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Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy.
Chan, Matilda F. MD, PhD *,+; Pan, Peipei PhD ++; Wolfreys, Finn D. MS, DPhil *
doi : 10.1097/ICO.0000000000003292
Volume 42(8) pgs. 929-1061,e15-e16 August 2023
AB Major advances in genomics have dramatically increased our understanding of Fuchs endothelial corneal dystrophy (FECD) and identified diverse genetic causes and associations. Biomarkers derived from these studies have the potential to inform both clinical treatment and yield novel therapeutics for this corneal dystrophy. Copyright (C) 2023 Wolters Kluwer Health, Inc. All rights reserved.
Rate of Endothelial Cell Loss and Graft Survival in Descemet Membrane Endothelial Keratoplasty in Eyes Requiring a Rebubble.
Tapley, Jeffrey L. MD *; Hill, Jordan R. MD +; Bauer, Alex J. BS ++; Straiko, Megan M. W. PhD ++; Straiko, Michael D. MD +; Terry, Mark A. MD +
doi : 10.1097/ICO.0000000000003118
We aimed to compare the rate of 6-month endothelial cell loss (ECL) and 6-month graft survival in eyes that did not require a postoperative rebubble with eyes that did require a postoperative rebubble after Descemet membrane endothelial keratoplasty (DMEK) surgery.
Influence of Descemet Membrane Endothelial Keratoplasty Graft Preparation Patterns on Postoperative Clinical Outcome.
Schrittenlocher, Silvia MD *; Matthaei, Mario MD *; Rokohl, Alexander C. MD *; Franklin, Jeremy +; Bachmann, Bjorn MD *; Cursiefen, Claus MD *,++
doi : 10.1097/ICO.0000000000003141
The aim of this study was to quantify preparation difficulties and complications during DMEK graft preparation and their influence on clinical outcome.
Clinical and Microbiological Spectra and Therapeutic Outcomes of Polymicrobial Keratitis.
Rathi, Anubha MD *; Ramazanova, Khuraman MD *; Murthy, Somasheila I. MD *; Mohamed, Ashik MBBS MTech, PhD, MAMS +; Joseph, Joveeta PhD ++,[S]; Doctor, Mariya Bashir DNB *; Pandey, Suchita MSc ++; Rathi, Varsha M. MD *
doi : 10.1097/ICO.0000000000003107
The aim of this study was to evaluate the risk factors, microbiology, and treatment outcomes of polymicrobial keratitis (PMK). Methods: We retrospectively analyzed 65 patients diagnosed with PMK between 2016 and 2019.
Descemet Membrane Endothelial Keratoplasty-Induced Refractive Shift and Descemet Membrane Endothelial Keratoplasty-Induced Intraocular Lens Calculation Error.
Debellemaniere, Guillaume MD; Ghazal, Wassim MD; Dubois, Mathieu MD; Rampat, Radhika MD; Fabre, Laura MD; Panthier, Christophe MD; Courtin, Romain MD; Mazharian, Adrien MD; Zeboulon, Pierre MD; Rouger, Helene PhD; Saad, Alain MD; Gatinel, Damien MD, PhD
doi : 10.1097/ICO.0000000000003100
The aim of this study was to determine the mechanisms leading to the refractive shift and intraocular lens calculation error induced by Descemet membrane endothelial keratoplasty (DMEK), using ocular biometry and corneal elevation tomography data.
Intrastromal Corneal Ring Segments Implantation After Deep Anterior Lamellar Keratoplasty for Astigmatism Correction: Mid-term and Long-term Follow-up.
Alfonso-Bartolozzi, Belen MD *; Fernandez-Vega-Cueto, Luis MD, PhD *; Poo-Lopez, Aranzazu BSc *; Lisa, Carlos MD, PhD *; Madrid-Costa, David PhD +; Alfonso, Jose F. MD, PhD *
doi : 10.1097/ICO.0000000000003110
The aim of this study was to assess the long-term outcomes of implanting intrastromal corneal ring segments (ICRSs) using a femtosecond laser for correcting astigmatism in patients who had previous deep anterior lamellar keratoplasty (DALK) throughout a 5-year follow-up period.
Impact of Fuchs Endothelial Corneal Dystrophy Severity on Scheimpflug-Derived Parameters After Descemet Membrane Endothelial Keratoplasty.
Voncken Santana, Stefanie BOptom *,+; Vasiliauskaite, Indre MSc *,++; van Dijk, Korine PhD *,++; van Tilborg, Mirjam PhD +; Melles, Gerrit R. J. MD, PhD *,++; Kocaba, Viridiana MD, PhD *,++,[S]; Oellerich, Silke PhD *
doi : 10.1097/ICO.0000000000003115
The aim of this study was to evaluate how Scheimpflug-derived parameters of eyes with Fuchs endothelial corneal dystrophy (FECD) are influenced by Descemet membrane endothelial keratoplasty (DMEK) depending on FECD severity and the presence of subclinical edema.
Descemet Stripping Without Endothelial Keratoplasty in Early-Stage Central Fuchs Endothelial Dystrophy: Long-term Results.
Vieira, Rita MD; Castro, Catarina MD; Coelho, Joao MD; Mesquita Neves, Miguel MD; Gomes, Miguel MD; Oliveira, Luis MD
doi : 10.1097/ICO.0000000000003131
The purpose of this study was to report long-term results of Descemet stripping without endothelial keratoplasty (DWEK) associated with phacoemulsification in patients with early-stage central Fuchs endothelial corneal dystrophy.
Descemet Membrane Endothelial Keratoplasty and Triple Descemet Membrane Endothelial Keratoplasty in Eyes With Macular Comorbidity.
Steindor, Friedrich A.; Bu[Combining Diaeresis]chau, Till M.; Borgardts, Klara Charlotte; Borrelli, Maria; Guthoff, Rainer; Geerling, Gerd; Spaniol, Kristina
doi : 10.1097/ICO.0000000000003113
The aim of this study was to evaluate results after Descemet membrane endothelial keratoplasty (DMEK) and DMEK with cataract surgery (triple DMEK) in eyes with endothelial dysfunction and concomitant macular pathology.
Changes in Corneal Clouding Over Time in Patients With Mucopolysaccharidosis.
McGrath, Orlaith MB, BCh, BAO *,+; Sornalingam, Krishanthy MBBS, MD *,+; Aslam, Tariq MB, ChB, FRCSEd (Ophth), DIp.IT, MA (Oxon), DM (Oxon), PhD *,+; Ashworth, Jane BMCh, FRCOphth, PhD *,+
doi : 10.1097/ICO.0000000000003214
Mucopolysaccharidoses (MPSs) are a rare group of lysosomal storage disorders characterized by the accumulation of incompletely degraded glycosaminoglycans (GAGs) in multiple organ systems, including the eye.
Healing of Chemical Injury-Related Persistent Corneal Epithelial Defects With Topical Insulin.
Balal, Shafi *,+; Din, Nizar *; Ashton, Christopher *; Ahmad, Sajjad *
doi : 10.1097/ICO.0000000000003145
The purpose of this study was to evaluate the effectiveness of insulin eye drops for treating refractory persistent epithelial defects (PEDs). Methods: A prospective, single-center, case series was performed from March 2020 to September 2021.
IDO Regulates Macrophage Functions by Inhibiting the CCL2/CCR2 Signaling Pathway in Fungal Keratitis.
Yu, Feifei MD *,+; Jiang, Wei MD *; Zhang, Li MD ++; Jiang, Nan MD, PhD *
doi : 10.1097/ICO.0000000000003309
The aim of this study was to investigate the effects of indoleamine 2,3-dioxygenase (IDO) on macrophage polarization, phagocytosis, and killing through regulation of the CCL2/CCR2 signaling pathway in Aspergillus fumigatus keratitis.
Trends and Surgeon Variations in Early Regrafts After Endothelial Keratoplasty: Analysis of the National Medicare Data Set.
Huh, Dana D. BA *; Dun, Chen MHS +; Fliotsos, Michael J. MD *; Jeng, Bennie H. MD, MS ++; Stoeger, Christopher G. CEBT, MBA [S]; Makary, Martin MD, MPH +; Woreta, Fasika A. MD, MPH *; Wolle, Meraf MD, MPH *; Srikumaran, Divya MD *
doi : 10.1097/ICO.0000000000003252
The aims of this study were to determine national-level trends in early regraft rates and examine patient-level and surgeon-level characteristics associated with early regrafts.
An International External Quality Assessment Scheme to Assess the Diagnostic Performance of Polymerase Chain Reaction Detection of Acanthamoeba Keratitis.
Sarink, Maarten J. MD *; Koelewijn, Rob BSc *; Stelma, Foekje MD, PhD +; Kortbeek, Titia MD ++; van Lieshout, Lisette MD, PhD [S]; Smit, Pieter W. PhD [P]; Tielens, Aloysius G. M. PhD *; van Hellemond, Jaap J. PhD *
doi : 10.1097/ICO.0000000000003275
The purpose of this study was to assess the variation in methods and to determine whether an External Quality Assessment Scheme (EQAS) for polymerase chain reaction (PCR) detection of Acanthamoeba keratitis is valuable for the diagnostic process.
Use of Ethylenediaminetetraacetic Acid in Chronic Calcium-Based Chemical Injury.
Arora, Anchal MS *; Sahu, Srikant Kumar MS *; Muni, Ipsita MS *; Sharma, Aakash MS *
doi : 10.1097/ICO.0000000000003203
This study presents the successful management of a patient with chronic chemical-based injury using ethylenediaminetetraacetic acid (EDTA) chelation.
Recurrence of Guttae and Endothelial Dysfunction After Successful Descemet Stripping Only in Fuchs Dystrophy.
Kaufman, Aaron R. MD *,+; Bal, Sila MD, MPH *; Boakye, Jeffrey BS *,+,++; Jurkunas, Ula V. MD *,+
doi : 10.1097/ICO.0000000000003221
There are limited data about long-term durability of endothelial rejuvenation after Descemet stripping only (DSO). This study reports a case of bilaterally recurrent endothelial dysfunction and guttae formation after initially successful DSO in combination with cataract extraction (DSO-CE).
Repeated Intracameral Amphotericin B: A Safe Approach for Management of Fungal Anterior Chamber Reactivations After Therapeutic Penetrating Keratoplasty.
Okonkwo, Arthur MBBS, MRes(Transplant), PgCert(MedEd), PgDip(CRS), FRCOphth, CertLRS *,+; Sethi, Kavita MBBS, MD(Microbiol), DTM&HFRCPath *; Anand, Seema MBBS, MS(Ophth), DNB, FRCSEd(Ophth), FRCOphth, PgDip(CRS), CertLRS *
doi : 10.1097/ICO.0000000000003268
The aim of this study was to describe the safe use of repeated intracameral amphotericin B for anterior chamber reactivations after therapeutic penetrating keratoplasty for Fusarium solani keratitis.
Spontaneous Descemet Layer Dissection Without Pneumodissection in Femtosecond Laser-Assisted Mushroom-Type Deep Anterior Lamellar Keratoplasty.
Montolio-Marzo, Elena MD; Diaz-Valle, David PhD; Burgos-Blasco, Barbara PhD; Etxabe, Haizea MD; Gegundez-Fernandez, Jose Antonio PhD
doi : 10.1097/ICO.0000000000003232
The aim of this study was to describe a case of spontaneous Descemet layer dissection without pneumodissection in femtosecond laser-assisted mushroom-type deep anterior lamellar keratoplasty.
Anterior Segment Swept Source Optical Coherence Tomography and In Vivo Confocal Microscopy Findings in a Case With Bleb-Like Epithelial Basal Membrane Dystrophy.
Eker, Serhat MD, FEBO; Oflaz, Ayse Bozkurt MD; Bozkurt, Banu MD, FEBO
doi : 10.1097/ICO.0000000000003241
The aim of this study was to evaluate the anterior segment swept source optical coherence tomography (SS-OCT) and in vivo confocal microscopy (IVCM) features in a patient with bleb-like epithelial basement membrane dystrophy (EBMD).
Double-Docking Technique for Femtosecond Laser-Assisted Deep Anterior Lamellar Keratoplasty: A Retrospective Consecutive Case Series Study of Advanced Keratoconus.
Gabison, Eric E. MD PhD *; Gree, Eva MD *; Azar, Georges MD *; Cochereau, Isabelle MD PhD *,+,++; Guindolet, Damien MD PhD *,+,++
doi : 10.1097/ICO.0000000000003300
The aim of this study was to report the clinical outcomes and prognosis of femtosecond laser (FSL)-assisted double-docking deep anterior lamellar keratoplasty (DD-DALK) for advanced keratoconus (AK).
High Astigmatism After Conventional Diameter Deep Anterior Lamellar Keratoplasty in Keratoconus Can Be Successfully Managed With Repeat Wide Diameter Deep Anterior Lamellar Keratoplasty.
Panthagani, Jesse BSc, MBBS, MRCS, FEBO, FRCOphth *; Law, Elizabeth M. PhD, MCOptom *; Chipeta, Chimwemwe BSc, MBBS *; Roberts, Harry MSc, MD, FRCOphth +; Myerscough, James MBBS, FRCOphth *,++
Letter Regarding: Establishing a Biomarker for the Prediction of Short-Term Graft Detachment After Descemet Membrane Endothelial Keratoplasty.
Coco, Giulia *; Kaye, Stephen B. +; Romano, Vito ++,[S]
