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Transforming growth factor beta signaling functions during mammalian kidney development
Mihai G. Dumbrava, Jon L. Lacanlale, Christopher J. Rowan & Norman D. Rosenblum
doi : 10.1007/s00467-020-04739-5
Pediatric Nephrology volume 36, pages1663–1672 (2021)
Aberrant transforming growth factor beta (TGF?) signaling during embryogenesis is implicated in severe congenital abnormalities, including kidney malformations. However, the molecular mechanisms that underlie congenital kidney malformations related to TGF? signaling remain poorly understood. Here, we review current understanding of the lineage-specific roles of TGF? signaling during kidney development and how dysregulation of TGF? signaling contributes to the pathogenesis of kidney malformation.
Prematurity, perinatal inflammatory stress, and the predisposition to develop chronic kidney disease beyond oligonephropathy
Lieke A. Hoogenboom, Tim G. A. M. Wolfs, Matthias C. Hütten, Carine J. Peutz-Kootstra & Michiel F. Schreuder
doi : 10.1007/s00467-020-04712-2
Pediatric Nephrology volume 36, pages1673–1681 (2021)
Prematurity and perinatal stress, such as intrauterine growth restriction (IUGR) and chorioamnionitis, are pathological processes creating an impaired intrauterine environment. These intrauterine factors are associated with the development of proteinuria, hypertension, and chronic kidney disease (CKD) later in life. Initially, this was thought to be secondary to oligonephropathy, subsequent glomerular hypertrophy, and hyperfiltration, leading to glomerulosclerosis, a further decrease in nephron number, and finally CKD.
Pathophysiology and consequences of arterial stiffness in children with chronic kidney disease
Karolis Azukaitis, Augustina Jankauskiene, Franz Schaefer & Rukshana Shroff
doi : 10.1007/s00467-020-04732-y
Pediatric Nephrology volume 36, pages1683–1695 (2021)
Changes in arterial structure and function are seen early in the course of chronic kidney disease (CKD) and have been causally associated with cardiovascular (CV) morbidity. Numerous potential injuries encompassing both traditional and uremia-specific CV risk factors can induce structural arterial changes and accelerate arterial stiffening. When the buffering capacity of the normally elastic arteries is reduced, damage to vulnerable microcirculatory beds can occur.
Urine collection methods and dipstick testing in non-toilet-trained children
James Diviney & Mervyn S. Jaswon
doi : 10.1007/s00467-020-04742-w
Pediatric Nephrology volume 36, pages1697–1708 (2021)
Urinary tract infection is a commonly occurring paediatric infection associated with significant morbidity. Diagnosis is challenging as symptoms are non-specific and definitive diagnosis requires an uncontaminated urine sample to be obtained. Common techniques for sampling in non-toilet-trained children include clean catch, bag, pad, in-out catheterisation and suprapubic aspiration.
The progression of serum cystatin C concentrations within the first month of life after preterm birth—a worldwide systematic review
Anjana Renganathan, Barbara B. Warner, Phillip I Tarr & Vikas R. Dharnidharka
doi : 10.1007/s00467-020-04543-1
Pediatric Nephrology volume 36, pages1709–1718 (2021)
Multiple single-center studies have examined the progression of kidney function biomarkers such as serum cystatin C (Cys C) in the first 30 days of life (DOL) after preterm birth, but from different ethnicities and in different gestational ages (GA), without a functional summary available. We performed a systematic literature review within PubMed, Google Scholar, and Scopus, with additional use of the snowballing method to find studies including data on serum Cys C concentrations in the first 30 DOL.
Mechanisms and management of edema in pediatric nephrotic syndrome
Mahmoud Kallash & John D. Mahan
doi : 10.1007/s00467-020-04779-x
Pediatric Nephrology volume 36, pages1719–1730 (2021)
Edema is the abnormal accumulation of fluid in the interstitial compartment of tissues within the body. In nephrotic syndrome, edema is often seen in dependent areas such as the legs, but it can progress to cause significant accumulation in other areas leading to pulmonary edema, ascites, and/or anasarca.
Adult survivors of idiopathic childhood onset nephrotic syndrome
Dorota M. Marchel & Debbie S. Gipson
doi : 10.1007/s00467-020-04773-3
Pediatric Nephrology volume 36, pages1731–1737 (2021)
Like many pediatric chronic health conditions, idiopathic childhood onset nephrotic syndrome (iCONS) and late effects of iCONS medical management may continue to impact the affected population in adulthood. Approximately 15% of adult survivors of steroid-sensitive iCONS continue to relapse. Long-term kidney health is associated with steroid response patterns as well as pathology findings of FSGS, tubulointerstitial fibrosis, tubular atrophy, and global glomerulosclerosis. Long-term cardiovascular disease burden is largely unknown in adult survivors, but risk factors starting in childhood, including hypertension, dyslipidemia, and obesity, are common in iCONS.
Update on the creation and maintenance of arteriovenous fistulas for haemodialysis in children
Evgenia Preka, Rukshana Shroff, Lynsey Stronach, Francis Calder & Constantinos J. Stefanidis
doi : 10.1007/s00467-020-04746-6
Pediatric Nephrology volume 36, pages1739–1749 (2021)
Arteriovenous fistulas (AVFs) are widely used for haemodialysis (HD) in adults with stage 5 chronic kidney disease (CKD 5) and are generally considered the best form of vascular access (VA). The ‘Fistula First’ initiative in 2003 helped to change the culture of VA in adults. However, this cultural change has not yet been adopted in children despite the fact that a functioning AVF is associated with lower complication rates and longer access survival than a central venous line (CVL). For children with CKD 5, especially when kidney failure starts early in life, there is a risk that all VA options will be exhausted. Therefore, it is essential to develop long-term strategies for optimal VA creation and maintenance.
When should we start and stop ACEi/ARB in paediatric chronic kidney disease?
Eugene Yu-hin Chan, Alison Lap-tak Ma & Kjell Tullus
doi : 10.1007/s00467-020-04788-w
Pediatric Nephrology volume 36, pages1751–1764 (2021)
Renin-angiotensin-aldosterone inhibitors (RAASi) are the mainstay therapy in both adult and paediatric chronic kidney disease (CKD). RAASi slow down the progression of kidney failure by optimization of blood pressure and reduction of proteinuria.
Safety, efficacy, and acceptability of ADV7103 during 24 months of treatment: an open-label study in pediatric and adult patients with distal renal tubular acidosis
Aurélia Bertholet-Thomas, Catherine Guittet, Maria A. Manso-Silv?n, Sophie Joukoff, Victor Navas-Serrano, Véronique Baudouin, Mathilde Cailliez, Massimo Di Maio, Olivia Gillion-Boyer, Emilija Golubovic, Jérôme Harambat, Bertrand Knebelmann, François Nobili, Robert Novo, Ludmila Podracka, Gwenaëlle Roussey-Kesler & Luc-André Granier
doi : 10.1007/s00467-020-04873-0
Pediatric Nephrology volume 36, pages1765–1774 (2021)
A new prolonged-release formulation of potassium citrate and potassium bicarbonate, ADV7103, has been shown to improve metabolic control, palatability, and gastrointestinal safety in patients with distal renal tubular acidosis (dRTA) when compared to standard of care (SoC) treatments. The present work evaluates safety and efficacy of ADV7103 during 24 months.
Utility of contrast-enhanced ultrasound for solid mass surveillance and characterization in children with tuberous sclerosis complex: an initial experience
Joyce PK Chan, Susan J Back, Seth Vatsky, Juan S Calle-Toro, Dimitry Khrichenko, Anush Sridharan, Laura Poznick & Savvas Andronikou
doi : 10.1007/s00467-020-04835-6
Pediatric Nephrology volume 36, pages1775–1784 (2021)
Patients with tuberous sclerosis complex (TSC) can develop solid kidney masses from childhood. Imaging surveillance is done to detect renal cell carcinoma (RCC) and angiomyolipomas (AML), including AMLs at risk for hemorrhage. Intravenous contrast-enhanced ultrasound (CEUS) may be useful for screening as ultrasound is well tolerated by children and ultrasound contrast agents (UCA) are not nephrotoxic.
Plasma oxalate and eGFR are correlated in primary hyperoxaluria patients with maintained kidney function—data from three placebo-controlled studies
Dawn S. Milliner, Pierre Cochat, Sally-Anne Hulton, Jerome Harambat, Ana Banos, Bastian Dehmel & Elisabeth Lindner
doi : 10.1007/s00467-020-04894-9
Pediatric Nephrology volume 36, pages1785–1793 (2021)
In patients with primary hyperoxaluria (PH), endogenous oxalate overproduction increases urinary oxalate excretion, leading to compromised kidney function and often kidney failure. Highly elevated plasma oxalate (Pox) is associated with systemic oxalate deposition in patients with PH and severe chronic kidney disease (CKD).
Levamisole and ANCA positivity in childhood nephrotic syndrome
Leah Krischock, Pasan Pannila & Sean E. Kennedy
doi : 10.1007/s00467-020-04915-7
Pediatric Nephrology volume 36, pages1795–1802 (2021)
This study aimed to determine the prevalence of ANCA positivity in children managed with levamisole as a steroid-sparing agent for nephrotic syndrome (NS).
Determination of the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the diagnosis of asymptomatic pulmonary embolism in patients with nephrotic syndrome
Nasrin Hoseiny nejad, Amin Sadat Sharif, Hasan Otukesh, Rozita Hosseini shamsabadi, Sepideh Hekmat & Maryam Sakhaei
doi : 10.1007/s00467-020-04904-w
Pediatric Nephrology volume 36, pages1803–1808 (2021)
Thromboembolism is one of the most important and dangerous complications of nephrotic syndrome. This study aimed to determine the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the prediction of asymptomatic pulmonary embolism in patients with nephrotic syndrome in non-remission period.
Is ultrasonography mandatory in all children at their first febrile urinary tract infection?
Marco Pennesi, Stefano Amoroso, Giulia Pennesi, Manuela Giangreco, Elisabetta Cattaruzzi, Marco Pesce, Marina Busetti, Egidio Barbi & Ester Conversano
doi : 10.1007/s00467-020-04909-5
Pediatric Nephrology volume 36, pages1809–1816 (2021)
This study investigated whether performing kidney ultrasound (KUS) only in children presenting either a pathogen other than E. coli at their first febrile urinary tract infection (fUTI) or experiencing fUTI recurrence would increase missed diagnoses of kidney anomalies.
Evaluation of polyuria and polydipsia along with other established prognostic factors in posterior urethral valves for progression to kidney failure: experience from a developing country
Naveen Kumar, Priyank Yadav, Shrey Jain, Abhay Kumar G., Vinay N. Kaushik & M. S. Ansari
doi : 10.1007/s00467-020-04837-4
Pediatric Nephrology volume 36, pages1817–1824 (2021)
Up to 50% of children with posterior urethral valves (PUV) progress to kidney failure. This study aimed to evaluate polyuria and polydipsia and other established variables with later development of kidney failure in children with PUV.
Dilatation of the aorta in children with advanced chronic kidney disease
Sophie Quennelle, Caroline Ovaert?, Mathilde Cailliez, Florentine Garaix, Michel Tsimaratos & Fedoua El Louali
doi : 10.1007/s00467-020-04887-8
Pediatric Nephrology volume 36, pages1825–1831 (2021)
The peculiarity of the cardiovascular risk profile with increased arterial vulnerability is well known in adults with chronic kidney disease (CKD). It is explained by an increased incidence of traditional cardiovascular risk factors together with other comorbidities related to the uremic condition and cardiorenal syndrome (CRS). The present study aimed to determine the cardiovascular impact of the uremic condition in a pediatric population with advanced CKD.
Do children with solitary or hypofunctioning kidney have the same prevalence for masked hypertension?
Sibel Yel, Neslihan Günay, Ay?e Seda P?narba??, Aynur Gencer Balaban, Zeynep Cafero?lu, ?smail Dursun & Muammer Hakan Poyrazo?lu
doi : 10.1007/s00467-020-04896-7
Pediatric Nephrology volume 36, pages1833–1841 (2021)
Having a low nephron number is a well-known risk factor for hypertension. There is an inverse relationship between the filtration surface area and systemic hypertension. A significant percentage of masked hypertension can be detected in children with nephron loss by ambulatory blood pressure monitoring (ABPM).
Differential assessment of fluid compartments by bioimpedance in pediatric patients with kidney diseases
Sandra M. Frey, Bruno Vogt, Giacomo D. Simonetti, Rainer Büscher, Sandra Habbig & Franz Schaefer
doi : 10.1007/s00467-020-04912-w
Pediatric Nephrology volume 36, pages1843–1850 (2021)
The kidney is central for maintaining water balance. As a corollary, patients with impaired kidney function are prone to pathological fluid volumes. Total body water (TBW) is distributed between the extracellular (ECW) and intracellular fluid compartments (ICW).
Longitudinal outcomes of body mass index in overweight and obese children with chronic kidney disease
Nancy M. Rodig, Jennifer Roem, Michael F. Schneider, Patricia W. Seo-Mayer, Kimberly J. Reidy, Frederick J. Kaskel, Amy J. Kogon, Susan L. Furth & Bradley A. Warady
doi : 10.1007/s00467-020-04907-7
Pediatric Nephrology volume 36, pages1851–1860 (2021)
Longitudinal changes in body mass index (BMI) among overweight and obese children with chronic kidney disease (CKD) are not well characterized. We studied longitudinal trajectories and correlates of these trajectories, as results may identify opportunities to optimize health outcomes.
Association between insulin growth factor-1, bone mineral density, and frailty phenotype in children with chronic kidney disease
Vasiliki Karava, John Dotis, Athanasios Christoforidis, Vassilios Liakopoulos, Antonia Kondou, Georgios Tsigaras, Konstantina Tsioni, Konstantinos Kollios & Nikoleta Printza
doi : 10.1007/s00467-020-04907-7
Pediatric Nephrology volume 36, pages1861–1870 (2021)
This cohort study investigates the association between insulin growth factor-1 (IGF-1), bone mineral density, and frailty phenotype in children with chronic kidney disease (CKD).
Determinants of growth after kidney transplantation in prepubertal children
Julia Grohs, Rainer-Maria Rebling, Kerstin Froede, Kristin Hmeidi, Leo Pavi?i?, Jutta Gellermann, Dominik Müller, Uwe Querfeld, Dieter Haffner & Miroslav ?ivi?njak
doi : 10.1007/s00467-021-04922-2
Pediatric Nephrology volume 36, pages1871–1880 (2021)
Short stature is a frequent complication after pediatric kidney transplantation (KT). Whether the type of transplantation and prior treatment with recombinant human growth hormone (GH) affects post-transplant growth, is unclear.
Long-term outcomes during 37 years of pediatric kidney transplantation: a cohort study comparing ethnic groups
Miriam Davidovits, Lewis Reisman, Roxana Cleper, Nathan Bar-Nathan, Irit Krause, Amit Dagan, Neomi Zanhendler, Gabriel Chodick, Osnat Hocherman, Maya Mor, Sigal Aisner & Eytan Mor
doi : 10.1007/s00467-020-04908-6
Pediatric Nephrology volume 36, pages1881–1888 (2021)
This study aimed to evaluate short- and long-term outcomes of kidney transplantation over 37 years in a national referral center and compare outcomes between Israeli Jewish and Arab children.
Hemodynamic disturbances and oliguria during continuous kidney replacement therapy in critically ill children
Sarah N. Fern?ndez Lafever, Jorge L?pez, Rafael Gonz?lez, Mar?a J. Solana, Javier Urbano, Jes?s L?pez-Herce, Laura Butrague?o & Mar?a J. Santiago
doi : 10.1007/s00467-020-04804-z
Pediatric Nephrology volume 36, pages1889–1899 (2021)
About 1.5% of patients admitted to the Pediatric Intensive Care Unit (PICU) will require continuous kidney replacement therapy (CKRT)/renal replacement therapy (CRRT). Mortality of these patients ranges from 30 to 60%. CKRT-related hypotension (CKRT-RHI) can occur in 19–45% of patients. Oliguria after onset of CKRT is also common, but to date has not been addressed directly in the scientific literature.
Blood transfusion rates in Baby NINJA (Nephrotoxic Injury Negated by Just-in-Time Action)—a single-center experience
Hailey W. Gavigan, Cara L. Slagle, Kelli A. Krallman, Brenda B. Poindexter, David K. Hooper & Stuart L. Goldstein
doi : 10.1007/s00467-020-04917-5
Pediatric Nephrology volume 36, pages1901–1905 (2021)
Previous studies in non-critically ill hospitalized pediatric patients have shown that daily serum creatinine monitoring for the development of nephrotoxic medication–associated acute kidney injury decreases both the rate of high nephrotoxic medication exposure and associated acute kidney injury. Attempts to spread this successful screening program have been met with concerns that daily serum creatinine monitoring in critically ill neonates with high-risk nephrotoxic medication exposure would lead to iatrogenic anemia and an increase in blood transfusion requirements.
Impact of acute kidney injury in patients prescribed angiotensin-converting enzyme inhibitors over the first two years of life
Daishi Hirano, Saori Miwa, Daisuke Kakegawa, Chisato Umeda, Yoichi Takemasa, Ai Tokunaga, Kawakami Yuhei & Akira Ito
doi : 10.1007/s00467-021-04920-4
Pediatric Nephrology volume 36, pages1907–1914 (2021)
The association of long-term acute kidney injury (AKI) risk with angiotensin-converting enzyme (ACE) inhibitor use in neonates/infants is poorly understood. We examined this association to identify potential AKI risk factors.
Urinary neutrophil gelatinase-associated lipocalin rules out nephrotoxic acute kidney injury in children
Stuart L. Goldstein, Kelli A. Krallman, Alexandra Schmerge, Lynn Dill, Bradley Gerhardt, Praneeta Chodaparavu, Abigail Radomsky, Cassie Kirby & David J. Askenazi
doi : 10.1007/s00467-020-04898-5
Pediatric Nephrology volume 36, pages1915–1921 (2021)
Nephrotoxic medication exposure is a common cause of acute kidney injury (AKI) in hospitalized children. A key component of the NINJA quality improvement initiative is systematic daily serum creatinine assessment in non-critically ill children exposed to ? 3 nephrotoxic medications on 1 day, or intravenous aminoglycoside or vancomycin for ? 3 days. Daily venipuncture is invasive and associated with disposable and personnel healthcare costs. Urine neutrophil gelatinase-associated lipocalin (uNGAL) is a marker of renal tubular injury associated with certain nephrotoxic medications. We investigated whether uNGAL is a reliable screening tool for AKI in NINJA and could decrease the need for daily venipuncture.
Evaluation of neonatal acute kidney injury after critical congenital heart disease surgery
Serdar Beken, Burcu Bulum Akbulut, Eda Albayrak, Bengisu Güner, Yasemin ?nlü, Bahar Temur, Selim Aydin, Ender ?demi?, Ersin Erek & Ay?e Korkmaz
doi : 10.1007/s00467-020-04890-z
Pediatric Nephrology volume 36, pages1923–1929 (2021)
Acute kidney injury (AKI) is a common complication of congenital heart diseases (CHDs) after cardiac surgery. This study aimed to define the frequency and critical course, risk factors and short-term outcomes of AKI in postoperative CHD neonates.
Kidney function in patients with primary distal renal tubular acidosis
Jessica M. Forero-Delgadillo, Helena Gil-Pe?a, Marta Alonso-Varela, Fernando Santos & RenalTube Group
doi : 10.1007/s00467-021-05068-x
Pediatric Nephrology volume 36, pages1931–1935 (2021)
Recent reports indicate that chronic reduction of glomerular filtration rate (GFR) is common in patients with distal renal tubular acidosis (DRTA). Factors responsible for decreased GFR need clarification.
Correction to: Urine collection methods and dipstick testing in non-toilet-trained children
James Diviney & Mervyn S. Jaswon
doi : 10.1007/s00467-020-04824-9
Pediatric Nephrology volume 36, page1937 (2021)
Incidental chronic kidney disease in an obese child with high myopia: Questions
Aliza Mittal, Manjesh Jayappa, Binit Sureka & Kuldeep Singh
doi : 10.1007/s00467-020-04783-1
Pediatric Nephrology volume 36, pages1939–1941 (2021)
Incidental chronic kidney disease in an obese child with high myopia: Answers
Aliza Mittal, Manjesh Jayappa, Binit Sureka & Kuldeep Singh
doi : 10.1007/s00467-020-04785-z
Pediatric Nephrology volume 36, pages1943–1946 (2021)
A rare complication of pauci-immune crescentic glomerulonephritis in a child: Questions
Sidharth Kumar Sethi, Abhyuday Rana, Shyam Bihari Bansal, Alka Rana, Dinesh Kumar Yadav, Kritika Soni, Marie-Agnès Dragon-Durey, Rupesh Raina & Vijay Kher
doi : 10.1007/s00467-020-04784-0
Pediatric Nephrology volume 36, pages1947–1948 (2021)
A rare complication of pauci-immune crescentic glomerulonephritis in a child: Answers
Sidharth Kumar Sethi, Abhyuday Rana, Shyam Bihari Bansal, Alka Rana, Dinesh Kumar Yadav, Kritika Soni, Marie-Agnès Dragon-Durey, Rupesh Raina & Vijay Kher
doi : 10.1007/s00467-020-04786-y
Pediatric Nephrology volume 36, pages1949–1952 (2021)
An “old and new” complication in a child with nephrotic syndrome: Questions
Yosuke Inaguma, Hiroshi Kaito, Tomoko Horinouchi, Yoshiharu Ogawa, Makiko Yoshida, Norishige Yoshikawa & Ryojiro Tanaka
doi : 10.1007/s00467-020-04787-x
Pediatric Nephrology volume 36, pages1953–1954 (2021)
An “old and new” complication in a child with nephrotic syndrome: Answers
Yosuke Inaguma, Hiroshi Kaito, Tomoko Horinouchi, Yoshiharu Ogawa, Makiko Yoshida, Norishige Yoshikawa & Ryojiro Tanaka
doi : 10.1007/s00467-020-04794-y
Pediatric Nephrology volume 36, pages1955–1958 (2021)
Chronic kidney disease in a child—an unusual crossroad: Questions
Nivedita Pande, Kiran Sathe, Sushma Save & Dev Shetty
doi : 10.1007/s00467-020-04792-0
Pediatric Nephrology volume 36, pages1959–1961 (2021)
Chronic kidney disease in a child—an unusual crossroad: Answers
Nivedita Pande, Kiran Sathe, Sushma Save & Dev Shetty
doi : 10.1007/s00467-020-04795-x
Pediatric Nephrology volume 36, pages1963–1965 (2021)
A case of painless exercise-induced gross hematuria in a 9-year-old boy: Questions
Anna Zisi, Chrysoula Kosmeri, Ioanna Siatara, Anastasia Giantsouli, Vasileios Xydis & Ekaterini Siomou
doi : 10.1007/s00467-020-04803-0
Pediatric Nephrology volume 36, page1967 (2021)
A case of painless exercise-induced gross hematuria in a 9-year-old boy: Answers
Anna Zisi, Chrysoula Kosmeri, Ioanna Siatara, Anastasia Giantsouli, Vasileios Xydis & Ekaterini Siomou
doi : 10.1007/s00467-020-04807-w
Pediatric Nephrology volume 36, pages1969–1971 (2021)
Transient Bartter-like syndrome in a child with extensively drug-resistant tuberculosis: Questions
Vishrutha Sujith Poojari, Ira Shah, Naman S. Shetty & Akanksha Jaiswal
doi : 10.1007/s00467-020-04813-y
Pediatric Nephrology volume 36, pages1973–1974 (2021)
Transient Bartter-like syndrome in a child with extensively drug-resistant tuberculosis: Answers
Vishrutha Sujith Poojari, Ira Shah, Naman S. Shetty & Akanksha Jaiswal
doi : 10.1007/s00467-020-04822-x
Pediatric Nephrology volume 36, pages1975–1976 (2021)
Hypertensive crisis in an 11-year-old girl with kidney and inferior vena cava abnormalities and leg thrombosis: Questions
?ubica Kov??ikov?, M?ria Chocholov?, Milan Il??k, ?ofia Varényiov?, Tom?? Seeman & ?udmila Podrack?
doi : 10.1007/s00467-020-04825-8
Pediatric Nephrology volume 36, pages1977–1979 (2021)
Hypertensive crisis in an 11-year-old girl with kidney and inferior vena cava abnormalities and leg thrombosis: Answers
?ubica Kov??ikov?, M?ria Chocholov?, Milan Il??k, ?ofia Varényiov?, Tom?? Seeman & ?udmila Podrack?
doi : 10.1007/s00467-020-04830-x
Pediatric Nephrology volume 36, pages1981–1983 (2021)
Unusual cause of recurrent macroscopic hematuria in an adolescent girl: Questions
Abir Boussetta, Manel Jellouli, Raja Aouaidia, Rim Goucha & Taher Gargah
doi : 10.1007/s00467-020-04831-w
Pediatric Nephrology volume 36, pages1985–1986 (2021)
Unusual cause of recurrent macroscopic hematuria in an adolescent girl: Answers
Abir Boussetta, Manel Jellouli, Raja Aouaidia, Rim Goucha & Taher Gargah
doi : 10.1007/s00467-020-04845-4
Pediatric Nephrology volume 36, pages1987–1988 (2021)
Antenatally diagnosed renal tumor: Questions
Wiebke Solass, Hyunkyu Shin, Cristian Urla & Andreas Schmidt
doi : 10.1007/s00467-020-04848-1
Pediatric Nephrology volume 36, pages1989–1991 (2021)
Antenatally diagnosed kidney tumor: Answers
Wiebke Solass, Hyunkyu Shin, Cristian Urla & Andreas Schmidt
doi : 10.1007/s00467-020-04857-0
Pediatric Nephrology volume 36, pages1993–1994 (2021)
Surprise diagnosis in an adolescent case with chronic kidney damage: Questions
Güzide Do?an, Nurver Ak?nc?, Rasul Sharifov, Fatma Betül ?ak?r, Hakan ?entürk & Hac? Mehmet Türk
doi : 10.1007/s00467-020-04850-7
Pediatric Nephrology volume 36, pages1995–1996 (2021)
Surprise diagnosis in an adolescent case with chronic kidney damage: Answers
Güzide Do?an, Nurver Ak?nc?, Rasul Sharifov, Fatma Betül ?ak?r, Hakan ?entürk & Hac? Mehmet Türk
doi : 10.1007/s00467-020-04858-z
Pediatric Nephrology volume 36, pages1997–1999 (2021)
Thoracic mass lesion in a 14-year-old girl: Questions
Cuneyt Karagol, Fatma Ayd?n, ?zge Ba?aran, Banu ?elikel Acar, Hasan Ali Durmaz & Nilgun ?akar
Thoracic mass lesion in a 14-year-old girl: Answers
Cuneyt Karagol, Fatma Ayd?n, ?zge Ba?aran, Banu ?elikel Acar, Hasan Ali Durmaz & Nilgün ?akar
Hypokalemic quadriparesis in a 10-year-old girl: Questions
Amee Amin, Allyn Small, Youmna Mousattat & Myra Chiang
Hypokalemic quadriparesis in a 10-year-old girl: Answers
Amee Amin, Allyn Small, Youmna Mousattat & Myra Chiang
An easily overlooked cause of acute kidney injury: Questions
Sare Gülfem ?zlü, Zehra Aydin, Aylin Kilinç U?urlu, Mehmet Boyraz & Umut Selda Bayrakçi
An easily overlooked cause of acute kidney injury: Answers
Sare Gülfem ?zlü, Zehra Aydin, Aylin Kilinç U?urlu, Mehmet Boyraz & Umut Selda Bayrakç?
A rare cause of hypertension in an 11-year-old boy: Questions
Abir Boussetta, Manel Jellouli, Rim Meddeb, Ridha Mrad, Riadh Jouini, Amina Karray, Said Jlidi & Tahar Gargah
A rare cause of hypertension in an 11-year-old boy: Answers
Abir Boussetta, Manel Jellouli, Rim Meddeb, Ridha Mrad, Riadh Jouini, Amina Karray, Said Jlidi & Tahar Gargah
Profound metabolic acidosis and hyperammonemia in a 2-year-old child: Questions
Abir Boussetta, Manel Jellouli, Rim Meddeb, Ridha Mrad, Riadh Jouini, Amina Karray, Said Jlidi & Tahar Gargah
Profound metabolic acidosis and hyperammonemia in a 2-year-old child: Answers
Min-Hua Tseng, Ming-Wei Lai, Jhao-Jhuang Ding & Shih-Hua Lin
A rare cause of recurrent acute kidney injury in a 3-year-old girl: Questions
Shrutiprajna Kar, Sriram Krishnamurthy, Pediredla Karunakar, Malini Maya, Abarna Thangaraj & Yamini Agarwal
A rare cause of recurrent acute kidney injury in a 3-year-old girl: Answers
Shrutiprajna Kar, Sriram Krishnamurthy, Pediredla Karunakar, Malini Maya, Abarna Thangaraj & Yamini Agarwal
Strong mesangial IgA staining—does it always refer to IgA nephropathy in a patient with proteinuria and hematuria? Questions
Ilayda Altun, Seha Sayg?l?, Nur Canpolat, Yasemin ?zlük, ?zge Hürdo?an, G?zde Ye?il, Salim ?al??kan & Lale Sever
Strong mesangial IgA staining—does it always refer to IgA nephropathy in a patient with proteinuria and hematuria? Answers
Ilayda Altun, Seha Sayg?l?, Nur Canpolat, Yasemin ?zlük, ?zge Hürdo?an, G?zde Ye?il, Salim ?al??kan & Lale Sever
Flank pain and gross hematuria: an uncommon presentation of a rare disease: Questions
Erika T. Allred & Peter D. Yorgin
Flank pain and gross hematuria: an uncommon presentation of a rare disease: Answers
Erika T. Allred & Peter D. Yorgin
Proteinuria and progressive kidney failure due to an inborn error of metabolism: Questions
?zlem ?nal Uzun, Nurcan Cengiz, Bü?ra ?avdarl?, Umut Bayrakç?, Saba Kiremitçi & Aynur Küçükçongar Yava?
Proteinuria and progressive kidney failure due to an inborn error of metabolism: Answers
?zlem ?nal Uzun, Nurcan Cengiz, Bü?ra ?avdarl?, Umut Bayrakç?, Saba Kiremitçi & Aynur Küçükçongar Yava?
An unusual complication of peritoneal dialysis: Questions
Adem Yasin K?ksoy, Derya Bako, Metin ?im?ek, Sida Do?an & G?kçen ?zçiftçi
An unusual complication of peritoneal dialysis: Answers
Adem Yasin K?ksoy, Derya Bako, Metin ?im?ek, Sida Do?an & G?kçen ?zçiftçi
A rare cause of urolithiasis in an infant: Questions
Mustafa Koyun, Muhammet Sancaktar, Gül?ah Kaya Aksoy, Elif ?omak, Ayla Kaçar, Mehtap Adar, Afig Berdeli & Sema Akman
A rare cause of urolithiasis in an infant: Answers
Mustafa Koyun, Muhammet Sancaktar, Gül?ah Kaya Aksoy, Elif ?omak, Ayla Kaçar, Mehtap Adar, Afig Berdeli & Sema Akman
A hemodialysis patient with difficulty ambulating: Questions
Nina Mann, Annemarie Fayemi, Melissa Myles, Nicole Kelley, Brian Carmine, Camilla Richmond & Avram Z. Traum
A hemodialysis patient with difficulty ambulating: Answers
Nina Mann, Annemarie Fayemi, Melissa Myles, Nicole Kelley, Brian Carmine, Camilla Richmond & Avram Z. Traum
A child with a severe headache: Questions
Leyla Telhan, Murat Begenik, Yontem Yaman & Onder Yavascan
A child with a severe headache: Answers
Leyla Telhan, Murat Begenik, Yontem Yaman & Onder Yavascan
Tubulopathy and hepatomegaly in a 2-year-old boy: Questions
Pembe Soylu Ustkoyuncu, Funda Bastug, Asl?han Kiraz, Murat Erdogan, Esra Eren & Gokce Y?ld?z
Tubulopathy and hepatomegaly in a 2-year-old boy: Answers
Pembe Soylu Ustkoyuncu, Funda Bastug, Asl?han Kiraz, Murat Erdogan, Esra Eren & Gokce Y?ld?z
A rare cause of childhood hypertension detected in a school screening program: Questions
Cengiz Zeybek, Ahmet Bolat & Bedriye Nuray Alpman
A rare cause of childhood hypertension detected in a school screening program: Answers
Cengiz Zeybek, Ahmet Bolat & Bedriye Nuray Alpman
An uncommon cause of nephrocalcinosis in an infant: Questions
Adem Yasin K?ksoy, Derya Bako & Servet Yel
An uncommon cause of nephrocalcinosis in an infant: Answers
Adem Yasin K?ksoy, Derya Bako & Servet Yel
Nephrotic range proteinuria in an adolescent with a diagnosis of Wilson’s disease: Questions
Ay?e A?ba?, Eda Dilara Bay, Meryem Keçeli Ba?aran, Türkan ?kizceli, G?zde K?l?ç Kayhan & Yasemin ?zlük
Nephrotic range proteinuria in an adolescent with a diagnosis of Wilson’s disease: Answers
Ay?e A?ba?, Eda Dilara Bay, Meryem Keçeli Ba?aran, Türkan ?kizceli, G?zde K?l?ç Kayhan & Yasemin ?zlük
Two faces of lupus nephritis? Questions
?eyda Do?antan, Neslihan Günay, Sema Nur Ta?k?n, Aynur Gencer Balaban, Ay?enur Paç K?saarslan, Sibel Yel, Hülya Akgün, ?smail Dursun & Muammer Hakan Poyrazo?lu
Two faces of lupus nephritis? Answers
?eyda Do?antan, Neslihan Günay, Sema Nur Ta?k?n, Aynur Gencer Balaban, Ay?enur Paç K?saarslan, Sibel Yel, Hülya Akgün, ?smail Dursun & Muammer Hakan Poyrazo?lu
An unusual cause of hypertension: Questions
Ozlem Yuksel Aksoy, Funda Bastug, Aysenur Pac Kisaarslan & Binnaz Celik
An unusual cause of hypertension: Answers
Ozlem Yuksel Aksoy, Funda Bastug, Aysenur Pac Kisaarslan & Binnaz Celik
Hypokalemic metabolic alkalosis in an adolescent female: Questions
Elif Benderlio?lu, Hakan ??ütlü, Alk?m ?den Akman, Demet Ta?, Aylin Irmak Kuruç, Sare Gülfem ?zlü & Umut Selda Bayrakçi
Hypokalemic metabolic alkalosis in an adolescent female: Answers
Elif Benderlio?lu, Hakan ??ütlü, Alk?m ?den Akman, Demet Ta?, Aylin Irmak Kuruç, Sare Gülfem ?zlü & Umut Selda Bayrakçi
A hypertensive girl with failure to thrive accompanied by gastrointestinal symptoms: Questions
Senay Zirhli Selcuk, Ahmet Taner Elmas, Ismail Okan Yildirim, Ahmet Sigirci, Betul Sozeri & Yilmaz Tabel
A hypertensive girl with failure to thrive accompanied by gastrointestinal symptoms: Answers
Senay Zirhli Selcuk, Ahmet Taner Elmas, Ismail Okan Yildirim, Ahmet Sigirci, Betul Sozeri & Yilmaz Tabel
A rare cause of transitory hematuria and urinary tract dysfunction in children: Questions
Guillaume Dorval, Laureline Berteloot, Luca Pio, Olivia Boyer & Thomas Blanc
A rare cause of transitory hematuria and urinary tract dysfunction in children: Answers
Guillaume Dorval, Laureline Berteloot, Luca Pio, Olivia Boyer & Thomas Blanc
A rare cause of subnephrotic proteinuria in an adolescent: Questions
Lila Hawkinson, Sandra Iragorri, Amira Al-Uzri & Nicole K. Andeen
A rare cause of subnephrotic proteinuria in an adolescent: Answers
Lila Hawkinson, Sandra Iragorri, Amira Al-Uzri & Nicole K. Andeen
A case with kidney transplant and cystinosis: Questions
Tülay Becerir, ?lknur Giri?gen, Neslihan Y?lmaz, Olcay Güng?r, Emine ?eker ?n, Ergin Sa?ta? & Selçuk Yüksel
A case with kidney transplant and cystinosis: Answers
Tülay Becerir, ?lknur Giri?gen, Neslihan Y?lmaz, Olcay Güng?r, Emine ?eker ?n, Ergin Sa?ta? & Selçuk Yüksel
