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Periconceptional Use of OnabotulinumtoxinA: Need for Comparative Safety Studies.
Ponder, Madison MPS; Wood, Mollie E. PhD, MPH
doi : 10.1212/WNL.0000000000207469
Volume 101(2) pgs. 53-96,e103-e224 July 11, 2023
A Potential Forecast for Ischemic Stroke Burden in 2030: Are We There Yet?.
Cantu-Brito, Carlos MD, PhD *; Garcia-Grimshaw, Miguel MD *
Getting to the Heart of the Heart-Brain Connection: Association or Causation?.
Janssen, Esther MS; de Leeuw, Frank-Erik MD
Pregnancy Outcomes in Patients Exposed to OnabotulinumtoxinA Treatment: A Cumulative 29-Year Safety Update.
Brin, Mitchell F. MD, FAAN, FANA, FAHS; Kirby, Russell S. PhD, MS; Slavotinek, Anne MBBS, PhD; Adams, Aubrey Manack PhD; Parker, Lori; Ukah, Ahunna PhD; Radulian, Lavinia MS; Elmore, Monica R.P. PhD; Yedigarova, Larisa MD, PhD; Yushmanova, Irina MD
Long-term Outcomes After Periprocedural and Spontaneous Spinal Cord Infarctions: A Population-Based Cohort Study.
Stenimahitis, Vasilios MD; Fletcher-Sandersjoo, Alexander MD; El-Hajj, Victor Gabriel; Hultling, Claes MD, PhD; Andersson, Magnus MD, PhD; Sveinsson, Olafur MD, PhD; Elmi-Terander, Adrian MD, PhD; Edstrom, Erik MD, PhD
doi : 10.1212/WNL.0000000000207377
Spinal cord infarction (SCInf) is a rare condition where consensus regarding diagnostic criteria is lacking, and misdiagnosis or delayed diagnosis can be detrimental.
Association of Polysomnographic Sleep Parameters With Neuroimaging Biomarkers of Cerebrovascular Disease in Older Adults With Sleep Apnea.
Carvalho, Diego Z. MD, MS; McCarter, Stuart J. MD; St Louis, Erik K. MD, MS; Przybelski, Scott A. BS; Johnson Sparrman, Kohl L. BS; Somers, Virend K. MD, PhD; Boeve, Bradley F. MD; Petersen, Ronald C. MD, PhD; Jack, Clifford R. Jr MD; Graff-Radford, Jonathan MD; Vemuri, Prashanthi PhD
doi : 10.1212/WNL.0000000000207392
Our objective was to determine whether polysomnographic (PSG) sleep parameters are associated with neuroimaging biomarkers of cerebrovascular disease (CVD) related to white matter (WM) integrity in older adults with obstructive sleep apnea (OSA).
Global Burden, Risk Factor Analysis, and Prediction Study of Ischemic Stroke, 1990-2030.
Fan, Jiahui MS *; Li, Xiaoguang PhD *; Yu, Xueying MS; Liu, Zhenqiu PhD; Jiang, Yanfeng PhD; Fang, Yibin PhD; Zong, Ming BS; Suo, Chen PhD +; Man, Qiuhong MS +; Xiong, Lize PhD +
doi : 10.1212/WNL.0000000000207387
Ischemic stroke (IS), 1 of the 2 main subtypes of stroke, occurs because of brain ischemia caused by thrombosis of a cerebral blood vessel. IS is one of the most important neurovascular causes of death and disability.
Associations of Blood Cardiovascular Biomarkers With Brain Free Water and Its Relationship to Cognitive Decline: A Diffusion-MRI Study.
Ji, Fang PhD; Chai, Yuek Ling PhD; Liu, Siwei PhD; Kan, Cheuk Ni MSc; Ong, Marcus BSc; Richards, Arthur Mark MD; Tan, Boon Yeow MMed; Venketasubramanian, Narayanaswamy FRCP; Pasternak, Ofer PhD; Chen, Christopher MD; Lai, Mitchell K.P. PhD *; Zhou, Juan Helen PhD *
doi : 10.1212/WNL.0000000000207401
There is an increasing awareness of the "Heart-Brain Connection," whereby cardiovascular function is connected with cognition. Diffusion-MRI studies reported higher brain free water (FW) was associated with cerebrovascular disease (CeVD) and cognitive impairment. In this study, we investigated whether higher brain FW was related to blood cardiovascular biomarkers and whether FW mediated the associations between blood biomarkers and cognition.
Longitudinal Relationships of White Matter Hyperintensities and Alzheimer Disease Biomarkers Across the Adult Life Span.
Luo, Jingqin PhD; Ma, Yinjiao MS, MPH; Agboola, Folasade Jane MPH; Grant, Elizabeth PhD; Morris, John C. MD; McDade, Eric DO; Fagan, Anne M. PhD; Benzinger, Tammie L.S. MD, PhD; Hassenstab, Jason PhD; Bateman, Randall J. MD; Perrin, Richard J. MD, PhD; Gordon, Brian A. PhD; Goyal, Manu MD; Strain, Jeremy F. PhD; Yakushev, Igor MD; Day, Gregory S. MD; Xiong, Chengjie PhD; for Dominantly Inherited Alzheimer Network (DIAN)
doi : 10.1212/WNL.0000000000207378
White matter hyperintensities (WMH) correlate with Alzheimer disease (AD) biomarkers cross-sectionally and modulate AD pathogenesis.
[beta]-Amyloid Load on PET Along the Continuum of Dementia With Lewy Bodies.
Diaz-Galvan, Patricia PhD; Przybelski, Scott A. BS; Lesnick, Timothy G. MS; Schwarz, Christopher G. PhD; Senjem, Matthew L. MS; Gunter, Jeffrey L. PhD; Jack, Clifford R. MD; Min, Hoon-Ki Paul PhD; Jain, Manoj MD; Miyagawa, Toji PhD; Forsberg, Leah K. PhD; Fields, Julie A. PhD; Savica, Rodolfo MD, PhD; Graff-Radford, Jonathan MD; Jones, David T. MD; Botha, Hugo MD; St Louis, Erik K. MD; Knopman, David S. MD; Ramanan, Vijay K. MD, PhD; Ross, Owen PhD; Graff-Radford, Neill MBBCh; Day, Gregory S. MD; Dickson, Dennis W. MD; Ferman, Tanis J. PhD; Petersen, Ronald C. MD, PhD; Lowe, Val J. MD; Boeve, Brad F. MD; Kantarci, Kejal MD
doi : 10.1212/WNL.0000000000207393
[beta]-Amyloid (A[beta]) plaques can co-occur with Lewy-related pathology in patients with dementia with Lewy bodies (DLB), but A[beta] load at prodromal stages of DLB still needs to be elucidated.
Longitudinal Associations Between Blood Biomarkers and White Matter MRI in Sport-Related Concussion: A Study of the NCAA-DoD CARE Consortium.
Wu, Yu-Chien MD, PhD, DABMP *; Wen, Qiuting PhD *; Thukral, Rhea BS; Yang, Ho-Ching PhD; Gill, Jessica M. PhD, RN; Gao, Sujuan PhD; Lane, Kathleen A. MS; Meier, Timothy B. PhD; Riggen, Larry D. MS; Harezlak, Jaroslaw PhD; Giza, Christopher C. MD; Goldman, Joshua MD, FACSM; Guskiewicz, Kevin M. PhD, ATC; Mihalik, Jason P. PhD, CAT(C), ATC; LaConte, Stephen M. PhD; Duma, Stefan M. PhD; Broglio, Steven P. PhD; Saykin, Andrew J. PsyD; McAllister, Thomas Walker MD; McCrea, Michael A. PhD
doi : 10.1212/WNL.0000000000207389
To study longitudinal associations between blood-based neural biomarkers (including total tau, neurofilament light [NfL], glial fibrillary acidic protein [GFAP], and ubiquitin C-terminal hydrolase-L1) and white matter neuroimaging biomarkers in collegiate athletes with sport-related concussion (SRC) from 24 hours postinjury to 1 week after return to play.
Economic Cost of Functional Neurologic Disorders: A Systematic Review.
O'Mahony, Brian MB BCh, BAO; Nielsen, Glenn BSc, PhD; Baxendale, Sallie PhD; Edwards, Mark J. MBBS, BSc, PhD, FRCP, FEAN; Yogarajah, Mahinda MD
doi : 10.1212/WNL.0000000000207388
Functional neurologic disorder (FND) represents genuine involuntary neurologic symptoms and signs including seizures, weakness, and sensory disturbance, which have characteristic clinical features, and represent a problem of voluntary control and perception despite normal basic structure of the nervous system.
Pathogenic RHEB Somatic Variant in a Child With Tuberous Sclerosis Complex Without Pathogenic Variants in TSC1 or TSC2.
Lee, Wei Shern PhD *; Macdonald-Laurs, Emma *; Stephenson, Sarah PhD; D'Arcy, Colleen MBBS, PhD; Maixner, Wirginia MBBS; Harvey, A. Simon; Lockhart, Paul J. PhD +; Leventer, Richard J. MBBS, PhD +
doi : 10.1212/WNL.0000000000207177
To describe a child meeting diagnostic criteria for tuberous sclerosis complex (TSC) carrying a pathogenic somatic variant in RHEB, but no pathogenic variants in the 2 known TSC genes, TSC1 or TSC2.
What Is the Ideal Brain Criterion of Death? Clinical and Practical Considerations: The UDDA Revision Series.
Robbins, Nathaniel M. MD
What Is the Ideal Brain Criterion of Death? Nonclinical Considerations: The UDDA Revision Series.
Rubin, Michael A. MD, MA
Superficial Brainstem FLAIR Hyperintensity and Restricted Diffusion Leading to the Detection of Non-Small-Cell Lung Cancer.
Zoccarato, Marco MD, PhD; Ferrati, Chiara MD; D'Errico, Ignazio MD
Teaching NeuroImage: Glucose Hypermetabolism in the Basal Ganglia: The Decisive Clue to the Diagnosis of an Unusual Anti-LGI1 Encephalitis.
Kim, Ye Eun MD; Lim, Jae-Sung MD, PhD; Lee, Yoojin MD; Lee, Jae-Hong MD, PhD
Child Neurology: Reversible Dementia in an 18-Year-Old Woman Due to Undiagnosed Cobalamin-G Deficiency: A Case Report.
Gacita, Anthony M. MD, PhD; Bicknese, Alma MD; Kim, Katherine MS; Zelko, Frank PhD; Baker, Joshua DO
doi : 10.1212/WNL.0000000000207146
AB Cobalamin-G deficiency is an inborn error of metabolism which disrupts the biochemical utilization of vitamin B12 to covert homocysteine to methionine in the remethylation pathway.
Pearls & Oy-sters: Homozygous Complement Factor I Deficiency Presenting as Fulminant Relapsing Complement-Mediated CNS Vasculitis.
Levit, Elle MD; Leon, Janice MD; Lincoln, Matthew R. DPhil, MD, FRCP©
doi : 10.1212/WNL.0000000000207079
AB A 36-year-old man presented multiple times with fever, headache, alteration of mental status, and focal neurologic deficits. MRI revealed extensive white matter lesions that were partially reversed between episodes.
Teaching Video NeuroImage: Mirror Movements in a 57-Year-Old Woman With KMT2B-Related Dystonia.
Lin, Junyu MD *; Li, Chunyu MD *; Jiang, Qirui MD; Shang, Huifang MD
Editors' Note: Gender Representation Among Physician Authors of Practice Guidelines Developed, Endorsed, or Affirmed by the American Academy of Neurology.
Lewis, Ariane MD; Galetta, Steven MD
Reader Response: Gender Representation Among Physician Authors of Practice Guidelines Developed, Endorsed, or Affirmed by the American Academy of Neurology.
Pringsheim, Tamara; Benish, Sarah; Harden, Cynthia; Jones, Lyell; Narayanaswami, Pushpa; Patel, Anup; Potrebic, Sonja; Rae-Grant, Alex; Sanders, Amy; Webb, Adam; Schwarz, Heidi B.
Author Response: Gender Representation Among Physician Authors of Practice Guidelines Developed, Endorsed, or Affirmed by the American Academy of Neurology.
Ross, Lindsay A.; Hassett, Catherine; Hussain, M. Shazam; Brown, Peter; Spurgeon, Elizabeth; Mathew, Rachael; Bal, Gabriella; Martin, Amarilis; Silver, Julie K.; Rensel, Mary
Association of Nonalcoholic Fatty Liver Disease and Fibrosis With Incident Dementia and Cognition: The Rotterdam Study.
Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease.
