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CpG Methylation Levels in HPA Axis Genes Predict Chronic Pain Outcomes Following Trauma Exposure
Erica M. Branham,*,y,z Samuel A. McLean,*,y,x Ishani Deliwala,*,y Matthew C. Mauck,* ,y Ying Zhao,*,y Lauren A. McKibben,*,y Aaron Lee,*,y Alex B. Spencer,*,y Anthony S. Zannas,*,{,k, ** Megan Lechner,yy Teresa Danza,zz Marc-Anthony Velilla,xx Phyllis L. Hendry,{{ Claire Pearson,kk David A. Peak,*** Jeffrey Jones,yyy Niels K. Rathlev,zzz and Sarah D. Linnstaedt
doi : 10.1016/j.jpain.2023.03.001
Volume 24, Issue 7, July 2023, Pages 1127-1141
PD-1: A New Candidate Target for Analgesic Peptide Design
Long Zhao,* Yu Ma,y Xiaofei Song,y Yongjiang Wu,* Pengjie Jin,z and Gang Chen*
doi : 10.1016/j.jpain.2023.02.002
Volume 24, Issue 7, July 2023, Pages 1142-1150
Chronic pain is a common health problem in humans. The unique properties and valuable clinical applications of analgesic peptides make them attractive pharmacotherapy options for pain control.
Effect of Peripheral Magnetic Stimulation on Acute and Chronic Pain After Surgery: A Systematic Review and Meta-Analysis
Stephanie Park,* Rex Park,y Duncan Westwood,y,z Massieh Moayedi,x,{,k and James S. Khan
doi : 10.1016/j.jpain.2023.02.031
Volume 24, Issue 7, July 2023, Pages 1151-1162
Activation of Protease-Activated Receptor-1 Causes Chronic Pain in Lupus-Prone Mice Via Suppressing Spinal Glial Glutamate Transporter Function and Enhancing Glutamatergic Synaptic Activity
Fen Li,*,# Dongsheng Li,y,# Jianguang Liu,* Shifan Tang,y Jie Yan,z Hongwei Li,x Zhengyun Wan,x Lian Wang,x and Xisheng Yan
doi : 10.1016/j.jpain.2023.01.003
Volume 24, Issue 7, July 2023, Pages 1163-1180
Systemic lupus erythematosus (SLE) is an unpredictable autoimmune disease where the body's immune system mistakenly attacks healthy tissues in many parts of the body. Chronic pain is one of the most frequently reported symptoms among SLE patients.
The Impact of Varied Music Applications on Pain Perception and Situational Pain Catastrophizing
Carin A. Colebaugh,* Jenna M. Wilson,* K. Mikayla Flowers,* Demario Overstreet,* Dan Wang,y Robert R. Edwards,* Peter R. Chai,z,x,{,? and Kristin L. Schreiber*TaggedEnd
doi : 10.1016/j.jpain.2023.01.006
Volume 24, Issue 7, July 2023, Pages 1181-1192
We evaluated how pain processing and situational pain catastrophizing differed between 2 music interventions (Unwind and favorite music) and a control condition (white noise).
Positive Childhood Experiences and Chronic Pain Among Children and Adolescents in the United States
Sarah J. Pugh,* Caitlin Murray,* ,y and Cornelius B. Groenewald
doi : 10.1016/j.jpain.2023.02.001
Volume 24, Issue 7, July 2023, Pages 1193-1202
Positive childhood experiences (PCEs) are associated with better mental and physical health outcomes and moderate the negative effects of adverse childhood experiences (ACEs). However, knowledge of the associations between PCEs and childhood chronic pain is limited.
Fecal Microbiota Transplantation Revealed a Pain-related Gut Microbiota Community in Ovariectomized Mice
Renyuan Wang,*,1 Chang Jiang,y,1 Zhaoyi Wu,z,1 Zhe Wang,y Ying Peng,* Zhuoxuan Li,* Zhiyang Zhang,y Haodong Lin,* and Zixian Chen
doi : 10.1016/j.jpain.2023.02.003
Volume 24, Issue 7, July 2023, Pages 1203-1212
The Roles of Periaqueductal Gray and Dorsal Raphe Nucleus Dopaminergic Systems in the Mechanisms of Thermal Hypersensitivity and Depression in Mice
Xingfeng Liu,*,y,# Jingxin He,z,# Wei Jiang,z Song Wen,x and Zhi Xiao
doi : 10.1016/j.jpain.2023.02.004
Volume 24, Issue 7, July 2023, Pages 1213-1228
Depression and thermal hypersensitivity share pathogenic features and symptomology, but their pathophysiologic interactions have not been fully elucidated. Dopaminergic systems in the ventrolateral periaqueductal gray (vlPAG) and dorsal raphe nucleus have been implicated in these conditions due to their antinociception and antidepression effects, although their specific roles and underlying mechanisms remain obscure. In this study, chronic unpredictable mild stress (CMS) was used to induce depression-like behaviors and thermal hypersensitivity in C57BL/6J (wild-type) or dopamine transporter promoter mice to establish a mouse model of pain and depression comorbidity.
Acute Ostracism-Related Pain Sensitization in the Context of Accumulated Lifetime Experiences of Ostracism
N. Nanavaty,* ,a K.T. Walsh,* B.L. Boring,* A. Ganesan,*,b A.R. Carter-Sowell,*,y,c and V.A. Mathur*,
doi : 10.1016/j.jpain.2023.02.021
Volume 24, Issue 7, July 2023, Pages 1229-1239
Ostracism (ie, being ignored/excluded) is a form of social adversity that powerfully impacts health and well-being. While laboratory research indicates that experimentally manipulated experiences of ostracism impact pain, findings have been mixed.
Patient and Family Opioid Decision-Making for Pain Management in Sickle Cell Disease: A Qualitative Study
Shannon Phillips,* Alyssa M. Schlenz,y,z,2 Shannon D’Alton,* Mary Johnson,y and Julie Kanter
doi : 10.1016/j.jpain.2023.02.022
Volume 24, Issue 7, July 2023, Pages 1240-1250
Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study
Ojasvi Mehta,* ,y Amrita Vijay,*,y Sameer A. Gohir,*,y Tony Kelly,* Weiya Zhang,*,x Michael Doherty,*,x David A. Walsh,*,x Guruprasad Aithal,y,z and Ana. M. Valdes
doi : 10.1016/j.jpain.2023.02.023
Volume 24, Issue 7, July 2023, Pages 1251-1261
Osteoarthritis (OA) is the most common arthritis affecting synovial joints such as knees and hips of millions of people globally. Usage-related joint pain and reduced function are the most common symptoms experienced by people with OA. To improve pain management, there is a need to identify validated biomarkers predicting therapeutic responses in targeted clinical trials.
Mechanical and Heat Hyperalgesia upon Withdrawal From Chronic Intermittent Ethanol Vapor Depends on Sex, Exposure Duration, and Blood Alcohol Concentration in Mice
Adam J. Brandner,*,y,z,x,1 Annalisa M. Baratta,*,y,1 Richa S. Rathod,z Carolyn Ferguson,z Bradley K. Taylor,*,y,z,x,2 and Sean P. Farris
doi : 10.1016/j.jpain.2023.02.024
Volume 24, Issue 7, July 2023, Pages 1262-1274
Approximately half of patients with alcohol use disorder report pain and this can be severe during withdrawal. Many questions remain regarding the importance of biological sex, alcohol exposure paradigm, and stimulus modality to the severity of alcohol withdrawal-induced hyperalgesia.
Distress and Resilience Narratives within Pain Memories of Adolescents and Young Adults with Complex Regional Pain Syndrome: A Multi-Method Study
Emy Nimbley,MSc*,y,1 Line Caes,PhDz Melanie Noel,PhDx and Abbie Jordan,PhD*,
doi : 10.1016/j.jpain.2023.02.025
Volume 24, Issue 7, July 2023, Pages 1275-1287
A comprehensive understanding of pain memories requires consideration of risk and resilience factors across biopsychosocial domains. Previous research has typically focused on pain-related outcomes, largely ignoring the nature and context of pain memories. Using a multiple-method approach, this study explores the content and context of pain memories in adolescents and young adults with complex regional pain syndrome (CRPS).
Changes in Brain GABA and Glutamate and Improvements in Physical Functioning Following Intensive Pain Rehabilitation in Youth With Chronic Pain
Taylor Pigott,BSc*,y, ** Allison McPeak,MPHx Amanda de Chastelain,BSc, PT, MKin # Marilena M DeMayo,PhD{, ** ,yy,zz,xx Nivez Rasic,MD, FRCPCz,#,zz Laura Rayner,RN, MNz,# Melanie Noel,PhDy,z,#, ** ,yy,zz,xx Jillian Vinall Miller,PhDy,z,#, **,yy,zz,xx,1 and Ashley D Harris, PhD
doi : 10.1016/j.jpain.2023.02.027
Volume 24, Issue 7, July 2023, Pages 1288-1297
Spinal Cord Stimulation for Failed Back Surgery Syndrome: to Trial or Not to Trial?
Richard L. Witkam,*,y Elisabeth A.M. Kragt,*, # Inge J.J. Arnts,*,# Ewald M. Bronkhorst,z Robert van Dongen,* Erkan Kurt,y Monique A.H. Steegers,x Frank G.A.M. van Haren,* Natasja J.G. Maandag,{ Cees Gort,{ Dylan J.H.A. Henssen,k Jessica T. Wegener,{ and Kris C.P. Vissers
doi : 10.1016/j.jpain.2023.02.032
Volume 24, Issue 7, July 2023, Pages 1298-1306
Neurocognitive Mechanisms Underlying Attention Bias Towards Pain: Evidence From a Drift-Diffusion Model and Event-Related Potentials
Yinhua Zhang,*,1 Qian Ye,*,1 Hao He,* Richu Jin,y,z and Weiwei Peng
doi : 10.1016/j.jpain.2023.03.003
Volume 24, Issue 7, July 2023, Pages 1307-1320
