickson 9,10,17

doi : 10.1164/rccm.202112-2704PP  

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Exacerbation Profile and Risk Factors in a Type-2–Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes

P. Jane McDowell 1, John Busby 1, Catherine E. Hanratty 1, Ratko Djukanovic 2, Ashley Woodcock 3, Samantha Walker 4, Timothy Colin Hardman 5, Joseph R. Arron 6, David F. Choy 6, Peter Bradding 7, Chris E. Brightling 7, Rekha Chaudhuri 8, Douglas Cowan 9, Adel H. Mansur 10, Stephen J. Fowler 3, Sarah E. Diver 7, Peter Howarth 2, James Lordan 11, Andrew Menzies-Gow 12, Timothy Harrison 13, Douglas S. Robinson 14, Cecile T. J. Holweg 6, John G. Matthews 15, Ian D. Pavord 16, and Liam G. Heaney 1;

doi : 10.1164/rccm.202201-0129OC

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Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study

Russell G. Buhr 1,2, Igor Z. Barjaktarevic 1, P. Miguel Quibrera 3, Lori A. Bateman 3, Eugene R. Bleecker 4, David J. Couper 3, Jeffrey L. Curtis 5,6, Brett A. Dolezal 1, MeiLan K. Han 5, Nadia N. Hansel 7, Jerry A. Krishnan 8, Fernando J. Martinez 9, William McKleroy 10, Robert Paine III11,12, Stephen I. Rennard 13, Donald P. Tashkin 1, Prescott G. Woodruff 10, Richard E. Kanner 11*, and Christopher B. Cooper 1,14*;

doi : 10.1164/rccm.202201-0094OC  

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Risks of Mortality and Airflow Limitation in Japanese Individuals with Preserved Ratio Impaired Spirometry

Yasuyoshi Washio 1,2, Satoko Sakata 2,3,4, Satoru Fukuyama 1, Takanori Honda 2, Keiko Kan-o 1, Mao Shibata 2,3, Jun Hata 2,3,4, Hiromasa Inoue 5, Takanari Kitazono 3,4, Koichiro Matsumoto 1, and Toshiharu Ninomiya 2,3

doi : 10.1164/rccm.202110-2302OC     

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COVID-19 in Patients with Pulmonary Hypertension: A National Prospective Cohort Study

David Montani 1,2,3, Marie-Caroline Certain 1,2,3, Jason Weatherald 4,5, Xavier Jaïs 1,2,3, Sophie Bulifon 1,2,3, Elise Noel-Savina 6, Ana Nieves 7, Sébastien Renard 8, Julie Traclet 9, Hélène Bouvaist 10, Marianne Riou 11, Pascal de Groote 12, Pamela Moceri 13, Laurent Bertoletti 14, Nicolas Favrolt 15, Anne Guillaumot 16, Etienne-Marie Jutant 17, Antoine Beurnier 1,2,18, Athénaïs Boucly 1,2,3, Nathan Ebstein 1,2,3, Mitja Jevnikar 1,2,3, Jérémie Pichon 1,2,3, Sophia Keddache 1,2,3, Mariana Preda 1,2,3, Anne Roche 1,2,3, Sabina Solinas 1,2,3, Andrei Seferian 1,2,3, Martine Reynaud-Gaubert 7, Vincent Cottin 9, Laurent Savale 1,2,3, Marc Humbert 1,2,3*, Olivier Sitbon 1,2,3*, and French PH Network PULMOTENSION Investigators

doi : 10.1164/rccm.202112-2761OC

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Tacrolimus Prevents Mechanical and Humoral Alterations in Brain Death–induced Lung Injury in Pigs

Asmae Belhaj 1,2*, Laurence Dewachter 2*, Emeline Hupkens 2, Myriam Remmelink 3, Laurence Galanti 4, Sandrine Rorive 3, Christian Melot 2, Robert Naeije 2, and Benoît Rondelet 1,2

doi : 10.1164/rccm.202201-0033OC

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Thromboxane–Prostanoid Receptor Signaling Drives Persistent Fibroblast Activation in Pulmonary Fibrosis

Toshio Suzuki 1,2, Jonathan A. Kropski 1,3,4, Jingyuan Chen 1, Erica J. Carrier 1, Xinping Chen 1, Taylor P. Sherrill 1, Nichelle I. Winters 1, Jane E. Camarata 1, Vasiliy V. Polosukhin 1, Wei Han 1, Anandharajan Rathinasabapathy 1, Sergey Gutor 1, Peter Gulleman 1, Carleen Sabusap 1, Nicholas E. Banovich 5, Harikrishna Tanjore 1, Michael L. Freeman 6, Yuji Tada 7, Lisa R. Young 1,8, Jason J. Gokey 1, Timothy S. Blackwell 1,3,4*, and James D. West 1*

doi : 10.1164/rccm.202106-1503OC

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Macrophage–NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension

Ruaa Al-Qazazi 1*, Patricia D. A. Lima 1,2*, Sasha Z. Prisco 3, Francois Potus 1,4, Asish Dasgupta 1, Kuang-Hueih Chen 1, Lian Tian 1,5, Rachel E. T. Bentley 1, Jeff Mewburn 1, Ashley Y. Martin 1, Danchen Wu 1, Oliver Jones 2, Donald H. Maurice 6, Sebastien Bonnet 4, Steeve Provencher 4, Kurt W. Prins 3, and Stephen L. Archer 1,2

doi : 10.1164/rccm.202110-2274OC

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Congested: A Clinical Presentation of the Inferior Caval Vein Syndrome

Koen H. J. Bos 1,2, Marcel J. H. Ariës 1, Christiaan van der Leij 3, and Samuel Heuts 4

doi : 10.1164/rccm.202201-0118IM

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Virtual Bronchoscopy of Neonatal Airway Malacia via High-Resolution, Respiratory-gated Magnetic Resonance Imaging

Nara S. Higano 1,2,3,4, Deep B. Gandhi 3, Qiwei Xiao 1, Chamindu C. Gunatilaka 1, Erik B. Hysinger 1,2,4, Robert J. Fleck 3,4, Jason C. Woods 1,2,3,4, and Alister J. Bates 1,2,3,4

doi : 10.1164/rccm.202202-0362IM

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Predicting Mortality for Patients Eligible for Extracorporeal Membrane Oxygenation for COVID-19

Whitney D. Gannon 1*, John W. Stokes 1, Wu Gong 1, Christopher J. Lindsell 1, Joseph E. Tonna 2, Matthew Bacchetta 1, Todd W. Rice 1, Matthew W. Semler 1, and Jonathan D. Casey 1

doi : 10.1164/rccm.202202-0237LE  

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Obstructive Sleep Apnea and Hypertension with Longitudinal Amyloid-β Burden and Cognitive Changes

Omonigho M. Bubu 1*‡, Sonya S. Kaur 2, Alfred K. Mbah 3, Ogie Q. Umasabor-Bubu 4, Jaime Ramos Cejudo 1, Ludovic Debure 1, Anna E. Mullins 5, Ankit Parekh 5, Korey Kam 5, Zainab T. Osakwe 6, Ellita T. Williams 1, Arlener D. Turner 2, Lidia Glodzik 8, David M. Rapoport 5, Gbenga Ogedegbe 1, Els Fieremans 1, Mony J. de Leon 8, Indu Ayappa 5, Girardin Jean-Louis 1,2, Arjun V. Masurkar 1, Andrew W. Varga 5‡, and Ricardo S. Osorio 1,9‡

doi : 10.1164/rccm.202201-0107LE

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Gas Exchange and Respiratory Mechanics after a Cardiac Arrest: A Clinical Description of Cardiopulmonary Resuscitation–associated Lung Edema

François M. Beloncle 1,2,3*, Hamid Merdji 4,5, Arnaud Lesimple 2,3,6, Bertrand Pavlovsky 1,2 , Elise Yvin 1,2, Dominique Savary 1,2, Alain Mercat 1,2, Ferhat Meziani 4,5, and Jean-Christophe Richard 1,2,6

doi : 10.1164/rccm.202111-2644LE

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Decline in Prolonged Acute Mechanical Ventilation, 2011–2019

Anica C. Law 1,2*, Wei Tian 2, Yang Song 2, Jennifer P. Stevens 2, and Allan J. Walkey 1,3

doi : 10.1164/rccm.202203-0473LE  

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SARS-CoV-2 mRNA Vaccine Antibody Response in Patients with Asthma Receiving Biologic Therapy: A Real-World Analysis

Shu-Yi Liao , Anthony N. Gerber , Pearlanne Zelarney , Barry Make , and Michael E. Wechsler *

doi : 10.1164/rccm.202203-0599LE  

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Reply to Liao et al.: SARS-CoV-2 mRNA Vaccine Antibody Response in Patients with Asthma Receiving Biologic Therapy: A Real-World Analysis

Martin C. Runnstrom and F. Eun-Hyung Lee *

doi : 10.1164/rccm.202205-0979LE

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The Need for a CYFRA 21-1 Cutoff Value to Predict Clinical Progression of IPF in Clinical Practice

Hajime Fujimoto , Corina N. D’Alessandro-Gabazza , Taro Yasuma , Tetsu Kobayashi , and Esteban C. Gabazza *

doi : 10.1164/rccm.202204-0708LE

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Reply to Fujimoto et al.: The Need for a CYFRA 21-1 Cutoff Value to Predict Clinical Progression of IPF in Clinical Practice

Philip L. Molyneaux 1,2 and Toby M. Maher

doi : 10.1164/rccm.202205-0835LE

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Remote 6-minute-Walk Testing in Patients with Pulmonary Hypertension: Further Validation Needed?

Scott A. Helgeson , Charles D. Burger , John E. Moss , Tonya K. Zeiger , and Bryan J. Taylor *

doi : 10.1164/rccm.202204-0762LE

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Reply to Helgeson et al.: Remote 6-minute-Walk Testing in Patients with Pulmonary Hypertension: Further Validation Needed?

Tess LaPatra 1, Grayson L. Baird 2,3, Randi Goodman 1, Diane Pinder 1, Maeve Gaffney 3, James R. Klinger 3, Harold I. Palevsky 1, Jason Fritz 1, Christopher J. Mullin 3, Jeremy A. Mazurek 1, Steven M. Kawut 1, and Corey E. Ventetuolo 3*

doi : 10.1164/rccm.202205-0867LE

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Erratum: The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality

doi : 10.1164/rccm.v206erratum5

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Erratum: Comparison of 6-Month Outcomes of Survivors of COVID-19 versus Non–COVID-19 Critical Illness

doi : 10.1164/rccm.v206erratum7  

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