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3D printing – an alternative strategy for pediatric medicines
Alice P McCloskey, Louise Bracken, Nicola Vasey & Touraj Ehtezazi
doi : 10.1080/17512433.2023.2233416
Expert Review of Clinical Pharmacology, Volume 16, Issue 7 (2023)
A scoping review of legibility of hand-written prescriptions and drug-orders: the writing on the wall
Anderson Ariaga, Dustin Balzan, Stephen Falzon & Janet Sultana
doi : 10.1080/17512433.2023.2223972
Prescription and drug order writing are key components of patient care allowing physicians communicate their therapeutic plans. Although electronic prescriptions are becoming more common, handwritten prescriptions are still quite prevalent and a persistent issue with handwritten prescriptions is the illegibility of physician handwritings. Prescriptions have to be legible to avoid delays in healthcare provision and consequences as serious as patient death.
Clinical pharmacology of cardiac cyclic AMP in human heart failure: too much or too little?
Anastasios Lymperopoulos
doi : 10.1080/17512433.2023.2233891
Cyclic 3', 5'-adenosine monophosphate (cAMP) is a major signaling hub in cardiac physiology. Although cAMP signaling has been extensively studied in cardiac cells and animal models of heart failure (HF), not much is known about its actual amount present inside human failing or non-failing cardiomyocytes. Since many drugs used in HF work via cAMP, it is crucial to determine the status of its intracellular levels in failing vs. normal human hearts.
Past, present, and future of FGFR inhibitors in cholangiocarcinoma: from biological mechanisms to clinical applications
Elisabeth Amadeo, Federico Rossari, Francesco Vitiello, Valentina Burgio, Mara Persano, Stefano Cascinu, Andrea Casadei-Gardini & Margherita Rimini
doi : 10.1080/17512433.2023.2232302
Biliary tract carcinoma (BTC) is a heterogenous group of aggressive hepatic malignancies, second to hepatocellular carcinoma per prevalence. Despite clinical research advancement, the overall 5-year survival rate is just above 2%. With the identification of somatic core mutations in half of cholangiocarcinomas. In the intrahepatic subtype (iCCA), it is possible to target mutational pathways of pharmacological interest.
Time to incorporate preemptive NUDT15 testing before starting thiopurines in inflammatory bowel disease in Asia and beyond: a review
Devendra Desai, Anuraag Jena, Vishal Sharma & Toshifumi Hibi
doi : 10.1080/17512433.2023.2232300
Thiopurine toxicity is related to genetic polymorphism. Thiopurine methyltransferase (TPMT) variants do not explain thiopurine toxicity in more than half of patients. Asians, despite the low prevalence of TPMT variants, are more susceptible to thiopurine toxicity. Since 2014, studies from many Asian countries have shown a strong association between nucleoside diphosphate-linked moiety X-type motif (NUDT) 15 polymorphism and thiopurine-induced myelotoxicity.
Understanding the role of chronopharmacology for drug optimization: what do we know?
Akio Fujimura & Kentaro Ushijima
doi : 10.1080/17512433.2023.2233438
Circadian rhythm influences the pharmacokinetics and pharmacodynamics of a number of drugs and affects their therapeutic efficacy and toxicity depending on the time of day they are administered.
Updates in the diagnosis and practical management of allergic rhinitis
Chiara Trincianti, Maria Angela Tosca & Giorgio Ciprandi
doi : 10.1080/17512433.2023.2225770
Allergic rhinitis (AR) is a widespread disease that can be associated with other conditions, including conjunctivitis, rhinosinusitis, asthma, food allergy, and atopic dermatitis. Diagnosis is based on the history and documentation of sensitization, such as the production of allergen-specific IgE, preferably using molecular diagnostics.
Clinical outcomes of oral anticoagulant discontinuation in atrial fibrillation: a systematic review and meta-analysis
Adane Teshome Kefale, Woldesellassie M. Bezabhe & Gregory M. Peterson
doi : 10.1080/17512433.2023.2223973
Oral anticoagulants (OACs) should generally be continued lifelong in patients with atrial fibrillation (AF) to ensure optimal benefits, unless contraindications arise. However, discontinuation of OACs might occur for various reasons, potentially affecting clinical outcomes. In this review, we synthesized evidence on the clinical outcomes following OAC discontinuation in patients with AF.
