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Liberation from continuous kidney replacement therapy—is it an art or a science?
Akash DeepÂ
doi : 10.1007/s00467-023-05885-2
Volume 38, issue 7, July 2023
Hyperchloremia and acute kidney injury: chicken or the egg?
Matthew F. Barhight & David T. Selewski
Hiding in plain sight: genetics of childhood steroid-resistant nephrotic syndrome in Sub-Saharan Africa
Anna Elizabeth Williams, Christopher I. Esezobor, Brandon M. Lane & Rasheed A. Gbadegesin
doi : 10.1007/s00467-022-05831-8
Steroid-resistant nephrotic syndrome (SRNS) is the most severe form of childhood nephrotic syndrome with an increased risk of progression to chronic kidney disease stage 5. Research endeavors to date have identified more than 80 genes that are associated with SRNS.
Research progress of fibroblast growth factor 23 in acute kidney injury
Lina Zhang & Wei Qin
doi : 10.1007/s00467-022-05791-z
10.1007/s00467-022-05791-z
Incidence, predictors, and short-term outcomes of acute kidney injury in children with diabetic ketoacidosis: a systematic review
Jitendra Meena, Jaivinder Yadav, Jogender Kumar, Lesa Dawman, Karalanglin Tiewosh, Aliza Mittal, Rakesh Kumar & Devi Dayal
doi : 10.1007/s00467-023-05878-1
One-third of children with type 1 diabetes mellitus manifest with diabetic ketoacidosis (DKA). Most children presenting with DKA are in a volume-depleted state, leading to acute kidney injury (AKI). Besides volume depletion, hyperglycemia can induce tubular injury and kidney inflammation. Therefore, a thorough knowledge of incidence of AKI, risk factors, and outcomes in pediatric DKA is desirable to improve its management and outcomes.
Post-transplant education for kidney recipients and their caregivers
Pamela Singer
doi : 10.1007/s00467-022-05744-6
Successful outcomes in pediatric kidney transplantation require the involvement of the transplant team as well as recipients and their caregivers.
Kidney support for babies: building a comprehensive and integrated neonatal kidney support therapy program
Tahagod H. Mohamed, Jolyn Morgan, Theresa A. Mottes, David Askenazi, Jennifer G. Jetton & Shina Menon
doi : 10.1007/s00467-022-05768-y
Kidney support therapy (KST), previously referred to as Renal Replacement Therapy, is utilized to treat children and adults with severe acute kidney injury (AKI), fluid overload, inborn errors of metabolism, and kidney failure.
Rhabdomyolysis-associated acute kidney injury in a teenager: Questions
Manel Jellouli, Abir Boussetta, Meriem Hajji, Yosra Falfoul, Linda Hadj Kacem, Ezzeddine Abderrahim & Tahar Gargah
Rhabdomyolysis-associated acute kidney injury in a teenager: Answers
Manel Jellouli, Abir Boussetta, Meriem Hajji, Yosra Falfoul, Linda Hadj Kacem, Ezzeddine Abderrahim & Tahar Gargah
Diagnostic dilemma in a 3-year-old girl with acute nephritic syndrome and hematologic abnormalities: Questions
Samantha Innocenti, Silvia Bernardi, Maud Prévot, Antonin Saldmann, Maud Tusseau, Alexandre Belot, Jean-Paul Duong Van Huyen & Olivia Boyer
Diagnostic dilemma in a 3-year-old girl with acute nephritic syndrome and hematologic abnormalities: Answers
Samantha Innocenti, Silvia Bernardi, Maud Prévot, Antonin Saldmann, Maud Tusseau, Alexandre Belot, Jean-Paul Duong Van Huyen & Olivia Boyer
Failure to thrive in an 8-month-old female: Questions
Romina Kim, XinYi Ye, Pedro A. Sanchez-Lara, Dechu Puliyanda, Sanjeev Kumar & Helen Pizzo
Failure to thrive in an 8-month-old female: Answers
Romina Kim, XinYi Ye, Pedro A. Sanchez-Lara, Dechu Puliyanda, Sanjeev Kumar & Helen Pizzo
Three Tesla magnetic resonance imaging detects oxalate osteopathy in patients with primary hyperoxaluria type I
Lisa-Marie Merz, Mark Born, Guido Kukuk, Alois M. Sprinkart, Ingrid Becker, Cristina Martin-Higueras & Bernd Hoppe
doi : 10.1007/s00467-022-05836-3
With declining kidney function and therefore increasing plasma oxalate, patients with primary hyperoxaluria type I (PHI) are at risk to systemically deposit calcium-oxalate crystals. This systemic oxalosis may occur even at early stages of chronic kidney failure (CKD) but is difficult to detect with non-invasive imaging procedures.
Kidney concentrating capacity in children with autosomal recessive polycystic kidney disease is linked to glomerular filtration and hypertension
Tomáš Seeman, Kveta Bláhová, Filip Fencl, Richard Klaus, Bärbel Lange-Sperandio, Gabriela Hr�ková & Ĺudmila Podracká
doi : 10.1007/s00467-022-05834-5
Impaired kidney concentration capacity is present in half of the patients with autosomal dominant polycystic kidney disease (ADPKD). The kidney concentrating capacity was further impaired within the animal model of autosomal recessive polycystic kidney disease (ARPKD). To date, only one small study has investigated it in children having ARPKD. Therefore, we aimed to study the kidney concentrating ability in a larger cohort of children with ARPKD.
Treatment of idiopathic nephrotic syndrome at onset: a comparison between 8- and 12-week regimens in everyday clinical practice
Laura Lucchetti, Antonio Gatto, Alessandra Gianviti, Marina Vivarelli, Francesco Emma & Laura Massella
doi : 10.1007/s00467-022-05824-7
Optimal steroid treatment at onset of idiopathic nephrotic syndrome is still debated. The aim of this study was to analyze the clinical outcome at 24Â months of follow-up in patients admitted to our unit for the first episode of steroid-sensitive nephrotic syndrome comparing two different steroid regimens.
Is influenza vaccination associated with nephrotic syndrome relapse in children? A multicenter prospective study
Shingo Ishimori, Tomoko Horinouchi, Junya Fujimura, Tomohiko Yamamura, Natsuki Matsunoshita, Naohiro Kamiyoshi, Mai Sato, Masao Ogura, Koichi Kamei, Kenji Ishikura, Kazumoto Iijima & Kandai Nozu
doi : 10.1007/s00467-022-05783-z
Prospective research of children receiving heterogeneous vaccines has shown that immunization is not associated with pediatric idiopathic nephrotic syndrome (NS) relapses. However, prospective data concentrating only on influenza (flu) virus vaccines are not available.
Uromycobiome in infants and toddlers with and without urinary tract infections
Catherine S. Forster, Hui Liu, Marcia Kurs-Lasky, Wendy Ullmer, Janina A. Krumbeck & Nader Shaikh
doi : 10.1007/s00467-022-05844-3
The bacterial components of the urobiome have been described in children, both with and without urinary tract infections (UTI). However, less is known about the pediatric uromycobiome: the community of fungi in the urine. The objectives of this study were to describe the uromycobiome in children and determine whether the uromycobiome differs between children with and without UTI.
Comparison of axial and coronal axis MRI kidney volume measurement in pediatric congenital solitary kidney
Derya Bako, Adem Yasin Köksoy & Mehmet Turmak
doi : 10.1007/s00467-022-05858-x
Accurate estimation of kidney size and volume in the solitary functioning kidney is crucial because of a higher risk of developing kidney injury. MRI is an accurate method and is suitable for kidney volume measurement. Usually, axial axis images and measurement methods are preferred for kidney volume measurements.
Long-term kidney outcomes in non-dialyzed children with Shiga-toxin Escherichia coli associated hemolytic uremic syndrome
Laura F. Alconcher, Lucas I. Lucarelli & Sabrina Bronfen
doi : 10.1007/s00467-022-05851-4
Long-term kidney outcomes of non-dialyzed children with Shiga-toxin Escherichia Coli hemolytic uremic syndrome (STEC-HUS) have been scantily studied. Therefore, we aimed to evaluate kidney outcomes and prognostic markers in these patients.
An analysis of sex differences and socioeconomic deprivation among Canadian children with high blood pressure: a retrospective, cross-sectional study
Susan Telencoe, Alexander Singer, Leanne Kosowan & Allison B. Dart
doi : 10.1007/s00467-022-05841-6
Understanding which children are at highest risk for high blood pressure (HBP) can inform surveillance and treatment. This study evaluated sex differences in childhood HBP and its associations with socioeconomic status.
Nephrectomy improves both antihypertensive requirement and left ventricular mass for pediatric renal hypertension
Laura B. Cornwell, Andres Moreno Rojas, Eniola Ogundipe, Ian Golding, Sarah Marietti & Elizabeth G. Ingulli
doi : 10.1007/s00467-022-05854-1
Renal hypertension causes left ventricular (LV) hypertrophy leading to cardiomyopathy. Nephrectomy has been utilized to improve blood pressure and prepare for kidney transplantation in the pediatric population. We sought to investigate antihypertensive medication (AHM) requirement and LV mass in patients undergoing nephrectomy with renal hypertension.
Adverse childhood experiences are associated with vascular changes in adolescents that are risk factors for future cardiovascular disease
Cailin E. Kellum, Keri M. Kemp, Sylvie Mrug, Jennifer S. Pollock, Michael E. Seifert & Daniel I. Feig
doi : 10.1007/s00467-022-05853-2
Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, are associated with a higher risk of cardiovascular disease (CVD) and indicators of future CVD risk in adulthood, such as greater vascular stiffness.
Evaluation of lung ultrasound to detect volume overload in children undergoing dialysis
Lindsay Arthur, Parthak Prodhan, Richard Blaszak, Brendan Crawford, Clare C. Brown & Jason Arthur
doi : 10.1007/s00467-022-05723-x
Lung ultrasound is a well-established technique to assess extravascular lung water, a proxy for volume status, in the adult population. Despite its utility, the data are limited supporting the use of ultrasound to evaluate fluid volume status among pediatric patients. Our study uses a simplified ultrasound protocol to evaluate changes in extravascular lung water, represented by b-lines, among pediatric patients undergoing hemodialysis.
Outcomes and perception of cloud-based remote patient monitoring in children receiving automated peritoneal dialysis: a prospective study
Eugene Yu-hin Chan, Mei-shan Liu, Po-chu Or & Alison Lap-tak Ma
doi : 10.1007/s00467-022-05828-3
Remote patient monitoring (RPM) for automated peritoneal dialysis (APD) may improve clinical outcomes. Paediatric data, however, remain extremely scarce.
Plasma FGF23 is associated with left atrial remodeling in children on hemodialysis
Shilpa Sharma, Nisha R. Patel, Mark R. Hanudel, Joachim H. Ix, Isidro B. Salusky & Kim-Lien Nguyen
doi : 10.1007/s00467-022-05812-x
FGF23 mediates cardiac fibrosis through the activation of pro-fibrotic factors in in vitro models and is markedly elevated in kidney disease.
The effects of hospital and dialysis unit characteristics on hospitalizations for access-related complications among children on maintenance dialysis: a European, multicenter, observational, cross-sectional study
Yeşim Özdemir Atikel, Claus Peter Schmitt, Eszter Lévai, Shazia Adalat, Rukshana Shroff, Nadine Goodman, İsmail Dursun, Ayşe Seda Pınarbaşı, Burcu Yazıcıoğlu, Fabio Paglialonga, Karel Vondrak, Isabella Guzzo, Nikoleta Printza, Aleksandra Zurowska, Ilona Zagożdżon, Aysun Karabay Bayazıt, Bahriye Atmış, Marcin Tkaczyk, Maria do Sameiro Faria, Ariane Zaloszyc, Augustina Jankauskiene, Mesiha Ekim, Alberto Edefonti & Sevcan A. Bakkaloğlu
doi : 10.1007/s00467-022-05842-5
Previous studies investigating hospitalizations in dialysis patients have focused primarily on patient-centered factors. We analyzed the impact of hospital and dialysis unit characteristics on pediatric dialysis patients’ hospitalizations for access-related complications (ARCs).
Humoral and cellular immune response to SARS-CoV-2 mRNA BNT162b2 vaccine in pediatric kidney transplant recipients compared with dialysis patients and healthy children
Ruveyda Gulmez, Dogukan Ozbey, Ayse Agbas, Bagdagul Aksu, Nurdan Yildiz, Diana Uckardes, Seha Saygili, Esra Karabag Yilmaz, Zeynep Yuruk Yildirim, Mehmet Tasdemir, Ayca Kiykim, Haluk Cokugras, Nur Canpolat, Ahmet Nayir, Bekir Kocazeybek & Salim Caliskan
doi : 10.1007/s00467-022-05813-w
Compared with the general population, the immune response to COVID-19 mRNA vaccines is lower in adult kidney transplant recipients (KTRs). However, data is limited for pediatric KTRs. In this study, we aimed to assess humoral and cellular immune responses to the COVID-19 mRNA vaccine in pediatric KTRs.
Language barriers and kidney transplantation in children
Stephanie P. Kerkvliet, Carlos J. Perez Kerkvliet, Ziou Jiang, Michael Evans & Sarah J. Kizilbash
doi : 10.1007/s00467-022-05821-w
Understanding disparities in pediatric kidney transplants is important to provide equitable care. We compared transplant outcomes between English-speaking (ES) and interpreter-needing (IN) pediatric kidney transplant recipients.
Predictors of successful discontinuation of continuous kidney replacement therapy in a pediatric cohort
Elizabeth Y. Wei, Kim T. Vuong, Euyhyun Lee, Lin Liu, Elizabeth Ingulli & Nicole G. Coufal
doi : 10.1007/s00467-022-05782-0
Recognizing the optimal time to discontinue continuous kidney replacement therapy (CKRT) is necessary to advance patient recovery and mitigate complications. The aim of this study was to identify predictors of successful CKRT cessation in pediatric patients.
Hyperchloremia and association with acute kidney injury in critically ill children
Dylan Ginter, Elaine Gilfoyle, Andrew Wade, Brendan Cord Lethebe & Eli Gilad
doi : 10.1007/s00467-022-05823-8
Hyperchloremia has been associated with acute kidney injury (AKI) in critically ill adult patients. Data is limited in pediatric patients. Our study sought to determine if an association exists between hyperchloremia and AKI in pediatric patients admitted to the intensive care unit (PICU).
Positive fluid balance and diuretic therapy are associated with mechanical ventilation and mortality in preterm neonates in the first fourteen postnatal days
Mariah L. Wright, Brett G. Klamer, Elizabeth Bonachea, John D. Spencer, Jonathan L. Slaughter & Tahagod H. Mohamed
doi : 10.1007/s00467-022-05861-2
Fluid overload leads to poor neonatal outcomes. Diuretics may lower the rates of mechanical ventilation (MV) and mortality in neonates with fluid overload.
Hyperchloremia, hypernatremia, and acute kidney injury in critically ill children
Gema Manrique MartÃn & Jesús López-Herce
New-onset pediatric idiopathic nephrotic syndrome secondary to COVID-19
Yuhi Takagi & Shigemi Yoshihara
Correction to: Three Tesla magnetic resonance imaging detects oxalate osteopathy in patients with primary hyperoxaluria type I
Lisa-Marie Merz, Mark Born, Guido Kukuk, Alois M. Sprinkart, Ingrid Becker, Cristina Martin-Higueras & Bernd Hoppe
