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Clinical Efficacy and Safety of the Intra-articular Injection of Autologous Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial
Kang-Il Kim, MD, PhD , Myung Chul Lee, MD, PhD, Ju Hong Lee, MD, PhD, Young-Wan Moon, MD, PhD, Woo-Suk Lee, MD, PhD, Han-Jun Lee, MD, PhD, Sun-Chul Hwang, MD, PhD, Yong In, MD, PhD, Oog-Jin Shon, MD, PhD, Ki-Cheor Bae, MD, PhD, Sang-Jun Song, MD, PhD, and Kwan Kyu Park, MD, PhD
doi : 10.1177/03635465231179223
Volume 51 Issue 9, July 2023
Intra-articular injection of autologous culture-expanded adipose-derived mesenchymal stem cells (ADMSCs) has introduced a promising treatment option for knee osteoarthritis. Although the clinical efficacy and safety of ADMSCs have been reported, the treatment remains controversial owing to the small sample sizes and heterogeneous osteoarthritis grades in previous studies.
Efficacy and Safety of Stempeucel in Osteoarthritis of the Knee: A Phase 3 Randomized, Double-Blind, Multicenter, Placebo-Controlled Study
Pawan Kumar Gupta, * MD, DNB, PhD, MNAMS, Sunil Maheshwari, MS, Joe Joseph Cherian, MS, Vijay Goni, MS, MNAMS, Arun Kumar Sharma, MS, Sujith Kumar Tripathy, MS, DNB, MNAMS, MRCS, Keerthi Talari, MD, DM, Vivek Pandey, MS , Parag Kantilal Sancheti, MS, MCh, DNB, Saurabh Singh, MS, MCh, Nikhil N. Verma, MD, and Uday Kumar, PhD
doi : 10.1177/03635465231180323
Osteoarthritis is a chronic, progressive, and degenerative condition with limited therapy options. Recently, biologic therapies have been an evolving option for the management of osteoarthritis.
Development of Anatomic Risk Factors for ACL Injuries: A Comparison Between ACL-Injured Knees and Matched Controls
Pratik Pradhan, * BS, Shankar G. Kaushal,* MS , Mininder S. Kocher, * MD, MPH, and Ata M. Kiapour, *y PhD, MMSc
doi : 10.1177/03635465231177465
Several tibiofemoral anatomic features have been repeatedly associated with increased anterior cruciate ligament (ACL) injury risk. Previous studies have highlighted age and sex differences among these anatomic risk factors, but little is known about the normal and pathologic development of these differences during skeletal maturation.
Posterior Tibial Slope in Patients Undergoing Bilateral Versus Unilateral ACL Reconstruction: MRI and Radiographic Analyses
Sharif Garra,*yz MD, Zachary I. Li,y BA , Jairo Triana,y BS, Naina Rao,y BS, Michael J. Alaia,y MD, Eric J. Strauss,y MD, Guillem Gonzalez-Lomas,y MD, and Laith M. Jazrawi,y MD
doi : 10.1177/03635465231177086
An increased posterior tibial slope (PTS) is a risk factor for primary anterior cruciate ligament (ACL) tears and graft failure, but the PTS has not been well-defined in those who have experienced bilateral ACL injuries.
Tibial Slope on Conventional Lateral Radiographs in Anterior Cruciate Ligament–Injured and Intact Knees: Mean Value and Outliers
Andreas Weiler, * MD, PhD, Rosa Berndt, y MS, Michael Wagner, * MD, Sven Scheffler, * MD, PhD, Imke Schatka,z MD, and Clemens Gwinner,y§ MD
doi : 10.1177/03635465231178292
An increased tibial slope (TS) has been identified as a risk factor for anterior cruciate ligament (ACL) injury and graft failure after ACL reconstruction. However, different imaging modalities are used to determine the TS, resulting in divergent values. Consequently, no reference values and no consensus on thresholds can be reached, which in turn is mandatory for indicating correction osteotomies when facing outlier TS.
Effect of Tibiofemoral Rotation Angle on Graft Failure After Anterior Cruciate Ligament Reconstruction
Chilan Bou Ghosson Leite, *y MD , Gergo Merkely,y MD, PhD , Evan M. Farina,y MD, Richard Smith,y MD, DPhil, Simon Go¨ rtz,y MD, Sean Hazzard,z PA-C, MBA, Peter Asnis,z MD, and Christian Lattermann,y MD
doi : 10.1177/03635465231163856
Coronal and sagittal malalignment of the knee are well-recognized risk factors for failure after anterior cruciate ligament (ACL) reconstruction (ACLR). However, the effect of axial malalignment on graft survival after ACLR is yet to be determined.
Comparison of Primary Repair of the Anterior Cruciate Ligament and Anterolateral Structures to Reconstruction and Lateral Extra-articular Tenodesis at 2-Year Follow-up
Andrea Ferretti, * MD, Alessandro Carrozzo,y MD , Adnan Saithna,z MD , Giuseppe Argento, § MD, Alessandro Annibaldi,y MD, Francesca Latini,y MD, Antonio Schiro` ,y MD, Fabio Marzilli,y MD , and Edoardo Monaco,y|| MD
doi : 10.1177/03635465231178301
Lateral extra-articular procedures have been effective in reducing graft rupture rates after anterior cruciate ligament (ACL) reconstruction (ACLR), but the evidence supporting their role in ACL repair is sparse.
Predictors of Return to Activity at 2 Years After Anterior Cruciate Ligament Reconstruction Among Patients With High Preinjury Marx Activity Scores: A MOON Prospective Cohort Study
MOON Knee Group
doi : 10.1177/03635465231172769
Predictors of return to activity after anterior cruciate ligament reconstruction (ACLR) among patients with relatively high preinjury activity levels remain poorly understood.
Ceiling Effect of the Combined Norwegian and Danish Knee Ligament Registers Limits Anterior Cruciate Ligament Reconstruction Outcome Prediction
R. Kyle Martin, *yz MD , Solvejg Wastvedt, § BA, Ayoosh Pareek, || MD, Andreas Persson,{# ** MD, PhD, Ha? vard Visnes, ** MD, PhD, Anne Marie Fenstad, ** MSc, Gilbert Moatshe,{# MD, PhD, Julian Wolfson, § PhD, Martin Lind,yy MD, PhD, and Lars Engebretsen,{# MD, PhD
doi : 10.1177/03635465231177905
Clinical tools based on machine learning analysis now exist for outcome prediction after primary anterior cruciate ligament reconstruction (ACLR). Relying partly on data volume, the general principle is that more data may lead to improved model accuracy.
Semimembranosus Tendon Findings in Acute Anterior Cruciate Ligament Tears: MRI Evaluation and Associated Lesions
Guglielmo Torre, *yz MD , Francesco Buschini,z MD, Marcello Zappia, § MD, Michael J. Battaglia,z MD, Rocco Papalia,y MD, PhD, and Pier Paolo Mariani,z MD
doi : 10.1177/03635465231176565
The semimembranosus (SM) tendon acts as a secondary dynamic stabilizer of the knee. It restrains external rotation and anterior translation of the medial compartment. Its role in the mechanism of injury during anterior cruciate ligament (ACL) rupture is unknown.
Acute Bone Loss and Infrapatellar Fat Pad Fibrosis in the Knee After an In Vivo ACL Injury in Adolescent Mice
Taeyong Ahn,* PhD, Benjamin E. Loflin, * MS, Nicholas B. Nguyen,y BS, Ciena K. Miller, * BS, Kaitlyn A. Colglazier,z BS, Edward M. Wojtys, § MD, and Stephen H. Schlecht, *z||{ PhD
doi : 10.1177/03635465231180616
Young patients are 6 times more likely than adults to have a primary anterior cruciate ligament (ACL) graft failure. Biological factors (ie, tunnel osteolysis) may account for up to a third of these failures. Previous evaluations of patient ACL explants indicated significant bone loss within the entheseal regions. However, it remains unknown if the degree of bone loss within the ACL insertion regions, wherein ACL grafts are fixated, exceeds that of the femoral and tibial condylar bone.
The Impact of Meniscal Tear Type and Surgical Treatment on Quadriceps Strength: A Study of Adolescent Patients Post Anterior Cruciate Ligament Reconstruction
Adam P. Weaver,*y PT, DPT , Michelle C. Walaszek,z PT, DPT, MS, Dylan P. Roman,y PT, DPT , Matthew S. Harkey,§ PhD, ATC, and Christopher Kuenze,z PhD, ATC
doi : 10.1177/03635465231177626
Treatment of meniscal injuries at the time of anterior cruciate ligament reconstruction (ACLR) can result in restrictions on weightbearing and range of motion in the early rehabilitative phases. What is unknown is the effect of (1) meniscal tear type and location at the time of anterior cruciate ligament injury and (2) meniscal treatment at the time of ACLR on quadriceps strength in adolescents during the late rehabilitative phase.
A Biomechanical Comparison of All-Inside Versus Transtibial Meniscus Root Repair Techniques
Nicholas Pasic, * MSc, MD, Hunter Storaci,y MS, Roberto Guzman,y BS, Malcolm Debaun,z MD, Masahiro Maruyama,y MD, PhD, Kimberly Hall,y MD, Brett P. Salazar,y MD, and Jason L. Dragoo,*§ MD
doi : 10.1177/03635465231179960
Meniscus root tears are associated with chondral injury, early degenerative change, and a high conversion rate to total knee arthroplasty. It is well-established that meniscus root tears lead to decreased femorotibial contact area, increased peak contact pressures, and increased stress on the articular cartilage.
Effect of Lower Extremity Torsion on Clinical Outcomes After Medial Patellofemoral Ligament Reconstruction and Tibial Tubercle Transfer for Recurrent Patellofemoral Instability
Yi Qiao, * MD , Zipeng Ye,* MD, Xiuyuan Zhang,y MD, Xiaoyu Xu,z BS, Caiqi Xu, * MD, Yuehua Li,z§ MD, Song Zhao, * § MD, and Jinzhong Zhao, * § MD
doi : 10.1177/03635465231177059
Increased femoral torsion (FT) or tibial torsion (TT) has been suggested to be a potential risk factor for recurrent patellofemoral instability. However, the influence of increased FT or TT on the postoperative clinical outcomes of recurrent patellofemoral instability has rarely been investigated.
Ten-Year Survivorship, Outcomes, and Sports Participation in Athletes After Primary Hip Arthroscopy for Femoroacetabular Impingement Syndrome
Benjamin G. Domb,*y MD , Shawn Annin,y MD, Peter F. Monahan,y BS , Michael S. Lee,y BA , Andrew E. Jimenez,y MD , and David R. Maldonado,z MD
doi : 10.1177/03635465231180305
Hip arthroscopy is an effective treatment tool for athletes with femoroacetabular impingement (FAI) syndrome. However, long-term data are scarce.
Achilles Tendon Tissue Turnover Before and Immediately After an Acute Rupture
Allan Cramer, *y MD, PhD , Grith H?jfeldt,z§|| PhD, Peter Schjerling,z§ PhD, Jakob Agergaard,z§ PhD, Gerrit van Hall, §{ PhD, Jesper Olsen, # PhD, Per Ho¨ lmich,y MD, DMSc, Michael Kjaer,z|| MD, DMSc, and Kristoffer Weisskirchner Barfod,y MD, PhD
doi : 10.1177/03635465231177890
An Achilles tendon rupture (ATR) is a frequent injury and results in the activation of tendon cells and collagen expression, but it is unknown to what extent turnover of the tendon matrix is altered before or after a rupture.
Minimum 10-Year Outcomes After Arthroscopic Repair of Partial-Thickness Supraspinatus Rotator Cuff Tears
Rony-Orijit Dey Hazra, *y MD , Maria E. Dey Hazra, * MD, Jared A. Hanson, * MD , Joan C. Rutledge, * BS , Kent C. Doan, *z MD, Marilee P. Horan, * MPH, and Peter J. Millett, *z§ MD, MSc
doi : 10.1177/03635465231176557
The prevalence of partial-thickness rotator cuff tears (PTRCTs) has been reported to be 13% to 40% within the adult population, accounting for 70% of all rotator cuff tears. Approximately 29% of PTRCTs will progress to full-thickness tears if left untreated. The long-term clinical course after arthroscopic repair of PTRCTs is not well known.
Association of Severe Histological Degeneration of the Torn Supraspinatus Tendon and Retear After Arthroscopic Repair of Full-Thickness Rotator Cuff Tears Using the Suture Bridge Technique
Takuya Tokunaga, *y MD, PhD , Tatsuki Karasugi,y MD, PhD, Shuntaro Tanimura,y MD, and Takeshi Miyamoto,y MD, PhD
doi : 10.1177/03635465231178294
Previous studies have demonstrated several prognostic factors for retear after arthroscopic rotator cuff repair (ARCR). However, studies that histologically evaluate the quality of the torn rotator cuff (RC) tendon and its association with postoperative outcomes are limited.
Physiological Tensioning During Lower Trapezius Transfer for Irreparable Posterosuperior Rotator Cuff Tears May Be Important for Improvement in Shoulder Kinematics
Lukas N. Muench, *yz MD , Marco-Christopher Rupp,y MD , Elifho Obopilwe,z MS, Julian Mehl,y MD, Bastian Scheiderer,y MD, Sebastian Siebenlist,y MD, Bassem T. Elhassan, § MD, Augustus D. Mazzocca, § MS, MD, and Daniel P. Berthold,yz MD
doi : 10.1177/03635465231179693
Lower trapezius transfer (LTT) has been proposed for restoring the anteroposterior muscular force couple in the setting of an irreparable posterosuperior rotator cuff tear (PSRCT). Adequate graft tensioning during surgery may be a factor critical for sufficient restoration of shoulder kinematics and functional improvement.
Bioactive Scaffold With Spatially Embedded Growth Factors Promotes Bone-to-Tendon Interface Healing of Chronic Rotator Cuff Tear in Rabbit Model
Jian Han,* MD, PhD, Sheng Chen Han,y MD, Young Kyu Kim,z MD, Solaiman Tarafder, § PhD, Hun Jin Jeong, § PhD, Hyeon Jang Jeong,y MD, PhD , Ju Young Chung,y MD, Chang H. Lee, §|| PhD, and Joo Han Oh,y|| MD, PhD
doi : 10.1177/03635465231180289
Functional restoration of the bone-to-tendon interface (BTI) after rotator cuff repair is a challenge. Therefore, numerous biocompatible biomaterials for promoting BTI healing have been investigated.
Biomechanical Evaluation of Posterior Shoulder Instability With a Clinically Relevant Posterior Glenoid Bone Loss Model
Robert A. Waltz, *yz MD, CDR, MC, USN , Justin Brown,z MD, Alex W. Brady,z MS, Christopher Bartolomei, § MD, Grant J. Dornan,z MSc , Jon W. Miles,z MS, Justin W. Arner, || MD , Peter J. Millett,z{ MD, MSc , and Matthew T. Provencher,z{ MD, CAPT(Ret), MC, USNR
doi : 10.1177/03635465231177957
Existing biomechanical studies of posterior glenoid bone loss and labral pathology are limited by their use of anterior instability models, which differ in both orientation and morphology and have been performed in only a single, neutral arm position.
The Influence of Glenoid Bone Loss and Graft Positioning on Graft and Cartilage Contact Pressures After the Latarjet Procedure
Lukas Ernstbrunner, *yz§ MD, PhD, Dale L. Robinson,z PhD, Yichen Huang,z MSc, Karl Wieser, || MD, Greg Hoy, § MBBS , Eugene T. Ek, § MBBS, PhD, and David C. Ackland,z PhD
doi : 10.1177/03635465231179711
Glenohumeral joint contact loading before and after glenoid bone grafting for recurrent anterior instability remains poorly understood.
In Vitro Effects of Triamcinolone and Methylprednisolone on the Viability and Mechanics of Native Articular Cartilage
Nathan P. Fackler, * MD, Evelia Yareli-Salinas,y PhD, Kylie T. Callan, * BS, Kyriacos A. Athanasiou,y PhD , and Dean Wang, *yz MD
doi : 10.1177/03635465231162644
The chondrotoxic effects of methylprednisolone acetate (MP) and triamcinolone acetonide (TA) have been well described. However, the mechanical effects of these commonly used steroids on native cartilage are largely unknown.
The Subchondral Bone Condition During Microfracture Affects the Repair of the Osteochondral Unit in the Cartilage Defect in the Rat Model
Junichi Sumii, * MD, Tomoyuki Nakasa, *y MD, PhD, Yuichi Kato, * MD, Shigeru Miyaki, *z PhD, and Nobuo Adachi, * MD, PhD
doi : 10.1177/03635465231177586
Microfracture (MF) is frequently performed as a first-line treatment for articular cartilage defects. Although good clinical outcomes are often obtained in the short term, poor clinical outcomes sometimes occur because of subchondral bone deterioration. The condition of the subchondral bone treated with MF may affect the repair of the osteochondral unit.
Can We Identify Why Athletes Fail to Return to Sports After Arthroscopic Bankart Repair? A Systematic Review and Meta-analysis
Michael Kim, * BS, Aryan Haratian, * BA, Amir Fathi, * BS, Daniel R. Kim, * MD, Nilay Patel, * MD, Ioanna K. Bolia, * MD, MS, PhD, Laith K. Hasan, * BBA, Frank A. Petrigliano, * MD, and Alexander E. Weber, *y MD
doi : 10.1177/03635465221089980
No previous systematic reviews have reported on athletes who fail to return to sports after arthroscopic Bankart repair.
The Use of Intra-articular Platelet-Rich Plasma as a Therapeutic Intervention for Hip Osteoarthritis: A Systematic Review and Meta-analysis
Anthony Lim,* BA, John B. Zhu, * BA, and Vikas Khanduja,yz MA (Cantab), MSc, FRCS (Tr&Orth), PhD
doi : 10.1177/03635465221095563
There is a cohort of patients in whom hip preservation surgery is not indicated, because they have developed signs of early osteoarthritis (OA), and nor can they have a hip replacement, as they are too early in the disease process. Management of this cohort of patients is not standardised and both pharmacological and nonpharmacological measures are utilised to reduce pain. Interventions available for early OA include intra-articular injections of steroids, viscosupplementation and more recently platelet-rich plasma (PRP). However, the use of PRP in hip OA has not yet been studied systematically.
Closure of the Quadriceps Tendon Autograft Harvest Site for Anterior Cruciate Ligament Reconstruction: A Systematic Review
Wendell W. Cole III, * MD, Shreya M. Saraf, * MS, Michaela Stamm,y MS, and Mary K. Mulcahey, *z MD
doi : 10.1177/03635465221095233
The quadriceps tendon (QT) autograft is a commonly used and effective graft option for anterior cruciate ligament reconstruction (ACLR). Surgical techniques vary, and there is no current standard of care for management of the QT autograft harvest site.
Surgical Techniques and Clinical Outcomes for Medial Epicondylitis: A Systematic Review
Alfonso Arevalo, * DO, Somnath Rao,y MD, Donald P. Willier III,z BS , Christopher I. Schrock, * BS, Brandon J. Erickson,y MD , Robert A. Jack II, § MD, Steven B. Cohen,y MD, and Michael G. Ciccotti,y|| MD
doi : 10.1177/03635465221095565
Medial epicondylitis (ME) is a pathological condition that arises in laborers and athletes secondary to repetitive wrist flexion and forearm pronation causing degeneration of the common flexor tendon. Although nonoperative management has demonstrated high rates of success, no standardized surgical technique has been established for situations when operative management is indicated.
In Memoriam: Champ L. Baker Jr, MD (August 3, 1946, to March 18, 2022)
Mary Lloyd Ireland, MD
In Memoriam: Curtain Call: Remembering James Garrick (1936-2022)
Susan Lewis, MD
Intraoperative Channeling in Arthroscopic Rotator Cuff Repair: Letter to the Editor
Lei Yao, MD Long Pang, MD Yinghao Li, MD Xin Tang, MD, PhD
Intraoperative Channeling in Arthroscopic Rotator Cuff Repair: Response
Peter Lapner, MD, FRCSC
Corrigendum to “Medial Patellofemoral Ligament Reconstruction Using Allografts in Skeletally Immature Patients�
