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Nonsquamous Malignancies of Vagina and Vulva: 23-Year Experience at a Tertiary Center in the United Kingdom.
Elshennawy, Rawda A. M.B.B.Ch., M.Sc., DipRCPath.; Aird, Charlotte F.R.C.Path.; Boyle, William F.R.C.Path.; Yap, Jason M.R.C.O.G., Ph.D.; Williams, Anthony F.R.C.Path.; Ganesan, Raji F.R.C.Path.
doi : 10.1097/PGP.0000000000000924
Volume 42(4) pgs. 327-433 July 2023
AB Under 10% of gynaecological cancers are diagnosed in the vulva and vagina, mostly squamous cell carcinomas. Melanoma, Paget disease, basal cell carcinomas, and other cancers can present with vulval/vaginal symptoms.
HPV-associated Vulvar Intraepithelial Carcinoma With Sebaceous Differentiation: Report of 2 Cases.
Hamza, Mugahed A. M.D.; Quick, Charles M. M.D.; Williams, Heather R. M.D.; Patil, Ninad M. M.D.; Shalin, Sara C. M.D., Ph.D.
doi : 10.1097/PGP.0000000000000914
AB Sebaceous carcinoma (SC) is a malignant neoplasm demonstrating sebocytic differentiation, commonly in the periocular area. Sebocytic differentiation is recognized by multivesicular cytoplasmic clearing with frequent nuclear scalloping.
Cervical Pleuropulmonary Blastoma-like Tumor Associated With DICER1 and TP53 Mutations.
Stolnicu, Simona M.D., P.h.D.; Bartalis, Rolland-Jozsef M.D.; Mihut, Emilia M.D.; Szabo, Bela M.D., P.h.D.; Da Cruz Paula, Arnaud P.h.D.; Ye, Qiqi M.D.; Parkash, Vinita M.D.; Weigelt, Britta P.h.D.; Soslow, Robert A. M.D.
doi : 10.1097/PGP.0000000000000927
AB We describe a very unusual cervical tumor in a 12-yr-old patient with a clinical history indicative of DICER1 syndrome. Morphologic, immunohistochemical, and molecular genetic analysis together helped to diagnose this lesion as a cervical pleuropulmonary blastoma-like tumor, associated with TP53 and DICER1 mutations.
Targeted Molecular Testing in Endometrial Carcinoma: Validation of a Clinically Driven Selective ProMisE Testing Protocol.
Talhouk, Aline Ph.D; Jamieson, Amy M.B.Ch.B., F.R.A.N.Z.C.O.G., F.R.C.S.C.; Crosbie, Emma J. B.Sc., M.B.Ch.B., Ph.D., F.R.C.O.G.; Taylor, Alexandra M.B.B.S., M.R.C.P., F.R.C.R., M.D.; Chiu, Derek M.Sc.; Leung, Samuel M.Sc.; Grube, Marcel M.D.; Kommoss, Stefan M.D.; Gilks, C. Blake M.D., F.R.C.P.C.; McAlpine, Jessica N. M.D.; Singh, Naveena M.D., F.R.C.Path., F.R.C.P.C.
doi : 10.1097/PGP.0000000000000898
AB Incorporation of molecular classification into clinicopathologic assessment of endometrial carcinoma (EC) improves risk stratification.
Programmed Death Ligand 1 (PD-L1) Expression and CD8+ Tumor-infiltrating Lymphocyte-based Tumor Immune Microenvironment Classification in Gynecologic Carcinosarcoma: Prognostic Impact and Implications for Therapy.
Ordner, Jeffrey D.O.; Gutierrez Amezcua, Jose M. M.D.; Marcus, Alan M.D.; Shukla, Pratibha S. M.D.
doi : 10.1097/PGP.0000000000000890
AB To investigate the prevalence and prognostic significance of programmed death ligand-1 (PD-L1) expression and CD8+ tumor-infiltrating lymphocytes (TILs) in gynecologic carcinosarcoma, 81 cases (68 uterine, 12 ovarian, and 1 fallopian tube) were immunostained with PD-L1 and CD8 using tissue microarrays (3 mm core diameter) from intratumoral areas with the highest TILs.
Prognostic Significance of Size, Location, and Number of Lymph Node Metastases in Endometrial Carcinoma.
Tran, Lily M.D.; Christensen, Paul M.D.; Barroeta, Julieta E. M.D.; Hunter, Krystal M.B.A.; Sookram, Janhvi D.O.; McGregor, Stephanie M. M.D., Ph.D.; Wilkinson, Nafisa M.A., F.R.C.Path.; Orsi, Nicolas M. B.Sc., M.B.Ch.B., Ph.D., M.S.; Lastra, Ricardo R. M.D.
doi : 10.1097/PGP.0000000000000897
AB Regional lymph node metastasis is a well-established negative predictive prognostic factor in endometrial carcinomas.
Follicular Dendritic Cell Sarcoma of Uterine Corpus: Report of 2 Cases.
Boyraz, Baris M.D., Ph.D.; Post, Miriam D. M.D.; Hasserjian, Robert P. M.D.; Oliva, Esther M.D.
doi : 10.1097/PGP.0000000000000903
AB Follicular dendritic cell sarcoma is a rare dendritic/histiocytic tumor of intermediate malignant potential, which often involves extranodal sites, most commonly the gastrointestinal tract and mediastinum with only 5 cases reported in the female genital tract.
Metastatic Cholangiocarcinoma to the Uterus Morphologically Imitating Primary Intestinal-type Endometrioid Adenocarcinoma.
Kostelecky, Nicolas M.D.; Ozhegov, Evgeny M.D., Ph.D.; Cao, Dengfeng M.D. Ph.D.; Krigman, Hannah M.D.
doi : 10.1097/PGP.0000000000000904
AB Cholangiocarcinoma is an uncommon and aggressive malignancy of intrahepatic and extrahepatic bile ducts. We present a case of a 37-year-old woman with cholangiocarcinoma metastatic to the endometrium that mimicked a primary endometrial adenocarcinoma at resection.
Molecular Evidence for Epithelial Origin of Mixed Ovarian Epithelial-Germ Cell Neoplasms: Report of 2 Cases and Review of Literature.
Hall, Katie C. M.D.; Post, Miriam D. M.D.; Alldredge, Jill M.D.; Aisner, Dara L. M.D., Ph.D.; Berning, Amber M.D.
doi : 10.1097/PGP.0000000000000913
AB Ovarian germ cell tumors (GCT) account for 2% to 3% of malignant ovarian neoplasms in Western countries and typically occur within the first 2 decades.
Clinicopathologic Review of Metastatic Breast Cancer to the Gynecologic Tract.
Braun, Ankica M.D.; Reddy, Swathi M.D.; Cheng, Lin M.D.; Gattuso, Paolo M.D.; Yan, Lei M.D.
doi : 10.1097/PGP.0000000000000920
AB Metastatic spread is the single most significant predictor of poor survival in breast cancer. Some of the most common metastatic sites are the bones, lungs, liver, brain, and peritoneal cavity.
DICER1-Altered Extraovarian Moderately Differentiated Sertoli-Leydig Cell Tumor: Report of a Rare Case.
Lau, Joseph C.C. M.B.B.S.; McCluggage, W. Glenn F.R.C.Path; Yuen, Liz Y.P. M.B.Ch.B.; Shing, Matthew M.K. M.B.B.S.; Chan, Godfrey C.F. M.D.; Yam, Felix S.D. M.B.B.S.; Leung, Michael W.Y. F.R.C.S.; Ng, Wai-Fu M.B.B.S.; Liu, Anthony P.Y. M.B.B.S.
doi : 10.1097/PGP.0000000000000902
AB We report an unusual case of a pelvic extraovarian moderately differentiated Sertoli-Leydig cell tumor arising in a 4-yr-old female. The tumor contained a DICER1 pathogenic variant which was absent in the germline ruling out DICER1 syndrome. In reporting this case, we discuss the differential diagnosis and possible histogenesis and review reported cases of extraovarian Sertoli-Leydig cell tumor.
Ovarian Malignant Mixed Germ Cell Tumor With Prominent Embryoid Bodies (Polyembryoma Background): A Case Report and Literature Review.
Sun, Yu M.D., Ph.D.; Liu-Jarin, Xiaolin M.D., Ph.D.; Hamele-Bena, Diane M.D.; Murty, Vundavalli V. Ph.D.; Clancy, Emily B.Sc.; Chen, Xiaowei M.D.
Somatic BAP1 Loss in Ovarian Serous Borderline Tumor and Recurrent Low-grade Serous Carcinoma From a Germline BAP1 Mutation Carrier.
Chui, M. Herman M.D., F.R.C.P.C.; Grisham, Rachel N. M.D.
