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APOLLO Has Landed: PROMS and Histology in UC
Robert V Bryant, Simon P L Travis
doi : 10.1093/ecco-jcc/jjad040
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1027–1028
Thiopurines for Ulcerative Colitis: Old Favourite or Old Hat?
Peter M Irving
doi : 10.1093/ecco-jcc/jjad062
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1029–1030
ECCO Topical Review on Biological Treatment Cycles in Crohn’s Disease
Nurulamin M Noor, Paula Sousa, Dominik Bettenworth, Fernando Gomollón, Triana Lobaton, Peter Bossuyt, Maria Jose Casanova, Nik S Ding, Gabriele Dragoni, Federica Furfaro, Patrick F van Rheenen, Maria Chaparro, Javier P Gisbert, Edouard Louis, Konstantinos Papamichail
doi : 10.1093/ecco-jcc/jjad001
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1031–1045
There are now a growing number of licensed biological therapies for patients with Crohn’s disease. However, there can be significant costs associated with long-term maintenance treatment, as well as some concerns about potential side-effects.
Patient-reported Outcomes and Disability Are Associated with Histological Disease Activity in Patients with Ulcerative Colitis: Results from the APOLLO Study
Bram Verstockt, Lieven Pouillon, Florence Ballaux, Celine Jorissen, Eveline Hoefkens, Nikki Lembrechts, Peter Bossuyt
doi : 10.1093/ecco-jcc/jjad015
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1046–1054,
Treating beyond endoscopic remission, aiming for histological remission, is an emerging target in ulcerative colitis [UC]. Patient-reported outcome measurements [PROMs] become increasingly important, but their association with histology is unclear.
Mercaptopurine for the Treatment of Ulcerative Colitis: A Randomized Placebo-Controlled Trial
Mark Löwenberg, Adriaan Volkers, Sara van Gennep, Aart Mookhoek, Nahid Montazeri, Esmé Clasquin, Marjolijn Duijvestein, Adriaan van Bodegraven, Svend Rietdijk, Jeroen Jansen, Dirk van Asseldonk, Esmerij van der Zanden, Marcel Dijkgraaf, Rachel West, Nanne de Boer, Geert D’Haens
doi : 10.1093/ecco-jcc/jjad022
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1055–1065
Scepticism about the efficacy of thiopurines for ulcerative colitis [UC] is rising. This study aimed to evaluate mercaptopurine treatment for UC.
Declining Enrolment and Other Challenges in IBD Clinical Trials: Causes and Potential Solutions
Mathieu Uzzan, Yoram Bouhnik, Maria Abreu, Harris A Ahmad, Shashi Adsul, Hilde Carlier, Marla Dubinsky, Matthew Germinaro, Vipul Jairath, Irene Modesto, Eric Mortensen, Neeraj Narula, Ezequiel Neimark, Alessandra Oortwijn, Marijana Protic, David T Rubin, Young S Oh, Jolanta Wichary, Laurent Peyrin-Biroulet, Walter Reinisch
doi : 10.1093/ecco-jcc/jjad020
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1066–1078
Rates of enrolment in clinical trials in inflammatory bowel disease [IBD] have decreased dramatically in recent years. This has led to delays, increased costs and failures to develop novel treatments.
Development and Validation of a Remote Monitoring Tool for Assessment of Mild, Moderate, and Severe Infections in Inflammatory Bowel Disease
Ashkan Rezazadeh Ardabili, Dirk van Esser, Dion Wintjens, Mia Cilissen, Debbie Deben, Zlatan Mujagic, Fritzi Russ, Laurents Stassen, Adriaan A Van Bodegraven, Dennis Wong, Bjorn Winkens, Daisy Jonkers, Mariëlle Romberg-Camps, Marie J Pierik
doi : 10.1093/ecco-jcc/jjad023
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1079–1088
Immunomodulators and biologics are cornerstones in the management of inflammatory bowel disease [IBD], but are associated with increased risk of infections. Post-marketing surveillance registries are pivotal to assess this risk, yet mainly focus on severe infections.
Hocus Pocus: the Role of Hand-held Ultrasonography in Predicting Disease Extension and Endoscopic Activity in Ulcerative Colitis
Antonio Rispo, Giulio Calabrese, Anna Testa, Nicola Imperatore, Marta Patturelli, Mariangela Allocca, Alessia Dalila Guarino, Nicola Mattia Cantisani, Benedetta Toro, Fabiana Castiglione
doi : 10.1093/ecco-jcc/jjad024
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1089–1096
Ulcerative colitis [UC] assessment still requires ileocolonoscopy [IC]. Intestinal ultrasound [IUS] has emerged as a non-invasive assessment tool, and the Milan Ultrasound Criteria [MUC] score has been validated to estimate and grade UC disease activity.
Non-hepatic Solid Organ Transplant in Patients with Inflammatory Bowel Disease: An ECCO CONFER Multicentre Case Series
Davide Giuseppe Ribaldone, Sophie Vieujean, Mette Julsgaard, Angelo Armandi, Fabiana Zingone, Edoardo Savarino, Fiorella Cañete, Annalisa Aratari, Nicola Imperatore, Laura Ramos, Rocio Plaza, Daniela Pugliese, Brigida Barberio, David Drobne, MarÃa Chaparro
doi : 10.1093/ecco-jcc/jjad030
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1097–1102
Solid organ transplantation, with the exception of liver, has rarely been reported in patients affected by inflammatory bowel diseases [IBD].
Transient Suppression of Bacterial Populations Associated with Gut Health is Critical in Success of Exclusive Enteral Nutrition for Children with Crohn’s Disease
Joseph Runde, Iva Veseli, Emily C Fogarty, Andrea R Watson, Quentin Clayssen, Mahmoud Yosef, Alon Shaiber, Ritu Verma, Christopher Quince, Konstantinos Gerasimidis, David T Rubin, A Murat Eren
doi : 10.1093/ecco-jcc/jjad031
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1103–1113
Exclusive enteral nutrition [EEN] is a dietary intervention to induce clinical remission in children with active luminal Crohn’s disease [CD]. While changes in the gut microbial communities have been implicated in achieving this remission, a precise understanding of the role of microbial ecology in the restoration of gut homeostasis is lacking.
Combined Histological and Endoscopic Endpoints at Post-induction Lack Additional Prognostic Value Compared with Endoscopic Improvement Alone in Ulcerative Colitis: A Post hoc Analysis of the VARSITY study
Emily C L Wong, Parambir S Dulai, Badar Hasan, John K Marshall, Walter Reinisch, Neeraj Narula
doi : 10.1093/ecco-jcc/jjad033
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1114–1121
Evaluating histological outcomes in ulcerative colitis [UC] has become common in recent clinical trials. In this study, we explored the additional value of the combined endpoint of histo-endoscopic mucosal improvement [HEMI] compared with endoscopic improvement [EI] at post-induction [Week 14] and post-maintenance [1 year].
Accuracy of Transperineal Ultrasonography for Assessing Rectal Lesions in Paediatric Ulcerative Colitis: A Prospective Study
Keisuke Jimbo, Kenji Hosoi, Mitsuyoshi Suzuki, Reiko Kyodo, Kimiko Maruyama, Nobuyasu Arai, Masamichi Sato, Eri Miyata, Eri Hoshino, Takahiro Kudo, Toshiaki Shimizu
doi : 10.1093/ecco-jcc/jjad035
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1122–1127
Transabdominal ultrasonography [TAUS] appears comparable to colonoscopy for evaluating ulcerative colitis [UC] activity, but it has low accuracy in rectal evaluation. In this study, the accuracy of transperineal ultrasonography [TPUS] for evaluating rectal activity was compared to that of colonoscopy in paediatric UC cases.
TNFΔARE Pigs: A Translational Crohn’s Disease Model
Thomas Winogrodzki, Amira Metwaly, Alessandro Grodziecki, Wei Liang, Bernhard Klinger, Tatiana Flisikowska, Konrad Fischer, Krzysztof Flisikowski, Katja Steiger, Dirk Haller, Angelika Schnieke
doi : 10.1093/ecco-jcc/jjad034
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1128–1138
Crohn’s disease [CD] is a major subtype of inflammatory bowel diseases [IBD] with increasing incidence and prevalence. Results of studies using available small and large animal models are often poorly translatable to patients, and few CD models show small intestinal pathology.
Systematic Review with Meta-analysis: The Impact of Cancer Treatments on the Disease Activity of Inflammatory Bowel Diseases
Sigrun Grimsdottir, Mohamed Attauabi, Emilie Kristine Dahl, Johan Burisch, Jakob Benedict Seidelin
doi : 10.1093/ecco-jcc/jjad010
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1139–1153
The association between cancer treatments and exacerbation of inflammatory bowel diseases [IBD] is unclear. We aimed to evaluate the effects of cancer treatments on the disease activity of IBD.
Multi-item Measures for Paediatric Inflammatory Bowel Diseases: The ABCs of All Those Acronyms
Oren Ledder, Dan Turner
doi : 10.1093/ecco-jcc/jjad019
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1154–1168
With the recent acceptance of multiple treatment goals for inflammatory bowel diseases [IBD], it becomes increasingly important to accurately quantify the measurable concepts.
Should we Target Complete Endoscopic Healing in Patients with Acute Severe Ulcerative Colitis?
David Laharie, Jean-Yves Mary
doi : 10.1093/ecco-jcc/jjad032
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1169–1172
Achieving endoscopic healing is a recommended target in ulcerative colitis [UC]. However, little is known about desirable goals in patients with acute severe UC [ASUC]. Taking advantage of the long-term follow-up of clinical trial patients with steroid-refractory ASUC, the present analysis aimed to quantify the observed association between the Mayo endoscopic sub-score [MES], 0 or 1, at clinical trial end and patients’ long-term disease outcome.
Causal Effect of Visceral Adipose Tissue Accumulation on Inflammatory Bowel Disease: A Mendelian Randomization Study
Zhongyuan Wang, Jianfeng Gong
doi : 10.1093/ecco-jcc/jjad026
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Pages 1173–1174
Erratum to: Anogenital Crohn’s Disease and Granulomatosis: A Systematic Review of Epidemiology, Clinical Manifestations, and Treatment
doi : 10.1093/ecco-jcc/jjad044
Journal of Crohn's and Colitis, Volume 17, Issue 7, July 2023, Page 1175
