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One size fits all? How to optimize the prescribing of appropriate polypharmacy in chronic diseases, using a behavioral approach – a United Kingdom perspective
Carmel M. Hughes
doi : 10.1080/17512433.2022.2094767
Expert Review of Clinical Pharmacology, Volume 15, Issue 5 (2022)
Finerenone: a mineralocorticoid receptor antagonist for the treatment of chronic kidney disease associated with type 2 diabetes
Edgar V. Lerma & Daniel J. Wilson
doi : 10.1080/17512433.2022.2094770
Approximately 40% of people with type 2 diabetes (T2D) also have chronic kidney disease (CKD), which substantially increases their risk of cardiovascular (CV)-related complications and mortality. Until recently, no approved therapies have directly targeted inflammatory and fibrotic pathways that drive disease progression and organ damage in patients with CKD associated with T2D.
Voclosporin: a novel calcineurin inhibitor for the treatment of lupus nephritis
Teun van Gelder, Edgar Lerma, Kory Engelke & Robert B. Huizinga
doi : 10.1080/17512433.2022.2092470
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus. Standard-of-care immunosuppressive therapies achieve poor complete renal response (CRR) rates, with considerable toxicity. This article reviews voclosporin, a novel oral calcineurin inhibitor (CNI) approved for treatment in adults with active LN by the US Food and Drug Administration (the FDA) in January 2021.
The continuum of care of anticancer treatment-induced hypothyroidism in patients with solid non-thyroid tumors: time for an intimate collaboration between oncologists and endocrinologists
Maria V. Deligiorgi & Dimitrios T. Trafalis
doi : 10.1080/17512433.2022.2093714
Hypothyroidism is a common adverse event of various anticancer treatment modalities, constituting a notable paradigm of the integration of the endocrine perspective into precision oncology.
Antimicrobial safety considerations in critically ill patients: part I: focused on acute kidney injury
Foroud Shahbazi, Lida Shojaei, Fakhrossadat Farvadi & Sara Kadivarian
doi : 10.1080/17512433.2022.2093713
Antibiotic prescription is a challenging issue in critical care settings. Different pharmacokinetic and pharmacodynamic properties, polypharmacy, drug interactions, and high incidence of multidrug-resistant microorganisms in this population can influence the selection, safety, and efficacy of prescribed antibiotics.
Antimicrobial safety considerations in critically ill patients: part II: focused on anti-microbial toxicities
Foroud Shahbazi, Lida Shojaei, Fakhrossadat Farvadi & Sara Kadivarian
doi : 10.1080/17512433.2022.2093716
Antibiotic prescription is a challenging issue in critical care settings. Different pharmacokinetic and pharmacodynamic properties, polypharmacy, drug interactions, and high incidence of multidrug-resistant microorganisms in this population can influence the selection, safety, and efficacy of prescribed antibiotics.
Current status and prospects of IL-6–targeting therapy
Masashi Narazaki & Tadamitsu Kishimoto
doi : 10.1080/17512433.2022.2097905
Persistent and excess IL-6 production often contributes to a variety of immune diseases. IL-6–targeting therapy was first approved for Castleman disease, then rheumatoid arthritis, and now it is broadly used. Furthermore, it has been approved not only for chronic and acute inflammatory diseases but also for autoantibody-induced diseases such as neuromyelitis optica spectrum disorder and interstitial lung disease due to systemic sclerosis.
The effect of inhaled corticosteroids on the outcomes of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials
Chao-Hsien Chen, Cheng-Yi Wang, Ya-Hui Wang, Ching-Yi Chen, Kuang-Hung Chen, Chih-Cheng Lai, Yu-Feng Wei & Pin-Kuei Fu
doi : 10.1080/17512433.2022.2094769
The effect of inhaled corticosteroids (ICS) on the clinical outcomes of patients with coronavirus disease 2019 (COVID-19) was not known.
A systematic review and meta-analysis of the effect of statin treatment on sVCAM-1 and sICAM-1
Angelo Zinellu & Arduino A Mangoni
doi : 10.1080/17512433.2022.2072294
Statins might prevent cell adhesion to the endothelium, a key step in atherosclerosis. We conducted a systematic review and meta-analysis of the effect of statins on soluble vascular (sVCAM-1) and intercellular (sICAM-1) adhesion molecule 1.
Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder
Yan-Nan Zang, Wei Guo, Fang Dong, An-Ning Li, Jose de Leon & Can-Jun Ruan
doi : 10.1080/17512433.2022.2075849
This study reviewed all published valproic acid (VPA) population pharmacokinetic (PPK) models in adult patients and assessed them using external validation methods to determine predictive performance.
Association between hypertensive medication during pregnancy and risk of several maternal and neonatal outcomes in women with chronic hypertension: a population-based study
Anna Cantarutti, Gloria Porcu, Anna Locatelli & Giovanni Corrao
doi : 10.1080/17512433.2022.2072292
Several studies have reported an association between perinatal complications and the severity of the hypertensive disease. The increasing number of pregnancies complicated by hypertension and the small assurance about the perinatal effects of hypertensive drug use during pregnancy involves the need of studying the better management of hypertensive mothers.
Population pharmacokinetics and model-informed precision dosing of lamivudine in Chinese HIV-infected patients with mild and moderate impaired renal function
Haini Wen, Lin Yin, Jiangrong Wang, Lin Zhang, Tao Sun, Feng Xu, Minxin Zhang, Li Liu, Renfang Zhang, Xiaoqian Liu, Xianmin Meng, Yaru Xing, Hongzhou Lu, Zheng Jiao & Lijun Zhang
doi : 10.1080/17512433.2022.2078306
Lamivudine is a first-line medication used for human immunodeficiency virus (HIV) treatment. To date, the population pharmacokinetics of lamivudine in Chinese HIV-infected adults have not been assessed. This study aimed to develop a population pharmacokinetic model for oral lamivudine in Chinese HIV-infected adults and to determine the optimal lamivudine dosage regimens.
