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Merino, Jose G. MD, MPhil; Ciccarelli, Olga MD, PhD, FRCP; Worrall, Bradford B. MD, MSc; Aamodt, Whitley W. MD, MPH; Amato, Anthony A. MD; Burch, Rebecca MD; Hedera, Peter MD, PhD; Hershey, Linda A. MD, PhD; Jobst, Barbara C. MD, PhD; Kunchok, Amy C. MBBS, MMed, FRACP; Schneider, Andrea L.C. MD, PhD; Wusthoff, Courtney J. MD, MS
doi : 10.1212/WNL.0000000000207560
Volume 101(1) pgs. 1-52,e1-e93 July 4, 2023
The Mismeasure of Change: Better Cognitive Measurement Instruments Are Urgently Needed for Multiple Sclerosis Research.
Leavitt, Victoria M. PhD
Measuring Gait to Monitor Cognitive Function in Older Adults: An Important Step in the Right Direction.
Lo, On-Yee PhD; Manor, Brad PhD
Longitudinal Changes in Cognitive Test Scores in Patients With Relapsing-Remitting Multiple Sclerosis: An Analysis of the DECIDE Dataset.
Castrogiovanni, Nina BSc; Mostert, Jop MD, PhD; Repovic, Pavle MD, PhD; Bowen, James D. MD; Uitdehaag, Bernard M.J. MD, PhD; Strijbis, Eva M.M. MD, PhD; Cutter, Gary R. PhD; Koch, Marcus W. MD, PhD
doi : 10.1212/WNL.0000000000207301
AB Background and Objectives: Cognitive impairment is a common and impactful symptom of relapsing-remitting multiple sclerosis (RRMS).
Development of a Gait Feature-Based Model for Classifying Cognitive Disorders Using a Single Wearable Inertial Sensor.
Park, Jeongbin PhD *; Lee, Hyang Jun PhD *; Park, Ji Sun BA; Kim, Chae Hyun BA; Jung, Woo Jin MS; Won, Seunghyun PhD; Bae, Jong Bin MD; Han, Ji Won MD, PhD; Kim, Ki Woong MD, PhD
doi : 10.1212/WNL.0000000000207372
Gait changes are potential markers of cognitive disorders (CDs). We developed a model for classifying older adults with CD from those with normal cognition using gait speed and variability captured from a wearable inertial sensor and compared its diagnostic performance for CD with that of the model using the Mini-Mental State Examination (MMSE).
Genetic Moderation of the Association of [beta]-Amyloid With Cognition and MRI Brain Structure in Alzheimer Disease.
Insel, Philip S. PhD; Kumar, Atul PhD; Hansson, Oskar MD, PhD; Mattsson-Carlgren, Niklas MD, PhD; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000207305
There is considerable heterogeneity in the association between increasing [beta]-amyloid (A[beta]) pathology and early cognitive dysfunction in preclinical Alzheimer disease (AD). At this stage, some individuals show no signs of cognitive dysfunction, while others show clear signs of decline.
Associations of CSF PDGFR[beta] With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes.
10.1212/WNL.0000000000207358
doi : 10.1212/WNL.0000000000207358
Injured pericytes in the neurovascular unit release platelet-derived growth factor [beta] (PDGFR[beta]) into the CSF. However, it is not clear how pericyte injury contributes to Alzheimer disease (AD)-related changes and blood-brain barrier (BBB) damage.
Association of APOE-[epsilon]4, Osteoarthritis, [beta]-Amyloid, and Tau Accumulation in Primary Motor and Somatosensory Regions in Alzheimer Disease.
Du, Jing MSc *; Li, Anqi MSc *; Shi, Dai MD *; Chen, Xuhui MD; Wang, Qingyong MD; Liu, Zhen PhD; Sun, Kun PhD; Guo, Tengfei PhD; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000207369
One of the most prevalent chronic diseases, osteoarthritis (OA), may work in conjunction with APOE-[epsilon]4 to accelerate Alzheimer disease (AD) alterations, particularly in the primary motor (precentral) and somatosensory (postcentral) cortices.
CSF Synaptic Biomarkers in AT(N)-Based Subgroups of Lewy Body Disease.
Barba, Lorenzo MD; Abu-Rumeileh, Samir MD; Halbgebauer, Steffen PhD; Bellomo, Giovanni PhD; Paolini Paoletti, Federico MD, PhD; Gaetani, Lorenzo MD, PhD; Oeckl, Patrick PhD; Steinacker, Petra PhD; Massa, Federico MD; Parnetti, Lucilla MD, PhD *; Otto, Markus MD *
doi : 10.1212/WNL.0000000000207371
Patients with Lewy body disease (LBD) often show a co-occurring Alzheimer disease (AD) pathology. CSF biomarkers allow the detection in vivo of AD-related pathologic hallmarks included in the amyloid-tau-neurodegeneration (AT(N)) classification system.
Associations of Enlarged Perivascular Spaces With Brain Lesions, Brain Age, and Clinical Outcomes in Chronic Traumatic Brain Injury.
Hicks, Amelia J. BA, MA; Sinclair, Benjamin PhD; Shultz, Sandy R. PhD; Pham, William BSc; Silbert, Lisa C. MD; Schwartz, Daniel L. BA; Rowe, Christopher C. MD; Ponsford, Jennie L. PhD; Law, Meng MD; Spitz, Gershon PhD
doi : 10.1212/WNL.0000000000207370
Enlarged perivascular spaces (ePVS) have been identified as a key signature of glymphatic system dysfunction in neurologic conditions.
Effects of Season and Daylight Saving Time Shifts on Sleep Symptoms: Canadian Longitudinal Study on Aging.
Zolfaghari, Sheida MD; Cyr, Marieve MSc; Pelletier, Amelie PhD; Postuma, Ronald B. MD, MSc
doi : 10.1212/WNL.0000000000207342
There has been conflicting evidence regarding the association between seasonal changes and daylight saving time (DST) and sleep disorders.
Challenges to Brain Death in Revising the Uniform Determination of Death Act: The UDDA Revision Series.
Bernat, James L. MD
Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials.
Ferreira, Pamela C.L. PhD *; Ferrari-Souza, Joao Pedro *; Tissot, Cecile PhD; Bellaver, Bruna PhD; Leffa, Douglas T. MD, PhD; Lussier, Firoza MSc; Povala, Guilherme PhD; Therriault, Joseph BSc; Benedet, Andrea L. PhD; Ashton, Nicholas J. PhD; Cohen, Ann D. PhD; Lopez, Oscar L. MD; Tudorascu, Dana L. PhD; Klunk, William E. MD, PhD; Soucy, Jean-Paul MD, MSc; Gauthier, Serge MD; Villemagne, Victor MD; Zetterberg, Henrik MD, PhD; Blennow, Kaj MD, PhD; Rosa-Neto, Pedro MD, PhD; Zimmer, Eduardo R. PhD; Karikari, Thomas K. PhD; Pascoal, Tharick A. MD, PhD; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000207115
To test the utility of longitudinal changes in plasma phosphorylated tau 181 (p-tau181) and neurofilament light chain (NfL) as surrogate markers for clinical trials targeting cognitively unimpaired (CU) populations.
Clinical Reasoning: A 40-Year-Old Woman Presenting With Encephalopathy and Paraparesis.
AlSabah, Al-Alya BSc, MD; Brissette, Vincent MDCM; Altman, Robert Daniel MD, FRCPC
Teaching NeuroImage: Bloomy Rind Sign of Leptomeningeal Carcinomatosis.
Liu, Xi PhD, MD *; Tan, Changhong PhD, MD *; Zhu, Yuxia MD; Li, Sichen MD; Lai, Hongyu; Deng, Fen MD; Chen, Lifen PhD, MD
Teaching NeuroImage: Reversible Splenial Lesion Syndrome in a 43-Year-Old Man With Intracerebral Hemorrhage.
Yang, Tuanfeng MD; Lu, Jia MM; Liu, Xianzeng MD
Editors' Note: SARS-CoV-2 Vaccination Safety in Guillain-Barre Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multifocal Motor Neuropathy.
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
Reader Response: SARS-CoV-2 Vaccination Safety in Guillain-Barre Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multifocal Motor Neuropathy.
Harth, Cara E.
Author Response: SARS-CoV-2 Vaccination Safety in Guillain-Barre Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multifocal Motor Neuropathy.
Baars, Adaja E.; Van Doorn, Pieter A.; Jacobs, Bart C.; Kuitwaard, Krista
Presymptomatic Lesion in Childhood Cerebral Adrenoleukodystrophy: Timing and Treatment.
Natural History Study of STXBP1-Developmental and Epileptic Encephalopathy Into Adulthood.
Pearls & Oy-sters: Paroxysmal Exercise-Induced Dyskinesias Due to Pyruvate Dehydrogenase Deficiency.
de Gusmao, Claudio M. MD; Peixoto de Barcelos, Isabella MD; Pinto, Anna L.R. MD, PhD; Silveira-Moriyama, Laura MD PhD
doi : 10.1212/WNL.0000000000207142
AB Paroxysmal exercise-induced movement disorders may be caused by energy metabolism disorders, such as Glut 1 deficiency, pyruvate dehydrogenase deficiency, or mitochondrial respiratory chain disorders.
Spatial-Temporal Patterns of [beta]-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis.
Association of Copresence of Pathogenic Variants Related to Amyotrophic Lateral Sclerosis and Prognosis.
Chio, Adriano MD, PhD *; Moglia, Cristina MD, PhD *; Canosa, Antonio MD, PhD *; Manera, Umberto MD; Grassano, Maurizio MD; Vasta, Rosario MD; Palumbo, Francesca MD; Gallone, Salvatore MD; Brunetti, Maura BSc; Barberis, Marco BSc; De Marchi, Fabiola MD, PhD; Dalgard, Clifton PhD; Chia, Ruth PhD; Mora, Gabriele MD; Iazzolino, Barbara PsyD; Peotta, Laura PsyD; Traynor, Bryan J. MD, PhD; Corrado, Lucia PhD; D'Alfonso, Sandra PhD +; Mazzini, Letizia MD +; Calvo, Andrea MD, PhD +
doi : 10.1212/WNL.0000000000207367
Despite recent advances, it is not clear whether the various genes/genetic variants related to amyotrophic lateral sclerosis (ALS) interact in modifying patients' phenotype.
