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Eating reflex epilepsy of presumed autoimmune etiology after SARS-CoV-2 vaccination
Alberto Vogrig, Salvatore Versace, Gian Luigi Gigli, Martina Fabris, Jérôme Honnorat & Mariarosaria Valente
doi : 10.1007/s00415-023-11723-0
Volume 270, issue 7, July 2023
The association between the number of symptoms and the severity of Post-COVID-Fatigue after SARS-CoV-2 infection treated in an outpatient setting
Lena Schmidbauer, Inge Kirchberger, Yvonne Goßlau, Tobias D. Warm, Alexander Hyhlik-Dürr, Jakob Linseisen & Christa Meisinger
doi : 10.1007/s00415-023-11752-9
Post-COVID-Fatigue (PCF) is one of the most reported symptoms following SARS-CoV-2 infection. Currently, research on persistent symptoms focuses mainly on severe infections, while outpatients are rarely included in observations.
Brain hypoxia, neurocognitive impairment, and quality of life in people post-COVID-19
Damilola D. Adingupu, Ateyeh Soroush, Ayden Hansen, Rosie Twomey & Jeff F. Dunn
doi : 10.1007/s00415-023-11767-2
Systemic hypoxia occurs in COVID-19 infection; however, it is unknown if cerebral hypoxia occurs in convalescent individuals. We have evidence from other conditions associated with central nervous system inflammation that hypoxia may occur in the brain.
Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis
Ahmed Abdelhak, Lorenzo Barba, Michele Romoli, Pascal Benkert, Francesco Conversi, Lucio D’Anna, Ruturaj R. Masvekar, Bibiana Bielekova, Mercedes Prudencio, Leonard Petrucelli, James F. Meschia, Young Erben, Roberto Furlan, Rebecca De Lorenzo, Alessandra Mandelli, Raoul Sutter, Lisa Hert, Varenka Epple, Damiano Marastoni, Johann Sellner, Petra Steinacker, Anne Hege Aamodt, Lars Heggelund, Anne Margarita Dyrhol-Riise, …Samir Abu-Rumeileh
doi : 10.1007/s00415-023-11768-1
To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019 (COVID-19).
Myasthenia gravis, respiratory function, and respiratory tract disease
Nils Erik Gilhus
doi : 10.1007/s00415-023-11733-y
Myasthenia gravis (MG) is characterized by muscle weakness caused by autoantibodies that bind to the postsynaptic membrane at the neuromuscular junction and impair acetylcholine receptor function. Weakness of respiratory muscles represents the most severe MG manifestation, and 10–15% of all patients experience an MG crisis with the need of mechanical ventilatory support at least once in their life.
Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis
Sven Jarius, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Achim Berthele, Katrin Giglhuber, Vivien Häußler, Joachim Havla, Kerstin Hellwig, Martin W. Hümmert, Ingo Kleiter, Luisa Klotz, Markus Krumbholz, Tania Kümpfel, Friedemann Paul, Marius Ringelstein, Klemens Ruprecht, Makbule Senel, Jan-Patrick Stellmann, Florian Then Bergh, Hayrettin Tumani, Brigitte Wildemann, Corinna Trebst & Neuromyelitis Optica Study Group (NEMOS)
doi : 10.1007/s00415-023-11634-0
The term ‘neuromyelitis optica spectrum disorders’ (NMOSD) is used as an umbrella term that refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) and its formes frustes and to a number of closely related clinical syndromes without AQP4-IgG.
Early blood pressure management in hemorrhagic stroke: a meta-analysis
Kuangyang Yu, Yuxuan Sun, Kecheng Guo, Jianhua Peng & Yong Jiang
doi : 10.1007/s00415-023-11654-w
The aim of the present meta-analysis was to evaluate the outcomes and effects of different systolic blood pressure (SBP) lowering in patients with hemorrhagic stroke using data from randomized controlled trials. A total of 2592 records were identified for this meta-analysis. We finally included 8 studies (6119 patients; mean age 62.8 ± 13.0, 62.7% men).
Sleep counts! Role and impact of sleep in the multimodal management of multiple sclerosis
Maria P. Mogavero, Giuseppe Lanza, Oliviero Bruni, Lourdes M. DelRosso, Raffaele Ferri & Luigi Ferini-Strambi
doi : 10.1007/s00415-023-11655-9
In the last years, research on pharmacotherapy and non-pharmacological approaches to Multiple Sclerosis (MS) has significantly increased, along with a greater attention to sleep as a clinical outcome measure. This review aims to update the state of the art on the effects of MS treatments on sleep, but above all to evaluate the role of sleep and its management within the current and future therapeutic perspectives for MS patients.
Atrial cardiomyopathy and incident ischemic stroke risk: a systematic review and meta-analysis
Jiahuan Guo, Dandan Wang, Jiaokun Jia, Jia Zhang, Fei Peng, Jingjing Lu, Xingquan Zhao & Yanfang Liu
doi : 10.1007/s00415-023-11693-3
Growing evidence suggests that atrial cardiomyopathy may play an essential role in thrombosis and ischemic stroke. The aim of this systematic review and meta-analysis was to quantify the values of cardiomyopathy markers for predicting ischemic stroke risk.
Efficacy of acupuncture for tension-type headache prophylaxis: systematic review and meta-analysis with trial sequential analysis
Qing-Feng Tao, Xiao-Ying Wang, Si-Jia Feng, Xin-Yu Xiao, Yun-Zhou Shi, Chao-Rong Xie & Hui Zheng
doi : 10.1007/s00415-023-11695-1
Acupuncture has been shown to reduce tension-type headache (TTH) frequency in previous studies. Nevertheless, repeated significance testing might inflate type I error. We aimed to verify the effectiveness and safety of acupuncture in reducing TTH frequency by meta-analysis and trial sequential analysis (TSA).
Dysautonomia associated with immune checkpoint inhibitors
Toshiki Tezuka, Shinichi Okuzumi, Chiho Nakashima, Toshihiro Ide, Shungo Imai, Satoru Mitsuboshi, Yuki Kuwahara, Tsubasa Takizawa, Morinobu Seki, Naoto Minematsu, Naoko Aragane, Jin Nakahara, Satoko Hori, Shunya Nakane & Shigeaki Suzuki
doi : 10.1007/s00415-023-11667-5
The purpose of this study is to report the clinical characteristics of dysautonomia associated with immune checkpoint inhibitors (ICIs).
Good vibrations: tactile cueing for freezing of gait in Parkinson’s disease
E. C. Klaver, J. P. P. van Vugt, B. R. Bloem, R. J. A. van Wezel, J. Nonnekes & M. C. Tjepkema-Cloostermans
doi : 10.1007/s00415-023-11663-9
Cueing strategies can alleviate freezing of gait (FOG) in people with Parkinson’s disease (PD). We evaluated tactile cueing delivered via vibrating socks, which has the benefit of not being noticeable to bystanders.
The Behavioural Dysfunction Questionnaire discriminates behavioural variant frontotemporal dementia from Alzheimer’s disease dementia and major depressive disorder
Anna Semenkova, Olivier Piguet, Andreas Johnen, Matthias L. Schroeter, Jannis Godulla, Christoph Linnemann, Markus Mühlhauser, Thomas Sauer, Markus Baumgartner, Sarah Anderl-Straub, Markus Otto, Ansgar Felbecker, Reto W. Kressig, Manfred Berres & Marc Sollberger
doi : 10.1007/s00415-023-11666-6
Early-stage behavioural variant frontotemporal dementia (bvFTD) is often misdiagnosed, highlighting the need for new diagnostic instruments. Based on the revised diagnostic criteria for bvFTD, we developed the Behavioural Dysfunction Questionnaire (BDQ). In this explorative study, we aimed to determine the best scoring and analytical method for the BDQ to discriminate between bvFTD and non-bvFTD patients.
Transcranial direct current stimulation enhances motor learning in Parkinson’s disease: a randomized controlled trial
Sanne Broeder, Britt Vandendoorent, Pauline Hermans, Evelien Nackaerts, Geert Verheyden, Raf Meesen, Jean-Jacques Orban de Xivry & Alice Nieuwboer
doi : 10.1007/s00415-023-11669-3
Writing training has shown clinical benefits in Parkinson’s disease (PD), albeit with limited retention and insufficient transfer effects. It is still unknown whether anodal transcranial direct current stimulation (atDCS) can boost consolidation in PD and how this interacts with medication.
Assessment of cognitive performance in multiple sclerosis using smartphone-based training games: a feasibility study
Silvan Pless, Tim Woelfle, Yvonne Naegelin, Johannes Lorscheider, Andrea Wiencierz, Óscar Reyes, Pasquale Calabrese & Ludwig Kappos
doi : 10.1007/s00415-023-11671-9
Cognitive impairment occurs in up to 70% of people with MS (pwMS) and has a large impact on quality of life and working capacity. As part of the development of a smartphone-app (dreaMS) for monitoring MS disease activity and progression, we assessed the feasibility and acceptance of using cognitive games as assessment tools for cognitive domains.
The evolution of diagnosis from symptom onset to death in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) compared to Parkinson’s disease (PD)
Diane M. A. Swallow & Carl E. Counsell
doi : 10.1007/s00415-023-11629-x
Misdiagnosis and delayed diagnosis in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are common. Few studies have systematically evaluated the diagnostic process from symptom onset to death in representative cohorts.
Long-term outcome after decompressive hemicraniectomy for malignant middle cerebral artery infarction
Natalie Berger, Anna Brunner, Gerit Wünsch, Oliver Nistl, Daniela Pinter, Simon Fandler-Höfler, Melanie Haidegger, Alexander Pichler, Isra Hatab, Michael Mokry, Stefan Wolfsberger, Christian Enzinger, Thomas Gattringer & Markus Kneihsl
doi : 10.1007/s00415-023-11679-1
Although decompressive hemicraniectomy (DHC) is a lifesaving treatment strategy for patients with malignant middle cerebral artery infarction (mMCAi), only one in four patients achieves low to moderate post-stroke disability according to previous studies. However, the short follow-up periods in prior studies could have overestimated the poor clinical prognosis. This study therefore examined the long-term outcome after DHC for mMCAi.
Corneal confocal microscopy identifies corneal nerve loss and increased Langerhans cells in presymptomatic carriers and patients with hereditary transthyretin amyloidosis
Andreas Thimm, Alexander Carpinteiro, Sara Oubari, Maria Papathanasiou, Lukas Kessler, Christoph Rischpler, Rayaz Ahmed Malik, Ken Herrmann, Hans Christian Reinhardt, Tienush Rassaf, Christoph Kleinschnitz, Tim Hagenacker & Mark Stettner
doi : 10.1007/s00415-023-11689-z
Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is a rare, but life-threatening protein misfolding disorder due to TTR gene mutations. Cardiomyopathy (ATTRv-CM) and polyneuropathy (ATTRv-PN) with early small nerve fibre involvement are the most common manifestations. Timely diagnosis and treatment initiation are key to limiting progression of disease. Corneal confocal microscopy (CCM) is a non-invasive method to quantify corneal small nerve fibres and immune cell infiltrates in vivo.
Long-term outcome of patients with neurological form of Wilson’s disease compliant to the de-coppering treatment
Iva Stanković, Čarna Jovanović, Jelena Vitković, Marina Svetel, Tatjana Pekmezović, Aleksandra Tomić, Nikola Kresojević, Vladana Marković, Milica Je�menica Lukić, Igor Petrović, Nataša Dragašević-Mišković & Vladimir Kostić
doi : 10.1007/s00415-023-11681-7
A substantial proportion of Wilson’s disease (WD) patients exhibit residual neurological symptoms. Data on the prognostic value of initial clinical features and treatment choices in WD patients compliant to the therapy is relatively sparse.
The association of night shift work with the risk of all-cause dementia and Alzheimer's disease: a longitudinal study of 245,570 UK Biobank participants
Yitong Ling, Shiqi Yuan, Xiaxuan Huang, Shanyuan Tan, Tao Huang, Anding Xu & Jun Lyu
doi : 10.1007/s00415-023-11672-8
The purpose of this research was to investigate a possible link between night shift work and the development of all-cause dementia and Alzheimer's disease (AD), as well as determine the contribution of night shift work, genetic susceptibility to AD.
Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker opportunities
Marlene Tahedl, Ee Ling Tan, Rangariroyashe H. Chipika, Jennifer C. Hengeveld, Alice Vajda, Mark A. Doherty, Russell L. McLaughlin, We Fong Siah, Orla Hardiman & Peter Bede
doi : 10.1007/s00415-023-11682-6
Bulbar dysfunction is a cardinal feature of ALS with important quality of life and management implications. The objective of this study is the longitudinal evaluation of a large panel imaging metrics pertaining to bulbar dysfunction, encompassing cortical measures, structural and functional cortico-medullary connectivity indices and brainstem metrics.
Mortality risk in adults with intellectual disabilities and epilepsy: an England and Wales case–control study
James J. Sun, Lance Watkins, William Henley, Richard Laugharne, Heather Angus-Leppan, Indermeet Sawhney, Meissam Moghaddassian Shahidi, Kiran Purandare, Mogbeyiteren Eyeoyibo, Mark Scheepers, Geraldine Lines, Robert Winterhalder, Bhathika Perera, Benjamin Hyams, Samantha Ashby & Rohit Shankar
doi : 10.1007/s00415-023-11701-6
People with epilepsy (PWE) and people with intellectual disabilities (ID) both live shorter lives than the general population and both conditions increase the risk of death further. We aimed to measure associations between certain risk factors for death in PWE and ID.
Detection of patent foramen ovale in patients with ischemic stroke on prospective ECG-gated cardiac CT compared to transthoracic echocardiography
L. A. Rinkel, B. J. Bouma, S. M. Boekholdt, C. F. P. Beemsterboer, N. H. J. Lobé, L. F. M. Beenen, H. A. Marquering, C. B. L. M. Majoie, Y. B. W. E. M. Roos, A. van Randen, R. N. Planken & J. M. Coutinho
doi : 10.1007/s00415-023-11688-0
Cardiac CT acquired during the acute stroke imaging protocol is an emerging alternative to transthoracic echocardiography (TTE) to screen for sources of cardioembolism. Currently, its diagnostic accuracy to detect patent foramen ovale (PFO) is unclear.
Sleep disturbances associated with DPPX autoantibodies: a case series
Avi Gadoth, Michelle F. Devine, Sean J. Pittock, Andrew McKeon, W. Oliver Tobin, Thomas R. Gossard, Elena F. D. Cattaneo, Stuart J. McCarter & Erik K. St. Louis
doi : 10.1007/s00415-023-11698-y
To describe a case series of patients with prominent sleep disturbances and their polysomnography findings in six patients with dipeptidyl-peptidase-like protein-6 (DPPX) autoimmunity syndrome.
Effectiveness and safety profile of cladribine in an Italian real-life cohort of relapsing–remitting multiple sclerosis patients: a monocentric longitudinal observational study
Chiara Zanetta, Maria A. Rocca, Alessandro Meani, Vittorio Martinelli, Laura Ferrè, Lucia Moiola & Massimo Filippi
doi : 10.1007/s00415-023-11700-7
Cladribine is approved for the treatment of active relapsing MS (RRMS), but its positioning in MS therapeutic scenario still needs to be fully elucidated.
Correction to: Effectiveness and safety profile of cladribine in an Italian real-life cohort of relapsing–remitting multiple sclerosis patients: a monocentric longitudinal observational study
Chiara Zanetta, Maria A. Rocca, Alessandro Meani, Vittorio Martinelli, Laura Ferrè, Lucia Moiola & Massimo Filippi
Comparison of clinical features in patients with vestibular migraine and migraine
Neşe Çelebisoy, Ayşın Kısabay Ak, Ceyla Ataç, Hüseyin Nezih Özdemir, Figen Gökçay, Gülsüm Saruhan Durmaz, Dilek Top Kartı, Hülya Ertaşoğlu Toydemir, Vildan Yayla, İlksen Çolpak Işıkay, İrem Erkent, Ayşegül Şeyma Sarıtaş, Pınar Özçelik, Gülden Akdal, Şebnem Bıçakcı, Eylem Ozaydın Göksu & Feray Güleç Uyaroğlu
doi : 10.1007/s00415-023-11677-3
Vestibular migraine (VM) is accepted as the most common cause of spontaneous episodic vertigo. In most patients, vestibular symptoms follow migraine headaches that begin earlier in life.
Gender differences in microRNA expression in levodopa-naive PD patients
A. Vallelunga, T. Iannitti, G. Somma, M. C. Russillo, M. Picillo, R. De Micco, L. Vacca, R. Cilia, C. E. Cicero, R. Zangaglia, G. Lazzeri, S. Galantucci, F. G. Radicati, A. De Rosa, M. Amboni, C. Scaglione, A. Tessitore, F. Stocchi, R. Eleopra, A. Nicoletti, C. Pacchetti, A. Di Fonzo, M. A. Volontè, P. Barone & M. T. Pellecchia
doi : 10.1007/s00415-023-11707-0
Gender is an important factor influencing epidemiological and clinical features of Parkinson’s disease (PD). We aimed to evaluate gender differences in the expression of a panel of miRNAs (miR-34a-5p, miR-146a, miR-155, miR-29a, miR-106a) possibly involved in the pathophysiology or progression of disease.
Correction to: Gender differences in microRNA expression in levodopa‑naive PD patients
A. Vallelunga, T. Iannitti, G. Somma, M. C. Russillo, M. Picillo, R. De Micco, L. Vacca, R. Cilia, C. E. Cicero, R. Zangaglia, G. Lazzeri, S. Galantucci, F. G. Radicati, A. De Rosa, M. Amboni, C. Scaglione, A. Tessitore, F. Stocchi, R. Eleopra, A. Nicoletti, C. Pacchetti, A. Di Fonzo, M. A. Volontè, P. Barone & M. T. Pellecchia
Complications of reversible cerebral vasoconstriction syndrome in relation to age
Kristin Sophie Lange, Gabrielle Tuloup, Claire Duflos, Claire Gobron, Cécilia Burcin, Lucas Corti, Caroline Roos, Anne Ducros & Jérôme Mawet
doi : 10.1007/s00415-023-11708-z
Reversible cerebral vasoconstriction syndrome (RCVS) has a heterogenous clinical and radiological presentation. We investigated whether RCVS complications vary according to age.
High-efficacy therapies reduce clinical and radiological events more effectively than traditional treatments in neuromyelitis optica spectrum disorder
Tatum M. Moog, Alexander D. Smith, Katy W. Burgess, Morgan McCreary & Darin T. Okuda
doi : 10.1007/s00415-023-11710-5
People with neuromyelitis optica spectrum disorder (pwNMOSD) experience debilitating neurological attacks, resulting in permanent disability.
Steroids for the treatment of viral encephalitis: a systematic literature review and meta-analysis
Emira Hodzic, Rodrigo Hasbun, Alejandro Granillo, Anna R. Tröscher, Helga Wagner, Tim J. von Oertzen & Judith N. Wagner
doi : 10.1007/s00415-023-11715-0
Specific antiviral treatment is only available for a small subset of viral encephalitis (VE). Adjunctive steroids are used, but there is scant evidence evaluating its utility. We present a systematic review and meta-analysis on the outcome of steroid use in VE.
An observational cohort study on pulmonary function in adult patients with 5q-spinal muscular atrophy under nusinersen therapy
Bogdan Bjelica, Camilla Wohnrade, Alma Osmanovic, Olivia Schreiber-Katz & Susanne Petri
doi : 10.1007/s00415-023-11711-4
Few studies assessed the effect of nusinersen on respiratory function in adult patients with spinal muscular atrophy (SMA). The aim of this single-center study was to analyze pulmonary function and its association with muscle function and quality of life (QoL) in adult patients with 5q-SMA under nusinersen.
Longitudinal brain functional connectivity changes induced by neurosurgical thalamotomy for tremor in Parkinson’s disease: a preliminary study
Luigi Albano, Silvia Basaia, Daniele Emedoli, Roberta Balestrino, Edoardo Pompeo, Lina Raffaella Barzaghi, Antonella Castellano, Andrea Falini, Sandro Iannaccone, Pietro Mortini, Massimo Filippi & Federica Agosta
doi : 10.1007/s00415-023-11705-2
he hypothesis that the effectiveness of neurosurgical procedures in Parkinson’s disease (PD) would be related to connectivity dysfunctions between the site of the stimulation and other brain regions is growing.
Letter to the editors: comment on “Status dystonicus in adult patients with anti-N-methyl-d-asparate-acid receptor encephalitis�
Daniel E. Lumsden, Ming Lim & Sarosh Irani
Conceptual design of a biped-wheeled wearable machine for ALS patients
Giovanni Gerardo Muscolo, Francesca Di Pede, Luca Solero, Angelo Nicolì, Alessandra Russo, Paolo Fiorini, Adriano Chiò, Andrea Calvo & Antonio Canosa
Factors associated with migraine aura-like symptoms in acute ischemic stroke
Adrian Scutelnic, Lucie Justus, Mattia Branca, Thomas R. Meinel, Morin Beyeler, Norbert Silimon, Boudewijn R.H. Drop, David J. Seiffge, Urs Fischer, Marcel Arnold, Heinrich P. Mattle, Christoph J. Schankin & Simon Jung
Correction to: Factors associated with migraine aura-like symptoms in acute ischemic stroke
Adrian Scutelnic, Lucie Justus, Mattia Branca, Thomas R. Meinel, Morin Beyeler, Norbert Silimon, Boudewijn R.H. Drop, David J. Seiffge, Urs Fischer, Marcel Arnold, Heinrich P. Mattle, Christoph J. Schankin & Simon Jung
Saw-tooth vertical saccades in progressive supranuclear palsy
Min-Ku Kim, Dongje Lee, Xu Yang, Hyo-Jung Kim, Jeong‑Yoon Choi & Ji-Soo Kim
Functional movement disorders triggered by reality shifting and the Backrooms—another social media traps
Ján Necpál & Marcela Šoltýsová
High cervical spinal cord stimulation in Parkinson’s disease with dopamine-resistant axial disabilities: a case with 2-year follow-up
Zhengyu Lin, Linbin Wang, Peng Huang, Yixin Pan, Yuyan Tan, Shengdi Chen & Dianyou Li
Migraine: from pathophysiology to treatment
Francesca Puledda, Elisa Martins Silva, Kanokrat Suwanlaong & Peter J. Goadsby
doi : 10.1007/s00415-023-11706-1
Migraine is an extremely disabling, common neurological disorder characterized by a complex neurobiology, involving a series of central and peripheral nervous system areas and networks. A growing increase in the understanding of migraine pathophysiology in recent years has facilitated translation of that knowledge into novel treatments, which are currently becoming available to patients in many parts of the world and are substantially changing the clinical approach to the disease.
Precision diagnosis and precision treatment for the genetic epilepsies
Sabbiha Nadia Majumder & Khalid Hamandi
Charles Samuel Myers (1873–1946)
Ourania L. Loula & Lazaros C. Triarhou
Correction to: The Boston criteria version 2.0 increase the proportion of lobar intracerebral haemorrhage classifed as probable cerebral amyloid angiopathy
Yang Du, Wenpeng Zhang, Martina Locatelli, Robert J. Simister, H. Rolf Jäger & David J. Werring
Correction to: Sporadic Fatal Insomnia presenting with agrypnia excitata and rapidly progressive dementia: a case report
Miryam Cannizzaro, Valentina Pieri, Davide Gusmeo Curti, Mor Gueye, Giulia Rugarli, Giovanni Napoli, Rosalinda Cardamone, Andrea Falini, Daniela Perani, Marco Zucconi, Francesca Casoni, Giorgio Giaccone, Fabio Moda, Giuseppe Di Fede, Giuseppe Magnani, Francesca Caso & Massimo Filippi
