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Frontotemporal Degeneration with Transactive Response DNA-Binding Protein Type C at the Anterior Temporal Lobe
Marek-Marsel Mesulam MD, Tamar Gefen PhD, Margaret Flanagan MD, Rudolph Castellani MD, Pouya Jamshidi MD, Elena Barbieri PhD, Jaiashre Sridhar MA, Allegra Kawles BA, Sandra Weintraub PhD, Changiz Geula PhD, Emily Rogalski PhD
doi : 10.1002/ana.26677
The anatomical distribution of most neurodegenerative diseases shows considerable interindividual variations. In contrast, frontotemporal lobar degeneration with transactive response DNA-binding protein type C (TDP-C) shows a consistent predilection for the anterior temporal lobe (ATL).
Educational Attainment and Dementia: Mediation by Mid-Life Vascular Risk Factors
Chelsea Liu PhD, Yuan Ma MD, PhD, Albert Hofman MD, PhD, Reem Waziry MBBCh, MPH, PhD, Silvia Koton PhD, James R. Pike MBA, B. Gwen Windham MD, MHS, Melinda C. Power ScD, A. Richey Sharrett MD, Rebecca F. Gottesman MD, PhD
doi : 10.1002/ana.26647
Lower education is associated with higher burden of vascular risk factors in mid-life and higher risk of dementia in late life. We aim to understand the causal mechanism through which vascular risk factors potentially mediate the relationship between education and dementia.
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS
Brendan P. Lucey MD, MSCI, Haiyan Liu MD, Cristina D. Toedebusch BS, David Freund, Tiara Redrick MS, Samir L. Chahin MS, Kwasi G. Mawuenyega PhD, James G. Bollinger PhD, Vitaliy Ovod MS, Nicolas R. Barthélemy PhD, Randall J. Bateman MD
doi : 10.1002/ana.26641
In Alzheimer's disease, hyperphosphorylated tau is associated with formation of insoluble paired helical filaments that aggregate as neurofibrillary tau tangles and are associated with neuronal loss and cognitive symptoms.
Emerging Management Challenges Posed by Atrial Fibrillation Detected After Stroke
Shadi Yaghi MD, Lee Schwamm MD
doi : 10.1002/ana.26663
Atrial Fibrillation Detected before or after Stroke: Role of Anticoagulation
Flurina Lyrer MMed, Annaelle Zietz MMed, David J. Seiffge MD, Masatoshi Koga MD, PhD, Bastian Volbers MD, Duncan Wilson MD, PhD, Bruno Bonetti MD, PhD, Sabine Schaedelin MSc, Henrik Gensicke MD, Sohei Yoshimura MD, PhD, Kosmas Macha MD, Gareth Ambler PhD, Sebastian Thilemann MMed, Tolga Dittrich MD, Manabu Inoue MD, PhD, Kaori Miwa MD, PhD, Ruihao Wang MD, Gabriela Siedler MD, Luise Biburger MD, Martin M. Brown MD, PhD, Rolf H. Jäger MD, Keith Muir MD, Christopher Traenka MD, Kanta Tanaka MD, PhD, Masayuki Shiozawa MD, Leo H. Bonati MD, Nils Peters MD, Gregory Y. H. Lip MD, Philippe A. Lyrer MD, Manuel Cappellari MD, Kazunori Toyoda MD, PhD, Bernd Kallmünzer MD, Stefan Schwab MD, David J. Werring MD, PhD, Stefan T. Engelter MD, Gian Marco De Marchis MD, MSc, Alexandros A. Polymeris MD, PhD, for the NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, SAMURAI-NVAF and Verona Registry collaborators
doi : 10.1002/ana.26654
Atrial fibrillation (AF) known before ischemic stroke (KAF) has been postulated to be an independent category with a recurrence risk higher than that of AF detected after stroke (AFDAS). However, it is unknown whether this risk difference is confounded by pre-existing anticoagulation, which is most common in KAF and also indicates a high ischemic stroke recurrence risk.
Real-World Outcomes of Endovascular Thrombectomy for Basilar Artery Occlusion: Results of the BArONIS Study
Alis J. Dicpinigaitis BA, Rosalind Dick-Godfrey BS, Olivia Gellerson BS, Steven D. Shapiro MD, Haris Kamal MD, Sherief Ghozy MD, Gurmeen Kaur MD, Shashvat M. Desai MD, Santiago Ortega-Gutierrez MD, Shadi Yaghi MD, David J. Altschul MD, Ashutosh P. Jadhav MD, PhD, Ameer E. Hassan DO, Thanh N. Nguyen MD, Allan L. Brook MD, Stephan A. Mayer MD, Tudor G. Jovin MD, Raul G. Nogueira MD, Chirag D. Gandhi MD, Fawaz Al-Mufti MD
doi : 10.1002/ana.26640
To evaluate clinical outcomes of endovascular thrombectomy (EVT) for acute basilar artery occlusion (BAO) using population-level data from the United States.
Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation
Yannie Soo MB, ChB, Annaelle Zietz MMed, Brian Yiu BBA, Vincent C. T. Mok MD, Alexandros A. Polymeris MD, PhD, David Seiffge MD, Gareth Ambler PhD, Duncan Wilson MD, PhD, Thomas Wai Hong Leung MD, Suk Fung Tsang MPhil, Winnie Chu MD, Jill Abrigo MD, Cyrus Cheng MB, ChB, Keon-Joo Lee MD, Jae-Sung Lim MD, Masayuki Shiozawa MD,Â
doi : 10.1002/ana.26642
Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate the risks of intracranial hemorrhage and ischemic stroke associated with microbleeds in patients with atrial fibrillation treated with vitamin K antagonists, direct oral anticoagulants, antiplatelets, and combination therapy (i.e. concurrent oral anticoagulant and antiplatelet).
Cytokines in New-Onset Refractory Status Epilepticus Predict Outcomes
Aurélie Hanin PharmD, PhD, Jorge Cespedes MD, Karim Dorgham PhD, Yashwanth Pulluru MD, Margaret Gopaul PhD, MSCP, Guy Gorochov MD, PhD, David A. Hafler MD, Vincent Navarro MD, PhD, Nicolas Gaspard MD, PhD, Lawrence J. Hirsch MD
doi : 10.1002/ana.26627
The objective of this study was to investigate inflammation using cerebrospinal fluid (CSF) and serum cytokines/chemokines in patients with new-onset refractory status epilepticus (NORSE) to better understand the pathophysiology of NORSE and its consequences.
CRISPR-Based KCC2 Upregulation Attenuates Drug-Resistant Seizure in Mouse Models of Epilepsy
Jiaying Shi PhD, Huhu Xin PhD, Yuying Shao MD, Sijie Dai MD, Na Tan PhD, Zhisheng Li PhD, Fan Fei PhD, Di Wu PhD, Yi Wang PhD, Yuan Ping PhD, Zhong Chen PhD
doi : 10.1002/ana.26656
The precise intervention of K-Cl cotransporter isoform 2 (KCC2) as a promising target for drug-resistant epilepsy remains elusive.
Selective Neuronal Knockout of STAT3 Function Inhibits Epilepsy Progression, Improves Cognition, and Restores Dysregulated Gene Networks in a Temporal Lobe Epilepsy Model
Allison E. Tipton, Yasmin Cruz Del Angel, Kathryn Hixson, Jessica Carlsen, Dana Strode, Nicolas Busquet, Michael H. Mesches, Marco I. Gonzalez, Eleonora Napoli, Shelley J. Russek, Amy R. Brooks-Kayal
doi : 10.1002/ana.26644
Temporal lobe epilepsy (TLE) is a progressive disorder mediated by pathological changes in molecular cascades and hippocampal neural circuit remodeling that results in spontaneous seizures and cognitive dysfunction. Targeting these cascades may provide disease-modifying treatments for TLE patients.
Differences in Survival across Monogenic Forms of Parkinson's Disease
Aymeric Lanore MD, Fanny Casse MSc, Christelle Tesson PhD, Thomas Courtin MD, Poornima Jayadev Menon MD, Sara Sambin MD, PhD, Graziella Mangone MD, PhD, Louise-Laure Mariani MD, PhD, Suzanne Lesage PhD, Alexis Brice MD, Alexis Elbaz MD, PhD, Jean-Christophe Corvol MD, PhD, for the French Clinicians Network for Parkinson's Disease Genetics (the PDG Group)
doi : 10.1002/ana.26636
Survival of patients with monogenic Parkinson's disease may depend on the causative genes associated with the disease. In this study, we compare survival of patients with Parkinson's disease according to the presence of SNCA, PRKN, LRRK2, or GBA mutations.
Network Architecture of Verticality Processing in the Human Thalamus
Julian Conrad MD, Bernhard Baier MD, Laurenz Eberle MD, Ria Maxine Ruehl MD, Rainer Boegle PhD, Andreas Zwergal MD, Marianne Dieterich MD
doi : 10.1002/ana.26652
Thalamic dysfunction in lesions or neurodegeneration may alter verticality perception and lead to postural imbalance and falls. The aim of the current study was to delineate the structural and functional connectivity network architecture of the vestibular representations in the thalamus by multimodal magnetic resonance imaging.
Neurologic Manifestations of Long COVID Differ Based on Acute COVID-19 Severity
Gina S. Perez Giraldo MD, Sareen T. Ali BS, Anthony K. Kang BA, Tulsi R. Patel BA, Shreya Budhiraja BA, Jordan I. Gaelen BA, Grace K. Lank BS, Jeffrey R. Clark BA, Shreya Mukherjee BA, Tracey Singer BS, Aditi Venkatesh BS, Zachary S. Orban BS, Patrick H. Lim MS, Millenia Jimenez BS, Janet Miller BS, Carolyn Taylor APRN, April L Szymanski APRN, Jessica Scarpelli DNP, Edith L. Graham MD, Roumen D. Balabanov MD, Bianca E. Barcelo MD, Joshua G. Cahan MD, Kaitlyn Ruckman APRN, Alan G. Shepard MD, Marc W. Slutzky MD, Kathrin LaFaver MD, Priya U. Kumthekar MD, Neil K. Shetty MD, Katherine S. Carroll MD, Sam U. Ho MD, Rimas V. Lukas MD, Ayush Batra MD, Eric M. Liotta MD, Igor J. Koralnik MD
doi : 10.1002/ana.26649
To characterize neurologic manifestations in post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients.
Congenital Lumbosacral Malformations with Low-Grade Neuroepithelial Tumor Causing Progressive Postpoliomyelitis Paralytic Limb
Changjun Chen MD, Yanjun Ren MD, Yubin Qi MD, Guihui Zhang MD, Hongguang Hu MD, Kaining Zhang MD, Yingguang Wu MD, Yun Yang MD
doi : 10.1002/ana.26667
Astrocyte-Derived Exosomes Contribute to Pathologies of Neuromyelitis Optica Spectrum Disorder in Rodent Model
Yi Xie MD, PhD, Bo Chen MD, PhD, Qiong Wang MD, PhD, Xuejiao Chen BS, Wenwen Lai MS, Yaping Xu MS, Saiyue Deng BS, Zhiyuan Yu PhD, Minjie Xie PhD, Bitao Bu MD, PhD, Dapeng Mou MD, PhD, Chenju Yi MD, PhD, Fengfei Ding MD, Wei Wang MD, PhD
doi : 10.1002/ana.26650
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that leads to severe disability. A large proportion of NMOSD patients are seropositive for aquaporin-4 autoantibodies (AQP4-IgG, named as NMO-IgG) targeting AQP4, which is selectively expressed on astrocytes in the central nervous system. This study tests the hypothesis that in response to NMO-IgG, the pathogenic astrocyte-derived exosomes are released and injure the neighboring cells.
Choroid Plexus Enlargement Exacerbates White Matter Hyperintensity Growth through Glymphatic Impairment
Yifei Li MD, Ying Zhou PhD, Wansi Zhong MD, Xiao Zhu MD, Yuping Chen MD, Kemeng Zhang MD, Yaode He MD, Zhongyu Luo PhD, Wang Ran MD, Jianzhong Sun MD, Min Lou MD, PhD
doi : 10.1002/ana.26648
Choroid plexus (CP) is a key regulator in cerebrospinal fluid production, but its contribution to glymphatic clearance function and association with white matter hyperintensity (WMH) remains unclear.
A Deep Learning Framework for Deriving Noninvasive Intracranial Pressure Waveforms from Transcranial Doppler
Murad Megjhani PhD, Kalijah Terilli BA, Bennett Weinerman MD, Daniel Nametz BS, Soon Bin Kwon PhD, Angela Velazquez MD, Shivani Ghoshal MD, David J. Roh MD, Sachin Agarwal MD, MPH, E. Sander Connolly Jr MD, Jan Claassen MD, Soojin Park MD
doi : 10.1002/ana.26682
Increased intracranial pressure (ICP) causes disability and mortality in the neurointensive care population. Current methods for monitoring ICP are invasive. We designed a deep learning framework using a domain adversarial neural network to estimate noninvasive ICP, from blood pressure, electrocardiogram, and cerebral blood flow velocity.
A Carotid Web with Atherosclerotic Plaque
Ravinder-Jeet Singh MBBS, DM, Bijoy K. Menon MD, FRCPC
doi : 10.1002/ana.26683
Reply to “the Letter on A Carotid Web with Atherosclerotic Plaque�
Hui Zhang MD, Jian Deng MD, Yitao He MD, PhD
doi : 10.1002/ana.26680
Decreased Cerebrospinal Fluid Amyloid Beta 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy
Gregor Kuhlenbäumer MD, PhD, Ulf Jensen-Kondering MD, Nils G. Margraf MPsych, MD
doi : 10.1002/ana.26671
Reply to "Decreased Cerebrospinal Fluid Amyloid Beta 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy"
Anna M. de Kort MD, H. Bea Kuiperij PhD, Floris H. B. M. Schreuder MD, PhD, Catharina J. M. Klijn MD, PhD, Marcel M. Verbeek PhD
doi : 10.1002/ana.26666
Correction: Decreased Cerebrospinal Fluid Amyloid β 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy
Anna M. De Kort MD, H. Bea Kuiperij PhD, Tainá M. Marques PhD, Lieke Jäkel PhD, Emma van den Berg MSc, Iris Kersten BSc, Hugo E.P. van Berckel-Smit MD, Marco Duering MD, PhD, Erik Stoops MSc, Wilson F. Abdo MD, PhD, Ingeborg Rasing MD, Sabine Voigt MSc, Emma A. Koemans MD, Kanishk Kaushik, Andrew Davock Warren BSc, Steven M. Greenberg MD, PhD, Gunnar Brinkmalm PhD, Gisela M. Terwindt MD, PhD, Marieke J.H. Wermer MD, PhD, Floris H.B.M. Schreuder MD, PhD, Catharina J.M. Klijn MD, PhD, Marcel M. Verbeek PhD
doi : 10.1002/ana.26675
