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Persistent Airway Plugs: A Call for Clinical Recognition and Novel Therapies
Sarah Svenningsen and Parameswaran Nair
doi : 10.1164/rccm.202201-0147ED
Volume 205, Issue 9 | May 1 2022
Getting to the How and Why: Are Individuals with Chronic Obstructive Pulmonary Disease More Susceptible to the Health Effects of Air Pollution Exposure?
Coralynn S. Sack 1,2 and Anne M. Manicone 3
Should We Wean Patients off Vasopressors before Weaning Them off Ventilation?
Xavier Monnet
HALTing Nontuberculous Mycobacteria in Cystic Fibrosis Centers: Is There Something in the Water?
Kenneth N. Olivier 1 and D. Rebecca Prevots 2
Misuse of Pollution Reference Standards: No Safe Level of Air Pollution
Guy B. Marks
Chronic Cough in Idiopathic Pulmonary Fibrosis: The Same Difference?
Alyn H. Morice
Corticosteroids for Pleural Infection: Should We STOPPE Studying?
David T. Arnold and Nick A. Maskell
Prime Time for Proteomics in Pulmonary Arterial Hypertension Risk Assessment?
Navneet Singh 1 and Corey E. Ventetuolo 2,3
Providing Compassionate Care in the ICU
J. Randall Curtis 1,2 and Mitchell M. Levy 3
Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
Ganesh Raghu , Martine Remy-Jardin , Luca Richeldi , Carey C. Thomson , Yoshikazu Inoue , Takeshi Johkoh , Michael Kreuter , David A. Lynch , Toby M. Maher , Fernando J. Martinez , Maria Molina-Molina , Jeffrey L. Myers , Andrew G. Nicholson , Christopher J. Ryerson , Mary E. Strek , Lauren K. Troy , Marlies Wijsenbeek , Manoj J. Mammen , Tanzib Hossain , Brittany D. Bissell , Derrick D. Herman , Stephanie M. Hon , Fayez Kheir , Yet H. Khor , Madalina Macrea , Katerina M. Antoniou , Demosthenes Bouros , Ivette Buendia-Roldan , Fabian Caro , Bruno Crestani , Lawrence Ho , Julie Morisset , Amy L. Olson , Anna Podolanczuk , Venerino Poletti , Moisés Selman , Thomas Ewing , Stephen Jones , Shandra L. Knight , Marya Ghazipura , and Kevin C. Wilson ;
doi : 10.1164/rccm.202202-0399ST
Background: This American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior idiopathic pulmonary fibrosis (IPF) guidelines and addresses the progression of pulmonary fibrosis in patients with interstitial lung diseases (ILDs) other than IPF.
Autoimmune Pulmonary Alveolar Proteinosis
Cormac McCarthy 1,2, Brenna C. Carey 3,4, and Bruce C. Trapnell 3,4
doi : 10.1164/rccm.202112-2742SO
Autoimmune pulmonary alveolar proteinosis (PAP) is a rare disease characterized by myeloid cell dysfunction, abnormal pulmonary surfactant accumulation, and innate immune deficiency. It has a prevalence of 7–10 per million; occurs in individuals of all races, geographic regions, sex, and socioeconomic status; and accounts for 90% of all patients with PAP syndrome.
Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time
Monica Tang 1, Brett M. Elicker 2, Travis Henry 3, David S. Gierada 4, Mark L. Schiebler 5, Brendan K. Huang 1, Michael C. Peters 1, Mario Castro 6, Eric A. Hoffman 7, Sean B. Fain 7, Samuel Y. Ash 8, Jiwoong Choi 6, Chase Hall 6, Brenda R. Phillips 9, David T. Mauger 10, Loren C. Denlinger 11, Nizar N. Jarjour 11, Elliot Israel 8, Wanda Phipatanakul 12, Bruce D. Levy 8, Sally E. Wenzel 13, Eugene R. Bleecker 14, Prescott G. Woodruff 1,15, John V. Fahy 1,15, Eleanor M. Dunican 16,17; and the NHLBI Severe Asthma Research Program-3 (SARP-3)
doi : 10.1164/rccm.202110-2265OC
Rationale: Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug phenotype.
Impact of Exposure to Diesel Exhaust on Inflammation Markers and Proteases in Former Smokers with Chronic Obstructive Pulmonary Disease: A Randomized, Double-blinded, Crossover Study
Min Hyung Ryu 1, Tina Afshar 1, Hang Li 1,2, Denise J. Wooding 1, Juma Orach 1, Jin Sheng Zhou 1, Shane Murphy 1, Kevin S. K. Lau 1, Carley Schwartz 1, Agnes C. Y. Yuen 1, Christopher F. Rider 1, and Chris Carlsten 1 ... Show less
doi : 10.1164/rccm.202104-1079OC
Rationale: There is growing evidence that chronic obstructive pulmonary disease (COPD) can be caused and exacerbated by air pollution exposure.
Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions
Baharan Zarrabian 1, Hannah Wunsch 2,3, Henry T. Stelfox 4,5,6,7, Theodore J. Iwashyna 8,9,10,11, and Hayley B. Gershengorn 12,13
doi : 10.1164/rccm.202108-2004OC Â
Rationale: Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain.
Investigating Nontuberculous Mycobacteria Transmission at the Colorado Adult Cystic Fibrosis Program
Jane E. Gross 1,2, Silvia Caceres 2, Katie Poch 2, Nabeeh A. Hasan 3, Fan Jia 3, L. Elaine Epperson 3, Ettie Lipner 3, Charmie Vang 3, Jennifer R. Honda 3, Matthew Strand 4, Vinicius Calado Nogueira de Moura 5, Charles L. Daley 5, Michael Strong 3, Rebecca M. Davidson 3, and Jerry A. Nick 2 ... Show less
doi : 10.1164/rccm.202108-1911OC
Rationale: Healthcare-associated transmission of nontuberculous mycobacteria (NTM) among people with cystic fibrosis (pwCF) has been investigated at CF centers worldwide, with conflicting conclusions. We investigated transmission at the Colorado Adult CF Program.
Air Pollutants and Asthma Hospitalization in the Medicaid Population
Yaguang Wei 1, Xinye Qiu 1, Matthew Benjamin Sabath 2, Mahdieh Danesh Yazdi 1, Kanhua Yin 3, Longxiang Li 1, Adjani A. Peralta 1, Cuicui Wang 1, Petros Koutrakis 1, Antonella Zanobetti 1, Francesca Dominici 2, and Joel D. Schwartz 1,4 ... Show less
doi : 10.1164/rccm.202107-1596OC
Rationale: Risk of asthma hospitalization and its disparities associated with air pollutant exposures are less clear within socioeconomically disadvantaged populations, particularly at low degrees of exposure.
Phase 2B Study of Inhaled RVT-1601 for Chronic Cough in Idiopathic Pulmonary Fibrosis: A Multicenter, Randomized, Placebo-controlled Study (SCENIC Trial)
Fernando J. Martinez 1, Marlies S. Wijsenbeek 2, Ganesh Raghu 3,4, Kevin R. Flaherty 5, Toby M. Maher 6,7,8, Wim A. Wuyts 9, Michael Kreuter 10,11, Martin Kolb 12, Daniel C. Chambers 13,14, Charles Fogarty 15, Nesrin Mogulkoc 16, Ahmet S. Tutuncu 17, and Luca Richeldi 18
doi : 10.1164/rccm.202106-1485OC Â
Rationale: Chronic cough remains a major and often debilitating symptom for patients with idiopathic pulmonary fibrosis (IPF). In a phase 2A study, inhaled RVT-1601 (cromolyn sodium) reduced daytime cough and 24-hour average cough counts in patients with IPF.
Steroid Therapy and Outcome of Parapneumonic Pleural Effusions (STOPPE): A Pilot Randomized Clinical Trial
Deirdre B. Fitzgerald 1,2,3, Grant W. Waterer 2,4, Charley Budgeon 5, Ranjan Shrestha 6, Edward T. Fysh 2,7, Sanjeevan Muruganandan 8, Christopher Stanley 4, Tajalli Saghaie 9,10, Arash Badiei 11, Calvin Sidhu 1,3,12, Hilman Harryanto 6, Victor Duong 8, Maree Azzopardi 1, David Manners 7, Norris S. H. Lan 1, Natalia D. Popowicz 1,13, Carolyn J. Peddle-McIntyre 3,12,14, Najib M. Rahman 15,16, Catherine A. Read 3,17, Ai Ling Tan 3, Seng Khee Gan 2,18, Kevin Murray 5, and Y. C. Gary Lee 1,2,3 ... Show less
doi : 10.1164/rccm.202107-1600OC
Rationale: Pleural effusion commonly complicates community-acquired pneumonia and is associated with intense pleural inflammation. Whether antiinflammatory treatment with corticosteroids improves outcomes is unknown.
Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension
Christopher J. Rhodes 1, John Wharton 1, Emilia M. Swietlik 2, Lars Harbaum 1, Barbara Girerd 3, J. Gerry Coghlan 4, James Lordan 5, Colin Church 6, Joanna Pepke-Zaba 7, Mark Toshner 2, Stephen J. Wort 1, David G. Kiely 8,9, Robin Condliffe 8,9, Allan Lawrie 8, Stefan Gräf 2,10, David Montani 3, Athénaïs Boucly 3, Olivier Sitbon 3, Marc Humbert 3, Luke S. Howard 1, Nicholas W. Morrell 2, and Martin R. Wilkins 1;
doi : 10.1164/rccm.202105-1118OC
Rationale: NT-proBNP (N-terminal pro–brain natriuretic peptide), a biomarker of cardiac origin, is used to risk stratify patients with pulmonary arterial hypertension (PAH). Its limitations include poor sensitivity to early vascular pathology. Other biomarkers of vascular or systemic origin may also be useful in the management of PAH.
The Development and Distribution of the COVID-19 Vaccine
Brian Chinai , Renuka Rajagopal , Joseph J. Lee , and Sugeet Jagpal
Inhaled Nitric Oxide Improved Refractory Hypoxemia through Attenuation of Intrapulmonary Shunt
Yuxian Wang and Ming Zhong
Simultaneous Imaging of Ventilation and Gas Exchange with Hyperpolarized 129Xe MRI for Monitoring Patients with Endobronchial Valve Interventions
Hooman Hamedani 1,2, Kevin Ma 3, David DiBardino 3, Ryan Baron 1, Stephen Kadlecek 1, Faraz Amzajerdian 1,2, Kai Ruppert 1, Ian Duncan 1, and Rahim R. Rizi 1
Clinical Features and Outcomes of Severe Pneumonia Caused by Endemic Human Coronavirus in Adults
Hyemin Chung *, Sang-Bum Hong *, Jin Won Huh , Heungsup Sung , Kyung-Hyun Do , Sang-Oh Lee , Chae-Man Lim , Younsuck Koh , and Sang-Ho Choi ‡
Ventilation Is Not Depressed in Patients with Hypoxemia and Acute COVID-19 Infection
Kristina Kairaitis 1*, Piotr Harbut 2, Goran Hedenstierna 3†, G. Kim Prisk 4, Catherine E. Farrow 1, Terence Amis 1, Peter D. Wagner 4, and Atul Malhotra 4
HIV-associated Pulmonary Arterial Hypertension: A Report from the Pulmonary Hypertension Association Registry
Nicholas A. Kolaitis 1*, Matthew Lammi 2, Sula Mazimba 3, Jeremy Feldman 4, Wes McConnell 5, Jeffrey S. Sager 6, Abhijit A. Raval 7, Marc A. Simon 1, and Teresa De Marco 1;
Rome Criteria for Exacerbation of Chronic Obstructive Pulmonary Disease: Not Built in a Day
Surya P. Bhatt *
Chronic Obstructive Pulmonary Disease Exacerbations: Do All Roads Lead to Rome?
Sanjay Ramakrishnan 1,2*‡, Iwein Gyselinck 3,4*, Mona Bafadhel 1,5, and Wim Janssens 3,4
Reply to Bhatt and to Ramakrishnan et al.
Bartolome R. Celli 1* and Leonardo M. Fabbri 2; on behalf of all the authors
Why Would Physiologic Support with Continuous Positive Airway Pressure Not Improve Outcomes in Patients with Atrial Fibrillation with Sleep Apnea?
Kathryn M. Lalonde , P. Timothy Pollak , and Marcus Povitz *
Reply to Lalonde et al.: Why Would Physiologic Support with Continuous Positive Airway Pressure Not Improve Outcomes in Patients with Atrial Fibrillation with Sleep Apnea?
Gunn Marit Traaen 1,2*, Harriet Akre 1,2, Jan PÃ¥l Loennechen 3,4, and Lars Gullestad 1,2
Staging of Lung Cancer
Christopher Slatore , Suzanne C Lareau , and Bonnie Fahy
doi : 10.1164/rccm.2059P17
