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Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures
Joshua Ong, William Tarver, Tyson Brunstetter, Thomas Henry Mader, C Robert Gibson, Sara S Mason, Andrew Lee
doi : 10.1136/bjo-2022-322892
Spaceflight associated neuro-ocular syndrome (SANS) refers to a distinct constellation of ocular, neurological and neuroimaging findings observed in astronauts during and following long duration spaceflight. These ocular findings, to include optic disc oedema, posterior globe flattening, chorioretinal folds and hyperopic shifts, were first described by NASA in 2011.Â
Ocular adverse events associated with chimeric antigen receptor T-cell therapy: a case series and review
Aisha A Mumtaz, Andrew Fischer, Forat Lutfi, Lisa R Matsumoto, Djordje Atanackovic, Elif T Kolanci, Kim G Hankey, Nancy M Hardy, Jean A Yared, Mehmet H Kocoglu, Aaron P Rapoport, Saurabh Dahiya, Albert S Li, Sarah Brem Sunshine
doi : 10.1136/bjophthalmol-2021-320814
Background/aims Chimeric antigen receptor T-cell (CAR T) therapy has been shown to improve the remission rate and survival for patients with refractory haematological malignancies. The aim of this study is to describe ocular adverse effects associated with CAR T therapy in patients with haematological malignancies.
Lens capsule-related complications in femtosecond laser-assisted cataract surgery: a study based on video analysis
Wei Wang, Xinyi Chen, Xin Liu, Xiaobo Zhang, Danni Lyu, Ke Yao
doi : 10.1136/bjophthalmol-2021-320842
Purpose To analyse the occurrence and potential causes of lens capsule-related complications during femtosecond laser-assisted cataract surgery (FLACS).
Rethinking presbyopia: results of bilateral refractive lens exchange with trifocal intraocular lenses in 17 603 patients
Luis F Brenner, Kristin Nistad, Urban Schonbeck
doi : 10.1136/bjophthalmol-2021-319732
Purpose To evaluate the safety and effectiveness of bilateral refractive lens exchange (RLE) with trifocal intraocular lens (IOL) as the surgical treatment of presbyopia.
Comparison of long-term astigmatic changes following cataract surgery among types of corneal astigmatism
Ken Hayashi, Hiroshi Sasaki, Akira Hirata, Koichi Yoshimura
doi : 10.1136/bjophthalmol-2021-321026
Aims To examine whether long-term corneal astigmatic changes after stabilisation of surgically induced astigmatism (SIA) following cataract surgery differ among eyes having against-the-rule (ATR), with-the-rule (WTR), and oblique astigmatism.
Angle closure extent, anterior segment dimensions and intraocular pressure
Natalia Porporato, Rachel Chong, Benjamin Y Xu, Tin A Tun, Joanne HuiMin Quah, Marcus Tan, Mani Baskaran, Ching Yu Cheng, Tin Aung
doi : 10.1136/bjophthalmol-2021-320453
Aim To investigate the association between the extent of iridotrabecular contact and other quantitative anterior segment dimensions measured by swept-source optical coherence tomography (SS-OCT; CASIA SS-1000, Tomey, Nagoya, Japan) with intraocular pressure (IOP).
High myopia as risk factor for the 10-year incidence of open-angle glaucoma in the Beijing Eye Study
Ya Xing Wang, Hua Yang, Chuan Chuan Wei, Liang Xu, Wen Bin Wei, Jost B Jonas
doi : 10.1136/bjophthalmol-2021-320644
Purpose To assess the 10-year incidence of open-angle glaucoma (OAG) and its associations in an adult Chinese population.
Measurement of intraocular temperature in glaucoma: week-day and seasonal fluctuations
Kaweh Mansouri, Kevin Gillmann, Harsha Laxmana Rao, Peter Szurman, Robert N Weinreb
doi : 10.1136/bjophthalmol-2021-320495
Purpose To evaluate long-term intraocular temperature (IOT) variations in eyes with primary open-angle glaucoma (POAG) using an intraocular telemetric sensor.
Faster algorithms to measure visual field using the variational Bayes linear regression model in glaucoma: comparison with SITA-Fast
Kazunori Hirasawa, Hiroshi Murata, Satoshi Shimada, Mei Matsuno, Nobuyuki Shoji, Ryo Asaoka
doi : 10.1136/bjophthalmol-2021-320523
Aims To compare the visual field (VF) test results measured with the Swedish Interactive Threshold Algorithm Fast (SITA-Fast) and newly developed variational Bayes linear regression visual field (VBLR-VF) Fast or VBLR-VF Fast+.
Correlation of ganglion cell complex thinning with baseline deep and superficial macular vessel density in glaucoma
Jo-Hsuan Wu, Sasan Moghimi, Takashi Nishida, James A Proudfoot, Alireza Kamalipour, Linda M Zangwill, Robert N Weinreb
doi : 10.1136/bjophthalmol-2021-320663
Background/aims To investigate the relationship between ganglion cell complex (GCC) thinning and baseline deep and superficial macular vessel density (VD) in glaucoma.
Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis
Francesco Pichi, Ester Carreño, Carlos Pavesio, Alastair K Denniston, Dilraj S Grewal, Gabor Deak, Moncef Khairallah, Matilde Ruiz-Cruz, Joao Rafael de Oliveira Dias, Alfredo Adan, Tomas Burke, Alessandro Invernizzi, Ariel Schlaen, Meng Tian, Aniruddha Kishandutt Agarwal, William R Tucker, H Nida Sen, Phoebe Lin, Lyndell L Lim, Kathryn L Pepple, Marion R Munk
doi : 10.1136/bjophthalmol-2021-320021
Background/aims To establish a consensus in the nomenclature for reporting optical coherence tomography angiography (OCTA findings in uveitis.
Quantitative and qualitative assessment of anterior segment optical coherence tomography capture of disease state in childhood anterior uveitis
Katie Etherton, Jugnoo S Rahi, Harry Petrushkin, Andrew D Dick, Saira Akbarali, Reshma Pattani, Scott Hau, Sandrine Lacassagne, Xiaoxuan Liu, Alastair K Denniston, Ameenat Lola Solebo
doi : 10.1136/bjophthalmol-2021-320448
Background/aims Anterior segment optical coherence tomography (AS-OCT) assessment of anterior chamber inflammation is an emerging tool. We describe the performance of AS-OCT in a paediatric population.
Current practice in the management of ocular toxoplasmosis
Kengadhevi Yogeswaran, João M Furtado, Bahram Bodaghi, Janet M Matthews, International Ocular Toxoplasmosis Study Group, Justine R Smith
doi : 10.1136/bjophthalmol-2022-321091
Background Ocular toxoplasmosis is common across all regions of the world. Understanding of the epidemiology and approach to diagnosis and treatment have evolved recently. In November 2020, an international group of uveitis-specialised ophthalmologists formed the International Ocular Toxoplasmosis Study Group to define current practice.
Metformin and risk of age-related macular degeneration in individuals with type 2 diabetes: a retrospective cohort study
Krishna M Gokhale, Nicola J Adderley, Anuradhaa Subramanian, Wen Hwa Lee, Diana Han, Jesse Coker, Tasanee Braithwaite, Alastair K Denniston, Pearse A Keane, Krishnarajah Nirantharakumar
doi : 10.1136/bjophthalmol-2021-319641
Background Age-related macular degeneration (AMD) in its late stages is a leading cause of sight loss in developed countries. Some previous studies have suggested that metformin may be associated with a reduced risk of developing AMD, but the evidence is inconclusive.
Epimacular brachytherapy for previously treated neovascular age-related macular degeneration: month 36 results of the MERLOT randomised controlled trial
Timothy L Jackson, Cristina Soare, Caroline Petrarca, Andrew Simpson, James E Neffendorf, Robert Petrarca, Katherine Alyson Muldrew, Tunde Peto, Usha Chakravarthy, Luke Membrey, Richard Haynes, Mark Costen, David H W Steel, Riti Desai
doi : 10.1136/bjophthalmol-2021-320620
Background/aim To assess the long-term safety and efficacy of epimacular brachytherapy (EMB) for chronic, active, neovascular age-related macular degeneration (nAMD).
Combining retinal and choroidal microvascular metrics improves discriminative power for diabetic retinopathy
Bingyao Tan, Nicole-Ann Lim, Rose Tan, Alfred Tau Liang Gan, Jacqueline Chua, Simon Nusinovici, Chui Ming Gemmy Cheung, Usha Chakravarthy, Tien Yin Wong, Leopold Schmetterer, Gavin Tan
doi : 10.1136/bjophthalmol-2021-319739
Purpose To use optical coherence tomography angiography (OCTA) parameters from both the retinal and choroidal microvasculature to detect the presence and severity of diabetic retinopathy (DR).
Thiazolidinedione use and retinal fluid in the comparison of age-related macular degeneration treatments trials
Jason Q Core, Peiying Hua, Ebenezer Daniel, Juan E Grunwald, Glenn Jaffe, Maureen G Maguire, Gui-shuang Ying
doi : 10.1136/bjophthalmol-2021-320665
Background Thiazolidinediones, commonly used antidiabetic medications, have been associated with an increased risk of development of diabetic macular oedema and increased vascular endothelial cell permeability.
Prediction model to predict type 1 retinopathy of prematurity using gestational age and birth weight (PW-ROP)
Lawrence Pui Leung Iu, Wilson Wai Kuen Yip, Julie Ying Ching Lok, Michelle Ching Yim Fan, Connie Hong Yee Lai, Mary Ho, Alvin Lerrmann Young
doi : 10.1136/bjophthalmol-2021-320670
Purpose To develop a prediction model for type 1 retinopathy of prematurity (ROP) from an Asian population.
Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial
Akshay S Thomas, Luc Duchateau, Petra Kozma-Wiebe, Glenn Jaffe
doi : 10.1136/bjophthalmol-2021-319500
Background/aims To describe the clinical impact of external limiting membrane (ELM) disruption, ellipsoid zone (EZ) disruption and subretinal fluid (SRF) seen on optical coherence tomography (OCT) in eyes with vitreomacular traction (VMT) without macular hole (MH) in the Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole study.
Application of mydriasis and eye steering in ultrawide field imaging for detecting peripheral retinal lesions in myopic patients
Meiyan Li, Danjuan Yang, Yang Shen, Jianmin Shang, Lingling Niu, Yongfu Yu, Xiaoying Wang, Peijun Yao, Xingtao Zhou
doi : 10.1136/bjophthalmol-2021-319809
Purpose To compare mydriatic and eye-steering ultrawide field imaging (UWFI) with standard non-mydriatic UWFI examination in detecting peripheral retinal lesions in myopic patients.
Longitudinal association between visual disability and cognitive function among middle-aged and older adults in China
Ye He, Weitao Song, Xin Jiang, Chao Wang, Yi Zhou, Bing Lu, Minwen Zhou
doi : 10.1136/bjophthalmol-2021-320026
Background/aims To determine the associations between visual disability and cognitive decline in Chinese middle-aged and older adults.
Childhood versus early-teenage onset Leber’s hereditary optic neuropathy: visual prognosis and capacity for recovery
Jakob Siedlecki, Susanna Koenig, Claudia Catarino, Markus M Schaumberger, Benedikt Schworm, Siegfried Georg Priglinger, Guenther Rudolph, Bettina von Livonius, Thomas Klopstock, Claudia S Priglinger
doi : 10.1136/bjophthalmol-2021-320580
Objective In Leber’s hereditary optic neuropathy (LHON) in children and teenagers, the influence of age on visual prognosis has not yet been investigated.
Development and validation of a questionnaire-based myopia proxy in adults: the LifeLines Cohort Study
Nigus G Asefa, Anna Neustaeter, Jelle Vehof, Ilja M Nolte, Harold Snieder, Nomdo M Jansonius
doi : 10.1136/bjophthalmol-2021-319166
Aims To build a questionnaire-based myopia proxy and to validate the proxy by confirming its association with educational attainment and a Polygenic Risk Score (PRS) for myopia.
