New England Journal of Medicine




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PEPFAR at 20 — A Game-Changing Impact on HIV in Africa

Jean B. Nachega, M.D., Ph.D., M.P.H., David Serwadda, M.B., Ch.B., M.P.H., Alash’le Abimiku, Ph.D., Izukanji Sikazwe, M.B., Ch.B., M.P.H., and Quarraisha Abdool Karim, Ph.D.

doi : 10.1056/NEJMp2304600

Vol. 389 No. 1

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Strategic Masking to Protect Patients from All Respiratory Viral Infections

Michael Klompas, M.D., M.P.H., Meghan A. Baker, M.D., Sc.D., Chanu Rhee, M.D., M.P.H., and Lindsey R. Baden, M.D.

doi : 10.1056/NEJMp2306223

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Empowered or Traumatized? A Call for Evidence-Informed Armed-Assailant Drills in U.S. Schools

Mary Beth Miotto, M.D., M.P.H., and Robin Cogan, M.Ed., R.N.

doi : 10.1056/NEJMp2301804

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What I Learned in School Today

Mira G. Taichman, M.A.T.

doi : 10.1056/NEJMp2305761

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Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage

Ioannis Gallos, D.M.S., M.D., Adam Devall, B.Med.Sci., Ph.D., James Martin, Ph.D., Lee Middleton, M.Sc., Leanne Beeson, B.Sc., Hadiza Galadanci, F.R.C.O.G., Fadhlun Alwy Al-beity, M.D., Ph.D., Zahida Qureshi, M.B., B.S., M.Med., G. Justus Hofmeyr, M.B., B.Ch., D.Sc., Neil Moran, B.M., B.Ch., Sue Fawcus, M.B., B.S., Lumaan Sheikh, F.C.P.S., M.R.C.O.G., George Gwako, M.B., Ch.B., Ph.D., Alfred Osoti, M.B., Ch.B., Ph.D., Ashraf Aswat, B.Sc., Kristie-Marie Mammoliti, M.Sc., Kulandaipalayam N. Sindhu, M.B., B.S., M.D., Marcelina Podesek, M.Sc., Isobelle Horne, B.A., Rebecca Timms, M.Res., Idnan Yunas, M.B., B.Chir., D.C.H., Jenipher Okore, B.Sc., Mandisa Singata-Madliki, Ph.D., Edna Arends, B.A., Aminu A. Wakili, M.B., B.S., Ard Mwampashi, B.A.P.S&P.A., Sidrah Nausheen, M.B., B.S., Shah Muhammad, M.B., B.S., M.P.H., Pallavi Latthe, M.B., Ch.B., M.D., Cherrie Evans, Dr.P.H., C.N.M., Shahinoor Akter, Ph.D., Gillian Forbes, Ph.D., David Lissauer, M.B., Ch.B., Ph.D., Shireen Meher, M.B., B.S., M.D., Andrew Weeks, M.B., Ch.B., M.D., Andrew Shennan, M.B., B.S., M.D., Anne Ammerdorffer, Ph.D., Eleanor Williams, M.Sc., M.A., Tracy Roberts, Ph.D., Mariana Widmer, M.Sc., Olufemi T. Oladapo, M.D., M.P.H., Fabiana Lorencatto, Ph.D., Meghan A. Bohren, Ph.D., M.S.P.H., Suellen Miller, Ph.D., M.H.A., Fernando Althabe, M.D., Metin Gülmezoglu, M.D., Ph.D., Jeffrey M. Smith, M.D., M.P.H., Karla Hemming, Ph.D., and Arri Coomarasamy, M.B., Ch.B., M.D.

doi : 10.1056/NEJMoa2303966

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A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D

Heiner Wedemeyer, M.D., Soo Aleman, M.D., Ph.D., Maurizia Rossana Brunetto, M.D., Antje Blank, M.D., Pietro Andreone, M.D., Pavel Bogomolov, M.D., Ph.D., Vladimir Chulanov, M.D., Ph.D., Nina Mamonova, M.D., Natalia Geyvandova, Ph.D., Viacheslav Morozov, Ph.D., Olga Sagalova, M.D., Ph.D., Tatyana Stepanova, M.D., Annemarie Berger, Ph.D., Dmitry Manuilov, M.D., Vithika Suri, M.Sc., Qi An, Ph.D., Ben Da, M.D., John Flaherty, Pharm.D., Anu Osinusi, M.D., Yang Liu, Ph.D., Uta Merle, M.D., Julian Schulze zur Wiesch, M.D., Stefan Zeuzem, M.D., Sandra Ciesek, M.D., Markus Cornberg, M.D., and Pietro Lampertico, M.D., Ph.D. for the MYR 301 Study Group*

doi : 10.1056/NEJMoa2213429

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Pirtobrutinib after a Covalent BTK Inhibitor in Chronic Lymphocytic Leukemia

Anthony R. Mato, M.D., M.S.C.E., Jennifer A. Woyach, M.D., Jennifer R. Brown, M.D., Ph.D., Paolo Ghia, M.D., Ph.D., Krish Patel, M.D., Toby A. Eyre, M.B., Ch.B., M.D., Talha Munir, M.B., B.S., Ewa Lech-Maranda, M.D., Ph.D., Nicole Lamanna, M.D., Constantine S. Tam, M.D., Nirav N. Shah, M.D., Catherine C. Coombs, M.D., Chaitra S. Ujjani, M.D., Bita Fakhri, M.D., M.P.H., Chan Y. Cheah, M.D., Manish R. Patel, M.D., Alvaro J. Alencar, M.D., Jonathon B. Cohen, M.D., James N. Gerson, M.D., Ian W. Flinn, M.D., Ph.D., Shuo Ma, M.D., Ph.D., Deepa Jagadeesh, M.D., Joanna M. Rhodes, M.D., M.S.C.E., Francisco Hernandez-Ilizaliturri, M.D., Pier L. Zinzani, M.D., Ph.D., John F. Seymour, M.B., B.S., Ph.D., Minna Balbas, Ph.D., Binoj Nair, Ph.D., Paolo Abada, M.D., Ph.D., Chunxiao Wang, Ph.D., Amy S. Ruppert, Ph.D., Denise Wang, Ph.D., Donald E. Tsai, M.D., Ph.D., William G. Wierda, M.D., Ph.D., and Wojciech Jurczak, M.D., Ph.D.

doi : 10.1056/NEJMoa2300696

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Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest

Glenn Eastwood, Ph.D., Alistair D. Nichol, Ph.D., Carol Hodgson, Ph.D., Rachael L. Parke, Ph.D., Shay McGuinness, M.B., Ch.B., Niklas Nielsen, Ph.D., Stephen Bernard, M.D., Markus B. Skrifvars, Ph.D., Dion Stub, Ph.D., Fabio S. Taccone, Ph.D., John Archer, Ph.D., Demetrios Kutsogiannis, M.D., Josef Dankiewicz, M.D., Ph.D., Gisela Lilja, Ph.D., Tobias Cronberg, Ph.D., Hans Kirkegaard, D.M.Sc., Gilles Capellier, Ph.D., Giovanni Landoni, M.D., Janneke Horn, M.D., Theresa Olasveengen, Ph.D., Yaseen Arabi, M.D., Yew Woon Chia, M.Med., Andrej Markota, Ph.D., Matthias Hænggi, M.D., Matt P. Wise, Ph.D., Anders M. Grejs, M.D., Ph.D., Steffen Christensen, Ph.D., Heidi Munk-Andersen, M.D., Asger Granfeldt, D.M.Sc., Geir Ø. Andersen, M.D., Ph.D., Eirik Qvigstad, Ph.D., Arnljot Flaa, Ph.D., Matthew Thomas, M.B., Ch.B., Katie Sweet, D.Sc., Jeremy Bewley, M.B., Ch.B., Minna Bäcklund, Ph.D., Marjaana Tiainen, Ph.D., Manuela Iten, M.D., Anja Levis, M.D., Leah Peck, Grad.Cert.(Crit. Care Nurs.), James Walsham, M.B., Ch.B., Adam Deane, Ph.D., Angajendra Ghosh, M.D., Filippo Annoni, M.D., Yan Chen, M.Nurs., David Knight, M.B., Ch.B., Eden Lesona, M.N.Sc., Haytham Tlayjeh, M.D., Franc Svenšek, M.D., Peter J. McGuigan, M.B., B.Ch., B.A.O., Jade Cole, M.Sc., David Pogson, M.B., B.Ch., M.Sc., Matthias P. Hilty, M.D., Joachim P. Düring, Ph.D., Michael J. Bailey, Ph.D., Eldho Paul, Ph.D., Bridget Ady, M.Clin.Res., Kate Ainscough, Ph.D., Anna Hunt, Pg.Dip., Sinéad Monahan, B.Sc., Tony Trapani, B.Ed., Ciara Fahey, Ph.D., and Rinaldo Bellomo, Ph.D. for the TAME Study Investigators*

doi : 10.1056/NEJMoa2214552

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Hepatitis D Virus Infection

Tarik Asselah, M.D., and Mario Rizzetto, M.D.

doi : 10.1056/NEJMra2212151

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Clinical Examination of the Cranial Nerves

Rohin Singh, B.S., Jordan R. Pollock, B.S., M. Lane Moore, B.S., Yeonsoo S. Lee, B.S., Miles Hudson, M.D., Bernard R. Bendok, M.D., and Naresh P. Patel, M.D.

doi : 10.1056/NEJMvcm2103640

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Corneal Crystalline Deposits in a Patient with Multiple Myeloma

Takashi Ono, M.D., Ph.D., and Kazunori Miyata, M.D., Ph.D.

doi : 10.1056/NEJMicm2203995

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Hairy Tongue

Eric Karr, D.O., and Brian Elliott, M.D.

doi : 10.1056/NEJMicm2300789

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A Bumpy Road to Diagnosis

Jacob J. Cedarbaum, M.D., M.S.Ed., Deepak A. Rao, M.D., Ph.D., Hiroto Hatabu, M.D., Ph.D., Katherine H. Walker, M.D., and Joseph Loscalzo, M.D., Ph.D.

doi : 10.1056/NEJMcps2304844

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Early Detection and Bundled Treatment for Postpartum Hemorrhage

Adeline A. Boatin, M.D., M.P.H., and Joseph Ngonzi, M.D., M.Med., Ph.D.

doi : 10.1056/NEJMe2305857

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A Glimmer of Hope for an Orphan Disease

Marc G. Ghany, M.D., M.H.Sc.

doi : 10.1056/NEJMe2304147

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Inhibiting BTK in Chronic Lymphocytic Leukemia

Arnon P. Kater, M.D., Ph.D., and Barbara Eichhorst, M.D.

doi : 10.1056/NEJMe2302721

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Fentanyl-Associated Overdose Deaths Outside the Hospital

doi : 10.1056/NEJMc2304991

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Endovascular Thrombectomy for Acute Large Ischemic Strokes

doi : 10.1056/NEJMc2305915

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Fifteen-Year Outcomes of the ProtecT Trial for Localized Prostate Cancer

doi : 10.1056/NEJMc2306135

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Case 11-2023: A Man with Mantle-Cell Lymphoma and Hypoxemia

doi : 10.1056/NEJMc2305916

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