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Radiation-induced optic neuropathy: a review
Andrew R Carey, Brandi R Page, Neil Miller
doi : 10.1136/bjo-2022-322854
Radiation is a commonly used treatment modality for head and neck as well as CNS tumours, both benign and malignant. As newer oncology treatments such as immunotherapies allow for longer survival, complications from radiation therapy are becoming more common.Â
Treatment strategies and long-term outcomes in patients with congenital microphthalmia–anophthalmia with cyst
Sri Gore, Gabriela Grimaldi, Giacomilde Mazzone, Richard Collin, Gustavo Savino, Mario Pagnoni, Alessandra Modugno
doi : 10.1136/bjophthalmol-2020-318089
Background/Aims Microphthalmia and anophthalmia are rare conditions, which represent ocular maldevelopment; both may be associated with orbital cysts. Current literature recommends retention to stimulate orbital growth during socket rehabilitation but does not illustrate their potential to deform the periocular tissues. This study aims to illustrate the long-term outcomes when other elements, such as forniceal and lid development, are also considered when formulating bespoke treatment plans for patients.
Diffuse pattern, orbital invasion, perineural invasion and Ki-67 are associated with nodal metastasis in patients with eyelid sebaceous carcinoma
Xiang Gu, Minyue Xie, Yingxiu Luo, Xin Song, Shiqiong Xu, Xianqun Fan
doi : 10.1136/bjophthalmol-2021-320547
Background Metastasis dominates the prognosis of eyelid sebaceous carcinoma (SC). This study aimed to explore risk factors for nodal metastasis and develop a nomogram to predict nodal metastasis in patients with eyelid SC.
Possible association between viral infection and poor survival of the corneal graft after penetrating keratoplasty in patients with congenital corneal opacity: a cohort study
Sen Miao, Qi Lin, Xu Li, Lu Zhao, Zhiqiang Pan
doi : 10.1136/bjophthalmol-2021-320031
Background Congenital corneal opacity (CCO) is a rare disorder. Penetrating keratoplasty (PK) is the main surgical option for CCO, but many factors affect graft survival. Therefore, this study aimed to perform a virological examination of CCO specimens after PK to explore the relationship between virological factors and graft survival after PK.
Multidrug-resistant keratitis: challenging yet manageable
Sonali Sahoo, Himabindu Alluri, Sanchita Mitra, Smrutirekha Priyadarshini, Srikant K Sahu, Amrita Mohanty, Sujata Das
doi : 10.1136/bjophthalmol-2021-320203
Purpose To study the incidence, clinical features and outcomes of multidrug-resistant (MDR) bacterial keratitis.
Novel ADAMTSL4 gene mutations in Chinese patients with isolated ectopia lentis
Dongwei Guo, Fengmei Yang, Yijing Zhou, Xinyu Zhang, Qianzhong Cao, Guangming Jin, Danying Zheng
doi : 10.1136/bjophthalmol-2021-320475
Background To characterise the phenotype and genetic defects of isolated ectopia lentis (IEL) and to determine the ADAMTSL4 gene mutation frequencies in a Chinese congenital ectopia lentis (CEL) cohort.
Changing operating room practices: the effect on postoperative endophthalmitis rates following cataract surgery
Aravind Haripriya, Ravilla D Ravindran, Alan L Robin, Aakriti Garg Shukla, David F Chang
doi : 10.1136/bjophthalmol-2021-320506
Purpose To determine whether four new operating room (OR) protocols instituted because of COVID-19 reduced the cataract surgical postoperative endophthalmitis rate (POE).
Uveal lymphoid hyperplasia: treatment with combination antibiotics and steroids
Jasmine H Francis, James P Winebrake, David H Abramson
doi : 10.1136/bjophthalmol-2021-319483
Background/aims Uveal lymphoid hyperplasia (formerly benign reactive hyperplasia of the choroid) spans histopatholological characteristics ranging from reactive hyperplasia to low-grade lymphoid neoplasm. There is strong evidence that other low-grade lymphoid neoplasms, particularly of gastric derivations, respond to oral antibiotics. Here, we explore that response of uveal lymphoid hyperplasia to treatment with only oral antibiotics and steroids.
Impact of the COVID-19 pandemic on uveitis patient care
Alexander F Vu, Shilpa Kodati, Phoebe Lin, Bahram Bodaghi, Parisa Emami-Naeini
doi : 10.1136/bjophthalmol-2021-320368
Background The COVID-19 pandemic has significantly changed practice of medicine and patient care worldwide. The impact of the pandemic on patients with uveitis is unknown. We developed the COVID-19 Practice Patterns Study Group to evaluate the effect of the pandemic on uveitis patient care.
Optimal number and orientation of anterior segment OCT images to measure ocular biometric parameters in angle closure eyes: the Chinese American Eye Study
Jing Shan, Anmol Pardeshi, Xuejuan Jiang, Grace M Richter, Roberta McKean-Cowdin, Rohit Varma, Benjamin Y Xu
doi : 10.1136/bjophthalmol-2021-319275
Purpose To assess the optimal number and orientation of anterior segment optical coherence tomography (AS-OCT) images for accurately measuring ocular biometric parameters in angle closure eyes.
Reproducibility of deep learning based scleral spur localisation and anterior chamber angle measurements from anterior segment optical coherence tomography images
Peng Liu, Risa Higashita, Philip Yawen Guo, Keiichiro Okamoto, Fei Li, Anwell Nguyen, Rei Sakata, Lixin Duan, Makoto Aihara, Shan Lin, Xiulan Zhang, Christopher Kai-Shun Leung, Jiang Liu
doi : 10.1136/bjophthalmol-2021-319798
Aims To apply a deep learning model for automatic localisation of the scleral spur (SS) in anterior segment optical coherence tomography (AS-OCT) images and compare the reproducibility of anterior chamber angle (ACA) width between deep learning located SS (DLLSS) and manually plotted SS (MPSS).
Relationship of macular ganglion cell complex thickness to choroidal microvasculature drop-out in primary open-angle glaucoma
Eleonora Micheletti, Sasan Moghimi, Nevin El-Nimri, Takashi Nishida, Min Hee Suh, James A Proudfoot, Alireza Kamalipour, Linda M Zangwill, Robert N Weinreb
doi : 10.1136/bjophthalmol-2021-320621
Background/aims To investigate the rate of ganglion cell complex (GCC) thinning in primary open-angle glaucoma (POAG) patients with and without deep-layer microvasculature drop-out (MvD).
Relationship between macular intercapillary area measured by optical coherence tomography angiography and central visual field sensitivity in normal tension glaucoma
Ruyue Shen, Yu Meng Wang, Carol Y Cheung, Fang Yao Tang, Alexander Lam, Clement C Tham, Poemen PuiMan Chan
doi : 10.1136/bjophthalmol-2021-319923
Purpose To investigate the relationship of macular intercapillary area (ICA) with macular ganglion cell-inner plexiform layer (GCIPL) thickness and central visual field sensitivity (CVFS) in normal tension glaucoma (NTG).
Intraocular pressure and diurnal fluctuation of open-angle glaucoma and ocular hypertension: a baseline report from the LiGHT China trial cohort
Yangfan Yang, Xinyi Zhang, Zidong Chen, Yifan Wei, Qiaona Ye, Yanmei Fan, Neil Nathwani, Gus Gazzard, Minbin Yu
doi : 10.1136/bjophthalmol-2021-320128
Aims To report the baseline intraocular pressure (IOP) characteristics and its diurnal fluctuation in the Laser in Glaucoma and Ocular Hypertension China cohort.
Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma
Shengjie Li, Yichao Qiu, Jian Yu, Mingxi Shao, Yingzhu Li, Wenjun Cao, Xinghuai Sun
doi : 10.1136/bjophthalmol-2021-320541
Aim To evaluate the association between serum levels of complement component (C) 3, C4 and C1q and visual field (VF) loss in patients with primary angle closure glaucoma (PACG).
Choriocapillaris perfusion assessed using swept source optical coherence tomographic angiography and the severity of diabetic retinopathy
Wei Wang, Xiao Guo, Yifan Chen, Kun Xiong, Xia Gong, Meng Yuan, Xiaoling Liang, Wenyong Huang
doi : 10.1136/bjophthalmol-2021-320163
Aims To investigate the relationship between choriocapillaris (CC) blood perfusion and the severity of diabetic retinopathy (DR) using swept-source optical coherence tomography angiography (SS-OCTA).
Hemiretinal vein occlusion 12-month outcomes are unique with vascular endothelial growth factor inhibitors: data from the Fight Retinal Blindness! Registry
Adrian Robert Hunt, Vuong Nguyen, Jennifer J Arnold, Ian L McAllister, Hemal Mehta, Alessandro Invernizzi, Theodorus Ponsioen, Pierre-Henry Gabrielle, Louise O'Toole, Pavol Kusenda, Socorro Alforja, Daniel Barthelmes, Mark C Gillies
doi : 10.1136/bjophthalmol-2021-320482
Background/aims To describe baseline characteristics and 12-month outcomes with vascular endothelial growth factor (VEGF) inhibitors of treatment-naïve hemiretinal vein occlusion (HRVO) compared with branch (BRVO) and central (CRVO) variants in routine clinical care.
Quantitative analysis of optical coherence tomography imaging in patients with different severities of hydroxychloroquine toxicity
Raul F Membreno, Tharindu De Silva, Elvira Agrón, Tiarnan DL Keenan, Catherine A Cukras
doi : 10.1136/bjophthalmol-2021-319197
Purpose To determine the diagnostic validity of quantitative measures derived from optical coherence tomography (OCT) images in their ability to discriminate between cohorts of eyes unaffected by hydroxychloroquine (HCQ) and those with a range of toxicity severities, including mild toxicity.
Risk factors for epiretinal membrane in eyes with primary rhegmatogenous retinal detachment that received silicone oil tamponade
Qintuo Pan, Zhiqiang Gao, Xuting Hu, Qi Wu, Jing Wei Zheng, Zong-Duan Zhang
doi : 10.1136/bjophthalmol-2021-320121
Background/aims This study investigated the risk factors for epiretinal membrane (ERM) in eyes with primary rhegmatogenous retinal detachment (RRD) that received silicone oil (SO) tamponade.
Higher-order aberrations and their association with axial elongation in highly myopic children and adolescents
Yupeng Xu, Junjie Deng, Bo Zhang, Xian Xu, Tianyu Cheng, Jingjing Wang, Shuyu Xiong, Mengli Luan, Haidong Zou, Xiangui He, Chun Tang, Xun Xu
doi : 10.1136/bjophthalmol-2021-319769
Background Vision-dependent mechanisms play a role in myopia progression in childhood. Thus, we investigated the distribution of ocular and corneal higher-order aberrations (HOAs) in highly myopic Chinese children and adolescents and the relationship between HOA components and 1-year axial eye growth.
Association of progressive optic disc tilt with development of retinal nerve fibre layer defect in children with large cup-to-disc ratio
Ahnul Ha, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
doi : 10.1136/bjophthalmol-2021-320029
Background/aims Whereas myopic optic disc deformation has been posited as a risk factor for glaucomatous damage, longitudinal studies evaluating their association have been sparse. We investigated whether the optic nerve head (ONH)’s morphological alteration during myopia progression play any role in development of retinal nerve fibre layer defect (RNFLD) in children with a large vertical cup-to-disc ratio (vCDR).
Prevalence of blindness and distance vision impairment in the Gambia across three decades of eye health programming
Abba Hydara, Islay Mactaggart, Suzannah J Bell, John A Okoh, Segun I Olaniyan, Mildred Aleser, Hannaa Bobat, Andy Cassels-Brown, Ben Kirkpatrick, Min J Kim, Ian McCormick, Hannah Faal, Matthew J Burton
doi : 10.1136/bjophthalmol-2021-320008
Background/aims The 1986 Gambia National Eye Health Survey provided baseline data for a National Eye Health Programme. A second survey in 1996 evaluated changes in population eye health a decade later. We completed a third survey in 2019, to determine the current state of population eye health, considering service developments and demographic change.
National trends in surgical subspecialisation in ophthalmology in the USA
Cindy X Cai, Jiangxia Wang, Sumayya Ahmad, Janek Klawe, Fasika Woreta, Divya Srikumaran, Nicholas R Mahoney, Pradeep Ramulu
doi : 10.1136/bjophthalmol-2021-320295
Background/aims To assess surgical patterns in ophthalmology by subspecialty in the USA.
Scleral growth stunting via sub-Tenon injection of cross-linking solutions in live rabbits
Quan V Hoang, Quan Wen, David C Paik, Yong Yao Chun, Ronald Silverman, Takayuki Nagasaki, Stephen L Trokel, Mariya Zyablitskaya
doi : 10.1136/bjophthalmol-2021-319427
Background Scleral cross-linking is a potential method to inhibit axial elongation of the eye, preventing the progression of pathological myopia. Formaldehyde releasers, which are common preservatives found in cosmetics and ophthalmic solutions, have been shown to be not only effective in cross-linking corneal collagen in vitro and in vivo, but also have minimal toxicity effects on the eye. The present study aims to evaluate the efficacy of scleral cross-linking using sodium hydroxymethylglycinate (SMG) to inhibit eye growth using an in vivo rabbit model.
