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Living well with kidney disease by patient and care?partner empowerment: Kidney health for everyone everywhere
Kamyar Kalantar?Zadeh Philip Kam?Tao Li Ekamol Tantisattamo Latha Kumaraswami Vassilios Liakopoulos Siu?Fai Lui Ifeoma Ulasi Sharon Andreoli Alessandro Balducci Sophie Dupuis Tess Harris Anne Hradsky Richard Knight Sajay Kumar Maggie Ng Alice Poidevin Gamal Saadi Allison Tong for the World Kidney Day Steering Committee
doi : 10.1111/nep.13829
Volume 26, Issue 3, March 2021, Pages: 211-216
Understanding the opposite effects of sex hormones in mediating renal injury
Ixchel Lima?Posada Norma A. Bobadilla
doi : 10.1111/nep.13806
Volume 26, Issue 3, March 2021, Pages: 217-226
This paper reviews the area of sex in the development of renal injury. The authors discuss the mechanisms by which oestrogens and testosterone can mediate the development of acute and chronic kidney diseases and highlight the importance of considering sex differences in clinical trial design.
Adiponectin affects estimated glomerular filtration rate: A two?sample bidirectional Mendelian randomization study
Yulan Bai Zefeng Chen Zheng Wen Xinyang Long Zengnan Mo Jianfeng Xu
doi : 10.1111/nep.13836
Volume 26, Issue 3, March 2021, Pages: 227-233
This Mendelian randomization study analysed interaction between single nucleotide polymorphisms separately associated with adiponectin levels and estimated glomerular filtration rate (eGFR). Adiponectin level exhibited a causal effect on eGFR, but the reverse was not true. This is important in future discovery and therapeutic approaches to chronic kidney disease.
Are individual analyses of multiple short urine collections throughout the 24?hours superior to a standard 24?hour urine collection in precipitation risk assessment of healthy subjects?
Mohammad A. Shafiee Pouyan Shaker Sayyideh F. Hosseini Mohammad Alavinia Mehdi Aarabi Ali J. Rezaee Mitchel L. Halperin
doi : 10.1111/nep.13842
Volume 26, Issue 3, March 2021, Pages: 234-238
Individual analysis of multiple shorter urine collections throughout the day improves the ability of identifying supersaturation points, precipitation risk zones and may potentially improve risk assessment compared to the 24?hour urine collection in the assessment of the risks of stone formation.
Acute kidney injury associated with COVID?19—Cumulative evidence and rationale supporting against direct kidney injury (infection)
Malvinder S. Parmar
doi : 10.1111/nep.13814
Volume 26, Issue 3, March 2021, Pages: 239-247
The mechanisms of acute kidney injury (AKI) associated with COVID?19 are diverse. The author carefully analyzed all the previously?published studies and provided the rationale and cumulative evidence that AKI is secondary to hemodynamic and immunologic effects of SARS?CoV?2 infection rather than direct kidney injury. The use of immuno?electron or in?situ hybridization technique is warranted to confirm any direct viral infection in the kidney.
Chronic kidney disease is a very significant comorbidity for high risk of death in patients with COVID?19 in Mexico
Gaspar Manuel Parra?Bracamonte Francisco E. Parra?Bracamonte Nicolas Lopez?Villalobos Ana Laura Lara?Rivera
doi : 10.1111/nep.13827
Volume 26, Issue 3, March 2021, Pages: 248-251
This study evaluated the effect of the interaction of CKD status with other risk factors on the survival rate of COVID?19?positive patients in Mexico. The results support that CKD patients are at increased risk of death from COVID?19, and COVID?19?positive CKD and diabetic inpatients are very vulnerable to death.
High prevalence of Afro?Caribbean ethnicity and hypoglycaemia in patients with diabetes and end stage renal disease hospitalized with COVID?19
Antonella Corcillo Siew Cohen David Game Janaka Karalliedde
doi : 10.1111/nep.13809
Volume 26, Issue 3, March 2021, Pages: 252-254
This report stated the clinical features and outcomes of 39 ESKD patients with diabetes and admitted with COVID?19 infection. The mortality rate was about 36%. There is a high prevalence of patients of Afro?Caribbean ethnicity. Hypoglycaemic events were observed in nearly one third of HD patients and one fifth of transplant patients during hospitalization.
Exit site infection and peritonitis due to Serratia species in patients receiving peritoneal dialysis: Epidemiology and clinical outcomes
Christy W. H. Au Desmond Y. H. Yap Jasper F. W. Chan Terence P. S. Yip Tak M. Chan
doi : 10.1111/nep.13813
Volume 26, Issue 3, March 2021, Pages: 255-261
This paper presents an analysis of the outcomes of the largest number of Serratia exit site infections reported to date. Although retrospective, it underlines the importance of exit site care (ESI) in preventing peritonitis and catheter removal. It also hints that better exit site practices over time may have been associated with reduced incidence of Serratia ESI and better outcomes.
Bioinformatic investigation for candidate genes and molecular mechanism in the pathogenesis of membranous nephropathy
Peng Li Xiaojing Zhong Lihong Zhang Ying Yu Jianying Niu
doi : 10.1111/nep.13833
Volume 26, Issue 3, March 2021, Pages: 262-269
The authors investigated differentially expressed mRNA's in membranous nephropathy (MN) vs controls from a microarray data set, and identified that mRNAs including FOS and JUN might participate in MN development with SOX4 potentially contributing to MN progression. These findings assist with better understanding the molecular processes underpinning MN especially pertaining to the involvement of immune?associated gene expression.
Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline
Matthew R. Veitch Kerri Thai Yanling Zhang Jean?Francois Desjardins Golam Kabir Kim A. Connelly Richard E. Gilbert
doi : 10.1111/nep.13828
Volume 26, Issue 3, March 2021, Pages: 270-279
Although angiotensin?converting enzyme inhibition with enalapril or SIRT1 activation with SRT3025 improved proteinuria in a rat remnant kidney model and the former also reduced structural damage by histology, neither treatment restored kidney function.
Azygos vein cannulation, a rare complication of dialysis catheter insertion
Minh Huan Dang Wei Chen Yeoh Rajesh Raj
doi : 10.1111/nep.13801
Volume 26, Issue 3, March 2021, Pages: 280
Neck swelling following coronary angiogram in a renal transplant recipient
Jagadish S. Jamboti Azlan A. Mohd Jayant B. Kumar
doi : 10.1111/nep.13803
Volume 26, Issue 3, March 2021, Pages: 281-282
