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‘Clicked’ drugs: researchers prove the remarkable chemistry in humans
Mark PeplowÂÂ
Unprecedented blood biomarker enables ALS drug approval
Cormac SheridanÂÂ
Biotech patenting � 2022
Kathryn Paisner & Laura DeFrancescoÂ
Plant molecular farming in the wake of the closure of Medicago Inc
Eugenio Benvenuto, Inge Broer, Marc-André D’Aoust, Inga Hitzeroth, Penny Hundleby, Rima Menassa, Kirsi-Marja Oksman-Caldentey, Hadrien Peyret, Sancha Salgueiro, Pooja Saxena, Jennifer Stander, Heribert Warzecha & Julian MaÂ
A call for an ‘Asilomar’ for cultivated meat and seafood
Sveva Bottini, Claudia Fuoco, Nike Schiavo, Alessandro Bertero, Stefano Biressi, Luciano Conti & Cesare GargioliÂ
Guidelines for public database submission of uncultivated virus genome sequences for taxonomic classification
Evelien M. Adriaenssens, Simon Roux, J. Rodney Brister, Ilene Karsch-Mizrachi, Jens H. Kuhn, Arvind Varsani, Tong Yigang, Alejandro Reyes, Cédric Lood, Elliot J. Lefkowitz, Matthew B. Sullivan, Robert A. Edwards, Peter Simmonds, Luisa Rubino, Sead Sabanadzovic, Mart Krupovic & Bas E. DutilhÂ
The prevalence of drug patent term extensions in the United States, 2000–2018
Victor L. Van de Wiele, Aaron S. Kesselheim, Sarosh Nagar & S. Sean TuÂ
Transplanting soil microbial communities improves climate tolerance in trees
Julie N. ChuongÂ
Fluorescence microscopy resolution increases to near-atomic level
Julie N. ChuongÂ
Multiplex-GAM detects complex chromatin interactions
Julie N. ChuongÂ
Staple crops equipped for alkaline soils
Caitlin S. Byrt, A. Harvey Millar & Rana MunnsÂ
Real-time monitoring of tumor-homing bacteria and tumor cells in vivo using ultrasound
Accurate isoform discovery with IsoQuant using long reads
Andrey D. Prjibelski, Alla Mikheenko, Anoushka Joglekar, Alexander Smetanin, Julien Jarroux, Alla L. Lapidus & Hagen U. TilgnerÂ
Genomically mined acoustic reporter genes for real-time in vivo monitoring of tumors and tumor-homing bacteria
Robert C. Hurt, Marjorie T. Buss, Mengtong Duan, Katie Wong, Mei Yi You, Daniel P. Sawyer, Margaret B. Swift, PrzemysÅ‚aw Dutka, Pierina Barturen-Larrea, David R. Mittelstein, Zhiyang Jin, Mohamad H. Abedi, Arash Farhadi, Ramya Deshpande & Mikhail G. ShapiroÂ
Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy
Xinbo Yang, Daisuke Nishimiya, Sara Löchte, Kevin M. Jude, Marta Borowska, Christina S. Savvides, Michael Dougan, Leon Su, Xiang Zhao, Jacob Piehler & K. Christopher GarciaÂ
doi : 10.1038/s41587-022-01567-w
Monoclonal antibodies (Abs) that recognize major histocompatability complex (MHC)-presented tumor antigens in a manner similar to T cell receptors (TCRs) have great potential as cancer immunotherapeutics. However, isolation of ‘TCR-mimic’ (TCRm) Abs is laborious because Abs have not evolved the structurally nuanced peptide–MHC restriction of αβ-TCRs.
A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments
Tongrui Qian, Huan Wang, Peng Wang, Lan Geng, Long Mei, Takuya Osakada, Lei Wang, Yan Tang, Alan Kania, Valery Grinevich, Ron Stoop, Dayu Lin, Minmin Luo & Yulong LiÂ
doi : 10.1038/s41587-022-01561-2
Oxytocin (OT), a peptide hormone and neuromodulator, is involved in diverse physiological and pathophysiological processes in the central nervous system and the periphery. However, the regulation and functional sequences of spatial OT release in the brain remain poorly understood.
Heritable transgene-free genome editing in plants by grafting of wild-type shoots to transgenic donor rootstocks
Lei Yang, Frank Machin, Shuangfeng Wang, Eleftheria Saplaoura & Friedrich KraglerÂ
doi : 10.1038/s41587-022-01585-8
Generation of stable gene-edited plant lines using clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) requires a lengthy process of outcrossing to eliminate CRISPR–Cas9-associated sequences and produce transgene-free lines.
Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases
Connor J. Tou, Benno Orr & Benjamin P. KleinstiverÂ
doi : 10.1038/s41587-022-01574-x
CRISPR-associated transposases (CASTs) enable recombination-independent, multi-kilobase DNA insertions at RNA-programmed genomic locations. However, the utility of type V-K CASTs is hindered by high off-target integration and a transposition mechanism that results in a mixture of desired simple cargo insertions and undesired plasmid cointegrate products.
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform
Peter M. Bruno, Richard T. Timms, Nouran S. Abdelfattah, Yumei Leng, Felipe J. N. Lelis, Duane R. Wesemann, Xu G. Yu & Stephen J. ElledgeÂ
Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination
Yu-Lan Xiao, Shun Liu, Ruiqi Ge, Yuan Wu, Chuan He, Mengjie Chen & Weixin TangÂ
doi : 10.1038/s41587-022-01587-6
N6-methyladenosine (m6A), the most abundant internal messenger RNA modification in higher eukaryotes, serves myriad roles in regulating cellular processes. Functional dissection of m6A is, however, hampered in part by the lack of high-resolution and quantitative detection methods.
A spatial genome aligner for resolving chromatin architectures from multiplexed DNA FISH
Bojing Blair Jia, Adam Jussila, Colin Kern, Quan Zhu & Bing RenÂ
doi : 10.1038/s41587-022-01568-9
Multiplexed fluorescence in situ hybridization (FISH) is a widely used approach for analyzing three-dimensional genome organization, but it is challenging to derive chromosomal conformations from noisy fluorescence signals, and tracing chromatin is not straightforward.
Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design
Lukas Weilguny, Nicola De Maio, Rory Munro, Charlotte Manser, Ewan Birney, Matthew Loose & Nick GoldmanÂ
doi : 10.1038/s41587-022-01580-z
Nanopore sequencers can select which DNA molecules to sequence, rejecting a molecule after analysis of a small initial part. Currently, selection is based on predetermined regions of interest that remain constant throughout an experiment.
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
Rosa Lundbye Allesøe, Agnete Troen Lundgaard, Ricardo Hernández Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Cristina Leal RodrÃÂguez, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan Hong, Petra B. Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe Muilwijk, Marieke T. Blom, Leen M. ‘t Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin RidderstrÃ¥le, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil Dermitzakis, Paul W. Franks, Jochen M. Schwenk, Jerzy Adamski, Mark I. McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Søren Brunak & IMI DIRECT Consortium
Author Correction: A spatial genome aligner for resolving chromatin architectures from multiplexed DNA FISH
Bojing Blair Jia, Adam Jussila, Colin Kern, Quan Zhu & Bing RenÂ
The need for need-finding in medical education
Sainiteesh Maddineni & Wasan KumarÂ
