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Establishing a method to estimate the effect of antimyopia management options on lifetime cost of myopia
Tim R Fricke, Padmaja Sankaridurg, Thomas Naduvilath, Serge Resnikoff, Nina Tahhan, Mingguang He, Kevin D Frick
doi : 10.1136/bjophthalmol-2021-320318
Background Informed decisions on myopia management require an understanding of financial impact. We describe methodology for estimating lifetime myopia costs, with comparison across management options, using exemplars in Australia and China.
Ocular morbidity in Marfan syndrome: a nationwide epidemiological study
Sia Kjeldsen, Niels Andersen, Kristian Groth, Dorte Larsen, Jesper Hjortdal, Agnethe Berglund, Claus Gravholt, Kirstine Stochholm
doi : 10.1136/bjophthalmol-2021-320871
Background Ophthalmic complications are profound in Marfan syndrome (MFS). However, the overall burden is not well described. Our purpose was to evaluate the ocular morbidity in a nationwide perspective.
Real-world visual outcomes of cataract surgery based on population-based studies: a systematic review
Xiaotong Han, Jiaqing Zhang, Zhenzhen Liu, Xuhua Tan, Guangming Jin, Mingguang He, Lixia Luo, Yizhi Liu
doi : 10.1136/bjophthalmol-2021-320997
Background/aims Quantity of cataract surgery has long been an important public health indicator to assess health accessibility, however the quality of care has been less investigated. We aimed to summarise the up-to-date evidences to assess the real-world visual outcomes after cataract surgery in different settings.
Evaluation of the Nallasamy formula: a stacking ensemble machine learning method for refraction prediction in cataract surgery
Tingyang Li, Joshua Stein, Nambi Nallasamy
doi : 10.1136/bjophthalmol-2021-320599
Aims To develop a new intraocular lens power selection method with improved accuracy for general cataract patients receiving Alcon SN60WF lenses.
Predictors of long-term intraocular pressure control after lens extraction in primary angle closure glaucoma: results from the EAGLE trial
William G Mitchell, Augusto Azuara-Blanco, Paul J Foster, Omar Halawa, Jennifer Burr, Craig R Ramsay, David Cooper, Claire Cochran, John Norrie, David Friedman, Dolly Chang
doi : 10.1136/bjophthalmol-2021-319765
Background/aims To assess baseline ocular parameters in the prediction of long-term intraocular pressure (IOP) control after clear lens extraction (CLE) or laser peripheral iridotomy (LPI) in patients with primary angle closure (PAC) disease using data from the Effectiveness of Early Lens Extraction for the treatment of primary angle-closure glaucoma (EAGLE) tria.
Factors associated with glaucoma-specific quality of life in a US glaucoma clinic in a pilot implementation of an online computerised adaptive test (GlauCAT)
Omar A Halawa, Ana M Roldan, Ryan S Meshkin, Nazlee Zebardast, Eva K Fenwick, Ecosse Luc Lamoureux, David S Friedman
doi : 10.1136/bjophthalmol-2022-321145
Objectives Measure quality of life (QoL) outcomes using a novel computerised adaptive test in a clinical setting, and determine the social and demographic factors associated with specific QoL domains in patients with glaucoma.
Development and validation of the 40-item Glaucoma Visual Functioning Questionnaire
Haishun Huang, Junxiong Lin, Man Luo, Zhidong Li, Yingting Zhu, Jiaxu Han, Ling Jin, Yiqing Li, Yehong Zhuo
doi : 10.1136/bjophthalmol-2021-320985
Aims To evaluate the psychometric properties of a newly designed questionnaire, the 40-item Glaucoma Visual Functioning Questionnaire (GVFQ-40), in a Chinese sample to capture the visual ability of patients with glaucomatous vision impairment in five domains.
Clinical outcomes of penetrating canaloplasty in patients with traumatic angle recession glaucoma: a prospective interventional case series
Huanhuan Cheng, Wenqing Ye, Shaodan Zhang, Yanqian Xie, Juan Gu, Rongrong Le, Yuxuan Deng, Cheng Hu, Zhenquan Zhao, Zhisheng Ke, Yuanbo Liang
doi : 10.1136/bjophthalmol-2021-320659
Background/aim To evaluate the clinical outcomes of penetrating canaloplasty in traumatic angle recession glaucoma at 1 year.
Telemetric non-contact intraocular pressure monitoring with an implanted sensor in patients with glaucoma: long-term safety report and monitoring data
Ilka Schmidt, Niklas Plange, Peter Walter, Antonis Koutsonas
doi : 10.1136/bjophthalmol-2021-319786
Background/aims Glaucoma is a chronic disease that requires lifelong monitoring and treatment. However, its control is limited due to discontinuous intraocular pressure (IOP) monitoring related to the practitioners’ office hours. Implantable telemetric IOP sensors have made self-measurements possible and provide important information regarding the IOP profiles of patients. However, limited long-term monitoring data are currently available.
One-year surgical outcomes of the PreserFlo MicroShunt in glaucoma: a multicentre analysis
Alexander Tanner, Fadi Haddad, Julia Fajardo-Sanchez, Ethan Nguyen, Kai Xin Thong, Sarah Ah-Moye, Nicole Perl, Mohammed Abu-Bakra, Avinash Kulkarni, Sameer Trikha, Gerassimos Lascaratos, Miles Parnell, Obeda Kailani, Anthony J King, Pavi Agrawal, Richard Stead, Konstantinos Giannouladis, Ian Rodrigues, Saurabh Goyal, Pirro G Hysi, Sheng Lim, Cynthia Yu-Wai-Man
doi : 10.1136/bjophthalmol-2021-320631
Background/aims To evaluate the efficacy and safety of the PreserFlo MicroShunt glaucoma device in a multicentre cohort study.
Background polygenic risk modulates the association between glaucoma and cardiopulmonary diseases and measures: an analysis from the UK Biobank
Ajay Kolli, Sayuri Sekimitsu, Jiali Wang, Ayellet Segre, David Friedman, Tobias Elze, Louis R Pasquale, Janey Wiggs, Nazlee Zebardast
doi : 10.1136/bjophthalmol-2021-320305
Aims To assess whether associations of cardiopulmonary conditions and markers with glaucoma differ by background genetic risk for primary open angle glaucoma (POAG).
Changes in glaucoma management following visual field testing and optical coherence tomography
Michelle T. Sun, Kuldev Singh, Sophia Y. Wang
doi : 10.1136/bjophthalmol-2021-321010
Background Optimal utilisation of investigations in glaucoma management remains unclear. We aimed to assess whether a temporal association exists between such testing and management changes.
Ocular geometry in adults born extremely, very and moderately preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Eye Study
Achim Fieß, Hannah Nauen, Eva Mildenberger, Fred Zepp, Michael S Urschitz, Norbert Pfeiffer, Alexander Karl-Georg Schuster
doi : 10.1136/bjophthalmol-2021-320907
Background/aims To evaluate whether anterior segment anatomy and axial length are associated with prematurity and perinatal factors in adults.
Validation of DIGIROP models and decision support tool for prediction of treatment for retinopathy of prematurity on a contemporary Swedish cohort
Aldina Pivodic, Lois E.H. Smith, Anna-Lena Hård, Chatarina Löfqvist, Ana Catarina Almeida, Abbas Al-Hawasi, Eva Larsson, Pia Lundgren, Birgitta Sunnqvist, Kristina Tornqvist, Agneta Wallin, Gerd Holmstrom, Lotta Gränse
doi : 10.1136/bjophthalmol-2021-320738
Background/Aims Retinopathy of prematurity (ROP) is currently diagnosed through repeated eye examinations to find the low percentage of infants that fulfil treatment criteria to reduce vision loss.
Quantitative contrast sensitivity test to assess visual function in central serous chorioretinopathy
Filippos Vingopoulos, Itika Garg, Esther Lee Kim, Merina Thomas, Rebecca F Silverman, Megan Kasetty, Zakariyya Y Hassan, Gina Yu, Katherine Joltikov, Eun Young Choi, Inês LaÃns, Leo A Kim, David N Zacks, John B Miller
doi : 10.1136/bjophthalmol-2021-320415
Background To characterise the contrast sensitivity function (CSF) in central serous chorioretinopathy (CSCR) compared with healthy controls using novel computerised contrast sensitivity (CS) testing with active learning algorithms.
Disease-specific assessment of Vision Impairment in Low Luminance in age-related macular degeneration – a MACUSTAR study report
Jan Henrik Terheyden, Susanne G Pondorfer, Charlotte Behning, Moritz Berger, Jill Carlton, Donna Rowen, Christine Bouchet, Stephen Poor, Ulrich F O Luhmann, Sergio Leal, Frank G Holz, Thomas Butt, John E Brazier, Robert P Finger
doi : 10.1136/bjophthalmol-2021-320848
Background/aims To further validate the Vision Impairment in Low Luminance (VILL) questionnaire, which captures visual functioning and vision-related quality of life (VRQoL) under low luminance, low-contrast conditions relevant to age-related macular degeneration (AMD).
NDP-related retinopathies: clinical phenotype of female carriers
Li Huang, Limei Sun, Xiaoyu Li, Songshan Li, Ting Zhang, Zhaotian Zhang, Xiaoyan Ding
doi : 10.1136/bjophthalmol-2021-320084
Background/aims Norrin cysteine knot growth factor (NDP) located on the X chromosome, was previously reported to cause Norrie disease and familial exudative vitreoretinopathy (FEVR), which are blindness-causing ocular disorders, in males. In this study, we aimed to explore the clinical characteristics of female carriers with NDP mutations.
Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study: the Handan Eye Study
Jian Wu, Yifan Du, Caixia Lin, Yingting Zhu, Wei Chen, Qing Pan, Yehong Zhuo, Ningli Wang
doi : 10.1136/bjophthalmol-2021-320618
Purpose To examine the normative profile of retinal nerve fibre layer (RNFL) thickness and ocular parameters based on spectral-domain optical coherence tomography (SD-OCT) and its associations with related parameters among the Chinese population.
Change of peripapillary retinal nerve fiber layer and choroidal thickness during 4-year myopic progress: Boramae Myopia Cohort Study Report 4
Martha Kim, Kyoung Min Lee, Ho-Kyung Choung, Sohee Oh, Seok Hwan Kim
doi : 10.1136/bjophthalmol-2021-320596
Aims To investigate the longitudinal changes of peripapillary retinal nerve fibre layer (RNFL) and choroidal thickness during myopic axial elongation.
Quantitative evaluation of retinal and choroidal vascularity and retrobulbar blood flow in patients with myopic anisometropia by CDI and OCTA
Fang Liu, Lingling Niu, Jie Guo, Weijun Jian, Jianmin Shang, Jing Zhao, Kang Xue, Xingtao Zhou
doi : 10.1136/bjophthalmol-2021-320597
Aims To investigate the association between the myopic severity and retinal microvascular density, choroidal vascularity and retrobulbar blood flow in adult anisomyopes.
Prevalence and causes of visual impairment and blindness in Lao People’s Democratic Republic: the Vientiane Eye Study
Yiran Tan, Brad Guo, Stephen Nygaard, Cesar Carillo, Huy-Dat Pham, Kham Od Nouansavanh, Kitar Souksamone, Robert J Casson
doi : 10.1136/bjophthalmol-2021-320127
Aims To determine the prevalence and causes of visual impairment and blindness in Vientiane Province, the Lao People’s Democratic Republic (Lao PDR).
Barriers to uptake of referral eye care services among the elderly in residential care: the Hyderabad Ocular Morbidity in Elderly Study (HOMES)
Srinivas Marmamula, Thirupathi Reddy Kumbham, Satya Brahmanandam Modepalli, Subhabrata Chakrabarti, Jill Elizabeth Keeffe
doi : 10.1136/bjophthalmol-2021-320534
Background To report on the barriers to uptake of eye care services after referral in the elderly in ‘homes for the aged’ in Hyderabad, India.
Incidence, causes and risk factors of vision loss in rural Southern China: 6-year follow-up of the Yangxi Eye Study
Xinyu Zhao, Jianqiang Lin, Shanshan Yu, Liqiong Xie, Ling Jin, Kun Xiong, Ching-Kit Tsui, Yue Xu, Benjuan Wu, Bin Liu, Wei Wang, Nathan Congdon, Wenyong Huang, Mingguang He, Xiaoling Liang
doi : 10.1136/bjophthalmol-2021-320892
Purpose To report the 6-year incidence, causes and risk factors for vision loss (visual impairment (VI) and blindness), among elderly adults in rural southern China.
Utilisation of composite endpoint outcome to assess efficacy of tocilizumab for non-infectious uveitis in the STOP-Uveitis Study
Muhammad Hassan, Mohammad Ali Sadiq, Maria Soledad Ormaechea, Günay Uludağ, Muhammad Sohail Halim, Rubbia Afridi, Diana V Do, Yasir Jamal Sepah, Quan Dong Nguyen
doi : 10.1136/bjophthalmol-2021-320604
Background/aims To use a composite endpoint scoring system in assessing efficacy of two doses of intravenous tocilizumab (TCZ), in eyes with non-infectious uveitis.
Abnormal foveal morphology in carriers of oculocutaneous albinism
Helen J Kuht, Mervyn G Thomas, Rebecca J McLean, Viral Sheth, Frank A Proudlock, Irene Gottlob
doi : 10.1136/bjophthalmol-2020-318192
Background/aims To investigate the foveal morphology in carriers of oculocutaneous albinism (OCA) using spectral domain optical coherence tomography (SD-OCT). A cross-sectional, observational study.
Human intrinsic choroidal neurons do not alter the expression of intrinsic markers in response to pressure
Christian Platzl, Alexandra Kaser-Eichberger, Heidi Wolfmeier, Andrea Trost, Falk Schroedl
doi : 10.1136/bjophthalmol-2021-320211
Background The choroid is densely innervated by all parts of the autonomic nervous system and further harbours a network of local nerve cells, the intrinsic choroidal neurons (ICN). Their function in ocular control is currently unknown. While morphological data assume a role in intraocular pressure regulation, we here test if increased pressure on isolated choroids may activate ICN.
Association of SIX1-SIX6 polymorphisms with peripapillary retinal nerve fibre layer thickness in children
Shi Yao Lu, Xiu Juan Zhang, Yu Meng Wang, Nan Yuan, Ka Wai Kam, Poemen P Chan, Pancy OS Tam, Wilson WK Yip, Alvin L Young, Clement C Tham, Chi Pui Pang, Jason C Yam, Li Jia Chen
doi : 10.1136/bjophthalmol-2021-319756
Purpose Association of SIX1-SIX6 variants with peripapillary retinal nerve fibre layer (p-RNFL) thickness had been reported in adults. This study aimed to investigate these associations in children, with further explorations by spatial, age and sex stratifications.
