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Samidorphan for the treatment of weight gain associated with olanzapine in patients with schizophrenia and bipolar disorder
Junfa Gao, Junsheng Li, Xiuhua Lu & Junyi Yang
doi : 10.1080/17512433.2022.2118111
Expert Review of Clinical Pharmacology, Volume 15, Issue 9 (2022)
Olanzapine (OLZ) is one of the most effective antipsychotic agents, however, its clinical utility has been limited by weight gain. Samidorphan (SAM) is a μ-opioid receptor antagonist and it can reduce the weight gain associated with OLZ. A combination of OLZ and SAM (OLZ/SAM) has been developed to provide the antipsychotic efficacy of OLZ, while mitigating OLZ-associated weight gain.
Risk factors for a broken heart: understanding drug-induced causes for Takotsubo syndrome and pharmacological treatment options
Gao Jing Ong, Thanh Ha Nguyen, Sven Y Surikow & John D Horowitz
doi : 10.1080/17512433.2022.2121701
Takotsubo syndrome (TTS) is an acute inflammatory disorder involving first the vasculature and then the myocardium. It occurs relatively frequently, especially in aging women after acute physical and emotional stress. There is also increasing recognition that TTS attacks are sometimes precipitated by pharmacotherapy.
Antiplatelet therapy after noncardioembolic ischemic stroke or transient ischemic attack
Lorenzo Scalia, Dario Calderone & Davide Capodanno
doi : 10.1080/17512433.2022.2118713
Antiplatelet therapy is key to prevent recurrences in patients with an acute or prior non-cardioembolic stroke or transient ischemic attack (TIA). The narrow balance between the risks of ischemic recurrence and major bleeding is a relevant clinical dilemma in this population.
Novel pharmacological therapies for the treatment of endometriosis
Laura Buggio, Dhouha Dridi, Giussy Barbara, Camilla E.M. Merli, Giulia Emily Cetera & Paolo Vercellini
doi : 10.1080/17512433.2022.2117155
Endometriosis is a chronic, estrogen-dependent, inflammatory disease associated with pelvic pain, infertility, impaired sexual function, and psychological suffering. Therefore, tailored patient management appears of primary importance to address specific issues and identify the appropriate treatment for each woman. Over the years, abundant research has been carried out with the objective to find new therapeutic approaches for this multifaceted disease.
A review of recent advances in the treatment of adults with complicated urinary tract infection
Emanuele Rando, Francesca Giovannenze, Rita Murri & Emilio Sacco
doi : 10.1080/17512433.2022.2121703
Complicated urinary tract infections (cUTIs) entail diverse clinical conditions that could be managed differently and not necessarily with premature empiric therapy. Since multidrug-resistant organisms (MDROs) are widely spreading worldwide, the possibility of encountering these resistant bacteria is inevitably part of the daily life of physicians who manage cUTIs.
Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry
Migita D’Cruz & Chittaranjan Andrade
doi : 10.1080/17512433.2022.2121699
Ashwagandha (ASW) is the extract of the plant Withania somnifera. It is widely used in complementary, alternative, and integrative medicine (CAIM) but is little discussed in mainstream modern medical literature.
Opioid epidemic: lessons learned and updated recommendations for misuse involving prescription versus non-prescription opioids
Ajda Bedene, Albert Dahan, Frits R. Rosendaal & Eveline L.A. van Dorp
doi : 10.1080/17512433.2022.2114898
In the past decades, the opioid crisis has heavily impacted parts of the US society and has been followed by an increase in the use of opioids worldwide. It is of paramount importance that we explore the origins of the US opioid epidemic to develop best practices to tackle the rising tide of opioid overdoses.
The pharmacology of anticoagulant drug treatment options in COVID-19 patients: reviewing real-world evidence in clinical practice
Vincenzo Russo, Adriano Caputo, Egidio Imbalzano, Pierpaolo Di Micco, Antonio Frontera, Ambra Uccello, Luana Orlando, Paola Galimberti, Paolo Golino & Antonello D’Andrea
doi : 10.1080/17512433.2022.2117154
The optimal anticoagulation strategy for venous thromboembolism (VTE) prevention among COVID-19 patients, hospitalized or in the community setting, is still challenging and largely based on real-world evidence.
Effects of single-nucleotide polymorphism on the pharmacokinetics and pharmacodynamics of metformin
Shaoqian Li, Bo Xu, Shangzhi Fan, Bo Kang, Lijing Deng, Danjun Chen, Bo Yang, Fan Tang, Zunbo He, Yong Xue & Jie-Can Zhou
doi : 10.1080/17512433.2022.2118714
Metformin has been recognized as the first-choice drug for type 2 diabetes mellitus (T2DM). The potency of metformin in the treatment of type 2 diabetes has always been in the spotlight and shown significant individual differences. Based on previous studies, the efficacy of metformin is related to the single-nucleotide polymorphisms of transporter genes carried by patients, amongst which a variety of gene polymorphisms of transporter and target protein genes affect the effectiveness and adverse repercussion of metformin.
Comparison of weight loss and adverse events of obesity drugs in children and adolescents: a systematic review and meta-analysis
Guangming Zhao, Qi Zhang, Fan Wu, Shuang Yin, Yiqi Xie & Hongyan Liu
doi : 10.1080/17512433.2022.2117152
The global incidence of childhood obesity is increasing. Currently, there are only few established drugs for treating adolescent obesity. Randomized clinical trials (RCTs) comparing pharmacological interventions in children with obesity are scarce; therefore, we aimed to analyze the relative efficacy and adverse reactions of these drugs and compare the effects of each drug on body mass index (BMI).
Association between statins’ exposure with incidence and prognosis of gastric cancer: an updated meta�analysis
Dandi Lou, Rongrong Fu, Lihu Gu, Hui Su & like Guan
doi : 10.1080/17512433.2022.2112178
Previous research has revealed the role of statins in cancer prevention and treatment. This study aimed to determine the relationship between statins’ exposure and the incidence and prognosis of gastric cancer (GC).
Abiraterone acetate versus docetaxel for metastatic castration-resistant prostate cancer: a cohort study within the French nationwide claims database
Nicolas H. Thurin, Magali Rouyer, Jérémy Jové, Marine Gross-Goupil, Thibaud Haaser, Xavier Rébillard, Michel Soulié, Gérard de Pouvourville, Camille Capone, Marie-Laure Bazil, Fatiha Messaoudi, Stéphanie Lamarque, Emmanuelle Bignon, Cécile Droz-Perroteau, Nicholas Moore & Patrick Blin
doi : 10.1080/17512433.2022.2115356
To conduct the direct comparison of abiraterone acetate and docetaxel for first-line treatment of metastatic castration-resistant prostate cancer (mCRPC) in real-life settings.
